Combined visual and quantitative assessment of somatostatin receptor scintigraphy for staging and restaging of neuroendocrine tumors
ConclusionWe adapted the SUV to SRS and established the range of SUV for physiological uptake in the liver, kidney, and spleen. Combined visual and quantitative assessment is useful for imaging individual lesions in greater detail, and may serve as a new tumor marker of SRS for staging and restaging of NETs. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - May 1, 2024 Category: Radiology Source Type: research
Systematic training of LI-RADS CT v2018 improves interobserver agreements and performances in LR categorization for focal liver lesions
ConclusionSystematic training in the use of the LI-RADS can improve the interobserver agreements and performances in LR categorization for FLLs among radiologists with different levels of experience. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - May 1, 2024 Category: Radiology Source Type: research
Clinical value of [18F]AlF-NOTA-FAPI-04 PET/CT for assessing early-stage liver fibrosis in adult liver transplantation recipients compared with chronic HBV patients
Conclusion[18F]AlF-NOTA-FAPI-04 PET/CT could be applied to evaluate early-stage liver fibrosis in LT recipients and CHB patients properly, with the potential additional advantages in monitoring and predicting complications after LT. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - May 1, 2024 Category: Radiology Source Type: research
Pleural Port-A-Cath for Symptomatic Refractory Hepatic Hydrothorax in Nontransplant Liver Patients
Annals of the American Thoracic Society,Volume 21, Issue 5, Page 823-826, May 2024. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - May 1, 2024 Category: Respiratory Medicine Authors: Khaled Alshabani Estefania Rivera Alichia Paton Juan Camilo Lara Sebastian Fernandez-Bussy Adnan Majid Source Type: research
Mendelian randomization analyses reveal causal relationship between liver volume and stroke
This study aims to utilize Mendelian randomization (MR) to explore the genetic causal relationship between them. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 1, 2024 Category: Neurology Authors: Changyun Zhang, YuQiu Li, Chuanzhu Yan, Huijuan Yu, Xin Zhang Source Type: research
Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [68Ga]Ga-ABY-025: Results from a Pilot Study
Conclusion: The visualization of HER2-low mBC with [68Ga]Ga-ABY-025 PET/CT was feasible and safe. Areas of tracer uptake showed varying levels of HER2 expression on IHC. The observed intra- and interindividual heterogeneity in [68Ga]Ga-ABY-025 uptake suggested that HER2 PET might be used as a tool for the noninvasive assessment of disease heterogeneity and has the potential to identify patients in whom HER2-targeted drugs can have a clinical benefit. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Altena, R., Buren, S. a., Blomgren, A., Karlsson, E., Tzortzakakis, A., Brun, N., Moein, M. M., Jussing, E., Frejd, F. Y., Bergh, J., Tran, T. A., Hartman, J., Axelsson, R. Tags: Clinical Investigations Source Type: research
First-in-Human Safety, Imaging, and Dosimetry of a Carbonic Anhydrase IX-Targeting Peptide, [68Ga]Ga-DPI-4452, in Patients with Clear Cell Renal Cell Carcinoma
Conclusion: [68Ga]Ga-DPI-4452 showed exceptional tumor uptake in patients with clear cell renal cell carcinoma, with very high tumor-to-background ratios and no significant adverse events, suggesting potential diagnostic and patient selection applications. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Hofman, M. S., Tran, B., Feldman, D. R., Pokorska-Bocci, A., Pichereau, S., Wessen, J., Haskali, M. B., Sparks, R. B., Vlasyuk, O., Galetic, I. Tags: FEATURED ARTICLE OF THE MONTH Source Type: research
MIRD Pamphlet No. 29: MIRDy90--A 90Y Research Microsphere Dosimetry Tool
90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compart...
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Marquis, H., Ocampo Ramos, J. C., Carter, L. M., Zanzonico, P., Bolch, W. E., Laforest, R., Kesner, A. L., MIRD committee Tags: Basic Science Investigations Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
This study offers new understanding of stress’s role in cancer progression and potential targets for HCC treatment. The scientists concluded that more research is required to fully comprehend these results for future cancer therapies.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Experimental & Molecular Medicine, Published online: 01 May 2024; doi:10.1038/s12276-024-01224-zFor many years, scientists have been investigating the complex world of miRNAs. These tiny molecules can bind to target mRNAs, influencing translation and broadly affecting gene expression. This review delves into the intricate processes that modulate the biogenesis and degradation/trimming of miRNAs, with a focus on RNA-binding proteins (RBPs) and exoribonucleases. The review also underscores the importance of these miRNA modulators in the proliferation of the hepatitis C virus (HCV), which can chronically lead to liver can...
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Yoona Seo Jiho Rhim Jong Heon Kim Source Type: research
Long-term remnant liver volume dynamics after major hepatectomy for perihilar cholangiocarcinoma following portal vein embolization
CONCLUSION: Although the long-term LRV was nearly equal in both groups, short-term LRV hypertrophy was lower in the PVE group than in the non-PVE group.PMID:38688761 | DOI:10.1016/j.asjsur.2024.04.029 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 30, 2024 Category: Surgery Authors: Shiori Yamazaki Akira Shimizu Koji Kubota Tsuyoshi Notake Noriyuki Kitagawa Hitoshi Masuo Takahiro Yoshizawa Hiroki Sakai Shohei Hirano Yuji Soejima Source Type: research
Evaluation of the Efficacy and Safety of Tenofovir Disoproxil Fumarate in Intercepting Mother-to-Child Transmission of Hepatitis B Virus
This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. Ther...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Dongxiang Han Jianxiu Du Wei Wang Cui Wang Source Type: research
Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications
This article discusses the clinical applications of HP 13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP 13C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP 13C-MRI.PMID:38685736 | PMC:PMC11058429 | DOI:10.3348/kjr.2024.0069 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Ying-Chieh Lai Ching-Yi Hsieh Yu-Hsiang Juan Kuan-Ying Lu Hsien-Ju Lee Shu-Hang Ng Yung-Liang Wan Gigin Lin Source Type: research
Cholangiocarcinoma and Occupational Exposure to Asbestos: Insights From the Italian Pooled Cohort Study
CONCLUSION: Further studies are needed to explore the association between occupational exposure to asbestos and CC. Record linkage was hampered due to incomplete coverage of the study areas and periods by Cancer Registries. The identification of CC among unspecific histology cases is fundamental to establish more effective and targeted liver cancer screening strategies.PMID:38686579 | DOI:10.23749/mdl.v115i2.14649 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Stefania Curti Mena Gallo Daniela Ferrante Francesca Bella Lorenza Boschetti Veronica Casotto Marcello Ceppi Daniela Cervino Lucia Fazzo Ugo Fedeli Paolo Giorgi Rossi Lucia Giovannetti Paolo Girardi Cecilia Lando Enrica Migliore Lucia Miligi Enrico Oddone Source Type: research
Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications
This article discusses the clinical applications of HP 13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP 13C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP 13C-MRI.PMID:38685736 | PMC:PMC11058429 | DOI:10.3348/kjr.2024.0069 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Ying-Chieh Lai Ching-Yi Hsieh Yu-Hsiang Juan Kuan-Ying Lu Hsien-Ju Lee Shu-Hang Ng Yung-Liang Wan Gigin Lin Source Type: research
