Localization of Intramuscular mRNA Delivery using Deep Eutectic-Lipid Nanocomposites
This article is protected by copyright. All rights reserved.PMID:38693774 | DOI:10.1002/adhm.202400327 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: A M Curreri M Dunne G Bibbey N Kapate J Kim S Mitragotri Source Type: research
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
CONCLUSIONS: Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.PMID:38695168 | DOI:10.1161/ATVBAHA.123.320387 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Gissette Reyes-Soffer Anastasiya Matveyenko James Lignos Nelsa Matienzo Leinys S Santos Baez Antonio Hernandez-One Lau Yung Renu Nandakumar Sasha A Singh Masanori Aikawa Richard George Henry N Ginsberg Source Type: research
Hepatic PSMA-Avid Postradiation Inflammation
Clin Nucl Med. 2024 May 2. doi: 10.1097/RLU.0000000000005257. Online ahead of print.ABSTRACTA 62-year-old man with de novo large volume metastatic prostate cancer to the bone, liver, and nodes status post multiple lines of therapy including external beam radiation to T12-L2 approximately 13 months prior underwent 68Ga-PSMA PET/CT to determine eligibility for 177Lu-PSMA therapy. 68Ga-PSMA PET/CT demonstrated tracer-avid osseous and nodal lesions consistent with metastases. In addition, regional geographic tracer avidity was seen in the midline left hepatic lobe associated with capsular retraction and demonstrated no FDG avi...
Source: Clinical Prostate Cancer - May 2, 2024 Category: Cancer & Oncology Authors: Patrick Silveira Aria Razmaria Randy Yeh Source Type: research
GSE263973 EGR2 is upregulated in monocyte-derived macrophages in MASH liver
Contributors : Ayaka Iwata ; Akira Nishiyama ; Kenichi AsanoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis analysis was perfomed to explore the transcription factors that were enhanced in MASH liver macrophages. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE263974 EGR2 is required for the acquisition of hLAM phenotype by monocyte-derived macrophages in MASH.
Contributors : Ayaka Iwata ; kenichi AsanoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis analysis was performed to understand the difference between WT and EGR2 KO macrophages in MASH liver. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE263975 RNA-seq analysis of na ïve and MASH liver tissue.
Contributors : Ayaka Iwata ; Kenichi AsanoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis analysis was perfomed to explore microevironmental cues that may induce Egr2 expression in infiltrating monocytes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE266077 Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from MCD and regular chow diet mice
Contributors : Chuanfei Zeng ; Huan Li ; Mingliang Wei ; Linxin Yu ; Ziqi Mu ; Ziyin Huang ; Yujia Ke ; Min Wu ; Ming-Kai Chen ; Lian-Yun Li ; Yong XiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from Methionine- and choline-deficient diet (MCD) and regular chow diet mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE231487 RNA-seq of liver of DICER1 syndrome model mouse
Contributors : Shin-ichiro Ohno ; Masahiko KurodaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn order to identify mRNAs involved in tumor development of DICER1 syndrome model mouse, next-generation sequencing analysis of RNA extracted from liver tissue was performed. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation
Liver transplantation is an effective treatment for liver failure. There is a large unmet demand, even as not all donated livers are transplanted. The clinical selection criteria for donor livers based on hist... (Source: BMC Genomics)
Source: BMC Genomics - May 2, 2024 Category: Genetics & Stem Cells Authors: Ankita Srivastava, Alexandra Manchel, John Waters, Manju Ambelil, Benjamin K. Barnhart, Jan B. Hoek, Ashesh P. Shah and Rajanikanth Vadigepalli Tags: Research Source Type: research
Reply to the Letter to the Editor on “Prolactin is a Key Factor for
Nonalcoholic Fatty Liver Disease in Obese Children”
Horm Metab Res DOI: 10.1055/a-2301-3272Dear Editor,The authors thank the writers 1 of the
letter for reviewing and assessing our article 2, “Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children”. Overall, we agree that possible selection bias must be considered.
However, in clinical studies, we found that hyperprolactinemia is mainly caused by
pathological and idiopathic hyperprolactinemia. The former includes hypothalamic
pituitary lesions (pituitary prolactinoma and empty sella syndrome, etc.), systemic
diseases (hypothyroidism, e...
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Zhang, Jianwei Tags: Letter to the Editor Source Type: research
Re: Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children
Horm Metab Res DOI: 10.1055/a-2301-3225 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Triebel, Jakob Bertsch, Thomas Tags: Letter to the Editor Source Type: research
Control Compounds for Preclinical Drug-Induced Liver Injury Assessment: Consensus-driven systematic review by the ProEuroDILI Network
Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages remains a major challenge, in which the selection of validated in vitro systems and test drugs has a significant impact. This systematic review analyzed the compounds used in hepatotoxicity assays and established a list of DILI positive and negative control drugs for validation of in vitro models of DILI, supported by literature and clinical evidence and endorsed by an expert committee from COST Action ProEuroDILI Network (CA17...
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-Garc ía, Daniel Di Zeo-Sánchez, Hao Niu, Ismael Álvarez-Álvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav, Pierre Bagnaninchi, Raúl J. Andr Source Type: research
Hepatic phenotypes of EFL1-related Shwachman-Diamond syndrome in a biopsy-validated study
Shwachman Diamond Syndrome (SDS), an inherited bone marrow failure syndrome, is characterized by exocrine pancreatic deficiency, predisposition to myeloid malignancies, and skeletal dysplasia. Other symptoms also include hepatic and renal involvement. Hepatomegaly and aminotransaminase elevation can be observed at an early age in SDS patients, typically with an overall good prognosis. A follow-up with mild cholestasis may reflect primary alterations in liver metabolism in SDS. During the long follow-up, no major liver abnormalities appeared [1]. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Bing Zhu, Yibing Guo, Sa Lv, Xiuxin Ling, Shaoli You Source Type: research
Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In a recent study published in Molecular Cell, Zhou and colleagues provide evidence to suggest that the energy-sensing gamma ( γ) subunit of AMPK regulates translation via phosphatase PPP6C independently of the catalytic AMPK alpha (α) subunit.1 The authors used HEK239T cells to demonstrate that energy stress by glucose deprivation sequesters PPP6C to AMPKβγ dimer complexes, which alleviates dephosphorylation of eukaryo tic translation elongation factor 2 (eEF2) Thr56 and arrests protein translation elongation to conserve energy. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Rasmus Kj øbsted, Jesper Bratz Birk, Nicolas Oldenburg Eskesen, Jørgen Frank Pind Wojtaszewski Tags: Letter Source Type: research
Response to: Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In our paper “Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha,”1 we demonstrated that knockout (KO) of AMPKγ, but not AMPKα, suppressed phosphorylation of eukaryotic translation elongation factor 2 (eEF2) induced by energy starvation. We further identified PPP 6C as a phosphatase of eEF2, and AMP-bound AMPKγ sequesters PPP6C, thereby blocking dephosphorylation of eEF2. These findings implicate diverse mechanisms of energy sensor AMPKγ in regulating cellular energy response. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Qi Zhou, Xiaolei Cao, Bin Zhao Tags: Letter Source Type: research
