Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bis(monoacylglycero)phosphates Accumulate in Aged Tissues
Lipid metabolism is changed and disrupted with advancing age, as is the case for all complex mechanisms in the body. There are a great many different lipids present in the body; even the list of classes of lipid is a long one. Finding specific changes that relate to aging can be interesting, but the challenge lie in better understanding how those changes come about, and whether they causes significant harm to tissues. Many age-related changes in molecular biochemistry are far downstream of the important causes of aging and do not cause much further disruption in and of themselves.
In recent years, laboratory resea...
Source: Fight Aging! - April 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis
As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The bur...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Reversal of Atherosclerosis at Repair Biotechnologies
As some of you know, Repair Biotechnologies is the company I co-founded with Bill Cherman back in 2018. We've been working on an approach to reverse atherosclerosis for much of that time, and matters have progressed through the stage of great data in mice to present preparations for a pre-IND meeting with the FDA. While excess cholesterol has long been understood to be important to the development of atherosclerosis, it turns out that circulating cholesterol bound to LDL particles is less important than the amount of localized excess cholesterol in the liver and blood vessel walls.
Any localized excess of cholestero...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
LyGenesis Commences Phase II Trial for Growth of Liver Organoids in Patient Lymph Nodes
LyGenesis has been working towards liver organoid transplantation as a treatment for liver failure for some years now. Organs such as the liver, thymus, and a few others do not need to be in any specific place in the body to carry out many of their varied functions. Some of the vital work of the liver, for example, can be conducted in small organoids grown from liver cells transplanted into lymph nodes or other parts of the body that can act as stable bioreactors.
Even setting aside the possibility of growing functional liver organoids from patient cells or universal cell lines, it is worth noting that the old appro...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
What is the reason for sudden breathlessness at night in those with heart disease?
Sudden breathlessness at night in those with known heart disease is usually due to collection of fluid in the lungs (pulmonary edema). During day time, when one is walking about, any extra fluid in the body tends to collect in the legs, due to the effect of gravity.
Extra fluid in the body can occur due to failure of heart, kidneys, liver and rarely due to other causes. In heart failure, the extra fluid is due to inability of the heart to pump out blood well. This can occur if the heart muscle is weak or there is obstruction to a valve regulating the flow of blood inside the heart.
At night, when one is lying down, extra f...
Source: Cardiophile MD - April 8, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Common pitfalls underlying cause-and-effect relationships
In the realm of medicine, cause-and-effect relationships are those where a specific cause, such as a disease, condition, or treatment, directly leads to a specific outcome or effect. An example of this is the established fact that smoking causes lung cancer. Similarly, it is well-documented that regular, heavy alcohol consumption directly leads to liver cirrhosis.
Read more…
Common pitfalls underlying cause-and-effect relationships originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Arthur Lazarus, MD, MBA Tags: Physician Psychiatry Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MKK4 Inhibition Provokes Greater Liver Regeneration
Researchers here report on an approach to meaningfully stimulate the regenerative capacity of the liver. The liver is one of the few organs capable of significant regrowth in mammals, and the way in which it does so is quite different from the regenerative response found in other tissues. Thus while the results here are quite impressive, they don't apply to other organs. This is purely a way to manipulate the regulation of liver regeneration.
One key feature of acute and chronic liver diseases, and after extended liver resections, is the inability of hepatocytes to sufficiently regenerate and restore or maintain a...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
poem
The Un-Operative NoteI was not on call. I did not meet the 58 year old school teacher on her worst day. We did not review the films or a treatment plan. We did not discuss the risks and benefits of operative intervention. I did not drive in at 3 in the morning, half conscious, blasting the Strokes to wake the f. up. I did not make that vertical midline incision. Nor was I there to suction out a liter of foul contamination. I did not place those sutures to close the hole in her gut. It wasn ’t my decision to place a drain under the liver. I did not speak to the husband. Or console the teary eyed daughters whoâ...
Source: Buckeye Surgeon - March 25, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Biatrial Enlargement on Chest X-Ray PA View
Transcript of the video: Chest X-ray PA view. You can see that there is straightening of left border. Normally, the main pulmonary artery segment will be concave and left atrial appendage region also will be not prominent. Here both have enlarged slightly, but not enough to produce gross bulges. So that is why we see straightening of left border, typically heard of in mitral stenosis with left atrial enlargement and mild pulmonary hypertension. When there is gross pulmonary hypertension, instead of these being straight over here, it will form a bulge over here. And when there is gross enlargement of left atrial appendage, ...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Evaluation of JVP
Transcript of the video: Now we will discuss the basic principles of evaluation of jugular venous pressure and jugular venous pulse. These are assessed in the internal jugular vein and not in the external jugular vein. To revise the anatomy lessons, this is the external jugular vein and this is the internal jugular vein. Now, why we should not be looking at external jugual vein, though it is much easier to find out is that, in lower portion, it may be kinked so that it may not reflect the true right atrial pressure. The whole purpose of assessing the jugular venous pressure and pulse is that it reflects the right atrial pr...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
