THBD Signaling as a Novel Target for Senolytic Drugs
Researchers here show that THBD signaling inhibition is an approach to selectively destroy senescent cells. There is an approved drug that can do this, vorapaxar, though at first glance its safety profile looks worse than that of dasatinib, the only senolytic so far proven to clear senescent cells in humans. One might wonder how much of vorapaxar's successes in clinical trials are due to clearance of senescent cells versus other mechanisms.
As is the case in many lines of research into cellular senescence, the focus here is on fibrosis, a progressive failure of tissue maintenance in which scar-like deposits form to ...
Source: Fight Aging! - May 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
High blood cholesterol accelerates the onset of atherosclerosis, making it easier to reach the tipping point at which localized excesses of cholesterol form in blood vessel walls. The majority of cholesterol is generated in the liver, not obtained from the diet - and yet high fat diets are well proven to accelerate atherosclerosis. Researchers here provide evidence for the mechanism to be less direct than might be expected, involving the gut microbiome and its relationship with tissues and the immune system. Certain components of dietary fat lead to a cascade of events that provoke an inflammatory response, and the more fa...
Source: Fight Aging! - May 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Disease Killing Healthcare and Causing Physician Burnout
BY SCOTT MACDIARMID
We have a healthcare crisis . . . and the crisis is now. Costs are soaring out of control, threatening the financial health of individuals and our nation. Quality of care is deteriorating, in spite of “world class care” signs seemingly on every corner. And physicians are checking out and burning out. I believe it’s one of the greatest societal issues of our day.
So, you may be wondering: How in the heck did we get ourselves into such a mess? In the greatest country in the world who spends the most on healthcare and is regularly bragging on how great it is, what happened?
Experts and pun...
Source: The Health Care Blog - May 17, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Burnout Healthcare system Scott MacDiarmid Source Type: blogs
Mitochondrially Targeted Lipid Nanoparticles as a Delivery System
This study reports on an attempt to establish a system for delivering an antioxidant molecule CoQ10 to mitochondria and the validation of its therapeutic efficacy in a model of acetaminophen liver injury caused by oxidative stress in mitochondria. A CoQ10-MITO-Porter, a mitochondrial targeting lipid nanoparticle (LNP) containing encapsulated CoQ10, was prepared using a microfluidic device. It was essential to include polyethylene glycol (PEG) in the lipid composition of this LNP to ensure stability of the CoQ10, since it is relatively insoluble in water.
Based on transmission electron microscope observations and sma...
Source: Fight Aging! - May 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
NAFLD as an Age-Related Condition
Non-alcoholic fatty liver disease (NAFLD) is an excess of lipids in the liver, disruptive of liver function. In our modern society of cheap calories and machineries of comfort the most common way to achieve an excess of lipids in the liver is obesity. That perhaps obscures the point that aspects of aging, such as growing mitochondrial dysfunction, change liver metabolism, and metabolism in general, to increase the risk of suffering NAFLD at a given weight in later life. We might not tend to think of NAFLD as an age-related condition per se, but it is certainly influenced by aging.
Due to the decline in the regener...
Source: Fight Aging! - May 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senescent Cells Contribute to the Harms Caused by Aged Blood
The present state of parabiosis studies demonstrates that diluting blood in old animals produces improved health, whether this is achieved using saline or young blood. Thus we expect there to be few beneficial factors in young blood, and many harmful factors in old blood. So far there has been mixed or little benefit noted in studies in which young plasma is transfused into old recipients, but dilution appears more promising.
As noted here, the growing burden of senescent cells in aged tissue is a significant source of those harmful factors. Senescent cells are very active, generating a mix of factors known as the s...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Steroids And The Heart: A Revealing Study On Long-Term Risks
Conclusion: A Heartfelt Wake-Up Call
These pioneering studies serve as a stark reminder that every choice has consequences – and when it comes to anabolic steroids, those consequences can be heart-wrenching.
The results underscore the urgency of prioritizing health over fleeting performance gains.
As we step forward, awaiting more insights from larger studies, remember – your health is an invaluable asset, one that deserves more than temporary boosts.
Making conscious, informed choices today can shield your heart from undue harm tomorrow.
References
American Heart Association: Steroids, Other A...
Source: The EMT Spot - May 15, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wearable Ultrasound Measures Tissue Stiffness Under Skin
Researchers at the University of California San Diego have developed a wearable ultrasound patch that is intended to provide information on the stiffness of underlying tissues as deep as 4 cm below the surface of the skin. The patch consists of a flexible 16 x 16 ultrasonic array with a silver-epoxy composite backing layer that is designed to absorb excessive vibrations. It can provide tissue stiffness data, which could be useful in a wide array of medical scenarios, including monitoring liver cirrhosis, cancer progression, sports injuries, and myocardial ischemia. The technology is part of a new wave of wearable ultrasoun...
Source: Medgadget - May 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Radiology UCSD Source Type: blogs
GlyNAC Supplementation Slows Cognitive Decline in Mice
GlyNAC supplementation involves intake of comparatively large amounts of glycine and N-acetylcysteine in order to boost levels of the antioxidant glutathione, which normally decline with age. In small human trials this proved to be a surprisingly beneficial intervention for older people when it comes to reducing inflammation and improving measures of health. Animal studies still continue, of course, and here researchers demonstrate that GlyNAC supplementation slows cognitive decline in mice.
Researchers worked with three groups of mice. Two groups were aged naturally side-by-side until they were 90 weeks old, whic...
Source: Fight Aging! - May 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
Op Note XXXIXIt was starting to get ridiculous. I ’d remove a gallbladder and then another would appear. So I’d take that one out too. Blink of an eye and there’d be another. Same place too. Cornered right there between the liver, heart and a hazy kind of darkness. It kept growing back and growing back, over and over and over. But that’s ju st your life, she said. You’re always working. No, I said. You’re wrong. It was the same patient. The same gallbladder. Eternal recurrence and all that. She shook her head. You ’re getting confused, she said. You’re working too hard. The lack of sleep is caus...
Source: Buckeye Surgeon - May 4, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
How To Choose The Best Supplement For Your Blood Pressure Condition?
Conclusion
To sum up, natural supplements have become popular for controlling high blood pressure due to their perceived safety compared to prescription medications, which often cause unpleasant side effects.
Prioritizing your health is essential, and seeking medical advice before taking any supplements is especially crucial, particularly if you struggle with comorbidity, pregnancy, or breastfeeding.
When choosing a blood pressure supplement, consider the ingredients, dosage, brand reputation, and cost.
Remember that supplements are not a substitute for a healthy lifestyle that includes a balanced diet, regular...
Source: The EMT Spot - May 3, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Supplements Source Type: blogs
A Facial Sign Of Vitamin B12 Deficiency
Vitamin B12 levels can be boosted through supplementation or by eating foods such as dairy, liver, salmon and eggs. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 27, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Manganese: The Magical Element?
The element manganese is essential for human life. It’s aptly named after the Greek word for magic, and some mysteries surrounding its role in the body still exist today—like how our bodies absorb it, if very high or low levels can cause illness, or how it might play a role in certain diseases.
Manganese is necessary for metabolism, bone formation, antioxidation, and many other important functions in the body. The element is found in strong steel, bones and enzymes, and drink cans. Credit: Compound Interest CC BY-NC-ND 4.0. Click to enlarge.
Making Much With Manganese
Structure of the human manganese s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 26, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Proteins Source Type: blogs
