Commentary on More Drastic Scenarios of Partial Brain and Full Body Replacement
Is outright replacement of tissues a viable option for the treatment of aging? There are factions within the longevity-interested community who think that the paths to either (a) engineering replacement brain tissue for parts of the brain not involved in memory, or (b) transplantation of an old head onto a young body or brain into a young body, are short enough to be worth pursuing, where "short enough" means a few decades of work given sufficient funding. To my mind, major surgery of the sort implied by replacement of large sections of tissue or entire organs is something to be avoided in later life, given the risks and c...
Source: Fight Aging! - January 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extracellular Mitochondria Have Some Ability to Selectively Target Tissues Experiencing Mitochondrial Dysfunction
Mitochondria can be ejected and taken up by cells, or transferred via connections between cells, and this appears to one of the many ways in which cells communicate or attempt to assist in cases of damage. It is of great interest to the research community that intracellular mitochondria can be taken up and used by cells, given the existence of inherited diseases resulting from mitochondrial mutations, and given the late life decline in mitochondrial function that contributes to many age-related conditions. It may be possible to deliver fully functional mitochondria as a therapy, to be ingested by cells in order to repair t...
Source: Fight Aging! - January 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fujifilm Announces Asset Purchase Agreement with Inspirata, Inc. to Acquire the Company ’s Digital Pathology Business
Company to expand robust Enterprise Imaging offering with addition of Inspirata’s Digital Pathology technology and team
FUJIFILM Corporation (President and CEO, Representative Director: Teiichi Goto) today announced the company has entered into an asset purchase agreement to acquire the global digital pathology business of Tampa, Florida-based Inspirata, Inc. Upon completion of this agreement, Inspirata’s Dynamyx® digital pathology technology, employees and customers will become part of Fujifilm. The addition of digital pathology will expand Fujifilm’s robust Synapse® Enterprise Imaging offering to enable th...
Source: EMR and HIPAA - December 27, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Cardiology PACS digital pathology Dynamyx FUJIFILM FUJIFILM Corporation FUJIFILM Healthcare Americas Corporation FUJIFILM Healthcare Europe FUJIFILM Medical Systems Europe Fujifilm’s Robust Synapse® E Source Type: blogs
So Much to Do, So Little Selenium Needed
You may know that antioxidants can help protect your cells from oxidative damage, but do you know about selenium—an element often found in special proteins called antioxidant enzymes? Selenium is essential to your body, which means you must get it from the food you eat. But it’s a trace element so you only need a small amount to benefit from its effects. In addition to its antioxidant properties, it’s also important for reproduction, DNA synthesis, and hormone metabolism.
In our bodies, selenium works in antioxidant enzymes to help protect us from oxidative damage. The element is also found in antidandruf...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 21, 2022 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Proteins Source Type: blogs
Physicians: Are we still the good guys?
In the very realistic fictional world of The White Coat Diaries by Dr. Madi Sinha, a first-year internal medicine resident goes through a harsh initiation into the realities of medical training. Protagonist Norah Kapadia encounters a complication of a penile implant in an elderly patient with end-stage liver disease and dementia. Her senior resident talks
Read more…
Physicians: Are we still the good guys? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 20, 2022 Category: General Medicine Authors: Joan Naidorf, DO Tags: Physician Hospital-Based Medicine Primary Care Source Type: blogs
Bonus Features – December 18, 2022 – Half of Americans avoiding hospitals due to staffing shortages, 62% of patients don ’ t trust health plan info when searching for providers, and much more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The Federal Trade Commission released an updated Mobile Health Apps Tool created with input from ONC, OCR, and the FDA. An ONC blog post described how the tool works: Developers answer questions about the type of health dat...
Source: EMR and HIPAA - December 18, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Interoperability Telemedicine and Remote Monitoring Amazon AWS Axxess Best Buy Care Brightside Health CareSyntax Carta Healthcare CB Insights Cisco ConnectAmerica Current Health Cylera DailyPay Deciphex Dedalu Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Level Survey of Mechanisms of Brain Aging
Ultimately, we live and die as the brain lives and dies. The rest of the body is a support system, a complex one to be sure, but probably not as complex as the brain. Repairing the cell and tissue damage of aging in the body seems a more tractable challenge, in that replacement is always an option. Replace cells, replace the gut microbiome, add new tissues grown in a lab to organs like the liver and thymus, or grow a new body and transplant the brain. A path of ever increasing control over cells, cell signaling, and regeneration implies a future in which all damaged tissue can be replaced in one way or another ... except f...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Senolytics May Improve Organ Transplantation
Senescent cells accumulate with age and negatively affect surrounding tissue with their pro-inflammatory secretions. Greater understanding of this contribution to degenerative aging has led to the development of senolytic therapies to selectively destroy these errant cells and thus improve tissue function. Cellular senescence may also occur in tissues undergoing transplantation, a result of the stresses involved, and cause loss of function and related issues following transplantation. Thus senolytics may find a use in the organ transplant industry as a way to improve success rates and patient outcomes following successful ...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging.
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/
Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Long Discussion of the Role of Senescent Cells in Idiopathic Pulmonary Fibrosis
Senescent cells are constantly created and destroyed throughout life, largely as a result of the replicative senescence that marks the end of life for a somatic cell, the Hayflick limit on cell division. With age, the pace of creation and destruction is disrupted, perhaps largely because the immune system ages to the point at which it falters in all of its tasks, clearance of senescent cells included. Senescent cells accumulate, and while never making up more than a small fraction of all somatic cells in any given tissue, the pro-growth, pro-inflammatory signaling generated by senescent cells is highly disruptive to organ ...
Source: Fight Aging! - December 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
As Balwani and Holmes Head To Jail …Will Others in Health Tech Follow?
by MIKE MAGEE
This week’s headlines seemingly closed a chapter on the story of medical research criminality in America. Ramesh “Sunny” Balwani, former president and COO of Theranos was sentenced to 13 years in prison for fraud. That’s 2 years more than his former business and romantic partner, Elizabeth Holmes.
White crime criminal defense attorney for all things science tech, Michael Weinstein, took the opportunity to trumpet out a confident message that crime doesn’t pay in Medicine with these words, “It clearly sends a signal to Silicon Valley that puffery and fraud and misrepresentation will be pr...
Source: The Health Care Blog - December 9, 2022 Category: Consumer Health News Authors: matthew holt Tags: Medical Practice Ethics Henry K. Beecher Medical Ethics Mike Magee Theranos Source Type: blogs
