Reviewing Work on CISD2, a Mammalian Longevity Gene
Few genes have been shown to robustly alter mammalian longevity as a result of altered expression, with data obtained primarily in mice. Klotho is perhaps the most well known and well studied of that small but steadily growing portfolio. The topic of today's open access paper is another of these longevity genes, CISD2. Loss of CISD2 shortens lifespan, while increased expression extends life span in mice. CISD2 is upregulated after exercise, and may act through autophagy, a common factor in many approaches shown to modestly slow aging in laboratory species. Like other approaches to upregulation of autophagy, increased CISD2...
Source: Fight Aging! - December 5, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Supplementing physical and mental health
I’ve always been wary of taking vitamins and other supplements. There are good reasons not to do so, if you have a reasonably balanced diet. Excesses of some vitamins and minerals can lead to problems like kidney and liver damage, kidney stones, and some can interfere with the absorption and activity of prescription medicines.
However.
I have been feeling rather tired in recent months, becoming unaccustomedly exhausted after even light activity. I’m talking after a short walk, but sometimes even just after a shower. Was it long-COVID, was it my medication, was it just me getting older?
Mrs Sciencebase had an ir...
Source: David Bradley Sciencebase - Songs, Snaps, Science - November 22, 2022 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs
Where Does Diabetes Technology Stand In 2022?
Diabetes management went through a radical transformation in the last years due to technology: the diabetes patient community found a strong voice online, continuous glucose monitors are taking the place of finger pricks, digital patches and insulin pumps make the dosage of insulin more predictable, and connected devices promise the era of artificial pancreas real soon. We looked around where diabetes technology stands today and what could we expect in the next 5-10 years.
The diabetes community and digital health tech companies pushing for change
Diabetes continues to affect the lives of millions around the globe. A...
Source: The Medical Futurist - November 22, 2022 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine community diabetes digital digital health patient technology artificial pancreas blood diabetes management insulin diabetic health management blood sugar Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Path to Patient Empowerment: Hospitals are granting patients access to their health information, but is that enough?
The 21st Century Cures Act codifies immediate access to health information for patients. The Act paves the way for patients to become more pro-active partners in their care. Access alone, however, is not sufficient. There is little value for patients to access health information they cannot understand. This is especially the case with radiology. A typical radiology report contains a lot of medical jargon and data that can be misinterpreted easily by those without medical training. One radiologist-led health technology company, SCANSLATED is addressing this challenge by offering AI-powered report translation software to hel...
Source: EMR and HIPAA - November 18, 2022 Category: Information Technology Authors: Colin Hung Tags: Communication and Patient Experience Healthcare IT 21st Century Cures Act Dr. Nicholas T. Befera patient activation Patient Empowerment radiology reports RSNA 2022 SCANSLATED Source Type: blogs
High Intensity Aerobic Activity Correlates with a Sizable Reduction in Metastatic Cancer Risk
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Three Collision Rule
I imagine it was probably my first Prehospital Trauma Life Support class back in 1990 that I first heard of the three collision rule. Since then, it has remained a useful tool in examining the mechanism of injury after auto accidents. If you haven’t heard of it, please allow me to elaborate.
The three collision rule states that, in any auto accident, there are three collisions that occur and the keen EMT needs to be aware of all three. The next time you walk up to a vehicle accident, instead of imagining two large objects colliding with each other, imagine three separate collisions occurring with each respective vehic...
Source: The EMT Spot - November 15, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Rapid Diagnosis: Vomiting Blood
The dispatcher reports that the patient is vomiting blood. Hemataemesis if you want to be technical about it. It could be a whole bunch of things right? … Well yes it could. Before you e-mail me to say that you can’t believe I missed Bolivian Hemorrhagic Fever, here’s one web site that lists 113 possibilities.
But if you want to play the numbers, it’s going to be one of four things. And if you want to play “stump your partner” you can narrow it down quite a bit based on your patients age and disposition.
There are four things that tend to cause a person to vomit blood. Before you click on the little ...
Source: The EMT Spot - November 14, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Morderate Calorie Restriction Improves Late Life Health in Mice
Up to a point, greater calorie restriction in mice produces greater benefits to health and longevity. Most animal studies do not examine moderate calorie restriction, however, so it is interesting to see one that does. The results reported in this study are much as expected; it is by now well established that calorie restriction is beneficial, shifting metabolism into a state more conducive to lasting good health.
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30-40% calorie restriction to investigate these benefits. The goal of our ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Moderate Calorie Restriction Improves Late Life Health in Mice
Up to a point, greater calorie restriction in mice produces greater benefits to health and longevity. Most animal studies do not examine moderate calorie restriction, however, so it is interesting to see one that does. The results reported in this study are much as expected; it is by now well established that calorie restriction is beneficial, shifting metabolism into a state more conducive to lasting good health.
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30-40% calorie restriction to investigate these benefits. The goal of our ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Corsanum Review: Can This Be The Ultimate Heart Support?
Can supplements like Corsanum prove to be essential in sustaining your blood pressure? Well, there is more to it than you think. Check out our review.
There are a significant number of supplements in the market that are known to assist in helping maintain the blood pressure in an individual.
The said supplements are essentially rich in nutrients, minerals, vitamins, and organic compounds that are known to specifically check high blood pressure and bring it back in the ideal range of blood pressure.
Sometimes, we let slide the fact that our lifestyle and dietary habits affect our blood pressure to a great exten...
Source: The EMT Spot - November 12, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Blood Pressure Supplements Source Type: blogs
What Is Blood Anyway?
A few years ago I had a great opportunity to write an article series for EMS Magazine called Blood On Tap. It was all about the pioneering work being done by different pharmaceutical groups to create artificial substitutes for blood.
The technical name for the pharmaceutical products that mimic the properties of blood is “oxygen therapeutics.” Here’s the inside scoop, directly from the drug company big wigs, on why we don’t call them something cool like artificial blood.
The thing is, the drug company’s know full well that these fancy solutions are nowhere near advanced enough to mimic the many complex...
Source: The EMT Spot - November 10, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
The Still Largely Unmapped Neuroprotective Mechanisms of Exercise
Regular moderate exercise delays the onset of neurodegeneration in late life. Since exercise produces sweeping changes throughout the body and the operation of cellular metabolism. It is easy enough to look at what is known of the connections to brain aging, such as a reduction in the chronic inflammation associated with aging, or upregulation of beneficial metabolites leading to an increase in BDNF expression and consequent neurogenesis, and say that these are the most important factors. But one suspects that any number of other relevant mechanisms may remain to be discovered and characterized, and since researchers don't...
Source: Fight Aging! - November 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Is Ketosis Anyway?
The carb craze may be responsible for thrusting the term ketosis into the mainstream vernacular. Before that, it was a word you rarely heard outside of medicine. Before Dr. Atikins and the low carb evangelists came along, you could relegate ketosis to a power point slide in an occasional diabetes lecture and be done with it.
Now it seems like ketosis is the in-word with soccer moms and zone dieters alike. And, while its conceptual popularity has grown, there’s still a lot of misunderstanding floating around about what ketosis is and what it means for your body. Much like belly button ...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
