Optimism for the Future of Amyloid- β Clearance
In today's popular science article, the SENS Research Foundation offers a more rosy picture of the near future of amyloid-β clearance than is the usual fare these days. Amyloids are misfolded or otherwise altered proteins that can aggregate to form solid deposits that disrupt cellular biochemistry. In principle they should all be removed. Their existence is a form of harmful change that takes place with age, and the connections to cell dysfunction are quite clear. The failure of amyloid-β clearance to produce meaningful benefits in Alzheimer's patients has led to some disillusionment, however.
Alzheimer's may be a...
Source: Fight Aging! - June 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The inspirational journey of an 82-year-old WWII veteran battling cancer
He was 82 years old when he came into our ER, writhing in excruciating abdominal pain. After an ultrasound and a subsequent CT scan, the devastating diagnosis was revealed—end stage pancreatic and liver cancer. Despite enduring a pain level of 10, he managed to maintain his sense of humor, joking about “biting the bullet.” However,
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The inspirational journey of an 82-year-old WWII veteran battling cancer originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 21, 2023 Category: General Medicine Authors: Debbie Moore-Black, RN Tags: Conditions Critical Care Nursing Oncology/Hematology Source Type: blogs
Will Success in Reversing Aging Shape the Regulatory System to Accommodate It?
A sizable fraction of the therapies produced by the medical industry are, not to put too fine a point on it, garbage. The benefit is not worth the cost of diverting the resources into the full scale production of the drug, versus those resources going towards some better form of medical research and development. Giving a cancer patient an extra month or two of life, reducing fibrosis in the liver by 10% over a year of treatment, incrementally improving mitophagy to half the degree that exercise achieves, and so forth. Small molecule development in particular excels at producing this sort out outcome, as the effects on gene...
Source: Fight Aging! - June 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
St. John ’ s Wort: A Hidden Danger For Hypertension?
Conclusion: Navigating The Use Of St. John’s Wort Amidst Hypertension
While St. John’s Wort is generally safe for most people, it may pose challenges for individuals managing high blood pressure, especially those on specific medications, such as calcium blockers.
Reflecting on Trista Best’s wisdom, informed decision-making and regular healthcare consultations are key to safely traversing the landscape of supplements.
As we continually unearth the potentials of these natural remedies, balancing their benefits and risks is fundamental to our health journey.
This in-depth understanding helps ensur...
Source: The EMT Spot - June 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Senolytic Treatments as a Strategy to Improve Immune Function in Late Life
Senescent cells accumulate in tissues throughout the body with age. Cells become senescent constantly throughout life, largely by reaching the Hayflick limit on replication, but a small number due to potentially cancerous mutations, or other forms of damage and stress. Senescent cells are rapidly removed by the immune system in youth, keeping their numbers low, but the balance between creation and destruction is disrupted with aging. There is greater stress, but perhaps more importantly the immune system becomes less efficient, less able to clear senescent cells in a timely fashion. Since senescent cells actively secrete p...
Source: Fight Aging! - June 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
ChatGPT Alternatives For Healthcare And Research
ChatGPT has made a name for itself in the world of AI, along with Bard and MedPaLM. Following the success of these first-generation language models, a host of alternatives, including the open-source project Spark NLP for Healthcare, have emerged. Our exploration today focuses on alternative solutions that, while underpinned by the principles of ChatGPT, have potential utility in the healthcare and research sectors.
ChatGPT is remarkable, but it does have its drawbacks: a knowledge cut-off in November 2021, unilateral control and updates by OpenAI, an iOS-exclusive mobile app, and API-only integration, which can be quite...
Source: The Medical Futurist - June 13, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine digital health large language models GPT in healthcare ChatGPT in healthcare AI Source Type: blogs
poem
Write What You KnowAnytime you ' re stuck or sounding derivative that ’s what they always say. Write what you know. For the longest time I ignored it. Deluded by the arrogance of the overlooked. For fruitless years I wrote about rivers even though I’m clueless. Landlocked and sea sick. I hate to fish. All my rivers just wind and shimmer, wind and shimmer. They bec ome chlorinated lazy rivers lily padded with sunburnt bodies wafting along in blow up rafts. Meanwhile I ' m just using them to skip a stone to the other side. Do you know how long it takes to really know if you know anything? I know a little bit, I ' l...
Source: Buckeye Surgeon - June 6, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, June 5th 2023
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.
Betting Against Progress Turns Out Poorly, But Can Work in the Short Term in a Slow Field
https://www.fightaging.org/archives/2023/06/betting-against-progress-turns-out-poorly-but-can-work-in-the-short-term-in-a-slow-field/
Setting oneself up as a spokesperson for "we will not achieve this goal", as the fellow noted here is choosing to do, is a bet against technological progress. A glance at any few decade period in the past two hundred yea...
Source: Fight Aging! - June 4, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Myocardial Insulin Resistance
Myocardial insulin resistance is said to occur in about 60% of patients with type 2 diabestes mellitus and is associated with higher cardiovascular risk compared to those with insulin sensitive myocardium [1]. It is known that systemic insulin resistance is an independent risk factor for heart failure and cardiovascular death [2]. Myocardial insulin resistance occuring along with systemic insulin resistance is characterized by ineffecient energy metabolism and contributes to post ischemic heart failure. Myocardial insulin resistance can also be caused by myocardial hypertrophy, independent of systemic insulin resist...
Source: Cardiophile MD - June 3, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
LEAP2 / Ghrelin Ratio as a Marker of Cognitive Decline
Ghrelin signaling is a part of being hungry. The cell signaling involved in the state hunger appears to be an important part of the process by which fasting and calorie restriction improve cell metabolism, tissue function, and long-term health. Researchers here investigate LEAP2, an inhibitor of ghrelin signaling, finding that more of it correlates with worse cognitive function with age. Given what we know of the way in which hunger affects health, LEAP2 may also prove to be yet another target for future therapies that can mimic some of the effects of calorie restriction.
Elderly individuals frequently report cogn...
Source: Fight Aging! - June 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
siRNA as a COVID-19 Treatment
Researchers at UMass Chan Medical School have developed a small interfering RNA (siRNA) technology that is stable enough for inhalation into the lungs, where it can potentially treat diseases as diverse as asthma, pulmonary fibrosis, and viral infections such as COVID-19. siRNA is not typically stable enough to survive for long in the lungs, but the researchers chemically modified the constituent nucleotides to stabilize the molecules and help them to evade immune destruction. The technology is designed to silence genes that are crucial in disease processes. In a demonstration of the potential of the technique, the researc...
Source: Medgadget - May 30, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine UMass UMassChan Source Type: blogs
Clinical Examination of Cardiovascular System For Medical Students
Discussion on blood pressure is not included here as a separate topic is dedicated to it.
Though the most commonly examined pulse is the radial, to check some of the characteristics, a more proximal pulse like the brachial or carotid needs to be examined. Following parameters of the pulse are routinely documented: 1. The rate: Normal rate in adult is 60-100 per minute. It is higher in children. Younger the child, higher the pulse rate.
Rhythm: Regular and irregular rhythms are possible. Mild variation with respiration is called respiratory sinus arrhythmia, with higher rate in inspiration. Respiratory sinus arrhythmia may...
Source: Cardiophile MD - May 30, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Legalizing Organ Sales
This article appeared onSubStack on May 25, 2023.Organ sales are illegal in the United States and most other countries (Iran is a partial exception). The National Organ Transplantation Act of 1984states, “it shall be unlawful for any person to knowingly acquire, receive, or otherwise transfer any human organ for valuable consideration for use in human transplantation if the transfer affects interstate commerce.” The penalty for breaking the law is a fine of $50,000 or up to five years in prison , or both.In Libertarian Land, organ markets are legal. This makes everyone better off.Consider first kidneys. People have ...
Source: Cato-at-liberty - May 25, 2023 Category: American Health Authors: Jeffrey Miron Source Type: blogs
