Fight Aging! Newsletter, May 29th 2023

In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered transcriptional pathways related to stress response, including detoxification and xenobiotic stress pathways, that we demonstrate collectively contribute to the increased lifespan and improved health of dec2P384R mutants. Finally, we provide evidence that the short sleep phenotype observed in dec2P384R mutants may be a result of their improved health rather than altered core sleep programs. Taken together, our results highlight the dec2P384R mutation as a novel pro-longevity factor and suggest a link between pro-health pathways and reduced sleep pressure. Cellular Senescence in Skin as an Early Sign of Aging https://www.fightaging.org/archives/2023/05/cellular-senescence-in-skin-as-an-early-sign-of-aging/ While no-one likes to be reminded of it, there are clear, albeit minor signs of aging that arise in as young a stage of life as ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs