Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Case of the Week 731
The following objects were seen in fluid aspirated from a cyst in the liver. Identification?Some were still moving! (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 16, 2023 Category: Parasitology Source Type: blogs
Answer to Case 731
Answer to theParasite Case of the Week 731:Echinococcussp. protoscolex. Hopefully you all got to look at it moving! Given that this is a single liver cyst, it would fit withE. granulosus. Correlation with radiologic and epidemiologic features would be helpful for confirmation.Here are some of the key diagnostic features: (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 14, 2023 Category: Parasitology Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
3D Printing In Medicine And Healthcare – The Ultimate List
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. See the impressive list of 3D-printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of Buffalo have ...
Source: The Medical Futurist - November 7, 2023 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine 3d printed biomaterial tissue engineering Video bioprinting GC1 Innovation Source Type: blogs
The Vitamin-Like Deficiency Linked To Alzheimer ’ s Disease
Inadequate daily intake of this vitamin-like compound can lead to an enlarged heart, liver damage, weight gain as well as Alzheimer’s disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 4, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Dementia Source Type: blogs
The critical link between America ’ s obesity epidemic and the liver
Obesity has undeniably become the top health issue of our time, with its prevalence and impact on our bodies making headlines across health care and popular media. This isn’t merely a matter of carrying extra pounds; it’s about the multitude of serious health complications that come in its wake. The conversation around obesity often gravitates
Read more…
The critical link between America’s obesity epidemic and the liver originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 3, 2023 Category: General Medicine Authors: Darryn Potosky, MD Tags: Conditions Gastroenterology Source Type: blogs
Deathcap mushrooms – Amanita phalloides
What makes the death cap fungus (toadstool or mushroom), Amanita phalloides, so poisonous?
Well, the primary toxin present in this fungus is alpha-amanitin. This chemical goes by the following systematic name, although you’re unlikely to see it spelled out in full in the news about the ongoing murder trial that’s in the Australian news at the moment:
2-[(1R,4S,8R,10S,13S,16S,34S)-34-[(2S)-2-Butanyl]-13-[(2R,3R)-3,4-dihydroxy-2-butanyl]-8,22-dihydroxy-27-oxido-2,5,11,14,30,33,36,39-octaoxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11 .06,10.018,26.019,24]nonatriaconta-18(26),19,21,23-tetraen-4-yl]...
Source: David Bradley Sciencebase - Songs, Snaps, Science - November 2, 2023 Category: Science Authors: David Bradley Tags: Chemistry Health and Medicine Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microfluidic System Incorporates Eight Organ Tissues for Drug Testing
Researchers at Northwestern University have developed a sophisticated microfluidic system that incorporates tissue from up to eight different organ systems. The technology is unprecedented in allowing researchers to study complex interactions between different organs during disease. Moreover, it also allows for more comprehensive drug testing that investigates the effects of drug candidates on multiple organ systems at once. Called Lattice, the system is a significant advancement over pre-existing in vitro systems, which typically only allow researchers to study two organ tissues at once. The entire system fits into a spac...
Source: Medgadget - October 26, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine northwestern Source Type: blogs
poem
Op Note XLIOur diagnosis was never in doubt. It was the definitive treatment that remained elusive. Knowing the well-described occasional efficacy of placebo interventions we offered the patient a procedure of last resort. We were down to our last couple of bullets. A proposition strictly in the experimental stages, we told her. A double blinded study. But what other choice did we have? Unbeknownst to her it was a sham surgery. Nothing would be fixed, nothing cut out. We termed it her “special procedure”, as if she were a child being told that grandma was “only sleeping”. We reviewed the risks and benefits, t...
Source: Buckeye Surgeon - October 24, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Serum Galectin-3 Correlates with Frailty Risk
In this study, we aimed to address the change of Gal-3 levels in human whole blood with frailty. We performed serum biochemical and peripheral blood mononuclear cells (PBMC) microarray analyses in humans to determine the secretory phenotype characteristics of frailty. Furthermore, we used the frail mouse model to study the significantly altered behavioral phenotype and associated secreted Gal-3 levels in blood samples to reveal the Gal-3-dependent inflammatory dysregulation of frailty. (Source: Fight Aging!)
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How is forward cardiac output affected in MR & TR ?
AV valves exist to divert blood to the outflows when ventricles are contracting. If they leak significantly, obviously there are major consequences. What happens to the net cardiac output when these valves leak?
Clincally , we know ,fatigue is sign of reduced forward cardaic out put , that is more common in MR. But, edema , congestion, muscle fatigue is eqaully if not more common with TR. One importnat diference is MR jet is mainly a hemodynamic trouble in pulmonary circuit while TR jet , has one more component hits on liver function making it metabolic consequnce as well.
Can’t escape, tell us your answer for...
Source: Dr.S.Venkatesan MD - October 18, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized atrial functional tr cardiac out put in tr forward cardiac out out meer vs teer mitra clip RESEARCH TOPIC FOR DM CARDIOLOGY tricuspid annulus tricuspid vs mitral regurgitation Source Type: blogs
Imaging of Chromatin Structure as a Basis for an Aging Clock
Researchers here report a novel approach to building an aging clock, a system that can usefully measure biological age, the growing burden of damage and dysfunction. Epigenetic data, usually the status of DNA methylation at various sites on the genome, has been used to construct aging clocks in the past. Epigenetic changes of all sorts alter gene expression by altering the structure of chromatin, folded DNA in the cell nucleus, determining which regions and genes are exposed to transcriptional machinery. Thus why not directly assess changes in the structure of chromatin via microscopy imaging approaches? Researchers have n...
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
