Lipid Metabolism in Age-Related Disease
In this age of excess calories, in which a large proportion of the population is significantly overweight, research into lipid metabolism in the context of aging tends overlap with research into lipid metabolism in the context of obesity. People of normal weight still undergo complex changes in lipid metabolism and lipid transport throughout the body with age, however. These lead to prominent, important issues such as atherosclerosis, localized excesses of cholesterol and associated lesions in the arterial walls, for example. Looking at these conditions through the lens of lipid metabolism is looking at just one part of a ...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Aging of the Adrenal Gland
The smaller organs of the body tend to receive less attention from scientists in the field of aging research. There is a lot of ground to cover and only so many research groups. Attention is first given to better studied tissues with proven, direct connections to better studied diseases and causes of mortality. This includes the larger organs such as heart, lungs, liver, and so forth. Chemical factories and cell factories such as the adrenal gland and thymus are clearly important in aging, but indirect effects spread across many different age-related conditions are, it seems, more difficult to study and more difficult to o...
Source: Fight Aging! - August 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Young Plasma from Pigs Reduces Epigenetic Age in Old Rats
One interesting question in the development of new epigenetic clocks to measure biological age, particularly now that a large consortium of researchers has published a universal mammalian clock, is how one demonstrates that a new clock is in some way useful enough or interesting enough to spend time on. There are, after all, many published clocks at this point, and we might expect that the research community will attempt to standardize on the new universal clock. Why use another novel clock? One answer might be that the clock is optimized to give a large signal under a particular set of circumstances. Hence we arrive at st...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What does statin do to Cholesterol absorbtion from Intestine ?
A.Reduces
B Increases
C.No effect
D. Iam not sure
Does this sound a difficult question ?
Many felt so. Hence, I decided to ask the all too popular AI machine.
It became a brief little chat with GPT, that surprised me .
https://chat.openai.com/share/6b96c54e-ad52-472a-9ebd-b7b1e1c762be
Statin: Some untold story.
Last century’s rockstar drug, statin do stimulate Cholesterol abosorbtion as well as hepatic synthesis.We must be aware, It is a less popularised truth (Intentionally ? ) among the cardiolgy community,
Ofcourse LDL comes down, at the cost of residual pre -choleterol particles th...
Source: Dr.S.Venkatesan MD - August 19, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Raised Remnant Cholesterol Level Correlates with Frailty
Remnant cholesterol refers to circulating cholesterol in the bloodstream that is not attached to LDL transport particles coming from the liver or HDL transport particles going to the liver. The remnant is attached to some mix of VLDL and IDL particles that serve much the same purpose as LDL particles, or incorporated into much larger chylomicron transporters that carry dietary lipids from the intestines throughout the body.
Researchers have noted that remnant cholesterol appears to contribute to cardiovascular risk, speeding the progression of atherosclerosis and increasing the risk of stroke and heart attack. It is...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Complement-Producing Macrophages in Atherosclerosis
Atherosclerosis is, fundamentally, a condition centered around the function, capabilities, and age-related dysfunction of macrophage cells. These innate immune cells are responsible for clearing excess cholesterol, transported via LDL particles, from blood vessel walls. As macrophages become more dysfunctional with age, or otherwise shift in their activities due to rising inflammatory signaling, deposits of cholesterol can reach a tipping point at which they can no longer be cleared and turn into atherosclerotic lesions. Macrophages in the lesions are overwhelmed by the excess of cholesterol, become inflammatory, and die, ...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Heterochronic Parabiosis Produces Modest Extension of Life in the Older Paired Mouse
Heterochronic parabiosis is the surgical joining of the circulatory systems of an old and young mouse, both of the same genetic background. The younger mouse shows signs of accelerated aging, while the old mouse shows signs of rejuvenation. This has led to a broad range of research and development focused on age-related changes in levels of various signal molecules in the bloodstream. Some groups continue to look at declining levels of specific molecules such as GDF11 and oxytocin that might be boosted in old mice, but at present the consensus appears to be that old blood contains damaging signals, changing cell behavior f...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Study Warns That Even Light Drinking Can Raise Blood Pressure
Conclusion
In sum, the international research study underscores the significant impact of alcohol consumption on blood pressure, with effects noticed even at low levels. Contrary to common assumptions, it highlights no beneficial effects in low-level drinkers compared to non-drinkers.
The findings serve as a crucial reminder of the importance of moderation, or ideally, avoidance of alcohol for effective blood pressure management and optimal cardiovascular health. The global scale and comprehensive approach of the study lend weight to its findings, making them a key resource for individuals worldwide.
In the face o...
Source: The EMT Spot - August 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop
I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year. This event series provides a chance to make connections with some of the longevity industry figures and academic researchers in the field of aging that are associated with the Bay Area venture and futurist communities. The format this year was rapid-fire seven minute presentations and longer discussions; the presentations are shared online. I presented an informal, abbreviated version of the Repair Biotechnologies viewpoint on the role of cholesterol in aging and disease, trying to cover at least the important points in the time all...
Source: Fight Aging! - July 27, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Gradia Health Secures $4.2M in Seed Funding to Improve Ongoing Care for Patients with Chronic Conditions
The Platform is set to Reinvigorate Patient-Physician Communication Pathways by Partnering Directly with Brick-and-Mortar Practices to Deliver Superior Virtual Care Beyond the Doctor’s Office
Gradia Health, the integrated concierge care platform designed for clinics to support patients with chronic conditions, today announced its seed funding totaling $4.2M. The round was led by Adrian Fenty at MaC Venture Capital with participation from YCombinator, Soma Capital, Atlanta Ventures, and several angel investors, including Gene Lee (Ramp), Eric Feldman (Bolt), David Tsao (BillionToOne), Austen Allred (Bloomtech), Juan Bene...
Source: EMR and HIPAA - July 27, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Adrian Fenty Andrew Zelaya Atlanta Ventures Austen Allred BillionToOne Bloomtech Bolt Chronic Conditions David Tsao Eric Feldman Gene Lee Golden Gradia Gradia Health Health IT Funding Healt Source Type: blogs
Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, beta-blockers serve as an indispensable tool in the realm of modern medical treatment, particularly in managing a broad range of cardiovascular conditions.
Their unique mechanism of action, which includes decreasing heart rate and blood pressure, confers a significant cardio-protective effect.
This, combined with their versatility and the extensive clinical experience with their use, has cemented beta-blockers as a first-line treatment for various conditions, from hypertension and heart failure to anxiety and migraines.
Although beta-blockers present unique benefits, it’s crucial...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
