What does statin do to Cholesterol absorbtion from Intestine ?

A.Reduces B Increases C.No effect D. Iam not sure Does this sound a difficult question ? Many felt so. Hence, I decided to ask the all too popular AI machine. It became a brief little chat with GPT, that surprised me . https://chat.openai.com/share/6b96c54e-ad52-472a-9ebd-b7b1e1c762be Statin: Some untold story. Last century’s rockstar drug, statin do stimulate Cholesterol abosorbtion as well as hepatic synthesis.We must be aware, It is a less popularised truth (Intentionally ? ) among the cardiolgy community, Ofcourse LDL comes down, at the cost of residual pre -choleterol particles that spill over to circulation resulting in hepatic and skeltal muslce injury. There is an important corollary and a pharmacological cross invention and a new big market for a otherwise orphan drug called Eztimibe. It is not an optional accessory in statin therapy as many would like to think. There is good scientiifc logic, with and and without evidence though , that Ezetimibe, is an essential add on adjuct for optimal statin action.This is understandable, since statin consumption systematically depletes intracellular cholesterol, make the entire small intestine hungry for cholesterol by a bio – feed back mechansim once its synthesis is blocked. There is also some worrying evidence liver also synthesise some abmormal lipids , as its normal cholesterol pathway is blocked. These info were never released to clinical domain. Final message. St...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized Source Type: blogs