Breakthroughs in liver cancer treatment [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with health care executive Eugene Chan to explore the rising rates of liver cancer worldwide and the potential game-changer in its treatment: monoclonal antibodies. Join us as we delve into the factors contributing to liver cancer’s prevalence, the impact of vaccination,
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Breakthroughs in liver cancer treatment [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 17, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs
Why the Low Weight Group Exhibits Worse Outcomes in Some Epidemiological Studies
In this study, we first explored the association between WC, WHtR, and WWI change patterns and multimorbidity. WC and WHtR are considered to be important anthropometric indicators of abdominal obesity. Previous studies have suggested that WC and WHtR can reflect body fat percentage accurately and play an important role in predicting some chronic diseases, such as cardiovascular disease and metabolic syndrome. The pathway may explain that abdominal obesity significantly increased plasma triglycerides, low density lipoproteins, and very low density lipoproteins, which have been shown to increase the risk of adverse outcomes ...
Source: Fight Aging! - February 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Let ’ s Think of Patient-Centered Care, Not Value-Based Care
This article explores some fundamental changes that could accompany this shift in terminology, revolutionizing how we handle data and patient interventions.
Engagement For Life
We know that maintaining health is an endeavor that takes years, even decades. A successful endeavor must survive the departure of clinicians who have built relationships with the patient, as well as the patient’s own geographic moves, changes of provider, and changes of insurance. Treatment recommendations should also be tailored to the psychology of each patient.
Is there a message in this exhortation for people working with data and healt...
Source: EMR and HIPAA - February 13, 2024 Category: Information Technology Authors: Andy Oram Tags: Analytics/Big Data C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Interoperability Chronic Care Management Patient Centered Care Patients Society for Participatory Medic Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CISD2 Upregulation Reduces the Senescence-Associated Secretory Phenotype in Aged Skin
CISD2 expression declines with age, while upregulation of CISD2 expression has been shown in mice to improve liver function and extend life span. This strategy is expected to have broad effects on function in many tissues beyond the liver. At least some of those benefits result from an increase in the efficiency of the complex cell maintenance processes of autophagy, recycling damaged and unwanted proteins and cell structures. As is the case for other approaches to slowing aging that function via autophagy, CISD2 upregulation has the effect of reducing senescent cell burden and suppressing the harmful senescence-associated...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Tour of Geroscience, Largely Focused on Unambitious Goals in the Treatment of Aging
Geroscience is a philosophy of development, suggesting that aging can be slowed and we should work towards means to do so. In practice, geroscience is, more or less, the the name given to that part of the research and development community that aims to produce means to alter metabolism to modestly slow aging. It is best represented by the development of supplements and repurposing of very well studied drugs, near all of which produce smaller benefits to long-term heath than regular moderate exercise, and none of which can match the benefits provided by the practice of calorie restriction. It is entirely unambitious. This l...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Potential for Klotho as a Basis for Therapy
Klotho is one of the few robustly longevity-associated genes discovered over the past few decades. Increased levels of the circulating α-klotho protein slows aging in mice and is associated with better late life health in humans. Additionally, more of this α-klotho appears to slow cognitive aging and also boost cognitive function in younger animals. While klotho is thought to be primarily active in the kidneys, and thus indicates the importance of declining kidney function in degenerative aging, researchers are discovering potentially relevant interactions in the brain. It remains an open question as to how exactly kloth...
Source: Fight Aging! - January 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Do Fats Do in the Body?
It’s common knowledge that too much cholesterol and other fats can lead to disease and that a healthy diet involves watching how much fatty food we eat. However, our bodies need a certain amount of fat to function—and we can’t make it from scratch.
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. One important role they play is producing bile, a liquid that aids in digesting fats. Credit: Donna Beer Stolz, University of Pittsburgh.
Triglycerides, cholesterol, and other essential fatty acids—the fats our bodies can’t make on their own—store energy, ins...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Common questions Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Parasite Case of the Week 735
This week ' s case features a liver cyst (6 cm in diameter) that was removed and send to the parasitology laboratory for evaluation. The following images were taken by our fabulous Education Specialists, Felicity Norrie. Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - January 17, 2024 Category: Parasitology Source Type: blogs
Answer to Case 735
Answer to theParasite Case of the Week 735:Echinococcusspecies.The diagnosis can be made by the finding of the characteristic protoscoleces. As noted by Florida Fan, " On a closer look, the hooklets are clearly visible as well as the numerous calcareous particles. Since there is one cyst, the indication is that the agent isEchinococcus granulosis.A Hamburg-based Oregon alumni further noted that forE. granulosus, " The liver is the most frequent location of echinococcal cysts (approx. 70% of cases). The lungs are the second most common location. "Thanks again to Felicity from my lab to taking these beautiful phot...
Source: Creepy Dreadful Wonderful Parasites - January 16, 2024 Category: Parasitology Source Type: blogs
A Facial Sign Of Vitamin B12 Deficiency
Vitamin B12 levels can be boosted by eating foods such as dairy, liver, salmon and eggs. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 16, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
