HDL dysfunction & It ’ s clinical Implication

High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are excreted as bile and feces. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL .It must be emphasized apart from RCT, it has antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Two good reference : One is a book ,that was a surprise . (Review article on HDL) (A text book on HDL ) Structure and shape HDLs are real complex lipids occurring as pseudomicellar, quasi-spherical lipidomes. It has at-least 80 different binding sites for various proteins and ligands. APO A1 is the major apo-lipoprotein which mediates its action. In one way, it looks like an International Space Station orbiting in the bloodstream, with multiple docking and releasing points. We are far away, from understanding the role and function of various molecules that get either activated or deactivated either ...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized Source Type: blogs