Antihypertensive Drug Rilmenidine is a Calorie Restriction Mimetic
Researchers here use nematode worms to demonstrate that a commonly used antihypertensive drug is a calorie restriction mimetic. The beneficial response to calorie restriction, resulting in improved health and longevity, evolved very early in the development of life, and the underlying mechanisms are surprisingly similar across near all species, even if the end results vary in degree. Long-lived species do not exhibit the sizable gains in life span observed in short-lived species, for example, even though the health benefits remain noteworthy. In the nematode study, the drug produces less impressive results than actual calo...
Source: Fight Aging! - January 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Microneedle Delivery of LNP-mRNA Gene Therapies for Skin Aging
The skin is arguably one of the easiest of the large organs in the body to target for delivery of gene therapies, via established microneedle approaches. Nonetheless, much of the initial thrust of gene therapy clinical development focused instead on the liver, one of the other more tractable targets. Most material injected into the bloodstream ends up in the liver, and a single injection is logistically easier than coverage of large amounts of skin via microneedle patches, among other reasons.
Given the advent of messenger RNA (mRNA) encapsulated in lipid nanoparticles (either artificial or repurposed extracellular ...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Osteopontin Plays Diverse Roles in Degenerative Aging
Osteopontin levels are higher in blood samples taken from older people than in those taken from young people. It is a component of the senescence-associated secretory phenotype (SASP) produced by senescent cells, disruptive to tissue function. Osteopontin acts as a regulator in a number of tissues, and appears to be relevant to the age-related decline, such as of hematopoiesis and muscle function. Here, researchers review what is known of the role of osteopontin in aging.
Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is expressed both intracellularly and extracellularly in variou...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Communication Between Blood and Brain in Aging and Rejuvenation
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are interested in how changes in the blood signaling environment might be involved. While research initially focused on factors in young blood that are reduced in old blood, it is increasingly thought that the important mechanism is a dilution of harmful factors carried in the old bloodstream. This has led to a few studies of plasma transfer and dilution in humans, and at least one company attempting to determine the optimal dose and protocol to make...
Source: Fight Aging! - January 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An Example of Senolytics Impoving Metabolic Function in Old Mice
The first senolytic therapy to be tested in mice and humans was the combination of dasatinib and quercetin. This continues to be tested in human trials by the Mayo Clinic, and has been shown to reduce the burden of senescent cells in humans to much the same degree as it does in mice. It remains to be seen as to whether any of the many forms of senolytic treatment under development are very much better at clearing senescent cells from aged tissues than dasatinib and quercetin. Either way, it is likely that the use of multiple different senolytics will be better than one alone, due to tissue by tissue differences in biodistr...
Source: Fight Aging! - January 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The “open data” movement runs aground on FOURIER
BY ANISH KOKA
Reanalysis of a trial used to approve a commonly used injectable cholesterol-lowering drug confirms the original analysis by accident.
The open-data movement seeks to liberate the massive amount of data generated in running clinical trials from the grasp of the academic medical-pharmaceutical industrial complex that mostly runs the most important trials responsible for bringing novel therapeutics to market.
There are only a few elite academic trialist groups capable of running large trials and there’s ample reason to be suspicious about the nexus that has developed between academia and the pharmace...
Source: The Health Care Blog - January 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Uncategorized Source Type: blogs
The Open Data Movement Runs Aground on FOURIER
BY ANISH KOKA
Reanalysis of a trial used to approve a commonly used injectable cholesterol-lowering drug confirms the original analysis by accident.
The open-data movement seeks to liberate the massive amount of data generated in running clinical trials from the grasp of the academic medical-pharmaceutical industrial complex that mostly runs the most important trials responsible for bringing novel therapeutics to market.
There are only a few elite academic trialist groups capable of running large trials and there’s ample reason to be suspicious about the nexus that has developed between academia and the pharmace...
Source: The Health Care Blog - January 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka FDA regulations Fourier open data Source Type: blogs
Periodic Reprogramming via Gene Therapy Doubles Remaining Life Span in Old Mice
Perhaps the most important early measure of the quality of a given approach to the treatment of aging is its effect on remaining life span in old mice. Prevention is a good approach, but it has the disadvantage of only working to its greatest effect in those who are not yet old. The best approaches to the treatment of aging will produce rejuvenation, and thus be applicable to both (a) prevention of degenerative aging in people who are entering later life and (b) reversal of degenerative aging in those already suffering its effects. Reversal of the cell and tissue damage that causes aging, when periodically applied prior to...
Source: Fight Aging! - January 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Physical Sign Of Vitamin B12 Deficiency
Supplements or foods such as dairy, liver, salmon and eggs can rectify a vitamin B12 deficiency. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 13, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Researchers here report on an interesting approach to treating scar tissue in skin. Noting that hair follicles appear to promote regeneration in healthy skin, they implant follicles into scar tissue. The result is some degree of beneficial remodeling of the scar. While the next logical step is to better understand the signaling involved in this effect, it is worth noting that researchers have been attempting to understand the mechanisms of skin regeneration for some time now. It is a very complex situation involving many different cell types, structures, and phases of activity that change over time. There is unlikely to be...
Source: Fight Aging! - January 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Using Engineered Cancer Cells to Rouse an Immune Response Against Tumors
Researchers here report on an interesting approach to encouraging the immune system to attack cancer cells in an established tumor. They engineer cancer cells to be more visible to the immune system and then return them to the body, where they will naturally home to the site of the tumor. At present the proof of concept is established in animal models; time will tell as to whether this line of work attracts the support needed to progress further towards the clinic.
Cancer vaccines are an active area of research for many labs, but the new approach to treating the brain cancer glioblastoma that researchers have take...
Source: Fight Aging! - January 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Commentary on More Drastic Scenarios of Partial Brain and Full Body Replacement
Is outright replacement of tissues a viable option for the treatment of aging? There are factions within the longevity-interested community who think that the paths to either (a) engineering replacement brain tissue for parts of the brain not involved in memory, or (b) transplantation of an old head onto a young body or brain into a young body, are short enough to be worth pursuing, where "short enough" means a few decades of work given sufficient funding. To my mind, major surgery of the sort implied by replacement of large sections of tissue or entire organs is something to be avoided in later life, given the risks and c...
Source: Fight Aging! - January 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
