A patient with yellow palms of hands ✋️
Yellow palms in a 55-year-old female. Some of the more common causes include:* Carotenemia: This is a condition that occurs when you have too much carotene in your blood. Carotene is a pigment found in many fruits and vegetables, such as carrots, sweet potatoes, and spinach. When you eat too much carotene, it can build up in your skin and give it a yellow tint.* Liver disease: Liver disease can cause a yellowing of the skin, including the palms of the hands. This is because the liver is responsible for breaking down carotene and other pigments. If the liver is not functioning properly, these pigments can build up in the sk...
Source: cochinblogs - July 23, 2023 Category: Radiology Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Human Lung Fibroblasts Produce Lung Fibrosis when Transplanted into Mice
From the evidence accumulated to date in animal models and studies of human tissue, it seems clear that senescent cells play an important role in the development of fibrosis in a variety of tissues. Fibrosis is a dysfunction of normal tissue maintenance processes, an excessive deposition of collagen extracellular matrix that is disruptive to tissue structure and function. Senescent cells secrete signals that encourage both growth and inflammation, and that sort of signaling sustained for the long term may be necessary for the development of fibrosis. Many age-related fibrotic diseases exist, in lungs, liver, and heart for ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Drug-Free Treatment For Non-Alcoholic Fatty Liver Disease (NAFLD)
As NAFLD treatments are limited, scientists looked into whether diet and exercise can improve patients' lives. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 20, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
Career Conversations: Q & A With Biomedical Engineer Elizabeth Wayne
Courtesy of Dr. Elizabeth Wayne.
“It’s so fun to try to make meaning from a confusing experimental result and talk to other scientists who are excited by the same questions you are,” says Elizabeth Wayne, Ph.D., an assistant professor of biomedical engineering and chemical engineering at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. We talked to Dr. Wayne about her career trajectory, research on immune cells, and belief that scientists can change the world.
Q: How did you first become interested in science?
A: I was introduced to atoms during 6th grade science class. The idea that we’re ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Imaging Profiles Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
How Alcohol Affects Blood Pressure: A Detailed Insight
Conclusion
In this guide, we’ve explored the complex relationship between alcohol and blood pressure. We’ve seen that alcohol, whether consumed moderately, heavily, or in a binge pattern, can impact blood pressure.
We also delved into the biological mechanisms at play, the role of various drinking patterns, and the sobering revelations of recent research.
While the pleasure of a drink might be fleeting, its effects on our body, particularly on our blood pressure, can be long-lasting.
The key takeaway? Moderation. Even a small reduction in alcohol intake can have significant health benefits, partic...
Source: The EMT Spot - July 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
My Most Intense Psychedelic Journey So Far
I blocked off Friday evening for another magic mushroom journey. For the two experiences last month, I used about 1.5g of dried mushrooms each time. This time I opted to take 4.2g, eating the dried mushrooms plain, starting at 5pm. I trust my intuition regarding how much to take, figuring this much could invite a fairly intense experience. It was actually super intense, way beyond what I experienced with ayahuasca and my two prior mushroom trips.
It really started kicking in after about 40 minutes. I put on an eye mask and laid back on the couch while listening to music. It flowed nicely at first with lots of red-orange...
Source: Steve Pavlina's Personal Development Blog - July 17, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Droplet Accumulation in Aging and Age-Related Disease
Researchers here consider dysregulation of lipid metabolism at the cellular level as an aspect of aging that causes downstream issues. Like many manifestations of aging observed in cells in aged tissues, why this happens is a matter for debate, setting aside situations such as the environment of a fatty liver or atherosclerotic plaque in which there is a localized excess of lipids to explain the overload inside cells. In a number of neurodegenerative conditions, the presence of cells loaded with lipid droplets is a prominent feature. It remains to be seen as to whether new classes of therapy under development, capable of c...
Source: Fight Aging! - July 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
If Probiotics in their Present Form Were a Truly Effective Intervention, We Would Already Know
There is an increasing focus in the research community on the role of the gut microbiome in aging. This is in large part driven by the ability to accurately, cost-effectively measure the composition of the gut microbiome from a stool sample, using 16S rRNA sequencing. The 16S rRNA gene is differs between bacterial species, without being subject to a high rate of mutation and change. Using low-cost modern techniques, researchers can thus read out the relative numbers of different species in the gut microbiome, a service now available to the public at large as well. This allows researchers to see exactly how the balance of p...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Metabolic Disorders Increase the Burden of Cellular Senescence
Why do patients with metabolic disorders such as obesity and type 2 diabetes exhibit what appears to be an accelerated progression of aging, such as increased risk of disease, shorter life expectancy, and so forth? One increasingly well established candidate mechanism is the presence of a greater burden of senescent cells, these cells generating chronic inflammation and harmful alterations to the behavior of other cells via their secretions. Senolytic therapies to clear these senescent cells may prove to be a first step towards decoupling obesity from the consequences of obesity, but there are numerous other ways in which ...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How one liver disease patient found hope and overcame adversity
The first day I came to the liver service, I met Mr. S, who was struggling with complications of liver disease. In the long term, he required a TIPS procedure that would better distribute his abdominal pressure and eventually a liver transplant. He was at high risk for the procedure and was struggling to maintain
Read more…
How one liver disease patient found hope and overcame adversity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 22, 2023 Category: General Medicine Authors: Johnathan Yao, MD, MPH Tags: Conditions Gastroenterology Source Type: blogs
