Fight Aging! Newsletter, December 19th 2022

In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging. Association of LDL-Cholesterol with Mortality https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/ Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces enough cellular dysfunction to form a fatty streak and then an atherosclerotic plaque. For other forms of mortality, I would suspect that the unhealthy lifestyle or ongoing chronic disease required to have either an abnormally low or abnormally high LDL-cholesterol level in blood samples is the cause of increased mortality, rather than anything to do with cholesterol metabolism per se. Low density lipoprotein cholesterol (LDL-C) is a well established causal risk factor for the development of atherosclerosis and cardiovascular disease. High levels of LDL-C consistently predict a risk of future atherosclerotic cardiovascular events in a variety of populations throughout the world. Also, many randomised controlled trials of treatment with lipid lowering agents have clearly shown that lowering LDL-C levels reduces the risk of atherosclerotic cardiovascul...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs