The fatty acid omega hydroxylase genes (CYP4 family) in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD): An RNA sequence database analysis and review
Biochem Pharmacol. 2024 Apr 30:116241. doi: 10.1016/j.bcp.2024.116241. Online ahead of print.ABSTRACTFatty acid omega hydroxylase P450s consist of enzymes that hydroxylate various chain-length saturated and unsaturated fatty acids (FAs) and bioactive eicosanoid lipids. The human cytochrome P450 gene 4 family (CYP4) consists of 12 members that are associated with several human diseases. However, their role in the progression of metabolic dysfunction-associated fatty liver disease (MASLD) remains largely unknown. It has long been thought that the induction of CYP4 family P450 during fasting and starvation prevents FA-related...
Source: Biochemical Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Authors: Charles Leahy Nicholas Osborne Leticia Shirota Paula Rote Yoon-Kwang Lee Byoung-Joon Song Liya Yin Yanqiao Zhang Victor Garcia James P Hardwick Source Type: research
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
CONCLUSIONS: Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.PMID:38695168 | DOI:10.1161/ATVBAHA.123.320387 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Gissette Reyes-Soffer Anastasiya Matveyenko James Lignos Nelsa Matienzo Leinys S Santos Baez Antonio Hernandez-One Lau Yung Renu Nandakumar Sasha A Singh Masanori Aikawa Richard George Henry N Ginsberg Source Type: research
Deceased Donor Liver Transplantation With Hepatic Artery Aneurysm
Exp Clin Transplant. 2024 Mar;22(3):242-243. doi: 10.6002/ect.2024.0025.ABSTRACTFew case reports have documented the long-term outcomes of liver donor aneurysms, illustrating the apprehension of transplant surgeons about using these grafts. However,the presence of an aneurysm in the donor liver should not be an absolute contraindication for its use. As shown in our described patient, such grafts have the potential to achieve good results.PMID:38695594 | DOI:10.6002/ect.2024.0025 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Andrea Gonz ález De Godos Francisco Javier Tejero Pintor Andrea Carlota Lizarralde Capelastegui David Pacheco S ánchez Source Type: research
Donor Complications Following Living Donor Hepatectomy: 17-Year Experience of a Single Team in One Institution of Japan
CONCLUSIONS: There were no significant differences in the incidence of postoperative donor complications, except upper gastrointestinal complications, among the 3 types of graft.PMID:38695591 | DOI:10.6002/ect.2024.0026 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Masashi Kadohisa Yukihiro Inomata Keita Shimata Kaori Isono Masaki Honda Shintaro Hayashida Yuki Ohya Hidekazu Yamamoto Hideaki Okajima Taizo Hibi Source Type: research
Current State of Liver Transplantation for Cholangiocarcinoma: A Comprehensive Literature Review
Exp Clin Transplant. 2024 Mar;22(3):167-179. doi: 10.6002/ect.2023.0343.ABSTRACTCholangiocarcinoma is the second most common primary hepatic neoplasm, accounting for 10% to 20% of primary liver tumors and 3% of all gastrointestinal neoplasms. The 3 anatomic types (intrahepatic, perihilar, and distal) have distinct epidemiologies, etiopathogenesis, and clinical outcomes. Surgical resection remains the current standard of treatment, but outcomes remain poor. With the continued expansion of liver transplant programs, use of liver transplant for malignant indications has also increased, with reports of encouraging outcomes. Ho...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Junaid Mansoor Nigel Heaton Zartash Junaid Source Type: research
Terf2ip deficiency accelerate non-alcoholic steatohepatitis through regulating lipophagy and fatty acid oxidation via Sirt1/ AMPK pathway
CONCLUSIONS: These results revealed that Terf2ip played a protective role in the progression of NASH through regulating lipophagy and FAO by binding to Sirt1 promoter. Our findings provided a potential therapeutic target for the treatment of NASH.PMID:38697492 | DOI:10.1016/j.freeradbiomed.2024.04.238 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Yirui Wang Shuochen Liu Ming Ni Yananlan Chen Ruixiang Chen Jifei Wang Wangjie Jiang Tao Zhou Shilong Fan Jiang Chang Xiao Xu Yaodong Zhang Yue Yu Xiangcheng Li Changxian Li Source Type: research
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis
Biochim Biophys Acta Mol Basis Dis. 2024 May 1;1870(5):167205. doi: 10.1016/j.bbadis.2024.167205. Online ahead of print.ABSTRACTProcollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (Plod2) is a key collagen lysyl hydroxylase mediating the formation of collagen fiber and stabilized collagen cross-links, and has been identified in several forms of fibrosis. However, the potential role and regulatory mechanism of Plod2 in liver fibrosis remain unclear yet. Mouse liver fibrosis models were induced by injecting carbon tetrachloride (CCl4) intraperitoneally. The morphology and alignment of collagen was observed under transmission a...
Source: Biochimica et Biophysica Acta - May 2, 2024 Category: Biochemistry Authors: Wenhui Yue Hang Zhang Yue Gao Jingru Ding Renmin Xue Chengbin Dong Fuquan Liu Lin Yang Le Yang Liying Li Source Type: research
Ocimum gratissimum essential oil in the transport water of Brycon hilarii: implications at water quality, blood parameters and residues in tissue and plasma
This study aimed to assess the impact of Ocimum gratissimum L. essential oil (OGEO) on water quality, hematological parameters, and residue levels in the plasma, fillet, and liver of juvenile piraputanga (Brycon hilarii) during a two-hour transportation period. The fish were divided into plastic bags (4 L) and exposed to three different OGEO concentrations (10, 20, and 30 mg L-1), while a control group received no OGEO (three repetitions each). After the two-hour transportation, blood samples were collected, as well as portions of the fillet and liver for quantifying essential oil compounds, which were also measured in the...
Source: Braz J Biol - May 2, 2024 Category: Biology Authors: F C Oliveira A P Moreira A L Ferreira D C Costa C A L Cardoso F C M Chaves E C Chagas C M Campos Source Type: research
Complement Proteins and Liver Diseases: A Response to the Correspondence
Clin Mol Hepatol. 2024 May 2. doi: 10.3350/cmh.2024.0320. Online ahead of print.NO ABSTRACTPMID:38697652 | DOI:10.3350/cmh.2024.0320 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - May 2, 2024 Category: Gastroenterology Authors: Mohammad Saeid Rezaee-Zavareh Naomy Kim Ju Dong Yang Source Type: research
Augmented reality improving intraoperative navigation in minimally invasive liver surgery: an interplay between 3D reconstruction and indocyanine green
Updates Surg. 2024 May 2. doi: 10.1007/s13304-024-01857-9. Online ahead of print.ABSTRACTTechnology have helped surgeons to increase MILS feasibility, so that currently liver surgery evolution is strongly based on technological advances and the same trend is expected even further soon. Aim of the present technical report is to provide insights regarding the possible interplay between 3D reconstructions based on augmented reality and intraoperative navigation by indocyanine green fluorescence. Augmented reality methods based on reconstructions created through artificial intelligence interact synergistically. The better the ...
Source: Hand Surgery - May 2, 2024 Category: Surgery Authors: Francesca Ratti Matteo Serenari Diletta Corallino Luca Aldrighetti Source Type: research
Improvement of β-Cell Function After Switching From DPP-4 Inhibitors to Oral Semaglutide: SWITCH-SEMA2 Post Hoc Analysis
CONCLUSION: Switching to oral semaglutide ameliorated β-cell function compared with DPP-4is, presumably via tissue-to-tissue crosstalk between liver and β-cells.PMID:38695547 | DOI:10.1210/clinem/dgae213 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Hiroshi Nomoto Sho Furusawa Hiroki Yokoyama Yuka Suzuki Rimi Izumihara Yuki Oe Kiyohiko Takahashi Aika Miya Hiraku Kameda Kyu Yong Cho Jun Takeuchi Yoshio Kurihara Akinobu Nakamura Tatsuya Atsumi Source Type: research
Approval of Mycophenolate Mofetil for Prophylaxis of Organ Rejection in Pediatric Recipients of Heart or Liver Transplants: A Regulatory Perspective
Clin Pharmacol Ther. 2024 May 2. doi: 10.1002/cpt.3288. Online ahead of print.ABSTRACTOn June 6, 2022, the FDA expanded the indications for mycophenolate mofetil (MMF) to include the prophylaxis of organ rejection in combination with other immunosuppressants in pediatric recipients of allogeneic heart or liver transplants aged 3 months and older. The approved oral dosing regimen for these patients was a starting dose of 600 mg/m2 with titration up to a maximum of 900 mg/m2 twice daily. Data to support efficacy in pediatric patients were derived from established pharmacokinetic (PK) relationships across approved populations...
Source: Clinical Pharmacology and Therapeutics - May 2, 2024 Category: Drugs & Pharmacology Authors: Amer Al-Khouja Nadia Chaudhri Ergun Velidedeoglu Ozlem Belen Youwei Bi Suresh Doddapaneni Jianmeng Chen Source Type: research
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
Pharmacol Rev. 2024 May 2;76(3):454-499. doi: 10.1124/pharmrev.123.001087.ABSTRACTSteatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions. In parallel, noninvasive tools for diagnosing and monitoring responses to therapeutic interventions are being studied, and clinically feasible findings are being explored as primary outcomes in interventional trials. The realization that distinct subgroups ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Michail Kokkorakis Emir Muzurovi ć Špela Volčanšek Marlene Chakhtoura Michael A Hill Dimitri P Mikhailidis Christos S Mantzoros Source Type: research
Molecular Pathways Governing the Termination of Liver Regeneration
Pharmacol Rev. 2024 May 2;76(3):500-558. doi: 10.1124/pharmrev.123.000955.ABSTRACTThe liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called "hepatostat." The initiation and growth phases have been the subj...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Lianne R de Haan Rowan F van Golen Michal Heger Source Type: research
Healthcare resource utilization and costs among patients with alpha-1 antitrypsin deficiency with liver and/or lung disease: a longitudinal retrospective study in the USA
Conclusion: Patients with AATD had increased HCRU and healthcare costs in the presence of LD and/or LgD. HCRU and healthcare costs were highest in the AATD with LD and LgD health state.PMID:38696696 | DOI:10.57264/cer-2023-0186 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 2, 2024 Category: General Medicine Authors: May Hagiwara Victoria Divino Swapna Munnangi Mark Delegge Suna Park Ed G Marins Kaili Ren Charlie Strange Source Type: research
