Patients' early engagement in research proposal development (PEER-PD): patients guiding the proposal writing.
Authors: Natafgi N, Tafari AT, Chauhan C, Bekelman JE, Mullins CD Abstract Patient engagement often starts after research funding is secured with little or no involvement of patients in the proposal development phase. This paper compares three levels of patient engagement and describes patients' early engagement in research proposal development process and its contemporary relevance to clinical and translational research. Authentic patient engagement is illustrated using an example of an ongoing pragmatic clinical trial. The paper also addresses key patient considerations and questions that have an impact on the pr...
Source: Journal of Comparative Effectiveness Research - April 7, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budget impact of niraparib as maintenance treatment in recurrent ovarian cancer following platinum-based chemotherapy.
CONCLUSION: Factoring in all treatment-related costs, the use of niraparib could result in significant cost savings compared with other maintenance treatment options. PMID: 30935213 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 4, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of pan-genotypic therapies for the treatment of patients with hepatitis C virus infection in Bulgaria.
CONCLUSION: Sofosbuvir/velpatasvir/voxilaprevir is a noninferior therapy offering a simple and short-term treatment regimen with high efficacy, favorable safety profile and good tolerability. PMID: 30920311 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 30, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment of gynecological malignancies: long-term follow-up of health-related quality of life and healthcare costs.
CONCLUSION: The long-term HRQoL of surviving gynecological cancer patients was good and similar to that of age-standardized general female population. PMID: 30922069 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 30, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of standard utilization of zoledronic acid for bone metastases from advanced lung cancer in China.
CONCLUSION: Standard utilization of ZA dominated real-world utilization of ZA for BM in Chinese patients with advanced lung cancer from cost-effectiveness perspective. PMID: 30922074 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 30, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Persistence and adherence of biologics in US patients with psoriatic arthritis: analyses from a claims database.
CONCLUSION: Patients who initiated secukinumab had the lowest discontinuation rate and highest persistence and adherence over 12 months. PMID: 30912454 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 28, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison between porous tantalum metal implants and autograft in anterior cervical discectomy and fusion: a meta-analysis.
The objective of this study was to systematically compare the safety and efficacy of porous tantalum metal (TM) implants and autograft in single-level anterior cervical discectomy and fusion. METHODS: Potential academic articles were acquired from the Cochrane Library, Medline, PubMed, Embase, Science Direct and other databases. The time range used was from the inception of the electronic databases to March 2018. Gray studies were identified from the references of included literature reports. STATA version 11.0 (Stata Corporation, TX, USA) was used to analyze the pooled data. RESULTS: Four randomized, controlled tr...
Source: Journal of Comparative Effectiveness Research - March 26, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The evolution of European HTA and access to innovative medicines.
Authors: Kolotourou K, Ermacora P, Grosvenor A PMID: 30892064 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 22, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Sickle cell disease and readmissions rates after lower extremity arthroplasty: a multistate analysis 2007-2014.
CONCLUSION: Following TKA and THA, SCD is associated with higher readmissions and worse outcomes. PMID: 30892071 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 22, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic burden and treatment patterns for patients with diffuse large B-cell lymphoma and follicular lymphoma in the USA.
Authors: Ren J, Asche CV, Shou Y, Galaznik A Abstract AIM: Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are common types of non-Hodgkin's lymphoma, and real-world evidence continues to be lacking for healthcare costs and utilization among DLBCL and FL patients. Our study aims to describe medical and pharmacy costs and health resource utilization and to characterize longitudinal treatment patterns among these patients. METHODS: A retrospective observational study was performed among adult patients with DLBCL or FL using the US MarketScan (Truven) administrative claims data from 1 January&nb...
Source: Journal of Comparative Effectiveness Research - March 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of selective serotonin reuptake inhibitors in the veteran population: 10-year risk outcomes.
CONCLUSION: SSRI usage was associated with greater risk of hip fracture and osteoporosis over a 10-year period in the veteran population, with similar effect sizes to smaller studies. PMID: 30855179 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.
CONCLUSION: Oral applications of TXA are comparable to intravenous applications of TXA in primary unilateral THA for blood conservation and cost-saving measures. PMID: 30859850 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Clinician-reported symptomatic adverse events in cancer trials: are they concordant with patient-reported outcomes?
CONCLUSION: Frequently, information obtained via PRO measures and clinician-reported AEs do not favor the same treatment arm in RCT settings. PMID: 30838883 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 8, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Sexually transmitted infections in privately insured adults with intellectual and developmental disabilities.
CONCLUSION: Findings may, in part, be explained by fewer sexual experiences, increased supervision in social settings and delayed onset of sexual activity among those with I/DD. PMID: 30838884 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 8, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment patterns and outcomes for patients with unresectable stage III and metastatic melanoma in the USA.
CONCLUSION: This study provides important insights into real-world advanced melanoma treatment patterns and demonstrates encouraging treatment safety and patient survival data. PMID: 30832505 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 6, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis.
CONCLUSION: In the mid to long term, patients receiving secukinumab were more likely to achieve ACR 20/50 responses than those receiving infliximab. PMID: 30806520 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 27, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of weighting methods used in multicriteria decision analysis frameworks in healthcare with focus on low- and middle-income countries.
CONCLUSION: The selection of the most appropriate method depends on the decision-making context. The simple multiattribute rating technique (SMART) method combined with swing-weighting technique and the analytic hierarchy process methods may be the most feasible approaches for low- and middle-income countries. PMID: 30767661 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 17, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Corrigendum.
Authors: PMID: 30767671 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 17, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of teriflunomide and dimethyl fumarate in patients with relapsing forms of MS in the retrospective real-world Teri-RADAR study.
CONCLUSION: The effectiveness of teriflunomide was superior to DMF on whole brain atrophy and similar to DMF on other MRI/clinical end points. PMID: 30754997 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 14, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Discontinuation and primary care visits in nonvalvular atrial fibrillation patients treated with apixaban or warfarin.
Authors: Ramagopalan SV, Graham S, Carroll R, Raluy-Callado M, Nordstrom BL, Donaldson R, Colby C, Mehmud F, Alikhan R Abstract AIM: Nonvalvular atrial fibrillation (NVAF) requires long-term anticoagulation treatment, which may necessitate frequent primary care visits. MATERIALS & METHODS: NVAF patients initiating warfarin or apixaban in 2012-2017 were identified from linked primary (Clinical Practice Research Datalink) and secondary care (Hospital Episode Statistics) data. A propensity score matched Cox regression model compared discontinuation risk. Primary care visits were compared via negative binomial ...
Source: Journal of Comparative Effectiveness Research - February 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Medicaid spending burden among beneficiaries with treatment-resistant depression.
Authors: Pilon D, Sheehan JJ, Szukis H, Singer D, Jacques P, Lejeune D, Lefebvre P, Greenberg PE Abstract AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with major depressive disorder (MDD) beneficiaries without TRD (non-TRD-MDD) and randomly selected patients without MDD (non-MDD). Differences in HRU and per-patient-per-year costs were reported in incidence rate ratios (IRRs) and cost differences (CDs), respect...
Source: Journal of Comparative Effectiveness Research - February 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of elagolix versus leuprolide acetate for treating moderate-to-severe endometriosis pain in the USA.
CONCLUSION: Elagolix was cost effective versus leuprolide acetate in the management of moderate to severe endometriosis pain over 1- and 2-year time horizons. Results were robust in sensitivity analyses. PMID: 30724096 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 7, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A 90-day episode-of-care cost analysis of robotic-arm assisted total knee arthroplasty.
Authors: Cool CL, Jacofsky DJ, Seeger KA, Sodhi N, Mont MA Abstract AIM: To evaluate 90-day episode-of-care (EOC) costs associated with robotic-arm assisted total knee arthroplasty (rTKA) versus manual TKA (mTKA). PATIENTS & METHODS: TKA procedures were identified in Medicare 100% data. Accounting for baseline differences, propensity score matching was performed 1:5. 90-day EOC and index costs, lengths-of-stay, discharge disposition and readmission rates were assessed. RESULTS:  A total of 519 rTKA and 2595 mTKA were included. Overall 90-day EOC costs were US$2391 less for rTKA (p 
Source: Journal of Comparative Effectiveness Research - January 30, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Using flowable gelatin in anterior cervical spine surgery in real-world practice: a retrospective cohort study.
Authors: Wu Y, Wu Y, Gangoli G, Bourcet A, Danker W, Gong Q, Zhan H, Chen W, Wang Z Abstract AIM: To assess the clinical and economic impact of flowable gelatin hemostatic matrix (FGHM) in anterior cervical spine surgery (ACSS). PATIENTS & METHODS: A total of 451 patients with performed ACSS were included to compare FGHM with conventional hemostatic methods for clinical and cost outcomes using propensity score matching method. RESULTS: The comparisons of the matched 125 pairs observed that FGHM was associated with significantly lower blood transfusion volume (11.2 vs 36.3 ml; p = 0.039), ...
Source: Journal of Comparative Effectiveness Research - January 28, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Multi-gene assays: effect on chemotherapy use, toxicity and cost in estrogen receptor-positive early stage breast cancer.
CONCLUSION: MGAs differ in chemotherapy use and related outcomes for women with estrogen receptor-positive early breast cancer. PMID: 30663337 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 23, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Facing real-life with direct oral anticoagulants in patients with nonvalvular atrial fibrillation: outcomes from the first observational and prospective study in a Spanish population.
CONCLUSION: This was the first prospective study that analyzed the use of all DOACs in AF patients in Spain, showing a good profile in terms of safety and effectiveness in accordance with pivotal studies. PMID: 30654626 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 20, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Willingness to pay for medical treatments in chronic diseases: a multicountry survey of patients and physicians.
The objective was to investigate factors influencing patients' willingness to pay (WTP) and physician's views on the cost of therapy for two contrasted chronic diseases, chronic heart failure and psoriasis. METHODS: A cross-sectional survey was conducted in ten developing countries, using a stated WTP contingent valuation method. Multivariate analyses were performed by linear regression. RESULTS: Independent factors influencing patient WTP were income (+0.04 $PPP [purchasing power parity] in WTP per $PPP in monthly income; p 
Source: Journal of Comparative Effectiveness Research - January 18, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A cost-utility analysis of dulaglutide versus insulin glargine as third-line therapy for Type 2 diabetes in Canada.
CONCLUSION: A computer simulation analysis showed that dulaglutide 1.5 mg would likely be cost-effective relative to insulin glargine in patients with Type 2 diabetes inadequately controlled on metformin and sulfonylurea in Canada. PMID: 30644328 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 17, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective, observational study.
Authors: Serban ED, Manolache M Abstract AIM: To evaluate the effectiveness and safety of gelatin tannate (GT) for acute gastroenteritis (AGE) in children. MATERIALS & METHODS: In this retrospective, observational study, children admitted for AGE received GT ± oral rehydration solution (ORS; n = 46) or other antidiarrheal medications ± ORS (n = 46). Number and consistency of stools were recorded. RESULTS: Children were aged 6 months to 7.9 years. GT ± ORS reduced diarrhea duration (29.0 vs 45.4 h, p 
Source: Journal of Comparative Effectiveness Research - January 17, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Use of echocardiograms in the Medicare population: a diagnostic tool in the fight against severe aortic stenosis.
CONCLUSION: In the Medicare population, patients aged 65 years or older, with increased risk factors for and symptoms common in AS patients, should be considered for diagnostic ECHOs. PMID: 30638067 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 16, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Population-based validation of the National Comprehensive Cancer Network  recommendations for baseline imaging for bladder cancer: a case for routine baseline bone scan?
CONCLUSION: Imaging per current NCCN guidelines results in few patients with undetected asymptomatic lung or liver metastases. A routine baseline bone scan should be additionally considered for some asymptomatic patients with muscle-invasive disease. PMID: 30624081 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost minimization analysis of catheter ablation for paroxysmal atrial fibrillation by catheter technology.
CONCLUSION:  The 1-year expected hospital visit costs for PAF ablation were lower with ST than with SF or CB. PMID: 30628479 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative and combined effectiveness of innovative therapies in cancer: a literature review.
This study reviewed published clinical trials and real-world studies of targeted and immune therapies. In total, 48 studies compared and/or combined multiple novel products on breast, colorectal, lung and melanoma cancers. To a great extent, products evaluated in each study were owned by one manufacturer. However, cross-manufacturer assessments are also needed. Next to costs and intensive market competition, the absence of a regulatory framework enforcing real-world multiproduct studies prevents these from being conducted. Trusted third parties could facilitate such real-world studies, for which appropriate and efficient d...
Source: Journal of Comparative Effectiveness Research - January 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors related to the comparative effectiveness of clozapine in patients with schizophrenia.
CONCLUSION: Several factors can be used to identify patients who are more likely to benefit from clozapine than other second-generation antipsychotics. PMID: 30618273 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Variation in prostate surgery costs and outcomes in the USA: robot-assisted versus open radical prostatectomy.
CONCLUSION: Compared with ORP, RARP had significantly better perioperative outcomes at a higher cost. PMID: 30620207 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic impact of atrial fibrillation ablation with radiofrequency contact force catheter versus cryoballoon catheter.
CONCLUSION: Differential health utilization outcomes are associated with the CF catheter versus the CB catheter in AF ablation. PMID: 30572711 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 24, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Hospitalization risk factors in antipsychotic-treated schizophrenia, bipolar I disorder or major depressive disorder.
CONCLUSION: Prior hospitalization, previous antipsychotic treatment and substance abuse were associated with increased hospitalization risk in schizophrenia, BD-I or MDD. PMID: 30556736 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost minimization comparison of oral UFT/leucovorin versus 5-fluorouracil/leucovorin as adjuvant therapy for colorectal cancer in Taiwan.
CONCLUSION: UFT/LV was the more cost-effective treatment as adjuvant chemotherapy. PMID: 30560687 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Mental state, psychoemotional status, quality of life and treatment compliance in patients with Type 2 diabetes mellitus.
Authors: Babenko AY, Mosikian AA, Lebedev DL, Khrabrova EA, Shlyakhto EV Abstract AIM: To identify correlations between quality of life (QoL), emotional and mental state in patients with Type 2 diabetes mellitus (T2DM) and to evaluate its contribution in prediction of compliance. MATERIALS & METHODS:  The T2DM patients aged 18-75 years with at least 12 weeks of stable hypoglycemic therapy were included to this cross-sectional study. We used Mini Mental State Examination (MMSE) for mental state assessment, Hospital Anxiety and Depression Scale (HADS) for anxiety and depression level and EQ-5D ...
Source: Journal of Comparative Effectiveness Research - December 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact   of an integral assistance model between primary care and cardiology on the management of patients with ischemic heart disease or atrial fibrillation.
CONCLUSION: The implementation of the new care model was associated with a significant reduction of 31.2% in requests of first visits. In addition, the delay to the cardiologist consultation significantly decreased by 54.5% for the first visits, and by 57.1% for the follow-up visits. The proportion of patients that achieved recommended low density lipoprotein-cholesterol goals significantly increased from 20.8 to 29.6%. The proportion of patients submitted to anticoagulant therapy significantly increased from 69.3 to 74.2%, as well as the proportion of patients taking direct oral anticoagulants (from 7.9 to 28.4%). PMI...
Source: Journal of Comparative Effectiveness Research - December 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Gastrointestinal complications in patients treated with ipilimumab and nivolumab combination therapy or monotherapy.
Authors: Irwin DE, Davis B, Bell JA, Galaznik A, Garcia-Ribas I Abstract Aim & methods: A retrospective study using the IBM Explorys Universe Database assessed the risk of gastrointestinal events (enterocolitis or diarrhea) among melanoma and lung cancer patients treated with ipilimumab and nivolumab combination or monotherapy. Results & conclusion: There were 904 melanoma patients (607 ipilimumab, 140 nivolumab and 157 combo) and 1641 lung cancer patients (68 ipilimumab, 1542 nivolumab and 31 combo). Approximately, 37% of lung patients and 46% of melanoma patients experienced at least one adverse event. Af...
Source: Journal of Comparative Effectiveness Research - December 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic evaluation of trifluridine and tipiracil hydrochloride in the treatment of metastatic colorectal cancer in Greece.
CONCLUSION: The results indicate that FTD/TPI may represent a cost-effective treatment option compared with other alternative therapies as a third-line treatment of metastatic colorectal cancer in Greece. PMID: 30547679 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative outcome of induced labor by intracervical Foley catheter with misoprostol versus misoprostol alone.
CONCLUSION: The outcome of combination of intracervical Foley catheter and misoprostol is superior for labor induction, without affecting maternal or perinatal outcome. PMID: 30525956 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Using a society database to evaluate a patient safety collaborative: the Cardiovascular Surgical Translational Study.
CONCLUSION: Using external databases such as those of professional societies may permit comparative effectiveness assessment by providing concurrent comparison groups, additional outcome measures and longer follow-up. This can better inform evaluation of continuous QI in healthcare organizations. PMID: 30525958 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Introducing Volume 8 of the  Journal of Comparative Effectiveness Research.
Introducing Volume 8 of the Journal of Comparative Effectiveness Research. J Comp Eff Res. 2018 Dec 10;: Authors: Dormer L PMID: 30525960 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Early cost-effectiveness modeling for better decisions in public research investment of personalized medicine technologies.
We describe a stepwise approach to conducting cost-effectiveness analyses that are performed early in the technology's development process and can help mitigate the potential risks of investment. Decision analytic modeling can identify the key drivers of cost effectiveness and provide minimum criteria that the technology needs to meet for adoption by public and private healthcare systems. A value of information analysis can quantify the added value of conducting more research to provide further evidence for policy decisions. These steps will allow public research funders to make better decisions on their investments to max...
Source: Journal of Comparative Effectiveness Research - December 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost associated with hematopoietic stem cell transplantation: a retrospective claims data analysis in Germany.
CONCLUSION: Direct and indirect costs associated with HSCT are substantial for patients with ALL, DLBCL and FL. Novel therapies that reduce HSCT use could reduce medical costs. PMID: 30517020 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 7, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of overactive bladder treatments: from the US payer perspective.
CONCLUSION: Compared with BSC, onabotA 100U was the most cost-effective treatment option for patients with refractory OAB. PMID: 30511584 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 5, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Intramedullary versus extramedullary alignment guides on total knee arthroplasty: a meta-analysis.
CONCLUSION: Our meta-analysis shows that the alignment of the extramedullary distal femur osteotomy is as accurate as intramedullary systems. Furthermore, extramedullary distal femur osteotomy without invading the femoral medullary cavity could reduce postoperative bleeding and the transfusion rate. Furthermore, research is required to test the robustness of our findings when more data is available and by undertaking both Bayesian and frequentist methods. When more data are available, the heterogeneity can be further explored through sensitivity analysis, and the available data can be combined to verify the hypothesis. ...
Source: Journal of Comparative Effectiveness Research - December 1, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Validity and reliability of the Dundee difficult times of the day scale in Chinese children and adolescents with attention-deficit/hyperactivity disorder.
Authors: Du Y, Zheng Y, Ke X, Su L, Coghill D, Chen Y, Zhang Y, Yuan Z, Cheng Y, Chen W Abstract METHODS: A cross-sectional study enrolled 200 children and adolescents with attention-deficit/hyperactivity disorder visiting four Chinese tertiary care psychiatric clinics to assess the validity and reliability of the Dundee difficult times of the day scale (D-DTODS), using the Weiss functional impairment rating scale for parents form (WFIRS-P) and the Swanson, Nolan and Pelham, version IV 26-item teacher and parent rating scale (SNAP-IV-26). RESULTS: The calculated Cronbach's-α for the D-DTODS total score wa...
Source: Journal of Comparative Effectiveness Research - November 25, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research