Real-world efficacy: intravenous palonosetron three-drug regimen for chemotherapy-induced nausea and vomiting with highly emetogenic chemotherapy.
CONCLUSION: Even within a recommended three-drug antiemetic regimen, palonosetron may provide suboptimal chemotherapy-induced nausea and vomiting control with HEC in real-world settings. PMID: 30304955 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Demonstrating efficacy and effectiveness in clinical studies with recurrent event as primary end point: a chronic obstructive pulmonary disease example.
Authors: Khatry DB Abstract Pivotal clinical trials of persistent disorders such as chronic obstructive pulmonary disease and severe asthma often utilize recurrent event (e.g., exacerbations) as primary study end point. Such infrequent and correlated end points usually have skewed distributions, which can result in clinical efficacy criterion being met even while clinical effectiveness may be poor. Patients, prescribers and, increasingly, payers want evidence of both a medicine's clinical efficacy and its effectiveness. This duality in evidentiary requirements is causing a shift from the traditional one-size-fits-a...
Source: Journal of Comparative Effectiveness Research - October 5, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison between minimally invasive plate osteosynthesis and open plating for proximal humeral fractures: a meta-analysis.
CONCLUSION: Minimally invasive plate osteosynthesis in proximal humeral fractures provided significantly shorter operative times, length of hospital stays, less blood loss and better clinical outcomes without increasing complications. PMID: 30270641 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Importance of assessing and adjusting for cross-study heterogeneity in network meta-analysis: a case study of psoriasis.
CONCLUSION: Failure to adjust for cross-trial differences in NMA can have important implications for clinical interpretations when studying the comparative efficacy of healthcare interventions. PMID: 30277080 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effectiveness and safety of anti-TNF in psoriatic arthritis patients in Brazil: a post-incorporation analysis.
CONCLUSION: Anti-TNF-α drugs were effective and safe. The incorporation of them into the Brazilian Public Health System has provided therapeutic alternatives to the treatment of psoriatic arthritis. PMID: 30277088 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The economic and humanistic burden of patients in receipt of current available therapies for nAMD.
CONCLUSION: The burden of care associated with nAMD on EU and US healthcare systems, and on patients who are in receipt of nAMD therapy, is significant and likely to be unsustainable. PMID: 30238792 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 22, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis.
CONCLUSION: In the full populations, secukinumab demonstrated good efficacy across all outcomes. All treatments for active PsA included in this comprehensive network meta-analysis demonstrated superiority to placebo. PMID: 30230361 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 21, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost impact of the transitional care model for hospitalized cognitively impaired older adults.
Authors: Pauly MV, Hirschman KB, Hanlon AL, Huang L, Bowles KH, Bradway C, McCauley K, Naylor MD Abstract AIM: The goal of this study was to compare postacute care costs of three care management interventions. MATERIALS & METHODS: A total of 202 hospitalized older adults with cognitive impairment received either Augmented Standard Care, Resource Nurse Care or the Transitional Care Model. The Lin method was used to estimate costs at 30 and 180 days postindex hospital discharge. RESULTS: The Transitional Care Model had significantly lower costs than the Augmented Standard Care group at both 30 (p 
Source: Journal of Comparative Effectiveness Research - September 12, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Costs associated with adverse events for systemic therapies in metastatic melanoma.
CONCLUSION: The costs of AEs associated with systemic therapies for MM are substantial. PMID: 30192155 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 9, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

M-bioscore: proposing a new statistical model for prognostic factors in metastatic breast cancer patients.
Authors: Abdel-Rahman O Abstract AIM: The current study aims to propose and internally validate 'M-bioscore', which is a model to help predict the outcomes of untreated metastatic breast cancer patients. METHODOLOGY: Surveillance, epidemiology and end results (SEER) database (2010-2013) was accessed. Patients were divided into two groups: a training set and a validation set. Through a Cox proportional model, multivariate analysis for potential prognostic factors was performed. M-bioscore was calculated for all patients. Survival analyses were conducted through Kaplan-Meier analysis/log-rank testing. RESULTS...
Source: Journal of Comparative Effectiveness Research - September 9, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Some issues for the evaluation of noninferiority trials.
Authors: Xie X, Wang M, Ng V, Sikich N Abstract Although published noninferiority trials (NITs) generally conclude that the experimental intervention being studied is noninferior compared with standard therapy or active control, NIT quality is often not satisfactory. We have proposed 14 questions to assist in evaluating the clinical evidence of the experimental versus standard therapy. The aim of these questions is to critically appraise NITs and support proper interpretation of study results. Readers should not only consider whether the confidence interval of the primary effect measure falls within the prespecifie...
Source: Journal of Comparative Effectiveness Research - September 9, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Meropenem/colistin versus meropenem/ampicillin-sulbactam in the treatment of carbapenem-resistant pneumonia.
CONCLUSION: In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups. PMID: 30192166 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 9, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Relative effectiveness of sunitinib versus everolimus in advanced pancreatic neuroendocrine tumors: an updated matching-adjusted indirect comparison.
CONCLUSION: Findings indicate comparable PFS and OS with sunitinib and everolimus. PMID: 30168349 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 2, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Characteristics of early sacubitril/valsartan patients and considerations for studies in electronic health record data.
CONCLUSION: Overall, sacubitril/valsartan patients resembled those in the HF with reduced ejection fraction cohort, and commonly used other drugs for HF. PMID: 30156128 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 30, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world assessment of treatment with extended-release topiramate (Trokendi  XR®) and comparison with previous immediate-release topiramate treatment.
Real-world assessment of treatment with extended-release topiramate (Trokendi XR®) and comparison with previous immediate-release topiramate treatment. J Comp Eff Res. 2018 Aug 23;: Authors: Neal WO, Hur EE, Liranso T, Patel B Abstract AIM: Examine clinical profile of extended-release topiramate (Trokendi XR®) and compare treatment-emergent adverse events (TEAEs) associated with Trokendi XR versus previous immediate-release topiramate (TPM-IR) treatment. PATIENTS & METHODS: Pilot retrospective study analyzing data extracted from medical charts of patients ≥6 years of a...
Source: Journal of Comparative Effectiveness Research - August 24, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of initiating long-acting injectable antipsychotics on hospitalization in patients with bipolar I disorder.
CONCLUSION: AOM 400 may be more beneficial at reducing hospitalization rates in BD-I versus haloperidol-LAI and risperidone-LAI. PMID: 30129771 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Systematic review and network meta-analysis: effect of biologics on radiographic progression in rheumatoid arthritis.
CONCLUSION: Biologics inhibit radiographic progression in patients with RA at 1 year; however, published evidence beyond 1 year is limited. PMID: 30129776 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Assessing the robustness of direct meta-analysis in the presence of heterogeneity.
Authors: Ainsworth C Abstract AIM: To assess robustness of findings in recent systematic reviews of atypical antipsychotics in schizophrenia patients in the presence of heterogeneity. METHODS: Relative efficacy was measured in seven direct comparisons of mean difference (MD) in average positive and negative syndrome scale total score and comparisons between conventional meta-analysis results and four alternate meta-analytic strategies using the difference in MD (ΔMD). RESULTS: MDs in positive and negative syndrome scale total score were smaller in the conventional meta-analyses than those for three of...
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Conditional power for assessing population interventions.
CONCLUSION: Pre-post designs can be initiated after the baseline period is over. Power calculations that are conditioned on observed baseline data account differently for variability in the baseline and follow-up periods. PMID: 30130977 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Development and validation of a Health Policy Model of Type 2 diabetes in Chinese setting.
CONCLUSION: The COMT diabetes model simulated the long-term patient outcomes observed in eastern Asian T2DM patients with prediction accuracy. This study supports the COMT as a credible tool for Chinese healthcare decision makers. Further work is necessary to incorporate new local data to improve model validity and credibility. PMID: 30132342 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The effectiveness of the follow-up of patients after surgery due to cancer of the head and neck.
CONCLUSION: The FU therapeutic profit in the form of high percentages of preclinical relapse at a reasonable cost is justified medically and socially. PMID: 30132371 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of avelumab versus chemotherapy in Merkel cell carcinoma: innovative use of patient insights.
CONCLUSION: This approach merging qualitative and quantitative data suggests that mMCC patients report a better experience with avelumab than with chemotherapy. PMID: 30107762 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 17, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Patient characteristics and bleeding events in nonvalvular atrial fibrillation patients treated with apixaban or vitamin K antagonists: real-world evidence from Italian administrative databases.
CONCLUSION: In this analysis, apixaban was associated with a lower risk of major bleeding compared with VKA. PMID: 30101611 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 14, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparing outcomes between barbed and conventional sutures in patients undergoing knee or hip arthroplasty.
CONCLUSION: Use of barbed sutures was associated with shorter length of stay, operating room time and less resource intensive discharge status as compared with conventional sutures alone. PMID: 30070596 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Evaluation of a mobile social networking application for improving diabetes Type 2 knowledge: an intervention study using WhatsApp.
CONCLUSION: The WhatsApp application can be effectively used for enhancing diabetes knowledge, self-efficacy and awareness among the Saudi population. PMID: 29943647 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness from a single-arm trial and real-world data: alectinib versus ceritinib.
CONCLUSION: Alectinib was associated with prolonged overall survival versus ceritinib, which is consistent with efficacy evidence from clinical trials. PMID: 29944008 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Application and comparison of generalized propensity score matching versus pairwise propensity score matching.
CONCLUSION: The generalized PSM analyses were able to retain 61.2% of patients, while the conventional PSM analyses were able to match from 24.1 to 77.1% of patients from each treatment comparison. The generalized PSM achieved statistical significance (p 
Source: Journal of Comparative Effectiveness Research - June 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis.
This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV. MATERIALS & METHODS: A retrospective propensity score-matched analysis was conducted, which retrieved the encounter data from 5582 hypertensive inpatients (with a median age of 69, female percentage of 48%, diastolic blood pressure ≥40 and
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Examples of dramatic failures and their effectiveness in modern surgical disciplines: can we learn from our mistakes?
Authors: Ball CG, Grondin SC, Pasieka JL, Kirkpatrick AW, MacLean AR, Cantle P, Dixon E, Schneider P, Hamilton M Abstract Innovation can be variably defined, but when applied to healthcare is often considered to be the introduction of something new, whether an idea, method or device, into an unfilled void or needy environment. Despite the introduction of many positive surgical subspecialty altering concepts/devices however, epic failures are not uncommon. These failures can be dramatic in regards to both their human and economic costs. They can also be very public or more quiet in nature. As surgical leaders in our...
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Evaluation of antihypertensive adherence and its determinants at primary healthcare facilities in rural South Africa.
CONCLUSION: Adherence and BP control were suboptimal, only smoking was an independent risk factor for adherence. Adherent patients were twice as likely to have controlled BP, although results were sensitive to the definition of adherence. Initiatives are in place to improve adherence, which will be monitored. PMID: 29888972 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Daclatasvir combined with asunaprevir is a cost-effective and cost-saving treatment for hepatitis C infection in China.
CONCLUSION: Treatment with DUAL provides significant clinical benefit, while accruing lower lifetime costs. PMID: 29860879 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 6, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A decision framework for treating chronic immune thrombocytopenia with thrombopoietin receptor agonists.
CONCLUSION: This framework facilitates decision-making in the management of chronic immune thrombocytopenia with eltrombopag and romiplostim. PMID: 29848048 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of EQ-5D and SF-36 in untreated patients with symptoms of intermittent claudication.
CONCLUSION: Both instruments have clinical validity for use in the PAD and can be used alongside each other to provide a holistic assessment of the HRQoL. Before using these two instruments interchangeably for utility score calculations and healthcare resource allocation, a thorough sensitivity analysis is necessary to explore the robustness of the value argument based on these utility scores. PMID: 29855189 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Pretreatment costs of care and time to initial treatment for patients with cancer of unknown primary.
Authors: Walker MS, Weinstein L, Luo R, Marino I Abstract AIM: Time to treatment and pretreatment costs may be affected by unknown primary tumor site. METHODS: This retrospective study used electronic medical record data from patients in ten US community oncology practices. Eligible patients were ≥18 years, diagnosed with cancer of unknown primary (CUP) or known metastatic solid tumor, and presented between 1 January 2012 and 30 June 2014. RESULTS: Patients with CUP (n = 294) had a longer interval than non-CUP patients (n = 92) from presentation to treatment initiation (1.18...
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Intravitreal aflibercept versus intravitreal ranibizumab in patients with age-related macular degeneration: a comparative effectiveness study.
CONCLUSION: With no difference in clinical effectiveness, longer treatment intervals for aflibercept should be investigated. PMID: 29855194 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Development of a veteran engagement toolkit for researchers.
Conclusion: Investigators wishing to engage the veteran community may benefit from the experience and lessons summarized in this veteran-informed toolkit, in addition to resources directed at informing community engagement more generally. PMID: 29856238 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effect of frailty on resource use and cost for Medicare patients.
CONCLUSION: Frailty contributes greatly to cost of care, but while often correlated, is not synonymous with MCCs. Thus, it is important to control separately for frailty in studies that compare medical care use and cost. PMID: 29808714 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Multi-stakeholder engagement in health services research.
Authors: Ladeji EO PMID: 29808715 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors influencing dabigatran or warfarin medication persistence in patients with nonvalvular atrial fibrillation.
CONCLUSION: Unadjusted persistence was significantly lower among dabigatran users (n = 1025) compared with matched warfarin users (38 vs 46%). Adjusting for covariates rendered this difference insignificant (hazard ratio = 0.930). PMID: 29808717 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers.
CONCLUSION: BLC versus FBCD showed significant differences in both time to and frequency of healing suggesting that BLCC may provide significant cost savings compared with FBCD. PMID: 29809059 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.
CONCLUSION: Initiating lesinurad would result in an incremental per-member per-month cost of US$0.06 over 5 years. PMID: 29792516 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Authors' lack of awareness and use of core outcome set on postoperative pain in children is hindering comparative effectiveness research.
CONCLUSION: Further discussions about the adequacy of COS for acute pediatric pain, as well as interventions to increase the uptake of COS may be warranted. PMID: 29775075 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparing efficacy of enteral nutrition plus ranitidine and enteral nutrition alone as stress ulcer prophylaxis.
CONCLUSION: EN was at least effective as ranitidine plus EN as SUP. PMID: 29775083 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Health state utilities in patients with advanced non-small-cell lung cancer in China.
CONCLUSION: This study provides the Chinese-specific health utility data for advanced NSCLC using the EQ-5D. PMID: 29775084 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Healthcare utilization and costs of multiple sclerosis patients in the Netherlands: a healthcare claims database study.
CONCLUSION: Dutch incidence and cost estimates based on claims were consistent with previous estimates. Prevalence estimates were somewhat higher. Drug and hospital costs were highest shortly after the diagnosis. Healthcare consumption related to comorbidities was in-line with the previously reported comorbidity estimates. PMID: 29775086 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Estimating efficiency of Directive 2011/24/EU cross-border healthcare in member states.
CONCLUSION: Our findings confirm that there is country-level variation in cross-border healthcare policy efficiency. PMID: 29770704 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 18, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effects of calcimimetics on long-term outcomes in dialysis patients: literature review and Bayesian meta-analysis.
CONCLUSION: The results of this meta-analysis indicate that treatment of secondary hyperparathyroidism with calcimimetic therapy may in fact reduce mortality among patients receiving maintenance dialysis. This finding provides justification for a well-designed and adequately powered randomized trial to definitively address the question. PMID: 29762046 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 17, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost of treating peripheral neuropathic pain with pregabalin or gabapentin at therapeutic doses in routine practice.
CONCLUSION: At therapeutic doses, pregabalin was found to have lower healthcare and non-healthcare costs than gabapentin in routine practice. PMID: 29754518 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Adherence and economic impact of paliperidone palmitate versus oral atypical antipsychotics in a Medicare population.
Authors: Joshi K, Muser E, Xu Y, Schwab P, Datar M, Suehs B Abstract AIM: To compare adherence, healthcare utilization and costs among real world, Medicare-eligible patients with schizophrenia using long-acting injectable paliperidone palmitate (PP) versus oral atypical antipsychotics. Patients & methods: Historical cohort study used Medicare Advantage claims data. Inverse probability of treatment weighting was applied to adjust for baseline differences. 12-month adherence, healthcare utilization and costs were compared. RESULTS: Patients using PP were more adherent (proportion of days covered ≥0.8; 48.1 vs 32.6%; p
Source: Journal of Comparative Effectiveness Research - May 5, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Efficacy and metabolic effects of lurasidone versus brexpiprazole in schizophrenia: a network meta-analysis.
CONCLUSION: This network meta-analysis suggested that lurasidone had similar efficacy and fewer metabolic effects than brexpiprazole in patients with acute schizophrenia. PMID: 29697278 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 28, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research