A prospective, randomized, controlled, crossover study comparing three multilayered foam dressings for the management of chronic wounds.
Authors: Alvarez OM, Granick MS, Reyzelman A, Serena T Abstract Aim: Compare foam dressings - Mepilex Border Flex (MxBF), Allevyn Life (AL) and Optifoam Gentle EX (OGEX) - in treatment of chronic wounds. Materials & methods: Prospective, randomized, controlled trial (crossover design). Subjects received one dressing for 2 weeks, then comparator dressing for following 2 weeks. Wound/periwound characteristics evaluated weekly at dressing change. Primary end point: dressing durability (incidence of exudate strikethrough). Results: Higher incidence of intact dressings (no strikethrough) at ...
Source: Journal of Comparative Effectiveness Research - February 21, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

End-of-life cost for lung cancer patients in Greece: a hospital-based retrospective study.
Conclusion: The findings of the present study indicate that lung cancer treatment incurs high costs in Greece, mainly attributed to pharmaceutical expenses, even at the EOL phase. PMID: 33605788 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 21, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of an oral anticoagulation self-monitoring and self-management program in patients with mechanical heart valve prosthesis.
Conclusion: Oral anticoagulation self-monitoring and self-management program seems an appropriate approach that could provide additional benefits in selected patients with mechanical valve prosthesis. PMID: 33594899 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 19, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Estimates of the value of life lost from COVID-19 in Ohio.
Authors: Mallow PJ Abstract The economic burden of mortality due to the novel coronavirus (COVID-19) extends beyond the lives lost. Data from the Ohio Department of Public Health and Social Security Administration was used to estimate the years of potential life lost, 72,274 and economic value of those lost lives, US$17.39 billion. These estimates may be used to assess the risk-trade off of COVID-19 mitigation strategies in Ohio. PMID: 33594901 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 19, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Endovascular treatment with the Enterprise stent versus the Neuroform or Low-Profile Visualized Intraluminal Support stent for unruptured aneurysms.
Conclusion: Enterprise stent use was associated with significantly lower readmissions versus competitor stent, with no difference in other study outcomes. PMID: 33595342 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 19, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness analysis of empagliflozin compared with glimepiride in patients with Type 2 diabetes in China.
Conclusion: Empagliflozin is cost-effective treatment versus glimepiride applying a threshold of $30,290 (CNY212,676). PMID: 33576249 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 14, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The effects of pregnancy on relapse rates, disability and peripartum outcomes in women with multiple sclerosis: a systematic review and meta-analysis.
Authors: Modrego PJ, Urrea MA, de Cerio LD Abstract Background: Although previous cohort studies of women with multiple sclerosis (MS) yielded a reduction in relapse rate during pregnancy, the effect size has not been quantified in a comprehensive manner. In addition, the effects on disability progression and peripartum outcomes have been controversial. The purpose of this work is to assess the effect of pregnancy on disease activity, and to assess the effects of MS on pregnancy as well. Materials & methods: We searched in PubMed, Cochrane Library and EMBASE for cohort studies dealing with the effects of p...
Source: Journal of Comparative Effectiveness Research - February 12, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-per-remitter with esketamine nasal spray versus standard of care for treatment-resistant depression.
Conclusion: The findings suggest that ESK + oral AD is a cost-efficient alternative treatment for treatment-resistant depression compared with oral AD + PBO. PMID: 33565893 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 12, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Strategies to improve the availability of medicines in primary health care in Brazil: findings and implications.
Conclusion: Strategies, such as the RFM can promote improvements in medicine availability. PMID: 33541125 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 6, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The prognostic impact of renal function decline during hospitalization for myocardial infarction.
Authors: Mayer O, Seidlerová J, Bruthans J, Opatrný J, Hromádka M, Jirák J, Filipovský J Abstract Aim: We analyzed the mortality risk of myocardial infarction (MI) patients according to renal function, observed during hospitalization. Materials & methods: Patients hospitalized for MI between 2006 and 2018 were followed (n = 5659). We divided the sample into four groups by estimated glomerular filtration (eGFR) [ml/min]: normal functions (lowest eGFR during hospitalization>60); transiently moderate insufficiency (lowest eGFR>30 and ≤60, highest>60); perman...
Source: Journal of Comparative Effectiveness Research - February 6, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Heterogeneity in renal end  points of cardiovascular outcomes trials in Type 2 diabetes.
We examined the heterogeneity in the definitions of composite renal end point and ESRD in CVOTs. Five criteria (macroalbuminuria, doubling of serum creatinine, estimated glomerular filtration rate [GFR], ESRD and renal death), were considered for the renal composite end point across the trials. Only three of the 12 trials included all five criteria, whereas the other trials included different combinations of four, three and two criteria. ESRD definition also showed considerable heterogeneity across the trials. Heterogeneity exists in the definitions of renal composite and ESRD end points in CVOTs making it challenging...
Source: Journal of Comparative Effectiveness Research - February 6, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Medication review with follow-up for cardiovascular outcomes: a trial based cost-utility analysis.
Conclusion: The intervention was cost-effective in the public primary care setting. PMID: 33543637 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 6, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors affecting treatment selection and overall survival for first-line EGFR-tyrosine kinase inhibitor therapy in non-small-cell lung cancer.
Conclusion: Though recent approval of osimertinib offers a potential new standard of care in the first-line setting, earlier generation TKIs remain pillars in treatment of non-small-cell lung cancer therapeutic armamentarium. Our findings may contribute to optimizing treatment sequencing of EGFR-TKIs to maximize clinical benefits. PMID: 33543641 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 6, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Do implantable loop recorders impact the survival of patients with recurrent unexplained syncope?
This study compares the outcomes of patients who receive an implantable loop recorder (ILR) for unexplained syncope to a control group without the diagnostic device in German claims data. Methods  and materials: Patients with ILR were matched to a control group based on prior syncope events, age, gender and Charlson Comorbidity index (CCI). Survival, syncope hospitalizations, treatment and costs were compared. Results/conclusion: Four hundred and twelve ILR patients were matched with controls, mean age was 68, mean CCI was 2.7, 42% females. ILR patients lived on average 1.2 years longer than patients in...
Source: Journal of Comparative Effectiveness Research - January 29, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world healthcare resource utilization and costs of weekly versus every-2-week cetuximab in metastatic colorectal cancer.
Conclusion: HRU was lower and HC were similar between the Q2W and Q1W regimens. PMID: 33502247 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 29, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic impact of multigene panel testing for hereditary breast and ovarian cancer.
Conclusion: Healthcare utilization and costs were comparable between the SS and panel tests overall and for patients with VUS. PMID: 33491479 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 26, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A qualitative evaluation of patient and healthcare provider knowledge, attitudes, and behavior for safety and use of pexidartinib.
Conclusion: Qualitative research prior to KAB surveys is recommended to improve comprehension and data quality. PMID: 33474977 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 23, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

TELEmedicine as an intervention for sepsis in emergency departments: a multicenter, comparative effectiveness study (TELEvISED Study).
The objective of this study is to evaluate the impact of tele-ED consultation on sepsis care and outcomes in rural ED patients. The TELEvISED study is a multicenter (n = 25) retrospective propensity-matched comparative effectiveness study of tele-ED care for rural sepsis patients in a mature tele-ED network. Telemedicine-exposed patients will be matched with non telemedicine patients using a propensity score to predict tele-ED use. The primary outcome is 28-day hospital free days, and secondary outcomes include adherence with guidelines, mortality and organ failure. ClinicalTrials.gov: NCT04441944. PMID: 3347...
Source: Journal of Comparative Effectiveness Research - January 22, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Adoption of video laryngoscopy by a major academic anesthesia department.
Authors: Samuels JD, Tangel VE, Lui B, Turnbull ZA, Pryor KO, White RS, Jiang SY Abstract Aim: To describe the adoption patterns of intubating devices used at a major teaching and research facility. Materials & methods: Retrospective analysis of 2012-2019 data on frequency and trends in airway management devices collected from our anesthesia information management system. Results: Use of direct laryngoscopy was more frequent, but there was a downward trend in use over time (p 
Source: Journal of Comparative Effectiveness Research - January 22, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Network meta-analysis of nivolumab plus ipilimumab in the second-line setting for advanced hepatocellular carcinoma.
Conclusion: Nivolumab 1 mg/kg + ipilimumab 3 mg/kg had a superior efficacy versus cabozantinib 60 mg, regorafenib 160 mg and nivolumab 3 mg/kg monotherapy as second-line therapy for advanced hepatocellular carcinoma. PMID: 33442996 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 16, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Patient-related barriers to some virtual healthcare services among cancer patients in the USA: a population-based study.
Conclusion: Older patients, those with African-American race, lower education, lower earnings and weak English proficiency are less likely to access the above studied virtual healthcare tools. Further efforts are needed to tackle disparities in telemedicine access. PMID: 33448874 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 16, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative efficacy of dabrafenib  + trametinib versus treatment options for metastatic melanoma in first-line settings.
Conclusion: Long-term survival data of dabrafenib + trametinib establishes the combination as one of the preferred treatment options for previously untreated melanoma patients. PMID: 33448878 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 16, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Social determinants of health affect unplanned readmissions following acute myocardial infarction.
Authors: Hoyler MM, Abramovitz MD, Ma X, Khatib D, Thalappillil R, Tam CW, Samuels JD, White RS Abstract Background: Low socioeconomic status predicts inferior clinical outcomes in many patient populations. The effects of patient insurance status and hospital safety-net status on readmission rates following acute myocardial infarction are unclear. Materials & methods: A retrospective review of State Inpatient Databases for New York, California, Florida and Maryland, 2007-2014. Results: A total of 1,055,162 patients were included. Medicaid status was associated with 37.7 and 44.0% increases in ris...
Source: Journal of Comparative Effectiveness Research - January 15, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Introducing Volume 10 of the Journal of Comparative Effectiveness Research.
Authors: Dormer L Abstract I am very pleased to welcome readers to the tenth volume of the Journal of Comparative Effectiveness Research (JCER). As in previous years, it is great to start off this issue with a look back on some of our article highlights from 2020, alongside some of this month's key content. PMID: 33438479 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 15, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Corrigendum.
Authors: PMID: 33416405 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 10, 2021 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Understanding characteristics of patients newly initiating ixekizumab: findings from the Corrona Psoriasis Registry.
Conclusion: Psoriasis patients initiating ixekizumab had more severe disease, biologic experience, and worse patient-reported outcomes than those initiating other biologics. PMID: 33355477 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Reasons and factors associated with inconclusiveness of systematic reviews about interventions for neuropathic pain.
Conclusion statements for efficacy and safety, and characteristics of SRs were analyzed. Conclusiveness was defined as explicit statement by the SR authors that one intervention is better/similar to the other in terms of efficacy and safety. Methodological quality of SRs was assessed with the AMSTAR (A MeaSurement Tool to Assess systematic Reviews) tool. Results: Of 160 SRs, 37 (23%) were conclusive for efficacy and/or safety. In the SRs, conclusions about safety were missing in half of the analyzed abstracts, and a third of the full texts. Conclusive SRs included significantly more trials and participants, searched m...
Source: Journal of Comparative Effectiveness Research - December 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Efficacy and safety of GP40021 insulin lispro biphasic compared with Humalog Mix 25 in Type 2 diabetes mellitus patients.
Conclusion: GP-Lis25 and Ly-Lis25 demonstrated similar safety and efficacy. ClincalTrials.gov identifier: NCT04023344. PMID: 33355484 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Autograft versus allograft tenodesis for chronic ankle instability: a single-center retrospective comparative study.
Authors: Legnani C, Borgo E, Macchi V, Ventura A Abstract Aim: To compare the outcomes of patients who underwent autograft tenodesis with those who underwent allograft tenodesis for the treatment of chronic mechanical ankle instability. Patients & methods: Ten patients who underwent allograft lateral tenodesis were compared with 15 patients who underwent lateral tenodesis using a split peroneus brevis tendon. Patients were followed up after an average time of 10.5 years. Results: No statistically significant differences concerning American Orthopaedic Foot and Ankle Society and Karlsson-Peterson ...
Source: Journal of Comparative Effectiveness Research - December 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of second-line nivolumab for platinum-treated advanced non-small-cell lung cancer.
Conclusion: The combination of chemotherapy, nivolumab is not a cost-effective choice in the second-line treatment of NSCLC. PMID: 33325265 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Core temperature monitoring during cesarean delivery under spinal anesthesia: a quality improvement descriptive study.
Conclusion: Bladder temperature is a useful surrogate for core temperature and offers a practical solution to continuous temperature monitoring in awake patients. PMID: 33325275 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Reliability of quantitative ultrasound measurement of flexor digitorum superficialis and profundus muscles in stroke.
This study aims to investigate reliability of quantitative ultrasound measurement of the flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) muscles in stroke. Materials & methods: Patients with a history of stroke were recruited. FDP and FDS muscles on both upper extremities were investigated with ultrasound. Two independent assessors acquired images and analyzed them using a program and Heckmatt scale. Results: Forty-eight patients were included. The inter-rater intraclass correlation coefficient for echo intensities was calculated as 0.91 while intrarater intraclass correlation coeffi...
Source: Journal of Comparative Effectiveness Research - December 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The terminology conflict on efficacy and effectiveness in healthcare.
Authors: Porzsolt F, Wiedemann F, Phlippen M, Weiss C, Weiss M, Schmaling K, Kaplan RM Abstract Designers and architects created the rule 'form follows function (FFF)' for their own profession. Our paper demonstrates that this FFF rule applies equally well to the designers of clinical studies. Four examples present are as follows: disregarding this FFF rule causes an inconsistent terminology to differentiate between efficacy and effectiveness, inconsistent differentiation of efficacy and effectiveness interferes with the consistent interpretation of the results of clinical studies, inconsistent interpretation ...
Source: Journal of Comparative Effectiveness Research - December 16, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in patients with cryptogenic stroke.
Authors: Sawyer LM, Witte KK, Reynolds MR, Mittal S, Grimsey Jones FW, Rosemas SC, Ziegler PD, Kaplon RE, Yaghi S Abstract Background: We assessed cost-effectiveness of insertable cardiac monitors (ICMs) in a US cryptogenic stroke population. Materials & methods: We modelled lifetime costs and quality-adjusted life years for three monitoring strategies post cryptogenic stroke: ICM starting immediately, ICM starting after Holter monitoring (delayed ICM) and standard of care involving intermittent ECG and Holter monitoring. Patient characteristics and detection efficacy were based on the CRYSTAL-AF...
Source: Journal of Comparative Effectiveness Research - December 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

USA stockpiling of remdesivir: How should the world respond?
Authors: Dawoud D, Chalkidou K, Sullivan R, Ruiz FJ, Adler A Abstract The race to find an effective treatment for coronavirus disease 2019 (COVID-19) is still on, with only two treatment options currently authorized for emergency use and/or recommended for patients hospitalized with severe respiratory symptoms: low-dose dexamethasone and remdesivir. The USA decision to stockpile the latter has resulted in widespread condemnation and in similar action being taken by some other countries. In this commentary we discuss whether stockpiling remdesivir is justified in light of the currently available evidence. PMID: ...
Source: Journal of Comparative Effectiveness Research - December 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Optimizing electronic capture of patient-reported outcome measures in oncology clinical trials: lessons learned from a qualitative study.
Conclusion: Symptoms associated with cancers and anticancer treatments can impact the use of technologies. The recommendations for optimizing the electronic implementation of patient-reported outcome instruments in this population provides the potential to improve data quality in oncology trials and places patient needs at the forefront to ensure 'fit-for-purpose' solutions. PMID: 33274651 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A Delphi panel on treatment of high disease activity relapsing remitting multiple sclerosis in the Netherlands.
Conclusion: Effectiveness and side effects along with patient's lesion load were the most important factors for choosing a disease modifying therapy (DMTs). Respondents felt restricted to optimally treat their patients due to reimbursement restrictions for certain disease modifying therapies, although agreed that satisfactory treatment options are currently available. The answers show consensus between the participating MS neurologists with high certainty of answers. PMID: 33275036 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of socioeconomic status on presentation, treatment and outcomes of patients with pancreatic cancer.
Authors: Abdel-Rahman O Abstract Objective: To assess the impact of socioeconomic status (SES) on the patterns of care and outcomes of patients with pancreatic cancer. Materials & methods: Surveillance, Epidemiology and End Results specialized SES registry has been accessed and patients with pancreatic cancer diagnosed (2000-2015) were evaluated. The following SES variables were included: employment percentage, percent of people above the poverty line, percent of people identified as working-class, educational level, median rent, median household value and median household income. Within this SES...
Source: Journal of Comparative Effectiveness Research - December 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The societal impact of a biologic treatment of ankylosing spondylitis: a case study based on secukinumab.
Conclusion: The improvements in functional impairment due to biologics could lead to sizable productivity effects. PMID: 33252266 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 1, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Corticosteroid use in viral pneumonia: experience so far and the dexamethasone breakthrough in coronavirus disease-2019.
Authors: Rafiullah M, Siddiqui K Abstract Dexamethasone was shown to decrease the mortality in coronavirus disease-2019 (COVID-19) recently. Use of corticosteroids was harmful in other coronavirus infections previously. WHO recommended against routine use of corticosteroids in COVID-19. In view of these, we reviewed the evidence about the use of corticosteroids in virus-induced acute respiratory distress syndrome (ARDS). Corticosteroids are beneficial in ARDS regardless of etiology. However, they increased the mortality rate in influenza-associated ARDS. In SARS and the Middle East respiratory syndrome, cortic...
Source: Journal of Comparative Effectiveness Research - November 29, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Healthcare utilization in clinically significant tricuspid regurgitation patients with and without heart failure.
Conclusion: All three co-morbidities were associated with increased healthcare utilization, with HF showing the greatest impact across all measures. PMID: 33174767 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 13, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The cost-effectiveness of low-dose budesonide as a Step 2 treatment for pediatric asthma in China.
Conclusion: These findings may improve the use of low-dose budesonide, an economically and clinically preferable treatment to montelukast in pediatric patients. PMID: 33153279 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Assessing direct costs of treating metastatic triple-negative breast cancer in the USA.
Conclusion: The majority of costs were attributable to hospitalization and emergency department services, suggesting a need for effective interventions to reduce utilization of costly services. PMID: 33167695 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of nivolumab versus standard of care for third-line patients with small-cell lung cancer.
Conclusion: Nivolumab was more efficacious in terms of OS as third-line treatment for small-cell lung cancer compared with current SOC in the USA. PMID: 33140652 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 4, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of pain and nonpain co-morbidities on opioid use in women with endometriosis.
Conclusion: Risk of opioid use after endometriosis diagnosis was greater in patients who used opioids before diagnosis. Risk of prolonged opioid use was greater if co-morbidities existed before diagnosis. PMID: 33140993 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 4, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of weekly versus every-2-weeks cetuximab in metastatic colorectal cancer in a US-insured population.
Authors: Lamy FX, Batech M, Boutmy E, Ronga P, Salim S, Pescott CP Abstract Aim: To test the noninferiority of cetuximab administered every 2 weeks (Q2W) versus once weekly (Q1W) in treating metastatic colorectal cancer (mCRC) with regard to overall survival (OS). Patients: Patients receiving cetuximab plus chemotherapy for mCRC in a line-agnostic setting. Methods: This cohort study in IBM MarketScan followed patients from initiation of cetuximab for mCRC until the end of the data availability period, proxy-based death or loss of insurance coverage for>30 days. Results: The hazard ratio for OS was...
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Identifying patient decisions and related information needs during decision making related to total knee arthroplasty.
Conclusion: Although further research is needed to generalize these findings, physicians should consider these questions during shared decision making with patients considering total knee arthroplasty. PMID: 33124898 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Six ways to foster community-engaged research during times of societal crises.
Authors: Edwards HA, Monroe DY, Mullins CD PMID: 33124935 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Network meta-analyses for EGFR mutation-positive non-small-cell lung cancer: systematic review and overview of methods and shortcomings.
Conclusion: We identified methodological issues to explain differences in the findings, criteria for inclusion in NMAs and the degree of lumping of treatments. These factors should be given particular consideration in future research. PMID: 33112179 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic burden of readmission due to postoperative cerebrospinal fluid leak in Chinese patients.
Conclusion: CSFL readmissions are a significant economic burden in China. Factors associated with higher readmission cost should be monitored. PMID: 33112181 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research