Indicator of access to medicines in relation to the multiple dimensions of access.
Conclusion: This developed indicator will enable a review of access to medicines, making comparisons possible as well as improving decision making about public policies in the field of Pharmaceutical Services. PMID: 31512925 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Guidance for a causal comparative effectiveness analysis using 'big real world' evidence: when to start statin treatment.
Conclusion: The study protocol can be applied to real-world data, in general. However, the structure and quality of the database play an essential role for the validity of the results, and database-specific potential for bias needs to be explicitly considered. PMID: 31512926 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment decisions in psoriasis.
Authors: Visconti MJ, Bashyam AM, Feldman SR PMID: 31512930 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma.
Authors: Kokabi N, Nezami N, Xing M, Ludwig JM, Strazzabosco M, Kim HS Abstract Aim: To simulate effects of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy on the patients' characteristics and post orthotopic liver transplantation (OLT) outcome. Materials & methods: The United Network for Organ Sharing database was used to identify patients with hepatocellular carcinoma who were listed for OLT 2002-2014. All patients (actual group) versus simulated group with new 6-month delay in assigning Model for End-Stage Liver Disease score exception and Model for End-Stage Liv...
Source: Journal of Comparative Effectiveness Research - September 13, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative clinical effects and cost-effectiveness of maximum androgen blockade, docetaxel with androgen deprivation therapy and ADT alone for the treatment of mHSPC in China.
Conclusion: Doc-ADT is likely the optimal option from the perspective of both clinical outcomes and economic considerations. PMID: 31476895 [PubMed - in process] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 5, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Osimertinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost-effectiveness analysis.
Conclusion: Osimertinib was more effective in terms of QALYs gained than comparators (erlotinib-gefitinib). However, to obtain a cost-effectiveness alternative, a discount greater than 60% in osimertinib acquisition cost is required. PMID: 31478399 [PubMed - in process] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 5, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Corrigendum.
Authors: PMID: 31464137 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Efficiency of acute public hospitals in the region of Murcia, Spain.
Conclusion: The management of the public hospitals analyzed was favorable, both regarding average level of efficiency and the number of hospitals qualified as efficient. However, the analysis revealed several ways to increase efficiency by reducing specific inputs and nondesirable outputs (mainly operating and personnel costs as well as average length of stay) while increasing desirable outputs (mostly the number of surgical interventions). To finish, specific policy measures are suggested to improve the performance of these hospitals. PMID: 31464149 [PubMed - as supplied by publisher] (Source: Journal of Comparative E...
Source: Journal of Comparative Effectiveness Research - August 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Indirect treatment comparison of valbenazine and deutetrabenazine efficacy and safety in tardive dyskinesia.
Conclusion: In this ITC of pooled trial data, valbenazine was generally favorable over deutetrabenazine, although dose titration and equivalency should be considered when interpreting results. PMID: 31464152 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Second-line rituximab-bendamustine versus rituximab-gemcitabine-oxaliplatin in diffuse large B-cell lymphoma in the real world.
Authors: Ionescu-Ittu R, Shang A, Velde NV, Guerin A, Lin Y, Shi L, Shi S, Qayum N Abstract Aim: Despite long-term responses to first-line immunochemotherapy, many patients with diffuse large B-cell lymphoma (DLBCL) have relapsed/refractory disease. Second-line treatment options are available. However, a large proportion of patients are ineligible for transplantation/intensive therapy. Patients & methods: This observational study of 702 patients in the USA, who used second-line therapies for relapsed/refractory DLBCL, evaluated treatment patterns and overall survival (OS). The study focused on the OS outcome of...
Source: Journal of Comparative Effectiveness Research - August 29, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Intravenous tranexamic acid reduces blood transfusions in revision total hip arthroplasty: a meta-analysis.
Authors: Xin WQ, Gao YL, Shen J, Yang XY Abstract Aim: We performed a meta-analysis to systematically assess the efficacy and safety of intravenous tranexamic acid in revision total hip arthroplasty. Method: Potential academic articles were identified from Cochrane Library, Medline, PubMed, EMBASE, ScienceDirect and other databases. The time range we retrieved from was that from the inception of electronic databases to February 2019. Gray studies were identified from the references of included literature reports. STATA version 11.0 was used to analyze the pooled data. Results: A total of eight articles were involve...
Source: Journal of Comparative Effectiveness Research - August 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

How different is research done by the Patient-centered Outcomes Research Institute, and what difference does it make?
Conclusion: PCORI-funded studies appear to have unique aspects relative to NIH and AHRQ that are consistent with PCORI's aims of patient-centeredness. PMID: 31436471 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Systematic review of societal costs associated with stroke, bleeding and monitoring in atrial fibrillation.
Conclusion: Limited data were available on societal costs in atrial fibrillation and further research is warranted. PMID: 31436488 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Putting patients first: an inventive service delivering cancer treatment at home.
Conclusion: The 'Cancer Treatment at Home' service has improved the patient experience for cancer care and has been recognized nationally for its achievements. PMID: 31441319 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Ospemifene versus local estrogen: adherence and costs in postmenopausal dyspareunia.
Authors: Faught BM, Soulban G, Yeaw J, Maroun C, Coyle K, Schaffer S, DeKoven M Abstract Aim: Objective was to compare adherence and persistence, as well as direct healthcare costs and utilization, of ospemifene to available local estrogen therapies (LETs). Patients & methods: This retrospective database study used integrated medical and pharmacy claims data from the IQVIA Real-World Data Adjudicated Claims - US Database. Results: Ospemifene patients had significantly greater adherence and persistence compared with the other nonring LETs. Ospemifene had the lowest mean outpatient costs of any of the LET cohorts...
Source: Journal of Comparative Effectiveness Research - August 23, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Incremental direct healthcare expenditures of valvular heart disease in the USA.
Conclusion: Identification of VHD at an earlier stage may reduce the economic burden. PMID: 31433207 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 23, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Ataluren use in patients with nonsense mutation Duchenne muscular dystrophy: patient demographics and characteristics from the STRIDE Registry.
Authors: Muntoni F, Desguerre I, Guglieri M, Osorio AN, Kirschner J, Tulinius M, Buccella F, Elfring G, Werner C, Schilling T, Trifillis P, Zhang O, Delage A, Santos CL, Mercuri E Abstract Aim: Strategic Targeting of Registries and International Database of Excellence (STRIDE) is an ongoing, multicenter registry providing real-world evidence regarding ataluren use in patients with nonsense mutation Duchenne muscular dystrophy (DMD) in clinical practice (NCT02369731). Here, we describe the initial demographic characteristics of the registry population. Patients & methods: Patients will be followed up from e...
Source: Journal of Comparative Effectiveness Research - August 17, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of a human fibroblast-derived dermal substitute and a viable cryopreserved placental membrane for the treatment of diabetic foot ulcers.
Conclusion: HFDS improved time and frequency of wound closure in DFUs versus vCPM. PMID: 31407588 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 14, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of first-line nab-paclitaxel versus paclitaxel monotherapy in triple-negative breast cancer.
Conclusion: Nab-paclitaxel and paclitaxel monotherapy showed similar efficacy, suggesting their interchangeability as 1L treatments for mTNBC. PMID: 31394922 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Negative pressure wound therapy in total hip and knee arthroplasty: a meta-analysis.
Conclusion: NPWT decreased the incidence of superficial surgical site infection. More blisters were noticed in patients with NPWT after total knee arthroplasty. PMID: 31397173 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 10, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Facilitators and barriers to successful recruitment into a large comparative effectiveness trial: a qualitative study.
Conclusion: We identified facilitators and addressable barriers to participation in research studies. PMID: 31368793 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 3, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A better strategy using barbed sutures for wound closure in total knee arthroplasty.
This study retrieved potential academic articles comparing the clinical outcomes between KBS and KTS in TKA from the MEDLINE database, the PubMed database, the EMBASE database and the Cochrane Library. The reference articles for the identified studies were carefully reviewed to ensure that all available documents were represented in the study. Results: A total of 14 articles (eight randomized controlled trials [RCTs], six non-RCTs) were involved in our study. The overall participants of barbed Sutures group were 1255, whereas it was 1247 in the traditional sutures. Our meta-analysis showed that KBS is preferable for wound ...
Source: Journal of Comparative Effectiveness Research - July 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Proximal gastrectomy versus total gastrectomy for adenocarcinoma of the esophagogastric junction: a meta-analysis.
Conclusion: PG is more preferable to TG for treatment of upper-third gastric cancer. PMID: 31361160 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Patient characteristics and stroke and bleeding events in nonvalvular atrial fibrillation patients treated with apixaban and vitamin K antagonists: a Spanish real-world study.
Authors: Ramagopalan SV, Sicras-Mainar A, Polanco-Sanchez C, Carroll R, de Bobadilla JF Abstract Aim: To compare the risk of stroke, systemic thromboembolism and bleeding, in patients initiating apixaban or acenocoumarol for the treatment of nonvalvular atrial fibrillation. Methods: An observational, retrospective study was performed using medical records of patients who initiated apixaban or acenocoumarol between 2015 and 2017. Propensity score matching was used to match patients; stroke, systemic thromboembolism, major and minor bleeding events were compared between the matched patients. Results: Patients&nb...
Source: Journal of Comparative Effectiveness Research - July 25, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Commonly used definitions in real-world studies may underestimate the prevalence of renal disease among nonvalvular atrial fibrillation patients.
Conclusion: Our findings emphasize the importance of using all available data when characterizing chronic conditions and highlights the high comorbidity burden in this population. PMID: 31317772 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 20, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Retraction notice.
Authors: PMID: 31313593 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 18, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Tools for the assessment of breast cancer screening beliefs in women: a literature review.
Conclusion: The conclusion of this review contributes to the development of a more comprehensive and objective instruments based on the deficiencies of the existing studies. PMID: 31298055 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 14, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Ability to pay for medication: a clustering analysis of 1404 patients with the Patient Financial Eligibility Tool.
Conclusion: The PFET is a versatile tool that can be adapted to each country's economic context to assess patients' ability to contribute to their medication costs. PMID: 31298554 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 14, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors associated with delay in presentation among patients for oral cancer.
Conclusion: Delay in presentation may be achieved through regular oral health screening and improved public education about factors influencing delay. PMID: 31290337 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors associated with evidence-based decision-making among patients and providers.
Conclusion: Efforts to promote evidence-based medical decision-making among patients and providers should focus on skills training to improve self efficacy, and messages that highlight the benefits of patient engagement in medical decisions. PMID: 31290682 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Evolution of functional class,  biochemical and echocardiographic parameters and clinical outcomes after sacubitril/valsartan initiation in daily practice.
Evolution of functional class, biochemical and echocardiographic parameters and clinical outcomes after sacubitril/valsartan initiation in daily practice. J Comp Eff Res. 2019 Jul 10;: Authors: Morillas-Climent H, Seller-Moya J, Vicedo-López Á, Galcerá-Jornet E, Alania-Torres E, Rodríguez-Pichardo Y, Larumbe-Rodríguez A, Valle-Muñoz A Abstract Aim: To analyze the impact of sacubitril/valsartan on functional class, surrogate parameters and clinical outcomes in clinical practice. Methods: Retrospective study of patients with heart failure and reduced ejectio...
Source: Journal of Comparative Effectiveness Research - July 12, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Awareness and acceptability of Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials core outcome set for chronic pain among surveyed neuropathic pain authors.
Conclusion: The adoption of IMMPACT-recommended COS and COM among NeuP authors was inadequate and their appropriateness needs to be further evaluated. PMID: 31290689 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Engaging parent-child dyad and healthcare provider stakeholders in a patient-centered comparative effectiveness study.
Conclusion: Results highlight diverse methods of engaging patient and professional stakeholders, critical recommendations for improving study engagement and retention, and future directions for this patient-engaged comparative effectiveness research. PMID: 31290702 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Indirect comparison of nivolumab ± ipilimumab (CheckMate 032) versus other treatments for recurrent small-cell lung cancer.
Conclusion: Compared with chemotherapies for recurrent small-cell lung cancer, nivolumab ± ipilimumab improves response duration, which may translate to long-term survival benefits. PMID: 31237143 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 28, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of lenalidomide plus low-dose dexamethasone for newly diagnosed multiple myeloma patients ineligible for stem cell transplantation in China.
Conclusion: The cost-effectiveness of Rd relative to BCT for ndMM in Chinese patients is highly attractive. PMID: 31232089 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 25, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment patterns, glycemic control & bodyweight with canagliflozin 300  mg versus GLP1RAs in Type II diabetes patients.
Treatment patterns, glycemic control & bodyweight with canagliflozin 300 mg versus GLP1RAs in Type II diabetes patients. J Comp Eff Res. 2019 Jun 06;: Authors: Coleman CI, Pandya S, Wang L, Baser O, Cai J, Ingham M, Bookhart B Abstract Aim: Real-world effectiveness of canagliflozin 300 mg versus glucagon-like peptide-1 receptor agonists (GLP1RAs) was examined in patients with Type II diabetes. Patients & methods: Patients were selected from the Optum integrated database of administrative claims and electronic health record data (1 January 2013 to 31 March 2015). Results: Patients were...
Source: Journal of Comparative Effectiveness Research - June 8, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Risk of acute kidney injury in patients with HIV receiving proton pump inhibitors.
Conclusion: A nationwide cohort study supported the relationship of an increased risk of AKI in patients receiving PPIs. PMID: 31167563 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 8, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Complications in type III open tibial shaft fractures treated with open reduction and internal fixation.
Conclusion: Patients with an ORIF procedure for Type III TSF have a high risk of FRI and nonunion and; FRI significantly increased the healthcare burden. PMID: 31172791 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 8, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effects of mindfulness-based interventions on quality of life of women with breast cancer: a systematic review.
Conclusion: The MBSR intervention on quality of life among women with breast cancer was effective and safe. The effect of MBCT intervention on quality of life still needs more research. PMID: 31166120 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 7, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of conservative treatment with appendectomy for acute uncomplicated pediatric appendicitis: a meta-analysis.
Authors: Bi LW, Yan BL, Yang QY, Cui HL Abstract Aim: We aimed to compare conservative treatment with surgery for uncomplicated pediatric appendicitis to estimate effectiveness and safety. Methods: Data recorded until September 2018 were searched, and relevant academic articles from PubMed, EMBASE, the Cochrane Library and other libraries were selected. STATA version 13.0 (Stata Corporation, TX, USA) was used for statistical analysis. Results: We identified nine eligible papers. The study reported a significant difference in the success rate of treatment in 1 month and in 1 year, and no difference in the incid...
Source: Journal of Comparative Effectiveness Research - May 31, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Agreement between manual and automatic analyses of home sleep examinations in pediatric obstructive sleep apnea.
Authors: Ørntoft M, Andersen IG, Homøe P Abstract Aim: Home sleep testing is becoming more common in the diagnostics of pediatric obstructive sleep apnea. The aim was to examine the agreement between manual and automatic analyses of home sleep examinations in children and adolescents. Materials & methods: Sleep examinations recorded with a type 3 sleep monitor (Nox T3) were analyzed manually by a registered polysomnographic technologist and automatically with Noxturnal version 5.1. Results: 51sleep examinations on children and adolescents with a median age of 13.6 years were included. Th...
Source: Journal of Comparative Effectiveness Research - May 29, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

As health technology assessment evolves so must its approach to patient involvement.
Authors: Facey KM PMID: 31116026 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

In vitro antioxidant activity and in vivo wound-healing effect of lecithin liposomes: a comparative study.
This study was conducted to determine the potentials of egg lecithin (egg-l) and soy lecithin (soy-l) liposomes in antioxidative and wound healing properties. Materials & methods: The suspensions of egg-l and soy-l were prepared using the fusion technique. The free radical scavenging activity of both lecithin liposomes was evaluated by DPPH and ABTS methods. Tissue staining was used to assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend of 1-10 mg/ml in radical-scavenging activities (p 
Source: Journal of Comparative Effectiveness Research - May 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

An evidence-based model to consolidate medication adherence cost estimation: the medication adherence cost estimation framework.
Conclusion: The medication adherence cost estimation framework enables the comparison of costing studies, facilitating informed health policy decision-making based on consistent evidence and terminology. PMID: 31116029 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Is routine baseline brain imaging needed for all newly diagnosed non-small-cell lung cancer patients?
Conclusion: In view of the poor specificity, the current study calls for reconsideration of the universal recommendation of dedicated brain imaging (in addition to PET/CT scan) among NSCLC patients beyond stage I. PMID: 31116030 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 24, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Complications and associated healthcare costs of transvenous cardiac pacemakers in Germany.
Conclusion: Pacemaker complications are common and represent a burden for patients and healthcare systems generating substantial costs. Most of the pacemaker complications involved the pacing lead or pacemaker pocket. PMID: 31099255 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment patterns and costs among biologic-naive patients initiating apremilast or biologics for psoriatic arthritis.
Authors: Feldman SR, Pelletier CL, Wilson KL, Mehta RK, Brouillette MA, Smith D, Bonafede MM Abstract Aim: We evaluated treatment patterns and healthcare costs of initiating psoriatic arthritis (PsA) treatment with oral apremilast versus biologics. Methods: Claims data identified biologic-naive adults with PsA who initiated either apremilast or a biologic from 2013 to 2016. Results: Medication adherence was similar at 12 months (76.9 vs 73.4%; p = 0.175) between apremilast (n = 381) and matched biologic (n = 761) patients. Apremilast users had $12,715 lower total costs per-patient-per-month (p 
Source: Journal of Comparative Effectiveness Research - May 15, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world effectiveness of palonosetron-based antiemetic regimens: preventing chemotherapy-induced nausea and vomiting.
Authors: Schwartzberg LS, Marks SM, Gabrail NY, Geller RB, Kish J Abstract Aim: To evaluate real-world effectiveness of guideline-recommended palonosetron-containing antiemetic regimens in patients receiving highly (HEC) or moderately emetogenic (MEC) chemotherapy. Patients & methods: This retrospective analysis used records of adults receiving first-line chemotherapy and a three-drug palonosetron-containing antiemetic regimen for HEC or palonosetron-containing antiemetic regimen for MEC (carboplatin). Results: A total of 1587 records were evaluated. For HEC and MEC, respectively, chemotherapy-induced nausea an...
Source: Journal of Comparative Effectiveness Research - May 11, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Paper and electronic versions of HM-PRO, a novel patient-reported outcome measure for hematology: an equivalence study.
Conclusion: Measurement equivalence has been demonstrated for the paper and electronic application of the HM-PRO. PMID: 31037971 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 2, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Ongoing initiatives within the Scottish National Health Service to affect the prescribing of selective serotonin reuptake inhibitors and their influence.
Conclusion: Multiple initiatives have increased the quality and efficiency of SSRI prescribing in Scotland providing direction to others. PMID: 31023070 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 28, 2019 Category: General Medicine Tags: J Comp Eff Res Source Type: research