Willingness to pay for a hypothetical malaria vaccine in  Brazil: a cross-sectional study and the implications
Conclusion: The northern region of Brazil is one of the largest markets for a malaria vaccine due to its epidemiological relevance. Consequently, economic studies will be important to assist in the assessment of the potential price and value of new vaccines.PMID:35029122 | DOI:10.2217/cer-2021-0073 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 14, 2022 Category: General Medicine Authors: Maria Jos é Labis da Costa Gesiane Cavalcante Nascimento Thannuse Silva Athie Juliana de Sales Silva Edna Afonso Reis Antony Paul Martin Brian Godman Isabella Piassi Dias God ói Source Type: research

Does off-hours endoscopic hemostasis affect outcomes of nonvariceal upper gastrointestinal bleeding?
Conclusion: Off-hours effect may affect outcomes of higher-risk NVUGIB patients receiving endoscopic hemostasis (GBS ≥12).PMID:35023357 | DOI:10.2217/cer-2021-0155 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Jia-Lun Guan Ge Wang Dan Fang Ying-Ying Han Mu-Ru Wang De-An Tian Pei-Yuan Li Source Type: research

Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in colorectal cancer: a meta-analysis
Conclusion: The authors' study indicates that PD-1/PD-L1 inhibitors manifest promising clinical responses in the treatment of CRC with deficient mismatch repair with acceptable treatment-related adverse events.PMID:35023361 | DOI:10.2217/cer-2021-0134 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Chunhui Jin Xiaodan Zhu Xiaona Huang Tingjie Gong Zhipeng Wei Jianliang You Source Type: research

Respiratory and nonrespiratory COVID-19 complications in patients with obesity: recent developments
J Comp Eff Res. 2022 Jan 13. doi: 10.2217/cer-2021-0237. Online ahead of print.ABSTRACTThis narrative review summarizes recent reports to provide an updated understanding of the multiorgan effects of SARS-CoV-2 infection in obese individuals. A PubMed search of 528 primary articles was performed, with inclusion based on novelty, relevance and redundancy. Obesity confers an increased risk for hospitalization, intensive care unit admission, severe pneumonia, intubation and acute kidney injury in COVID-19 patients. Obesity is also associated with higher levels of inflammatory and thrombotic markers. However, the associations ...
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Esther Liu Hudson Lee Briana Lui Robert S White Jon D Samuels Source Type: research

Does off-hours endoscopic hemostasis affect outcomes of nonvariceal upper gastrointestinal bleeding?
Conclusion: Off-hours effect may affect outcomes of higher-risk NVUGIB patients receiving endoscopic hemostasis (GBS ≥12).PMID:35023357 | DOI:10.2217/cer-2021-0155 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Jia-Lun Guan Ge Wang Dan Fang Ying-Ying Han Mu-Ru Wang De-An Tian Pei-Yuan Li Source Type: research

Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in colorectal cancer: a meta-analysis
Conclusion: The authors' study indicates that PD-1/PD-L1 inhibitors manifest promising clinical responses in the treatment of CRC with deficient mismatch repair with acceptable treatment-related adverse events.PMID:35023361 | DOI:10.2217/cer-2021-0134 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Chunhui Jin Xiaodan Zhu Xiaona Huang Tingjie Gong Zhipeng Wei Jianliang You Source Type: research

Respiratory and nonrespiratory COVID-19 complications in patients with obesity: recent developments
J Comp Eff Res. 2022 Jan 13. doi: 10.2217/cer-2021-0237. Online ahead of print.ABSTRACTThis narrative review summarizes recent reports to provide an updated understanding of the multiorgan effects of SARS-CoV-2 infection in obese individuals. A PubMed search of 528 primary articles was performed, with inclusion based on novelty, relevance and redundancy. Obesity confers an increased risk for hospitalization, intensive care unit admission, severe pneumonia, intubation and acute kidney injury in COVID-19 patients. Obesity is also associated with higher levels of inflammatory and thrombotic markers. However, the associations ...
Source: Journal of Comparative Effectiveness Research - January 13, 2022 Category: General Medicine Authors: Esther Liu Hudson Lee Briana Lui Robert S White Jon D Samuels Source Type: research

Impact analysis of expanding anti-TNF therapy for Crohn's disease
Conclusion: Expanding anti-TNF therapy use among US adult patients with moderate-to-severe Crohn's disease would reduce morbidity and mortality, decrease disease-related medical costs and increase treatment costs compared with current practice. Despite the higher costs, this approach could substantially benefit patients.PMID:35014551 | DOI:10.2217/cer-2021-0063 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2022 Category: General Medicine Authors: Amanda Honeycutt Andrew Breck Sarah Bass Dominick Esposito Source Type: research

Variant analysis of SARS-CoV-2 strains with phylogenetic analysis and the  Coronavirus Antiviral and Resistance Database
Conclusion: The Stanford CoV-RDB analysis method appears useful for SARS-CoV-2 lineage surveillance.PMID:35014556 | DOI:10.2217/cer-2021-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2022 Category: General Medicine Authors: Murat Sayan Ayse Arikan Murat Isbilen Source Type: research

Impact analysis of expanding anti-TNF therapy for Crohn's disease
Conclusion: Expanding anti-TNF therapy use among US adult patients with moderate-to-severe Crohn's disease would reduce morbidity and mortality, decrease disease-related medical costs and increase treatment costs compared with current practice. Despite the higher costs, this approach could substantially benefit patients.PMID:35014551 | DOI:10.2217/cer-2021-0063 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2022 Category: General Medicine Authors: Amanda Honeycutt Andrew Breck Sarah Bass Dominick Esposito Source Type: research

Variant analysis of SARS-CoV-2 strains with phylogenetic analysis and the  Coronavirus Antiviral and Resistance Database
Conclusion: The Stanford CoV-RDB analysis method appears useful for SARS-CoV-2 lineage surveillance.PMID:35014556 | DOI:10.2217/cer-2021-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 11, 2022 Category: General Medicine Authors: Murat Sayan Ayse Arikan Murat Isbilen Source Type: research

SPECT/CT versus planar imaging to determine treatment strategy for non-small-cell lung cancer: a cost-effectiveness analysis
Conclusion: SPECT/CT resulted in substantially improved health outcomes and was found to be highly cost-effective.PMID:35006007 | DOI:10.2217/cer-2021-0139 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 10, 2022 Category: General Medicine Authors: Jonathan Romsa Ryan J Imhoff Swetha R Palli Richard Inculet Sanjay Mehta Source Type: research

R WE ready for reimbursement? A round up of developments in real-world evidence relating to HTA: part 5
J Comp Eff Res. 2022 Jan 6. doi: 10.2217/cer-2021-0302. Online ahead of print.ABSTRACTIn the latest update we focus on recent publications which have provided insights into the importance of focusing on the development and consideration of a body of real-world evidence, and an approach to evaluating the complex area of treatment sequencing.PMID:34989244 | DOI:10.2217/cer-2021-0302 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 6, 2022 Category: General Medicine Authors: Alex Simpson Sreeram V Ramagopalan Source Type: research

Economics of implementing an early deterioration detection solution for general care patients at a US hospital
Conclusion: Costs and LOS were lower after implementation of an EDDS for general care patients.PMID:34905953 | DOI:10.2217/cer-2021-0222 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 15, 2021 Category: General Medicine Authors: Belinda A Mohr Diane Bartos Stephen Dickson Libby Bucsi Mariska Vente Goran Medic Source Type: research

An economic evaluation of reducing colorectal cancer surveillance intensity
Conclusion: National implementation of low intensity post-treatment colorectal cancer surveillance has the potential to significantly reduce burden and costs on patients and their caregivers with no added risks to health.PMID:34903040 | DOI:10.2217/cer-2021-0065 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 14, 2021 Category: General Medicine Authors: Benjamin Allaire Robbie Skinner Grant King Amanda Honeycutt Dominick Esposito Source Type: research

Cost-effectiveness of brentuximab vedotin for the treatment of cutaneous T-cell lymphoma
Conclusion: BV is a highly cost-effective treatment for advanced cutaneous T-cell lymphoma.PMID:34879742 | DOI:10.2217/cer-2021-0201 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Tanja Podkonjak Holly Cranmer Julia Scarisbrick Grant McCarthy Cameron Lilley Lung-I Cheng Source Type: research

How the use of standardized protocols may paradoxically worsen disparities for safety-net hospitals
J Comp Eff Res. 2021 Dec 9. doi: 10.2217/cer-2021-0289. Online ahead of print.NO ABSTRACTPMID:34879744 | DOI:10.2217/cer-2021-0289 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Karam M Habchi Roniel Y Weinberg Robert S White Source Type: research

Cost-effectiveness of brentuximab vedotin for the treatment of cutaneous T-cell lymphoma
Conclusion: BV is a highly cost-effective treatment for advanced cutaneous T-cell lymphoma.PMID:34879742 | DOI:10.2217/cer-2021-0201 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Tanja Podkonjak Holly Cranmer Julia Scarisbrick Grant McCarthy Cameron Lilley Lung-I Cheng Source Type: research

How the use of standardized protocols may paradoxically worsen disparities for safety-net hospitals
J Comp Eff Res. 2021 Dec 9. doi: 10.2217/cer-2021-0289. Online ahead of print.NO ABSTRACTPMID:34879744 | DOI:10.2217/cer-2021-0289 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Karam M Habchi Roniel Y Weinberg Robert S White Source Type: research

Cost-effectiveness of brentuximab vedotin for the treatment of cutaneous T-cell lymphoma
Conclusion: BV is a highly cost-effective treatment for advanced cutaneous T-cell lymphoma.PMID:34879742 | DOI:10.2217/cer-2021-0201 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Tanja Podkonjak Holly Cranmer Julia Scarisbrick Grant McCarthy Cameron Lilley Lung-I Cheng Source Type: research

How the use of standardized protocols may paradoxically worsen disparities for safety-net hospitals
J Comp Eff Res. 2021 Dec 9. doi: 10.2217/cer-2021-0289. Online ahead of print.NO ABSTRACTPMID:34879744 | DOI:10.2217/cer-2021-0289 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Karam M Habchi Roniel Y Weinberg Robert S White Source Type: research

Cost-effectiveness of brentuximab vedotin for the treatment of cutaneous T-cell lymphoma
Conclusion: BV is a highly cost-effective treatment for advanced cutaneous T-cell lymphoma.PMID:34879742 | DOI:10.2217/cer-2021-0201 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Tanja Podkonjak Holly Cranmer Julia Scarisbrick Grant McCarthy Cameron Lilley Lung-I Cheng Source Type: research

How the use of standardized protocols may paradoxically worsen disparities for safety-net hospitals
J Comp Eff Res. 2021 Dec 9. doi: 10.2217/cer-2021-0289. Online ahead of print.NO ABSTRACTPMID:34879744 | DOI:10.2217/cer-2021-0289 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Karam M Habchi Roniel Y Weinberg Robert S White Source Type: research

Cost-effectiveness of brentuximab vedotin for the treatment of cutaneous T-cell lymphoma
Conclusion: BV is a highly cost-effective treatment for advanced cutaneous T-cell lymphoma.PMID:34879742 | DOI:10.2217/cer-2021-0201 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Tanja Podkonjak Holly Cranmer Julia Scarisbrick Grant McCarthy Cameron Lilley Lung-I Cheng Source Type: research

How the use of standardized protocols may paradoxically worsen disparities for safety-net hospitals
J Comp Eff Res. 2021 Dec 9. doi: 10.2217/cer-2021-0289. Online ahead of print.NO ABSTRACTPMID:34879744 | DOI:10.2217/cer-2021-0289 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 9, 2021 Category: General Medicine Authors: Karam M Habchi Roniel Y Weinberg Robert S White Source Type: research

Celebrating 10 years of the < em > Journal of Comparative Effectiveness Research < /em >
J Comp Eff Res. 2022 Jan;11(1):1-5. doi: 10.2217/cer-2021-0249.NO ABSTRACTPMID:34872331 | DOI:10.2217/cer-2021-0249 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 7, 2021 Category: General Medicine Authors: Laura Dormer Source Type: research

The cost-effectiveness of oral semaglutide versus empagliflozin in Type 2 diabetes in Denmark
Conclusion: Oral semaglutide+metformin seems not cost effective versus empagliflozin+metformin in patients uncontrolled on metformin in Denmark.PMID:34841893 | DOI:10.2217/cer-2021-0169 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 29, 2021 Category: General Medicine Authors: Lars H Ehlers Mark Lamotte Mafalda C Ramos Susanne Sandgaard Pia Holmgaard Evan C Frary Niels Ejskjaer Source Type: research

The cost-effectiveness of oral semaglutide versus empagliflozin in Type 2 diabetes in Denmark
Conclusion: Oral semaglutide+metformin seems not cost-effective versus empagliflozin+metformin in patients uncontrolled on metformin in Denmark.PMID:34841893 | DOI:10.2217/cer-2021-0169 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 29, 2021 Category: General Medicine Authors: Lars H Ehlers Mark Lamotte Mafalda C Ramos Susanne Sandgaard Pia Holmgaard Evan C Frary Niels Ejskjaer Source Type: research