Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis.
This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV. MATERIALS & METHODS: A retrospective propensity score-matched analysis was conducted, which retrieved the encounter data from 5582 hypertensive inpatients (with a median age of 69, female percentage of 48%, diastolic blood pressure ≥40 and
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Examples of dramatic failures and their effectiveness in modern surgical disciplines: can we learn from our mistakes?
Authors: Ball CG, Grondin SC, Pasieka JL, Kirkpatrick AW, MacLean AR, Cantle P, Dixon E, Schneider P, Hamilton M Abstract Innovation can be variably defined, but when applied to healthcare is often considered to be the introduction of something new, whether an idea, method or device, into an unfilled void or needy environment. Despite the introduction of many positive surgical subspecialty altering concepts/devices however, epic failures are not uncommon. These failures can be dramatic in regards to both their human and economic costs. They can also be very public or more quiet in nature. As surgical leaders in our...
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Evaluation of antihypertensive adherence and its determinants at primary healthcare facilities in rural South Africa.
CONCLUSION: Adherence and BP control were suboptimal, only smoking was an independent risk factor for adherence. Adherent patients were twice as likely to have controlled BP, although results were sensitive to the definition of adherence. Initiatives are in place to improve adherence, which will be monitored. PMID: 29888972 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 13, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Daclatasvir combined with asunaprevir is a cost-effective and cost-saving treatment for hepatitis C infection in China.
CONCLUSION: Treatment with DUAL provides significant clinical benefit, while accruing lower lifetime costs. PMID: 29860879 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 6, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A decision framework for treating chronic immune thrombocytopenia with thrombopoietin receptor agonists.
CONCLUSION: This framework facilitates decision-making in the management of chronic immune thrombocytopenia with eltrombopag and romiplostim. PMID: 29848048 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of EQ-5D and SF-36 in untreated patients with symptoms of intermittent claudication.
CONCLUSION: Both instruments have clinical validity for use in the PAD and can be used alongside each other to provide a holistic assessment of the HRQoL. Before using these two instruments interchangeably for utility score calculations and healthcare resource allocation, a thorough sensitivity analysis is necessary to explore the robustness of the value argument based on these utility scores. PMID: 29855189 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Pretreatment costs of care and time to initial treatment for patients with cancer of unknown primary.
Authors: Walker MS, Weinstein L, Luo R, Marino I Abstract AIM: Time to treatment and pretreatment costs may be affected by unknown primary tumor site. METHODS: This retrospective study used electronic medical record data from patients in ten US community oncology practices. Eligible patients were ≥18 years, diagnosed with cancer of unknown primary (CUP) or known metastatic solid tumor, and presented between 1 January 2012 and 30 June 2014. RESULTS: Patients with CUP (n = 294) had a longer interval than non-CUP patients (n = 92) from presentation to treatment initiation (1.18...
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Intravitreal aflibercept versus intravitreal ranibizumab in patients with age-related macular degeneration: a comparative effectiveness study.
CONCLUSION: With no difference in clinical effectiveness, longer treatment intervals for aflibercept should be investigated. PMID: 29855194 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Development of a veteran engagement toolkit for researchers.
Conclusion: Investigators wishing to engage the veteran community may benefit from the experience and lessons summarized in this veteran-informed toolkit, in addition to resources directed at informing community engagement more generally. PMID: 29856238 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effect of frailty on resource use and cost for Medicare patients.
CONCLUSION: Frailty contributes greatly to cost of care, but while often correlated, is not synonymous with MCCs. Thus, it is important to control separately for frailty in studies that compare medical care use and cost. PMID: 29808714 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Multi-stakeholder engagement in health services research.
Authors: Ladeji EO PMID: 29808715 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors influencing dabigatran or warfarin medication persistence in patients with nonvalvular atrial fibrillation.
CONCLUSION: Unadjusted persistence was significantly lower among dabigatran users (n = 1025) compared with matched warfarin users (38 vs 46%). Adjusting for covariates rendered this difference insignificant (hazard ratio = 0.930). PMID: 29808717 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers.
CONCLUSION: BLC versus FBCD showed significant differences in both time to and frequency of healing suggesting that BLCC may provide significant cost savings compared with FBCD. PMID: 29809059 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.
CONCLUSION: Initiating lesinurad would result in an incremental per-member per-month cost of US$0.06 over 5 years. PMID: 29792516 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Authors' lack of awareness and use of core outcome set on postoperative pain in children is hindering comparative effectiveness research.
CONCLUSION: Further discussions about the adequacy of COS for acute pediatric pain, as well as interventions to increase the uptake of COS may be warranted. PMID: 29775075 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparing efficacy of enteral nutrition plus ranitidine and enteral nutrition alone as stress ulcer prophylaxis.
CONCLUSION: EN was at least effective as ranitidine plus EN as SUP. PMID: 29775083 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Health state utilities in patients with advanced non-small-cell lung cancer in China.
CONCLUSION: This study provides the Chinese-specific health utility data for advanced NSCLC using the EQ-5D. PMID: 29775084 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Healthcare utilization and costs of multiple sclerosis patients in the Netherlands: a healthcare claims database study.
CONCLUSION: Dutch incidence and cost estimates based on claims were consistent with previous estimates. Prevalence estimates were somewhat higher. Drug and hospital costs were highest shortly after the diagnosis. Healthcare consumption related to comorbidities was in-line with the previously reported comorbidity estimates. PMID: 29775086 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 19, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Estimating efficiency of Directive 2011/24/EU cross-border healthcare in member states.
CONCLUSION: Our findings confirm that there is country-level variation in cross-border healthcare policy efficiency. PMID: 29770704 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 18, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Effects of calcimimetics on long-term outcomes in dialysis patients: literature review and Bayesian meta-analysis.
CONCLUSION: The results of this meta-analysis indicate that treatment of secondary hyperparathyroidism with calcimimetic therapy may in fact reduce mortality among patients receiving maintenance dialysis. This finding provides justification for a well-designed and adequately powered randomized trial to definitively address the question. PMID: 29762046 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 17, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost of treating peripheral neuropathic pain with pregabalin or gabapentin at therapeutic doses in routine practice.
CONCLUSION: At therapeutic doses, pregabalin was found to have lower healthcare and non-healthcare costs than gabapentin in routine practice. PMID: 29754518 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Adherence and economic impact of paliperidone palmitate versus oral atypical antipsychotics in a Medicare population.
Authors: Joshi K, Muser E, Xu Y, Schwab P, Datar M, Suehs B Abstract AIM: To compare adherence, healthcare utilization and costs among real world, Medicare-eligible patients with schizophrenia using long-acting injectable paliperidone palmitate (PP) versus oral atypical antipsychotics. Patients & methods: Historical cohort study used Medicare Advantage claims data. Inverse probability of treatment weighting was applied to adjust for baseline differences. 12-month adherence, healthcare utilization and costs were compared. RESULTS: Patients using PP were more adherent (proportion of days covered ≥0.8; 48.1 vs 32.6%; p
Source: Journal of Comparative Effectiveness Research - May 5, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Efficacy and metabolic effects of lurasidone versus brexpiprazole in schizophrenia: a network meta-analysis.
CONCLUSION: This network meta-analysis suggested that lurasidone had similar efficacy and fewer metabolic effects than brexpiprazole in patients with acute schizophrenia. PMID: 29697278 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 28, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

An indirect comparison of intravenous and subcutaneous belimumab efficacy in patients with SLE and high disease activity.
CONCLUSION: This indirect treatment comparison provides further evidence of the efficacy of belimumab IV and SC in patients with systemic lupus erythematosus and HDA, compared with standard therapy. PMID: 29692179 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budget impact analysis of long-acting injectable aripiprazole once-monthly 400 mg in bipolar I disorder in the USA.
CONCLUSION: As market shares of atypical antipsychotics are predicted to increase, payers may wish to re-evaluate their use. PMID: 29694243 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of long-acting injectable aripiprazole once-monthly 400  mg in bipolar I disorder in the USA.
CONCLUSION: AOM 400 may be considered cost effective in the maintenance monotherapy treatment of BP-I in adults. PMID: 29694244 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Clinical and economic benefits of advanced microplegia delivery system in cardiac surgery: evidence from 250 hospitals.
CONCLUSION: For hospitals with MPS2, significant reductions were seen in AEs, LOS and ICU days, which lead to reductions in total visit and medication costs. PMID: 29682984 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 25, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Analysis of indirect treatment comparisons in national health technology assessment assessments and requirements for industry submissions.
CONCLUSION: ITC is generally accepted as a technique that allows demonstration of noninferiority to a comparator provided the chosen methodology and underlying assumptions are clear and justified. However, HTA agencies are more likely to closely scrutinize submitted data and evaluate statistical significance of results when superiority is claimed. In addition, the HTA agencies in scope tended to be cautious and only accept ITC data as support for similarity of treatments. PMID: 29589475 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 29, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Therapeutic approach for patients with venous thromboembolism attended in emergency departments during routine clinical practice: the EDITH study.
Authors: Ruiz-Artacho P, Piñera P, Antolin A, Casal JR, Sanchez M, Suero C, Merlo M, Carriel J, Genis M, Jimenez S Abstract AIM: To analyze treatment at discharge/follow-up of patients diagnosed with venous thromboembolism (VTE) in the emergency department (ED). MATERIALS & METHODS: Ambispective study (50 Spanish centers) of consecutive patients (October-December 2014) with VTE diagnosed in ED. RESULTS: VTE was diagnosed in 775 patients (295 pulmonary embolism [PE] without deep vein thrombosis [DVT], 389 DVT without PE and 91 PE + DVT); 95.5% received anticoagulants (90.7% low-mole...
Source: Journal of Comparative Effectiveness Research - March 28, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Survival comparison of hepatocellular carcinoma patients treated with radioembolization versus nonoperative/interventional treatment.
Authors: Thayer D, Noda C, Charalel R, Mills A, Chang R, Tao Y, Akinwande O Abstract AIM: To compare the overall survival (OS) and liver cancer-specific survival of advanced-stage hepatocellular carcinoma (HCC) patients who received transarterial radioembolization (TARE) with those who received nonoperative/interventional treatment (NOT). MATERIALS & METHODS:  A total of 12,520 HCC patients from the Surveillance, Epidemiology and End Results database were categorized by treatment with either radioembolization or NOT. Kaplan-Meier and multivariate Cox regression were conducted. RESULTS: Th...
Source: Journal of Comparative Effectiveness Research - March 22, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic and organizational impact of the changing hospital funding practices of erythropoiesis-stimulating agents on the management of care of dialysis patients in France.
CONCLUSION: There is no significant impact of the change of funding of ESAs on the hospital activity. The DRG-based payment is negative for the budget of our hospitals but is positive for the French National Health Insurance. Indeed, with the price decrease, the ESAs are more costly for hospitals (not funded on top-of-DRG), but less costly for the society. PMID: 29537304 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 16, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Number needed to treat in indirect treatment comparison.
CONCLUSION: Using NNT to summarize the results of a matching adjusted indirect comparison can help the clinicians to better understand the results in addition to OR. PMID: 29537878 [PubMed - in process] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 16, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of therapies in lumbar degenerative disc disease: a network meta-analysis of randomized controlled trials.
CONCLUSION: activL substantially improves ODI success, back pain, and patient satisfaction compared with other therapies for single-level lumbar DDD. PMID: 29542364 [PubMed - in process] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 16, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Development and validation of a claims-based approach to proxy ECOG performance status across ten tumor groups.
CONCLUSION: Patients with poor PS can be identified in claims data. This prediction model enables future studies evaluating cancer treatments and outcomes to account for PS. PMID: 29533694 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 15, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Transitioning from learning healthcare systems to learning health care communities.
Authors: Mullins CD, Wingate LT, Edwards HA, Tofade T, Wutoh A Abstract The learning healthcare system (LHS) model framework has three core, foundational components. These include an infrastructure for health-related data capture, care improvement targets and a supportive policy environment. Despite progress in advancing and implementing LHS approaches, low levels of participation from patients and the public have hampered the transformational potential of the LHS model. An enhanced vision of a community-engaged LHS redesign would focus on the provision of health care from the patient and community perspective to c...
Source: Journal of Comparative Effectiveness Research - February 27, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Evaluation of comparative effectiveness research: a practical tool.
Authors: Schaumberg DA, McDonald L, Shah S, Stokes M, Nordstrom BL, Ramagopalan SV Abstract Comparative effectiveness research (CER) guidelines have been developed to direct the field toward the most rigorous study methodologies. A challenge, however, is how to ensure the best evidence is generated, and how to translate methodologically complex or nuanced CER findings into usable medical evidence. To reach that goal, it is important that both researchers and end users of CER output become knowledgeable about the elements that impact the quality and interpretability of CER. This paper distilled guidance on CER into ...
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Nine years of comparative effectiveness research education and training: initiative supported by the PhRMA Foundation.
This report describes the initiative of the Pharmaceutical Research and Manufacturers Association of America (PhRMA) Foundation. Through provision of grant funding to six academic Centers of Excellence, to spearheading and sponsoring three national conferences, the PhRMA Foundation has made significant contributions to creation of the scientific workforce that conducts and uses CER/PCOR. PMID: 29464964 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness and patient-centered outcomes research: enhancing uptake and use by patients, clinicians and payers.
Authors: Schumock GT, Pickard AS Abstract Evidence from comparative effectiveness research (CER) and patient-centered outcomes research (PCOR) studies are increasingly available in the literature. However, there remain opportunities to better integrate that evidence into decision-making. An invitation-only conference held in January 2017, titled "Comparative Effectiveness and Patient-Centered Outcomes Research: Enhancing Uptake and Use by Patients, Clinicians and Payers", sought to identify and discuss both gaps in the uptake and use of CER/PCOR, and approaches to enhance the uptake and use of CER/PCOR ev...
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Trends in transfusion rates after the FOCUS trial.
CONCLUSION: The FOCUS trial affected practice, but there are additional opportunities to reduce the use of transfusions. PMID: 29464966 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The Familias Saludables partnership: Engaging the Latino community to address early childhood obesity.
Authors: Thompson DA, Federspiel DA Abstract Darcy A Thompson is an Associate Professor of pediatrics at the University of Colorado School of Medicine. Her main research seeks to address early childhood obesity in low-income children. She works in the Lifestyle Medicine clinic at Children's Hospital Colorado, a clinic focused on caring for children with obesity and related comorbidities. She is also an Associate Medical Director for the Research Institute at Children's Hospital Colorado. Her training includes a Master of Public Health degree, a medical degree (Yale University) and the Robert Wood Johnson Clini...
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Increasing uptake of comparative effectiveness and patient-centered outcomes research among stakeholders: insights from conference discussion.
This report summarizes the conference discussion in the following sections: preconference survey; summary of barriers and strategies to the uptake of CER/PCOR identified by conference attendees; and future perspectives on the field. PMID: 29465252 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study.
CONCLUSION: 28% of patients had a poor adherence to anticoagulant treatment. 62% of patients were treated with the lower doses of DOACs. PMID: 29465254 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Experience with developing antibiotic stewardship programs in Serbia: potential model for other Balkan countries?
CONCLUSION: Concerns with inappropriate use and high resistance rates among some antibiotics used in the hospital are being used to develop guidance on future antibiotic use in this hospital, building on the recently introduced antibiotic stewardship program, as well as encourage other hospitals in Serbia to review their policies. PMID: 29465263 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 23, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Healthcare resource utilization and costs in amyloid light-chain amyloidosis: a real-world study using US claims data.
CONCLUSION: AL chemotherapy-based prescribing practices changed. Total annual healthcare costs increased over time among AL amyloidosis patients. PMID: 29390860 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 3, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost assessment of treatment of acute myocardial infarction and angiographically visible coronary thrombus.
CONCLUSION: A complex pharmaco-interventional strategy, with glycoprotein IIb/IIIa inhibitor and MT, though more expensive, may prove cost-effective. PMID: 29376402 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 31, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Outcomes research examining treatments, quality of life and costs in HER2-negative and triple-negative metastatic breast cancer: a systematic literature review.
CONCLUSION: Outcomes research in HER2-negative mBC in the USA was limited, specifically among TN patients, indicating an opportunity for further research in this high unmet need population. Endpoints and treatment options varied, thus, it is difficult to draw summary conclusions about these studies. Outcomes research examining real-world data in mBC has increased in recent years, and may continue to grow with the implementation of new policy programs. PMID: 29303361 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 7, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Introducing Volume 7 of the Journal of Comparative Effectiveness Research.
Authors: Dormer L Abstract Welcome to the seventh volume of the Journal of Comparative Effectiveness Research. It is great to start the year with a look back at some of our successes from 2017, as well as a look forward to the content of this issue and beyond. PMID: 29303364 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 7, 2018 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Study protocol for the dabigatran, apixaban, rivaroxaban, edoxaban, warfarin comparative effectiveness research study.
Authors: Krumme AA, Pawar A, Schneeweiss S, Glynn RJ, Choudhry NK, Kulldorff M, Ortiz AS, Avorn J, Gagne JJ Abstract Since 2010, four oral anticoagulants have been approved for marketing in addition to warfarin for treatment of thromboembolic disease. Limited head-to-head data exist comparing these treatments, leaving patients and clinicians with little guidance for selecting a strategy that balances recurrence reduction with bleeding risk. In the dabigatran, apixaban, rivaroxban, edoxaban and warfarin comparative effectiveness research study, we compare all five currently available oral anticoagulant agents for th...
Source: Journal of Comparative Effectiveness Research - December 22, 2017 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Pharmacoeconomic study comparing carbetocin with oxytocin for the prevention of hemorrhage following cesarean delivery in Lima, Peru.
CONCLUSION: Carbetocin is more cost-effective than oxytocin for prevention of uterine hemorrhage after cesarean delivery. PMID: 29264934 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 22, 2017 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness analysis of treatments involving radioembolization in intermediate-stage hepatocellular carcinoma.
CONCLUSION: Taking into consideration 16 patients for TTS and 22 patients for TS pathways, the TTS sequence provided a dominant strategy in comparison to TS. Further evidence is desirable to confirm these results. PMID: 29231047 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 14, 2017 Category: General Medicine Tags: J Comp Eff Res Source Type: research