Predicting optimal treatment regimens for patients with HR+/HER2-  breast cancer using machine learning based on electronic health records
Conclusion: RSF may help inform optimal treatment choices and improve outcomes for patients with HR+/HER2- MBC.PMID:33980048 | DOI:10.2217/cer-2020-0230 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 13, 2021 Category: General Medicine Authors: Zhanglin Lin Cui Zbigniew Kadziola Ilya Lipkovich Douglas E Faries Kristin M Sheffield Gebra Cuyun Carter Source Type: research

Shifting demographics and comorbidity burden in adult Chinese urban patients with chronic hepatitis B, 2013 and 2016
J Comp Eff Res. 2021 Jun;10(8):647-657. doi: 10.2217/cer-2020-0080. Epub 2021 May 10.ABSTRACTChronic hepatitis B demographics and comorbidity data are limited in China. Materials & methods: The China Health Insurance Association claims database from 2013 and 2016 was used to augment the existing data: the proportion of patients aged>45 years increased significantly from 40.3% in 2013 to 49% in 2016 (p
Source: Journal of Comparative Effectiveness Research - May 10, 2021 Category: General Medicine Authors: Jinlin Hou Wendong Chen Ying Han Lei Wang I-Heng Lee Ling-I Hsu Dongying Xie Xueru Yin Fengqin Hou Yida Yang Source Type: research

Shifting demographics and comorbidity burden in adult Chinese urban patients with chronic hepatitis B, 2013 and 2016
J Comp Eff Res. 2021 May 10. doi: 10.2217/cer-2020-0080. Online ahead of print.ABSTRACTChronic hepatitis B demographics and comorbidity data are limited in China. Materials & methods: The China Health Insurance Association claims database from 2013 and 2016 was used to augment the existing data: the proportion of patients aged>45 years increased significantly from 40.3% in 2013 to 49% in 2016 (p
Source: Journal of Comparative Effectiveness Research - May 10, 2021 Category: General Medicine Authors: Jinlin Hou Wendong Chen Ying Han Lei Wang I-Heng Lee Ling-I Hsu Dongying Xie Xueru Yin Fengqin Hou Yida Yang Source Type: research

Current practice of stakeholder engagement: researchers' experiences in North America, DACH countries and China
Conclusion: Stakeholder engagement is perceived very differently among participants from DACH countries, North America and China. For a broader acceptance and implementation institutional support and motivational conditions might be needed.PMID:33955232 | DOI:10.2217/cer-2020-0279 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Anna Hei ß Jiani Wang Yutong Fei Ruyu Xia Katja Icke Daniel Pach Claudia M Witt Source Type: research

DAPA-RWE: a retrospective multicenter study comparing dapagliflozin and sitagliptin in patients with Type 2 diabetes treated under routine clinical practice in Spain
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2020-0264. Online ahead of print.ABSTRACTBackground: Weight reduction and glycemic control are key goals during Type 2 diabetes management. However, there are few country-specific, real-world data on cotransporter 2 inhibitors. Materials & methods: DAPA-RWE was a retrospective, multicenter study comparing the efficacy of dapagliflozin versus sitagliptin in Type 2 diabetes patients in Spain. Results: The study population comprised 1046 patients (594 with dapagliflozin, 452 with sitagliptin). Age was 61.8 ± 10.0 and 66.2 ± 11.4 years and glycosylated hemoglobin (...
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Cristobal Morales Virginia Bellido Cristina Tejera Fernando Go ñi Rafael Palomares Cristina Sevillano Diego Bellido Alfonso Soto Miguel Ángel Mangas Manuel A Botana Irene Caballero Source Type: research

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2021-0098. Online ahead of print.ABSTRACTHighlighting the latest developments in both real-world evidence as it relates to health technology assessment and acceptance of real-world evidence by health technology assessment agencies.PMID:33955236 | DOI:10.2217/cer-2021-0098 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Alex Simpson Sreeram V Ramagopalan Source Type: research

Current practice of stakeholder engagement: researchers' experiences in North America, DACH countries and China
Conclusion: Stakeholder engagement is perceived very differently among participants from DACH countries, North America and China. For a broader acceptance and implementation institutional support and motivational conditions might be needed.PMID:33955232 | DOI:10.2217/cer-2020-0279 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Anna Hei ß Jiani Wang Yutong Fei Ruyu Xia Katja Icke Daniel Pach Claudia M Witt Source Type: research

DAPA-RWE: a retrospective multicenter study comparing dapagliflozin and sitagliptin in patients with Type 2 diabetes treated under routine clinical practice in Spain
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2020-0264. Online ahead of print.ABSTRACTBackground: Weight reduction and glycemic control are key goals during Type 2 diabetes management. However, there are few country-specific, real-world data on cotransporter 2 inhibitors. Materials & methods: DAPA-RWE was a retrospective, multicenter study comparing the efficacy of dapagliflozin versus sitagliptin in Type 2 diabetes patients in Spain. Results: The study population comprised 1046 patients (594 with dapagliflozin, 452 with sitagliptin). Age was 61.8 ± 10.0 and 66.2 ± 11.4 years and glycosylated hemoglobin (...
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Cristobal Morales Virginia Bellido Cristina Tejera Fernando Go ñi Rafael Palomares Cristina Sevillano Diego Bellido Alfonso Soto Miguel Ángel Mangas Manuel A Botana Irene Caballero Source Type: research

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2021-0098. Online ahead of print.ABSTRACTHighlighting the latest developments in both real-world evidence as it relates to health technology assessment and acceptance of real-world evidence by health technology assessment agencies.PMID:33955236 | DOI:10.2217/cer-2021-0098 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Alex Simpson Sreeram V Ramagopalan Source Type: research

Current practice of stakeholder engagement: researchers' experiences in North America, DACH countries and China
Conclusion: Stakeholder engagement is perceived very differently among participants from DACH countries, North America and China. For a broader acceptance and implementation institutional support and motivational conditions might be needed.PMID:33955232 | DOI:10.2217/cer-2020-0279 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Anna Hei ß Jiani Wang Yutong Fei Ruyu Xia Katja Icke Daniel Pach Claudia M Witt Source Type: research

DAPA-RWE: a retrospective multicenter study comparing dapagliflozin and sitagliptin in patients with Type 2 diabetes treated under routine clinical practice in Spain
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2020-0264. Online ahead of print.ABSTRACTBackground: Weight reduction and glycemic control are key goals during Type 2 diabetes management. However, there are few country-specific, real-world data on cotransporter 2 inhibitors. Materials & methods: DAPA-RWE was a retrospective, multicenter study comparing the efficacy of dapagliflozin versus sitagliptin in Type 2 diabetes patients in Spain. Results: The study population comprised 1046 patients (594 with dapagliflozin, 452 with sitagliptin). Age was 61.8 ± 10.0 and 66.2 ± 11.4 years and glycosylated hemoglobin (...
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Cristobal Morales Virginia Bellido Cristina Tejera Fernando Go ñi Rafael Palomares Cristina Sevillano Diego Bellido Alfonso Soto Miguel Ángel Mangas Manuel A Botana Irene Caballero Source Type: research

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2021-0098. Online ahead of print.ABSTRACTHighlighting the latest developments in both real-world evidence as it relates to health technology assessment and acceptance of real-world evidence by health technology assessment agencies.PMID:33955236 | DOI:10.2217/cer-2021-0098 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Alex Simpson Sreeram V Ramagopalan Source Type: research

Current practice of stakeholder engagement: researchers' experiences in North America, DACH countries and China
Conclusion: Stakeholder engagement is perceived very differently among participants from DACH countries, North America and China. For a broader acceptance and implementation institutional support and motivational conditions might be needed.PMID:33955232 | DOI:10.2217/cer-2020-0279 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Anna Hei ß Jiani Wang Yutong Fei Ruyu Xia Katja Icke Daniel Pach Claudia M Witt Source Type: research

DAPA-RWE: a retrospective multicenter study comparing dapagliflozin and sitagliptin in patients with Type 2 diabetes treated under routine clinical practice in Spain
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2020-0264. Online ahead of print.ABSTRACTBackground: Weight reduction and glycemic control are key goals during Type 2 diabetes management. However, there are few country-specific, real-world data on cotransporter 2 inhibitors. Materials & methods: DAPA-RWE was a retrospective, multicenter study comparing the efficacy of dapagliflozin versus sitagliptin in Type 2 diabetes patients in Spain. Results: The study population comprised 1046 patients (594 with dapagliflozin, 452 with sitagliptin). Age was 61.8 ± 10.0 and 66.2 ± 11.4 years and glycosylated hemoglobin (...
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Cristobal Morales Virginia Bellido Cristina Tejera Fernando Go ñi Rafael Palomares Cristina Sevillano Diego Bellido Alfonso Soto Miguel Ángel Mangas Manuel A Botana Irene Caballero Source Type: research

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment
J Comp Eff Res. 2021 May 6. doi: 10.2217/cer-2021-0098. Online ahead of print.ABSTRACTHighlighting the latest developments in both real-world evidence as it relates to health technology assessment and acceptance of real-world evidence by health technology assessment agencies.PMID:33955236 | DOI:10.2217/cer-2021-0098 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 6, 2021 Category: General Medicine Authors: Alex Simpson Sreeram V Ramagopalan Source Type: research

Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2021-0038. Online ahead of print.ABSTRACTHemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatme...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Philippe Godeberge Parvez Sheikh Varut Lohsiriwat Abel Jalife Yury Shelygin Source Type: research

Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2020-0228. Online ahead of print.ABSTRACTDecision-makers have become increasingly interested in incorporating real-world evidence (RWE) into their decision-making process. Due to concerns regarding the reliability and quality of RWE, stakeholders have issued numerous recommendation documents to assist in setting RWE standards. The fragmented nature of these documents poses a challenge to researchers and decision-makers looking for guidance on what is 'high-quality' RWE and how it can be used in decision-making. We offer researchers and decision-makers a structure to organize th...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Ashley Jaksa James Wu P áll Jónsson Hans-Georg Eichler Sarah Vititoe Nicolle M Gatto Source Type: research

Safety and efficacy of GP40071 compared with originator insulin aspart (NovoRapid < sup > ® < /sup > Penfill < sup > ® < /sup > ) in Type 1 diabetes mellitus
Conclusion: GP-Asp demonstrated similar safety and efficacy. Trial registration number: NCT04079413 (ClinicalTrials.gov).PMID:33928797 | DOI:10.2217/cer-2020-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Tatiana L Karonova Alexander Y Mayorov Maxim A Magruk Svetlana T Zyangirova Irina V Grigoryeva Oleg K Khmelnitski Anton Myshkovets Tatyana M Parfenova Anna A Mosikian Roman V Drai Source Type: research

Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2021-0038. Online ahead of print.ABSTRACTHemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatme...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Philippe Godeberge Parvez Sheikh Varut Lohsiriwat Abel Jalife Yury Shelygin Source Type: research

Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2020-0228. Online ahead of print.ABSTRACTDecision-makers have become increasingly interested in incorporating real-world evidence (RWE) into their decision-making process. Due to concerns regarding the reliability and quality of RWE, stakeholders have issued numerous recommendation documents to assist in setting RWE standards. The fragmented nature of these documents poses a challenge to researchers and decision-makers looking for guidance on what is 'high-quality' RWE and how it can be used in decision-making. We offer researchers and decision-makers a structure to organize th...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Ashley Jaksa James Wu P áll Jónsson Hans-Georg Eichler Sarah Vititoe Nicolle M Gatto Source Type: research

Safety and efficacy of GP40071 compared with originator insulin aspart (NovoRapid < sup > ® < /sup > Penfill < sup > ® < /sup > ) in Type 1 diabetes mellitus
Conclusion: GP-Asp demonstrated similar safety and efficacy. Trial registration number: NCT04079413 (ClinicalTrials.gov).PMID:33928797 | DOI:10.2217/cer-2020-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Tatiana L Karonova Alexander Y Mayorov Maxim A Magruk Svetlana T Zyangirova Irina V Grigoryeva Oleg K Khmelnitski Anton Myshkovets Tatyana M Parfenova Anna A Mosikian Roman V Drai Source Type: research

Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2021-0038. Online ahead of print.ABSTRACTHemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatme...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Philippe Godeberge Parvez Sheikh Varut Lohsiriwat Abel Jalife Yury Shelygin Source Type: research

Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2020-0228. Online ahead of print.ABSTRACTDecision-makers have become increasingly interested in incorporating real-world evidence (RWE) into their decision-making process. Due to concerns regarding the reliability and quality of RWE, stakeholders have issued numerous recommendation documents to assist in setting RWE standards. The fragmented nature of these documents poses a challenge to researchers and decision-makers looking for guidance on what is 'high-quality' RWE and how it can be used in decision-making. We offer researchers and decision-makers a structure to organize th...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Ashley Jaksa James Wu P áll Jónsson Hans-Georg Eichler Sarah Vititoe Nicolle M Gatto Source Type: research

Safety and efficacy of GP40071 compared with originator insulin aspart (NovoRapid < sup > ® < /sup > Penfill < sup > ® < /sup > ) in Type 1 diabetes mellitus
Conclusion: GP-Asp demonstrated similar safety and efficacy. Trial registration number: NCT04079413 (ClinicalTrials.gov).PMID:33928797 | DOI:10.2217/cer-2020-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Tatiana L Karonova Alexander Y Mayorov Maxim A Magruk Svetlana T Zyangirova Irina V Grigoryeva Oleg K Khmelnitski Anton Myshkovets Tatyana M Parfenova Anna A Mosikian Roman V Drai Source Type: research

Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2021-0038. Online ahead of print.ABSTRACTHemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatme...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Philippe Godeberge Parvez Sheikh Varut Lohsiriwat Abel Jalife Yury Shelygin Source Type: research

Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2020-0228. Online ahead of print.ABSTRACTDecision-makers have become increasingly interested in incorporating real-world evidence (RWE) into their decision-making process. Due to concerns regarding the reliability and quality of RWE, stakeholders have issued numerous recommendation documents to assist in setting RWE standards. The fragmented nature of these documents poses a challenge to researchers and decision-makers looking for guidance on what is 'high-quality' RWE and how it can be used in decision-making. We offer researchers and decision-makers a structure to organize th...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Ashley Jaksa James Wu P áll Jónsson Hans-Georg Eichler Sarah Vititoe Nicolle M Gatto Source Type: research

Safety and efficacy of GP40071 compared with originator insulin aspart (NovoRapid < sup > ® < /sup > Penfill < sup > ® < /sup > ) in Type 1 diabetes mellitus
Conclusion: GP-Asp demonstrated similar safety and efficacy. Trial registration number: NCT04079413 (ClinicalTrials.gov).PMID:33928797 | DOI:10.2217/cer-2020-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Tatiana L Karonova Alexander Y Mayorov Maxim A Magruk Svetlana T Zyangirova Irina V Grigoryeva Oleg K Khmelnitski Anton Myshkovets Tatyana M Parfenova Anna A Mosikian Roman V Drai Source Type: research

Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2021-0038. Online ahead of print.ABSTRACTHemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatme...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Philippe Godeberge Parvez Sheikh Varut Lohsiriwat Abel Jalife Yury Shelygin Source Type: research

Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
J Comp Eff Res. 2021 Apr 30. doi: 10.2217/cer-2020-0228. Online ahead of print.ABSTRACTDecision-makers have become increasingly interested in incorporating real-world evidence (RWE) into their decision-making process. Due to concerns regarding the reliability and quality of RWE, stakeholders have issued numerous recommendation documents to assist in setting RWE standards. The fragmented nature of these documents poses a challenge to researchers and decision-makers looking for guidance on what is 'high-quality' RWE and how it can be used in decision-making. We offer researchers and decision-makers a structure to organize th...
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Ashley Jaksa James Wu P áll Jónsson Hans-Georg Eichler Sarah Vititoe Nicolle M Gatto Source Type: research

Safety and efficacy of GP40071 compared with originator insulin aspart (NovoRapid < sup > ® < /sup > Penfill < sup > ® < /sup > ) in Type 1 diabetes mellitus
Conclusion: GP-Asp demonstrated similar safety and efficacy. Trial registration number: NCT04079413 (ClinicalTrials.gov).PMID:33928797 | DOI:10.2217/cer-2020-0208 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 30, 2021 Category: General Medicine Authors: Tatiana L Karonova Alexander Y Mayorov Maxim A Magruk Svetlana T Zyangirova Irina V Grigoryeva Oleg K Khmelnitski Anton Myshkovets Tatyana M Parfenova Anna A Mosikian Roman V Drai Source Type: research

Robot-assisted minimally invasive transforaminal lumbar interbody fusion versus open transforaminal lumbar interbody fusion: a retrospective matched-control analysis for clinical and quality-of-life outcomes
J Comp Eff Res. 2021 Apr 28. doi: 10.2217/cer-2021-0078. Online ahead of print.ABSTRACTAim: To compare the screw accuracy and clinical outcomes between robot-assisted minimally invasive transforaminal lumbar interbody fusion (RA MIS-TLIF) and open TLIF in the treatment of one-level lumbar degenerative disease. Materials & methods: From May 2018 to December 2019, a consecutive series of patients undergoing robot-assisted minimally invasive one-level lumbar fusion procedures were retrospectively compared with matched controls who underwent one-level open TLIF procedures for clinical and quality-of-life outcomes. Results:...
Source: Journal of Comparative Effectiveness Research - April 28, 2021 Category: General Medicine Authors: Xiuyuan Chen Qingxin Song Kun Wang Zhi Chen Yingchao Han Hongxing Shen Quan Li Source Type: research

Economic analysis of the use of video laryngoscopy versus direct laryngoscopy in the surgical setting
Conclusion: Video laryngoscopy may lower total costs, reduce LOS and decrease the likelihood of postoperative ICU admission.PMID:33904779 | DOI:10.2217/cer-2021-0068 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 27, 2021 Category: General Medicine Authors: Jianying Zhang Wei Jiang Felipe Urdaneta Source Type: research

Testing the efficacy of tocilizumab in patients with COVID-19 pneumonia
J Comp Eff Res. 2021 Apr 23. doi: 10.2217/cer-2021-0050. Online ahead of print.NO ABSTRACTPMID:33887951 | DOI:10.2217/cer-2021-0050 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 23, 2021 Category: General Medicine Authors: Mehmet Agirbasli Azra Tanr ıkulu Source Type: research

Letter to the Editor: critical appraisal to optimize clinical and economic impact of oxidized regenerated cellulose in surgical practice
J Comp Eff Res. 2021 Apr 21. doi: 10.2217/cer-2021-0007. Online ahead of print.NO ABSTRACTPMID:33880934 | DOI:10.2217/cer-2021-0007 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Gianluca Franceschini Source Type: research

Is Medicaid expansion associated with increases in palliative treatments for metastatic cancer?
J Comp Eff Res. 2021 Apr 21. doi: 10.2217/cer-2020-0178. Online ahead of print.ABSTRACTBackground: Medicaid expansion following the 2010 Affordable Care Act has an unknown impact on palliative treatments. Materials & methods: This registry-based study of individuals with metastatic cancer from 2010 to 2016 identified men and women with metastatic cancer in expansion and non-expansion states who received palliative treatments. A mixed effects logistic regression compared trends in expansion and non-expansion states and generated risk-adjusted probabilities or receiving palliative treatments each year. Results: Despite l...
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Alexander P Cole Stuart R Lipsitz Adam S Kibel Brandon A Mahal Nelya Melnitchouk Zara Cooper Quoc-Dien Trinh Source Type: research

The health-related quality of life of patients with a benign gynecological condition: a 2-year follow-up
Conclusion: The impaired HRQoL dimensions were improved by treatment but HRQoL still remained poorer than in the general female population. Treatment of unspecific pelvic pain and bleeding disorders needs further evaluation.PMID:33880938 | DOI:10.2217/cer-2020-0243 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Kristiina Pynn ä Pirjo R äsänen Harri Sintonen Risto P Roine Piia Vuorela Source Type: research

Usability evaluation of sufentanil sublingual tablet analgesia in patients following Enhanced Recovery After Surgery
Conclusion: The usability and the satisfaction of the patients and the caregivers from sufentanil sublingual tablet system analgesia in the context of Enhanced Recovery After Surgery protocol were good-to-excellent. The economic potential in the reduction of hospital stay should be studied. Trial registration number: NCT03373851 (ClinicalTrial.gov).PMID:33880939 | DOI:10.2217/cer-2020-0239 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Harry Amson Philippe Lasselin Bertille Naegels Gilda Pardey Bracho Fr édéric Aubrun Mikhail Dziadzko Source Type: research

Preferences, satisfaction and decision-making processes in osteoporosis treatment: a systematic review of the literature
Conclusion: Aligning treatment with patients' preferences, promoting physician-patient communication and identifying patients' concerns with treatment may contribute to improve treatment satisfaction and adherence and ultimately achieve the treatment goal.PMID:33880940 | DOI:10.2217/cer-2020-0216 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Laura Canals-Ruiz Marta Comellas Lu ís Lizán Source Type: research

Use of ibuprofen for the closure of patent ductus arteriosus in preterm infants: a systematic review of meta-analyses
Conclusion: Evidence on ibuprofen effectiveness and safety, including the dosage forms, is limited by heterogeneity in doses and the levels of methods quality and risk of bias.PMID:33880942 | DOI:10.2217/cer-2020-0235 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Samaher Al-Shaibi Dina Abushanab Eilan Alhersh Rasha Kaddoura Abdul Rouf Pallivalappila Daoud Al-Badriyeh Source Type: research

Letter to the Editor: critical appraisal to optimize clinical and economic impact of oxidized regenerated cellulose in surgical practice
J Comp Eff Res. 2021 Apr 21. doi: 10.2217/cer-2021-0007. Online ahead of print.NO ABSTRACTPMID:33880934 | DOI:10.2217/cer-2021-0007 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Gianluca Franceschini Source Type: research

Is Medicaid expansion associated with increases in palliative treatments for metastatic cancer?
J Comp Eff Res. 2021 Apr 21. doi: 10.2217/cer-2020-0178. Online ahead of print.ABSTRACTBackground: Medicaid expansion following the 2010 Affordable Care Act has an unknown impact on palliative treatments. Materials & methods: This registry-based study of individuals with metastatic cancer from 2010 to 2016 identified men and women with metastatic cancer in expansion and non-expansion states who received palliative treatments. A mixed effects logistic regression compared trends in expansion and non-expansion states and generated risk-adjusted probabilities or receiving palliative treatments each year. Results: Despite l...
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Alexander P Cole Stuart R Lipsitz Adam S Kibel Brandon A Mahal Nelya Melnitchouk Zara Cooper Quoc-Dien Trinh Source Type: research

The health-related quality of life of patients with a benign gynecological condition: a 2-year follow-up
Conclusion: The impaired HRQoL dimensions were improved by treatment but HRQoL still remained poorer than in the general female population. Treatment of unspecific pelvic pain and bleeding disorders needs further evaluation.PMID:33880938 | DOI:10.2217/cer-2020-0243 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Kristiina Pynn ä Pirjo R äsänen Harri Sintonen Risto P Roine Piia Vuorela Source Type: research

Usability evaluation of sufentanil sublingual tablet analgesia in patients following Enhanced Recovery After Surgery
Conclusion: The usability and the satisfaction of the patients and the caregivers from sufentanil sublingual tablet system analgesia in the context of Enhanced Recovery After Surgery protocol were good-to-excellent. The economic potential in the reduction of hospital stay should be studied. Trial registration number: NCT03373851 (ClinicalTrial.gov).PMID:33880939 | DOI:10.2217/cer-2020-0239 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 21, 2021 Category: General Medicine Authors: Harry Amson Philippe Lasselin Bertille Naegels Gilda Pardey Bracho Fr édéric Aubrun Mikhail Dziadzko Source Type: research