Tisagenlecleucel versus historical standard therapies for pediatric relapsed/refractory acute lymphoblastic leukemia.
Conclusion: The analysis demonstrated tisagenlecleucel was associated with substantially greater survival benefit versus all SOC regimens. PMID: 32602756 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 2, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.
Conclusion: Results suggest that empagliflozin+SoC is cost effective versus SoC and liraglutide+SoC. PMID: 32573253 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Minimally invasive surgery for low-grade spondylolisthesis: percutaneous endoscopic or oblique lumbar interbody fusion.
Conclusion: PELIF minimizes the iatrogenic damages and perioperative risks to a great extent, and seems to be a promising option for the treatment of symptomatic low-grade lumbar spondylolisthesis. PMID: 32551889 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 20, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Analyzing the concept of spillover effects for expanded inclusion in health economics research.
Conclusion: The analysis provides greater clarification around the dimensions of spillover effects and reveals opportunities to enhance methodological approaches to assessing spillovers. PMID: 32543221 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

European cooperation in health technology assessment implementation: the perspective of Central and Eastern European countries.
Authors: Németh B, Kaló Z PMID: 32501106 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 7, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Types and outcomes of cytopenia in critically ill patients.
Authors: Bagheri Z, Labbani-Motlagh Z, Mirjalili M, Karimzadeh I, Khalili H Abstract Cytopenia is common complication in critically ill patients. Aim: Incidence and pattern of different types of cytopenia as well as its impact on mortality and length of stay in critically ill patients were evaluated. Methods: Critically ill patients with any kind of cytopenia for more than 2 days were evaluated. Results: Anemia was the most common type of cytopenia in the patients (99.14%), followed by lymphocytopenia (32.17%), thrombocytopenia (27.82%), and leukopenia (19.13%). Mortality rate was significantly higher in patients with anemia (p
Source: Journal of Comparative Effectiveness Research - June 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Causal inference and adjustment for reference-arm risk in indirect treatment comparison meta-analysis.
Conclusion: Accumulating theoretical and empirical evidence underscores the importance of adjusting for reference-arm outcomes in indirect treatment comparison and network meta-analyses to make full use of data and reduce the risk of bias in estimated treatments effects. PMID: 32490682 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 5, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds.
Conclusion: PCMP demonstrated clinically meaningful benefits to patients with various types of cutaneous wounds. Clinical Trial registration number: NCT03286452. PMID: 32476449 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - June 3, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Patients' perceptions with dabigatran in patients with atrial fibrillation previously treated with vitamin K antagonists.
Conclusion: Convenience and satisfaction scores for nonvalvular atrial fibrillation patients treated with dabigatran at 6 months were significantly better than with previous vitamin K antagonists. PMID: 32469278 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Can a biomarker triage test reduce colonoscopy burden in fecal immunochemical test screening?
Conclusion: Adding a BM-TT to FIT-screening considerably reduces colonoscopy burden, but could also decrease screening effectiveness. Combining FIT15 with a high polyp sensitivity BM-TT seems most promising. PMID: 32462913 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Assessing risk of bias judgments for blinding of outcome assessors in Cochrane reviews.
Conclusion: Interventions to improve RoB assessments in systematic reviews should be explored. PMID: 32459105 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 28, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Lenvatinib versus sorafenib for unresectable hepatocellular carcinoma: a cost-effectiveness analysis.
Authors: Cai H, Zhang L, Li N, Zheng B, Liu M Abstract Aim: To investigate the cost-effectiveness of lenvatinib and sorafenib in the treatment of patients with nonresected hepatocellular carcinoma in China. Materials & methods: Markov model was used to simulate the direct medical cost and quality-adjusted life years (QALY) of patients with hepatocellular carcinoma. Clinical data were derived from the Phase 3 randomized clinical trial in a Chinese population. Results: Sorafenib treatment resulted in 1.794 QALYs at a cost of $43,780.73. Lenvatinib treatment resulted in 2.916 QALYs for patients weighing
Source: Journal of Comparative Effectiveness Research - May 20, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Surfactant therapy for meconium aspiration syndrome in neonates: a systematic overview of systematic reviews and recent clinical trials.
Conclusion: The evidence on surfactant effectiveness and its method of administration is sparse and inconsistent. PMID: 32394731 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 14, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Life after COVID-19: R WE going to help?
Authors: Ramagopalan SV, Wasiak R PMID: 32390452 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 13, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

What is a meta-epidemiological study? Analysis of published literature indicated heterogeneous study designs and definitions.
Conclusion: Research community would benefit from consensus about definition of meta-epidemiological study. PMID: 32372658 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Meta-analysis of immunogenicity and safety of human rabies vaccination under Zagreb and Essen regimens.
Conclusion: Rabies vaccination under the Zagreb regimen was noninferior to the Essen regimen in immunogenicity and had an acceptable safety profile. PMID: 32374178 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The problem of underdosing with direct-acting oral anticoagulants in elderly patients with nonvalvular atrial fibrillation.
Authors: Fernández CS, Gullón A, Formiga F Abstract Unless contraindicated, anticoagulant therapy should be prescribed to elderly patients with atrial fibrillation. Direct-acting oral anticoagulants (DOACs) are superior to vitamin K antagonists for preventing stroke. This, together with their higher net clinical benefit, makes DOACs the treatment of choice in this population. However, due to the concerns about bleeding and the need for dose adjustment based on clinical variables, underdosing of DOACs is common and the risk of stroke high. Drugs with more easily adjusted doses are likely associated wit...
Source: Journal of Comparative Effectiveness Research - April 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

US database study: burden and healthcare resource utilization in adults with systemic endemic mycoses and aspergillosis.
Conclusion: The total impact of SM is particularly severe in high-risk or vulnerable populations. PMID: 32316748 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 24, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative analysis of cost-effectiveness between isosorbide-5-mononitrate and isosorbide: a retrospective real-world evaluation.
Authors: Zhang G, Liu X, Xu J, Cheng G, Xu J Abstract Aim: The cost-effectiveness of isosorbide-5-mononitrate (5-ISMN) and isosorbide dinitrate (ISDN) in real-world use in patients with coronary heart disease (CHD; either angina pectoris or myocardial infarction) was retrospectively compared. Method: In this retrospective real-world evaluation, patients with established CHD satisfying the following criteria were selected from information system of two tertiary hospitals in China: with pharmacy claiming for at least one injection of 5-ISMN or ISDN between July 2008 and May 2017; and, CHD patients. By using...
Source: Journal of Comparative Effectiveness Research - April 18, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of osteosynthesis in fracture care: a cost comparison study.
Authors: Eichler K, Höglinger M, Meier F, Knöfler F, Scholz-Odermatt SM, Brügger U, Denk E, Gutzwiller F, Prein J, Renner N, Joeris A Abstract Aim: To estimate the health economic impact of osteosynthesis (OS) in fracture care over six decades in 17 high-income countries. Patients & methods: Applying a decision tree model, we assumed a hypothetical absence of OS and compared OS (intervention) with conservative treatment (CONS; comparator). We included patients with femur, tibia and radius fractures (age
Source: Journal of Comparative Effectiveness Research - April 18, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Disease burden of schizophrenia patients visiting a Chinese regional mental health centre.
Conclusion: The burden of schizophrenia was mainly driven by the mortality associated with relapsed schizophrenia and direct medical costs for schizophrenia in local mental health rehabilitation institutes. PMID: 32301625 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 18, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Erratum.
Authors: PMID: 32270700 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Knowledge, awareness and perceptions of diabetes mellitus among the Saudi population.
Conclusion: A significant lack of knowledge about DM in Saudi society was identified. Social media and educational curriculum can improve knowledge and awareness of DM. PMID: 32253916 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A proposed framework for patient engagement throughout the broader research enterprise.
This article presents a new framework for patient engagement by first describing the goals of patient engagement at each stage of the research enterprise and then establishing how to prioritize the types of patient expertise that are needed to achieve these goals. PMID: 32253919 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of cytoreductive surgery on outcomes of metastatic appendiceal carcinoma: a real-world, population-based study.
Authors: Abdel-Rahman O Abstract Aim: To evaluate the impact of cytoreductive surgery on the outcomes of patients with metastatic appendiceal carcinoma. Methods: Surveillance, Epidemiology and End Results (SEER) database was accessed and patients with metastatic appendiceal carcinoma diagnosed (2010-2015) were reviewed. Kaplan-Meier survival estimates/log-rank testing were then used to assess overall survival outcomes according to cytoreductive surgery. Multivariable Cox regression analysis was then used to evaluate factors affecting cancer-specific survival. Factors included in this model were age, race, sex, stag...
Source: Journal of Comparative Effectiveness Research - April 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world direct healthcare costs of treating recurrent high-grade serous ovarian cancer with cytotoxic chemotherapy.
Conclusion: After the third relapse of HGSC, cytotoxic chemotherapy did not prolong survival but was associated with substantially increased healthcare costs. PMID: 32223298 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 1, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The economic cost of racial disparities in perioperative care.
Authors: Jotwani R, Turnbull ZA, White RS PMID: 32212936 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 29, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Propensity score matching and inverse probability of treatment weighting to address confounding by indication in comparative effectiveness research of oral anticoagulants.
Authors: Allan V, Ramagopalan SV, Mardekian J, Jenkins A, Li X, Pan X, Luo X Abstract After decades of warfarin being the only oral anticoagulant (OAC) widely available for stroke prevention in atrial fibrillation, four direct OACs (apixaban, dabigatran, edoxaban and rivaroxaban) were approved after demonstrating noninferior efficacy and safety versus warfarin in randomized controlled trials. Comparative effectiveness research of OACs based on real-world data provides complementary information to randomized controlled trials. Propensity score matching and inverse probability of treatment weighting are increasingly ...
Source: Journal of Comparative Effectiveness Research - March 19, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world evidence on clinical outcomes in immune thrombocytopenia treated with thrombopoietin receptor agonists.
Conclusion: There may be a potential advantage for the use of eltrombopag versus romiplostim in the practice settings studied, based on rates of BREs and AEs and rescue medication utilization. PMID: 32175766 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 18, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Approaches for the identification of chronic kidney disease in CPRD-HES-linked studies.
Conclusion: To identify CKD status in CPRD-HES, a combination of test records and codes should be used. Using diagnostic codes only significantly underestimates CKD prevalence. PMID: 32148084 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The use of real-world effectiveness measurements in clinical settings at Helsinki University Hospital: a systematic literature review.
Conclusion: The number of articles assessing RWE is very limited compared with all the articles published from HUS. Thus, we still have limited information about the effectiveness of the treatment in real life. PMID: 32141305 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Clinical therapeutic efficacy of mesenchymal stem cells derived from adipose or bone marrow for knee osteoarthritis: a meta-analysis of randomized controlled trials.
Authors: Han X, Yang B, Zou F, Sun J Abstract Aim: This meta-analysis, only including randomized controlled trials (RCTs), was conducted to assess separately and compare the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADMSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) for knee osteoarthritis (OA) at the same follow-up time. Methods: Potential relevant researches were identified from PubMed, Web of Science, Embase, Cochrane Library and clinicaltrials.gov. The data, from clinical trials concentrating on knee OA treated with ADMSCs or BMSCs, were extracted and pooled for meta-analysis t...
Source: Journal of Comparative Effectiveness Research - March 8, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Intracardiac echocardiography use and outcomes after catheter ablation of ventricular tachycardia.
Conclusion: Patients with implantable cardioverter defibrillator/cardiac resynchronization therapy-defibrillator undergoing VT ablation with ICE use had significantly lower likelihood of VT-related readmission. PMID: 32134325 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 7, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Letter in Reply: considering equity in clinical trials for highlighting impact of social determinants and inequities on health outcomes.
Authors: Puljak L PMID: 32100556 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 28, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budget impacts associated with improving diagnosis and treatment of atrial fibrillation in high-risk stroke patients.
Conclusion: The detection and perfection gaps are key areas for investment. PMID: 32100562 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 28, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

CAR-T therapy and historical trends in effectiveness and cost-effectiveness of oncology treatments.
Conclusion: CAR-T therapy breaks a pattern of stagnant efficacy growth in pharmaceutical innovation and demonstrates significantly greater incremental effectiveness and similar cost-effectiveness to prior innovations. PMID: 32056442 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 16, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Nonindependence of patient data in the clinical practice research datalink: a case study in atrial fibrillation patients.
Conclusion: While strategies which longitudinally append patient registration periods under different CPRD IDs maintain independence while using all available data, their implementation had little impact on the results of our case study. PMID: 32056446 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 16, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Adding pertuzumab to adjuvant therapy for high-risk HER2-positive early breast cancer in APHINITY: a GRADE analysis.
Authors: Zambelli A, Pappagallo G, Marchetti P Abstract Aim: Adding pertuzumab to standard trastuzumab-based adjuvant therapy significantly improved invasive disease-free survival (IDFS) in the APHINITY trial. However, the magnitude of benefit was marginal in the overall population. Methods: We used GRADE (Grading of Recommendations Assessment, Development and Evaluation) analysis on data from APHINITY to build summary-of-findings tables to evaluate the efficacy, safety and quality of evidence of predefined clinical outcomes for the addition of pertuzumab to trastuzumab-based adjuvant therapy in patients with high-...
Source: Journal of Comparative Effectiveness Research - February 16, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Attitudes of older people/seniors to completion of electronic patient-reported outcome measures and use of mobile applications in clinical trials: results of a qualitative research study.
Conclusion: The younger group of older individuals had similar experiences and attitudes toward touchscreen devices as the rest of the population. While the older participants expressed some reluctance toward unfamiliar technology, all participants were using technology and accepting of it. PMID: 32048516 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 14, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Reducing preoperative blood orders and costs for radical prostatectomy.
Conclusion: MSBOS implementation and compliance decreases unnecessary preoperative blood orders. PMID: 32043362 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 13, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Safety and efficacy of GP40061 compared with originator insulin glargine (Lantus ®): a randomized open-label clinical trial.
Conclusion: GP-Gla and Sa-Gla demonstrated similar safety and efficacy. ClinicalTrials.gov Identifier: NCT04022993. PMID: 32027167 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 7, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Safety and effectiveness of ataluren: comparison of results from the STRIDE Registry and CINRG DMD Natural History Study.
We examined the effectiveness of ataluren + standard of care (SoC) in the registry versus SoC alone in the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS), DMD genotype-phenotype/-ataluren benefit correlations and ataluren safety. Patients & methods: Propensity score matching was performed to identify STRIDE and CINRG DNHS patients who were comparable in established disease progression predictors (registry cut-off date, 9 July 2018). Results & conclusion: Kaplan-Meier analyses demonstrated that ataluren + SoC significantly delayed age at ...
Source: Journal of Comparative Effectiveness Research - February 1, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Letter to the Editor: reporting and analyses of sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals.
Authors: Lui B, White RS PMID: 31992052 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Use of hyperbaric oxygen in hematopoietic cell transplantation to aid post-transplant recovery.
Authors: Mina A, Aljitawi OS PMID: 31992055 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Budesonide/formoterol therapy: effective and appropriate use in asthma and chronic obstructive pulmonary disease.
Conclusion: We found available, good quality BFC CE and appropriate-use articles; however, all had limitations. PMID: 31983228 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 28, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Meta-analysis of short-term outcomes comparing robot-assisted and laparoscopic distal pancreatectomy.
Conclusion: Both robotic and laparoscopic DP are safe and feasible. Although robotic DP increases the operation cost, the spleen-preserving rate is much higher. Robotic surgery may be an alternative approach to DP. PMID: 31975614 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Strengthening pharma's contract with society: the value of trusted partnerships between pharma and healthcare facilitated by real-world data.
Authors: Seewald MJ, Plumb JM, Gutierrez B, Liwing J, Tepie MF, Hammer M, LoCasale R, Khosla S, Yin D, Pashos CL, Nagy M Abstract This White Paper is authored by 11 industry real-world evidence (RWE) experts, with support from IQVIA, as part of the 'RWE Leadership Forum': a group of Industry Leaders who come together as noncompetitive partners to understand and respond to internal or external RWD/E challenges and opportunities with a single expert voice. Herein we aim to clarify the rules of engagement between pharma and healthcare in order to establish trust-based partnerships, which will unlock unique value for s...
Source: Journal of Comparative Effectiveness Research - January 24, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Crizotinib versus chemotherapy: a real-world cost-effectiveness study in China.
Authors: Huang M, Tian Y, He M, Liu J, Ren L, Gong Y, Peng F, Wang Y, Ding Z, Wang J, Zhu J, Xu Y, Liu Y, Li L, Lu Y Abstract Aim: To assess the cost-effectiveness of crizotinib verses platinum-based doublet chemotherapy as the first-line treatment for Anaplastic Lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC) in the real-world setting. Methods: Data from 163 advanced ALK positive NSCLC patients were collected from West China Hospital, Sichuan University (Chengdu, China). They were categorized into two groups as treated with crizotinib (n = 83) or chemotherapy (n = 80) as a fir...
Source: Journal of Comparative Effectiveness Research - January 22, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-effectiveness analysis of ocriplasmin versus watchful waiting for treatment of symptomatic vitreomacular adhesion in the US.
Conclusion: Ocriplasmin was cost effective compared with standard of care in symptomatic VMA. PMID: 31961196 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 22, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis.
Conclusion: Ozanimod appears to have a favorable benefit-risk profile versus fingolimod. PMID: 31948278 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - January 18, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research