Healthcare utilization in clinically significant tricuspid regurgitation patients with and without heart failure.
Conclusion: All three co-morbidities were associated with increased healthcare utilization, with HF showing the greatest impact across all measures. PMID: 33174767 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 13, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The cost-effectiveness of low-dose budesonide as a Step 2 treatment for pediatric asthma in China.
Conclusion: These findings may improve the use of low-dose budesonide, an economically and clinically preferable treatment to montelukast in pediatric patients. PMID: 33153279 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Assessing direct costs of treating metastatic triple-negative breast cancer in the USA.
Conclusion: The majority of costs were attributable to hospitalization and emergency department services, suggesting a need for effective interventions to reduce utilization of costly services. PMID: 33167695 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of nivolumab versus standard of care for third-line patients with small-cell lung cancer.
Conclusion: Nivolumab was more efficacious in terms of OS as third-line treatment for small-cell lung cancer compared with current SOC in the USA. PMID: 33140652 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 4, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of pain and nonpain co-morbidities on opioid use in women with endometriosis.
Conclusion: Risk of opioid use after endometriosis diagnosis was greater in patients who used opioids before diagnosis. Risk of prolonged opioid use was greater if co-morbidities existed before diagnosis. PMID: 33140993 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 4, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of weekly versus every-2-weeks cetuximab in metastatic colorectal cancer in a US-insured population.
Authors: Lamy FX, Batech M, Boutmy E, Ronga P, Salim S, Pescott CP Abstract Aim: To test the noninferiority of cetuximab administered every 2 weeks (Q2W) versus once weekly (Q1W) in treating metastatic colorectal cancer (mCRC) with regard to overall survival (OS). Patients: Patients receiving cetuximab plus chemotherapy for mCRC in a line-agnostic setting. Methods: This cohort study in IBM MarketScan followed patients from initiation of cetuximab for mCRC until the end of the data availability period, proxy-based death or loss of insurance coverage for>30 days. Results: The hazard ratio for OS was...
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Identifying patient decisions and related information needs during decision making related to total knee arthroplasty.
Conclusion: Although further research is needed to generalize these findings, physicians should consider these questions during shared decision making with patients considering total knee arthroplasty. PMID: 33124898 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Six ways to foster community-engaged research during times of societal crises.
Authors: Edwards HA, Monroe DY, Mullins CD PMID: 33124935 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 31, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Network meta-analyses for EGFR mutation-positive non-small-cell lung cancer: systematic review and overview of methods and shortcomings.
Conclusion: We identified methodological issues to explain differences in the findings, criteria for inclusion in NMAs and the degree of lumping of treatments. These factors should be given particular consideration in future research. PMID: 33112179 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Economic burden of readmission due to postoperative cerebrospinal fluid leak in Chinese patients.
Conclusion: CSFL readmissions are a significant economic burden in China. Factors associated with higher readmission cost should be monitored. PMID: 33112181 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparative effectiveness of trastuzumab emtansine versus lapatinib plus capecitabine for HER2+ metastatic breast cancer.
Conclusion: Real-world data supports the effectiveness of T-DM1 in the second-line treatment of HER2+ mBC patients. PMID: 33095031 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of ofatumumab and other disease-modifying therapies for relapsing multiple sclerosis: a network meta-analysis.
Conclusion: Ofatumumab offers beneficial outcomes for RMS by reducing relapse and disability progression risk. PMID: 33090003 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 24, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Efficacy of immunotherapy with PD-1 inhibitor in colorectal cancer: a meta-analysis.
Conclusion: The monotherapy anti-PD-1 inhibitors are effective in treating mCRC and could be a new option for dMMR mCRC patient in first-line treatment. PMID: 33073605 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 21, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The patient experience in venous disease.
Authors: Sheikh P PMID: 33078959 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 21, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The prevalence, disease characteristics and treatment of chronic venous disease: an international web-based survey.
Conclusion: One in five adults had CVD, but most did not seek a physician's help. PMID: 33079592 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 21, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The prevalence, characteristics and treatment of hemorrhoidal disease: results of an international web-based survey.
Conclusion: The prevalence of hemorrhoidal disease in the adult population is 11%, mostly low-severity disease. PMID: 33079605 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 21, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The impact of implementation of a hysterectomy enhanced recovery pathway on anesthetic medication costs.
Authors: Street AD, Elia JM, McBroom MM, Hamilton AJ, Grundt JE, Blackwell JN, Romito BT Abstract Aim: To evaluate the effect of implementation of a hysterectomy Enhanced Recovery After Surgery (ERAS) protocol on perioperative anesthetic medication costs. Patients & methods: Historical cohort study of 84 adult patients who underwent a hysterectomy. Forty-two patients who underwent surgery before protocol implementation comprised the pre-ERAS group. Forty-two patients who underwent surgery after protocol implementation comprised the post-ERAS group. Data on anesthetic medication costs and outcomes were analyzed....
Source: Journal of Comparative Effectiveness Research - October 20, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Pharmaceutical pricing benchmarks: governmental versus private sector.
Conclusion: NADAC was the best pricing benchmark for reimbursement of pharmacy dispensed drugs. PMID: 33052057 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 20, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Cost-minimization analysis of negative pressure wound therapy technologies for the treatment of moderate-to-severe foot infections.
Conclusion: This study found that NPWT-C was expected to minimize the total costs over the episode of treatment. Larger and more clinically diverse studies are recommended to confirm these findings. PMID: 33034531 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 11, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Web-based decision aids to support breast cancer screening decisions: systematic review and meta-analysis.
Authors: Yu L, Li P, Yang S, Guo P, Zhang X, Liu N, Wang J, Zhang W Abstract Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the results have great heterogeneity. Therefore, further studies are needed to improve understanding of these tools. Objective: This systematic review and meta-analysis aimed to investigate the impact of using web-based DAs in women ag...
Source: Journal of Comparative Effectiveness Research - October 9, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

US cost-effectiveness of polatuzumab vedotin, bendamustine and rituximab in diffuse large B-cell lymphoma.
Conclusion: Pola + BR is cost-effective versus BR for the treatment of transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma in the US. PMID: 33028076 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 9, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The societal impact of obinutuzumab in the first-line treatment of patients with follicular lymphoma in Germany.
In this study, we assessed the productivity gains associated with the use of obinutuzumab in combination with chemoimmunotherapy (G-chemo) in first-line treatment among follicular lymphoma patients. Health benefits, measured as an increase in progression-free survival, were translated into productivity gains in both paid and unpaid work using gross value added as productivity measure. From 2017 to 2030, 11,870 overall progression-free years can be gained by utilizing obinutuzumab. These progression-free years correspond to undiscounted productivity gains of about €187.9 million in paid work and about €5...
Source: Journal of Comparative Effectiveness Research - October 6, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Translating stakeholder-driven comparative effectiveness research into practice: the PCORnet Bariatric Study.
Authors: Arterburn DE, Toh S, Williams N, Anau J, Courcoulas A, Tavakkoli A, Stilwell D, Tuzzio L, Lewis CC, Wilcox MN, McTigue KM PMID: 33000638 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - October 2, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Medical oncology referral and systemic therapy of patients with advanced stage urothelial carcinoma.
Authors: Aly A, Johnson C, Doleh Y, Shenolikar R, Botteman MF, Hussain A Abstract Aim: To understand physician visit patterns among patients with stage IV (including nonmetastatic [M0] and metastatic [M1] disease) urothelial carcinoma (UC) and understand factors associated with a timely referral to a medical oncologist and systemic treatment. Patients & methods: Retrospective analysis of Surveillance, Epidemiology and End Results-Medicare data. Results: First physician encounter was with a urologist (M0: 69%; M1: 53%) or primary care physician ([PCP]; M0: 19%, M1: 25%) for the majority of patients around U...
Source: Journal of Comparative Effectiveness Research - September 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Experiences of cancer patients with outpatient care in the USA: a population-based study.
Conclusion: Cancer patients with older age, higher income and better health status were more likely to be satisfied with the outpatient care they received. The biggest area for potential improvement of patient satisfaction seems to be related to the time spent with healthcare providers. PMID: 32965140 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Treatment of venous leg ulcers using bilayered living cellular construct.
Conclusion: Payers' coverage of BLCC results in reduction of the overall medical cost for treating VLU patients. PMID: 32969709 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The efficacy of 3D printing-assisted surgery in treating distal radius fractures: systematic review and meta-analysis.
Conclusion: In the treatment of distal radius fractures, 3D printing-assisted surgery may be superior to routine surgery. PMID: 32969712 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 25, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Clinical and economic impact of oxidized regenerated cellulose for surgeries in a Chinese tertiary care hospital.
Conclusion: When compared with conventional hemostatic technique, using ORC could impact blood transfusion and hospital costs differently by surgical settings. PMID: 32959666 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 24, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

A comparative network meta-analysis of standard  of care treatments in treatment-naïve chronic hepatitis B patients.
Conclusion: Our findings confirm available evidence around the comparative efficacy of available CHB treatments. Therefore, they can be used to update relevant cost-effectiveness analyses and clinical guidelines. PMID: 32945178 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 21, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Patient and caregiver experiences at a specialized primary care center for autistic adults.
Conclusion: A patient-centered medical home tailored to the needs of autistic adults is a promising approach to healthcare delivery for meeting this population's needs. PMID: 32914649 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 12, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Replication of randomized clinical trial results using real-world data: paving the way for effectiveness decisions.
Authors: Sheffield KM, Dreyer NA, Murray JF, Faries DE, Klopchin MN Abstract The FDA is preparing guidance about using real-world evidence (RWE) to support decisions about product effectiveness. Several ongoing efforts aim to replicate randomized clinical trial (RCT) results using RWE with the intent of identifying circumstances and methods that provide valid evidence of drug effects. Lack of agreement may not be due to faulty methods but rather to the challenges with emulating RCTs, differences in healthcare settings and patient populations, differences in effect measures and data analysis, bia...
Source: Journal of Comparative Effectiveness Research - September 12, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

The economic cost of racial disparities in chronic pain.
Authors: Lee J, Jotwani R, S White R PMID: 32883089 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 5, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Using the primary site as a prognostic tool for nodal mantle cell lymphoma: a SEER-based study.
Conclusion: NMCL primary site can serve as a prognostic factor. We encourage adding it to MCL International Prognostic Index. PMID: 32885984 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 5, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Impact of chronic obstructive pulmonary disease on mortality in community acquired pneumonia: a meta-analysis.
Conclusion: There is still no evidence to clear the impact of COPD on mortality in patients with community acquired pneumonia. More prospective studies with spirometrically-defined COPD and adequate adjustment for confounders are needed. PMID: 32885988 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - September 5, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Healthcare use and costs among Medicare enrollees on pirfenidone versus nintedanib for idiopathic pulmonary fibrosis.
Conclusion: In patients with IPF, pirfenidone compared with nintedanib has a moderate but significant protective effect on hospitalization, corresponding to lower inpatient costs. PMID: 32851849 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 29, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Meta-analyses of ataluren randomized controlled trials in nonsense mutation Duchenne muscular dystrophy.
Authors: Campbell C, Barohn RJ, Bertini E, Chabrol B, Comi GP, Darras BT, Finkel RS, Flanigan KM, Goemans N, Iannaccone ST, Jones KJ, Kirschner J, Mah JK, Mathews KD, McDonald CM, Mercuri E, Nevo Y, Péréon Y, Renfroe JB, Ryan MM, Sampson JB, Schara U, Sejersen T, Selby K, Tulinius M, Vílchez JJ, Voit T, Wei LJ, Wong BL, Elfring G, Souza M, McIntosh J, Trifillis P, Peltz SW, Muntoni F, PTC124-GD-007-DMD Study Group, ACT DMD Study Group, Clinical Evaluator Training Groups Abstract Aim: Assess the totality of efficacy evidence for ataluren in patients with nonsense mutation Duchenne musc...
Source: Journal of Comparative Effectiveness Research - August 29, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Health benefits and economic advantages associated with increased utilization of a smoking cessation program.
Conclusion: Health systems may achieve increased patient health and decreased healthcare costs by adding Best Practice Advisory and Population Outreach strategies to refer patients to smoking cessation services. PMID: 32815740 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 22, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Advancing community-engaged research: increasing trustworthiness within community-academic partnerships.
Authors: Mullins CD, Tanveer S, Graham G, Baquet CR PMID: 32815743 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 22, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Comparison of referral methods into a smoking cessation program.
Authors: Davis JM, Thomas LC, Dirkes JE, Datta SK, Dennis PA Abstract Rational, aims & objectives: The goal of this observational study was to compare three referral methods and determine which led to the highest utilization of the Duke Smoking Cessation Program (DSCP). Materials & methods: We conducted two assessments within the Duke health system: a 12-month assessment of Traditional Referral (a provider refers a patient during a patient visit) and Best Practice Advisory (BPA) (a provider refers a patient after responding to an alert within the electronic health record); and a 30-day a...
Source: Journal of Comparative Effectiveness Research - August 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world evidence and nonrandomized data in health technology assessment: use existing methods to address unmeasured confounding?
Authors: Sammon CJ, Leahy TP, Gsteiger S, Ramagopalan S PMID: 32757772 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - August 13, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Golimumab improves patient-reported outcomes in daily practice of inflammatory rheumatic diseases in Germany.
Conclusion: Golimumab induces sustained improvements in WPAI and QoL and reduces healthcare resource utilization in RA, PsA and AS. PMID: 32722921 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 30, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

No protocol and no liability: a call for COVID crisis guidelines that protect vulnerable populations.
Authors: Caraccio C, White RS, Jotwani R Abstract The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protection Act, which grants healthcare institutions full immunity from liability stemming from resource allocation/triage decisions. Here we examine the disparity literature against resource allocation guidelines, contending that these guidelines may propaga...
Source: Journal of Comparative Effectiveness Research - July 27, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Venous stenting for patients with outflow obstruction and leg ulcers: cost-effectiveness and budget impact analyses.
Conclusion: Stenting is a cost-effective option compared with SMT for patients with deep vein occlusion and ulceration in Italy. PMID: 32686480 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 22, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Engaging patients and stakeholders in preresearch: findings from the Pipeline to Proposal Awards Initiative.
Conclusion: P2P awardees increased capacity of patient and stakeholder partnerships to conduct PCOR. PMID: 32672474 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 17, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Factors influencing breast cancer awareness: a cross-sectional study in China.
Conclusion: History of screening and higher health information literacy levels are important positive factors linked to higher breast cancer awareness. PMID: 32648473 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Matching-adjusted indirect comparison: entrectinib versus crizotinib in ROS1 fusion-positive non-small cell lung cancer.
Conclusion: These results suggested improved outcomes with entrectinib versus crizotinib/chemotherapy and may help to make better informed treatment decisions. PMID: 32648475 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 12, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Opioid use disorder and maternal outcomes following cesarean delivery: a multistate analysis, 2007-2014.
Authors: Lui B, Aaronson JA, Tangel V, Quincy M, Weinberg R, Abramovitz SE, White RS Abstract Aim: To examine the association between opioid use disorder (OUD) and maternal outcomes following cesarean delivery. Methods: Retrospective analysis of over 2.4 million discharge records for in-patient cesarean delivery across five states from 2007 to 2014. Primary outcome was in-hospital mortality. Secondary outcomes included length of stay (LOS) and 30- and 90-day readmission rates. Results: OUD patients were 148% more likely than non-OUD patients to die during hospitalization (adjusted odds ratios [aOR]: 2.48, 95% ...
Source: Journal of Comparative Effectiveness Research - July 12, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Real-world switch patterns and healthcare costs in biologic-naive psoriasis patients initiating apremilast or biologics.
Conclusion: Apremilast initiators had lower healthcare costs even with treatment switching. PMID: 32638609 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 10, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

Burden of recurrent syncope and injuries and the usefulness of implantable cardiac monitors: insights from a nationwide longitudinal cohort analysis.
Conclusion: This study shows a high rate of recurrent syncope admissions and a parallel burden of hospitalizations for injuries. Use of an ICM appears to reduce syncope hospitalizations. PMID: 32639168 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - July 10, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research

High-concentration nonavian high-molecular  weight hyaluronan injections and time-to-total knee replacement surgery.
High-concentration nonavian high-molecular weight hyaluronan injections and time-to-total knee replacement surgery. J Comp Eff Res. 2020 Jul 09;: Authors: Etter K, Chitnis AS, Holy CE, Gray FS, Manalac FJ, Bisson B, Bhattacharyya SK Abstract Aim: To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections. Materials & methods: Using MarketScan® Commercial claims all patients aged 18-64 who underwent TKR surgery between 2008 and 2017 were identified. ...
Source: Journal of Comparative Effectiveness Research - July 10, 2020 Category: General Medicine Tags: J Comp Eff Res Source Type: research