Metabolic dysfunction-associated fatty liver disease increases the risk of complications after radical resection in patients with hepatocellular carcinoma
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in hepatocellular carcinoma (HCC) patients is increasing, yet its association with postoperative complications of HCC remains uncl... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - May 3, 2024 Category: Cancer & Oncology Authors: Ke-Gong Xiong, Kun-Yu Ke, Jin-Feng Kong, Tai-Shun Lin, Qing-Biao Lin, Su Lin and Yue-Yong Zhu Tags: Research Source Type: research
Epidemiology and Management of Infections in Liver Transplant Recipients
Surgical Infections, Ahead of Print. (Source: Surgical Infections)
Source: Surgical Infections - May 3, 2024 Category: Surgery Authors: Waseem Amjad Syed Hamaad Rahman Thomas D. Schiano Syed-Mohammed Jafri Source Type: research
Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial
This study has been registered with Chinese Clinical Trial Registry (ChiCTR2300070674). (Source: PLoS One)
Source: PLoS One - May 3, 2024 Category: Biomedical Science Authors: Yu-Hao Lin Source Type: research
Development and evaluation of a multi-target droplet digital PCR assay for highly sensitive and specific detection of < i > Yersinia pestis < /i >
ConclusionThe ddPCR assay presented good performance for detectingY.pestis DNA from soil and mouse tissue samples, showing great potential for improving the detection rate of low concentrations ofY.pestis in plague surveillance and facilitating the early diagnosis of plague cases. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - May 3, 2024 Category: Tropical Medicine Authors: Yanting Zhao Source Type: research
A novel role for the phosphatidylinositol-4,5-bisphosphate 3-kinase delta isoform in hepatocellular proliferation
The phosphatidylinositol-4,5-bisphosphate 3-kinase delta isoform (Pik3cd), usually considered immune-specific, was unexpectedly identified as a gene potentially related to either regeneration and/or differentiation in animals lacking hepatocellular Integrin Linked Kinase (ILK). Since a specific inhibitor (Idelalisib, or CAL101) for the catalytic subunit encoded by Pik3cd (p110 δ) has reported hepatotoxicity when used for treating Chronic Lymphocytic Leukemia and other lymphomas, we aimed to elucidate if there is a role for p110δ in normal liver function. (Source: American Journal of Pathology)
Source: American Journal of Pathology - May 3, 2024 Category: Pathology Authors: Nicole J. Martucci, John Stoops, William Bowen, Anne Orr, Mary-Claire Cotner, George K. Michalopoulos, Bharat Bhushan, Wendy M. Mars Tags: Regular Article Source Type: research
Infrarenal Aortic Aneurysm in a Patient with Remote History of Liver Transplant with Aorto-Hepatic Conduit
A 72-year-old male with a past medical history of hypertension, peripheral artery disease, and cadaveric liver transplant twenty-seven years prior for hepatitis C induced liver failure was found to have an asymptomatic ten cm infrarenal abdominal aortic aneurysm (AAA) during a CT scan for evaluation of genitourinary symptoms (Image A, Video 1). Notably, the Dacron aorto-hepatic conduit used for the transplant came off mid-aneurysm, making any method of repair especially challenging (Image B/Cover). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - May 3, 2024 Category: Surgery Authors: Moira A. McGevna, Anne Pierce, James Y. Lu, Aryan Borole, Kristen Lee, William E. Beckerman Source Type: research
Long-term survival after hepatic resection for colorectal liver metastases: a single-center study in Iran
Surgical resection of colorectal cancer liver metastasis (CRLM) has been associated with improved survival in these patients. The purpose of this study was to investigate the usefulness of liver metastasectomy... (Source: BMC Surgery)
Source: BMC Surgery - May 3, 2024 Category: Surgery Authors: Seyed Morteza Pourfaraji, Mehdi Nazari Moghadam, Ali Mohammad Moradi, Fatemeh Ojaghi Shirmard, Narjes Mohammadzadeh and Ali Jafarian Tags: Research Source Type: research
Deaths of Despair Surged Among Black People Over Past Decade
Guided by findings reported in 2015, researchers have thought that the uptick in midlife deaths of despair —those resulting from suicide, drug overdose, and alcoholic liver disease—disproportionately affected White people. Now, new data published in JAMA Psychiatry illustrate that the decrease in life expectancy from deaths of despair among people aged 45 to 54 years is not unique to White individual s. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 3, 2024 Category: General Medicine Source Type: research
The burden and predictors of 30-day unplanned readmission in patients with acute liver failure: a national representative database study
This study aimed to evaluate the 30-day unplanned readmission rates, causes of readmissions, readmission costs, and predictors of readmission... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 3, 2024 Category: Gastroenterology Authors: Xianbin Xu, Kai Gong, Liang Hong, Xia Yu, Huilan Tu, Yan Lan, Junjie Yao, Shaoheng Ye, Haoda Weng, Zhiwei Li, Yu Shi and Jifang Sheng Tags: Research Source Type: research
Multi-omic profiling reveals potential biomarkers of hepatocellular carcinoma prognosis and therapy response among mitochondria-associated cell death genes in the context of 3P medicine
ConclusionThis study developed a novel predictive model for LIHC, namely MCDI. Incorporating MCDI into the PPPM framework will enhance clinical decision-making processes and optimize individualized treatment strategies for LIHC patients.Graphical Abstract (Source: EPMA Journal)
Source: EPMA Journal - May 3, 2024 Category: International Medicine & Public Health Source Type: research
Viruses, Vol. 16, Pages 724: Hepatitis B Virus Infection: A Mini Review
Bonney
Hepatitis B and C viruses (HBV and HCV) are the leading causes of end-stage liver disease worldwide. Although there is a potent vaccine against HBV, many new infections are recorded annually, especially in poorly resourced places which have lax vaccination policies. Again, as HBV has no cure and chronic infection is lifelong, vaccines cannot help those already infected. Studies to thoroughly understand the HBV biology and pathogenesis are limited, leaving much yet to be understood about the genomic features and their role in establishing and maintaining infection. The current knowledge of the impact on disease ...
Source: Viruses - May 3, 2024 Category: Virology Authors: Diana Asema Asandem Selorm Philip Segbefia Kwadwo Asamoah Kusi Joseph Humphrey Kofi Bonney Tags: Review Source Type: research
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
Pharmacol Rev. 2024 May 2;76(3):454-499. doi: 10.1124/pharmrev.123.001087.ABSTRACTSteatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions. In parallel, noninvasive tools for diagnosing and monitoring responses to therapeutic interventions are being studied, and clinically feasible findings are being explored as primary outcomes in interventional trials. The realization that distinct subgroups ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Michail Kokkorakis Emir Muzurovi ć Špela Volčanšek Marlene Chakhtoura Michael A Hill Dimitri P Mikhailidis Christos S Mantzoros Source Type: research
Molecular Pathways Governing the Termination of Liver Regeneration
Pharmacol Rev. 2024 May 2;76(3):500-558. doi: 10.1124/pharmrev.123.000955.ABSTRACTThe liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called "hepatostat." The initiation and growth phases have been the subj...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Lianne R de Haan Rowan F van Golen Michal Heger Source Type: research
Healthcare resource utilization and costs among patients with alpha-1 antitrypsin deficiency with liver and/or lung disease: a longitudinal retrospective study in the USA
Conclusion: Patients with AATD had increased HCRU and healthcare costs in the presence of LD and/or LgD. HCRU and healthcare costs were highest in the AATD with LD and LgD health state.PMID:38696696 | DOI:10.57264/cer-2023-0186 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - May 2, 2024 Category: General Medicine Authors: May Hagiwara Victoria Divino Swapna Munnangi Mark Delegge Suna Park Ed G Marins Kaili Ren Charlie Strange Source Type: research
Pharmacogene expression during progression of metabolic dysfunction-associated steatotic liver disease: Studies on mRNA and protein levels and their relevance to drug treatment
Biochem Pharmacol. 2024 Apr 30:116249. doi: 10.1016/j.bcp.2024.116249. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is common worldwide. Genes and proteins contributing to drug disposition may show altered expression as MASLD progresses. To assess this further, we undertook transcriptomic and proteomic analysis of 137 pharmacogenes in liver biopsies from a large MASLD cohort. We performed sequencing on RNA from 216 liver biopsies (206 MASLD and 10 controls). Untargeted mass spectrometry proteomics was performed on a 103 biopsy subgroup. Selected RNA sequencing signals were ...
Source: Biochemical Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Authors: Olivier Govaere Simon J Cockell Michalina Zatorska Kristy Wonders Dina Tiniakos Andrew M Frey Pawel Palmowksi Ruth Walker Andrew Porter Matthias Trost Quentin M Anstee Ann K Daly Source Type: research
