Evaluation of potential auras in generalized epilepsy from EEG signals using deep convolutional neural networks and time-frequency representation.
In this study, it was aimed to evaluate pre-seizure warning symptoms of the electroencephalography (EEG) signals by a convolutional neural network (CNN) inspired by the epileptic auras defined in the medical field. In this context, one-dimensional EEG signals were transformed into a spectrogram display form in the frequency-time domain by applying a short-time Fourier transform (STFT). Systemic changes in pre-epileptic seizure have been described by applying the CNN approach to the EEG signals represented in the image form, and the subjective EEG-Aura process has been tried to be determined for each patient. Considering al...
Source: Biomedizinische Technik/Biomedical Engineering - December 13, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Thermography and colour Doppler ultrasound: a potential complementary diagnostic tool in evaluation of rheumatoid arthritis in the knee region.
Authors: Umapathy S, Thulasi R, Gupta N, Sivanadhan S Abstract The aim and objectives of this study were as follows: (i) to perform automated segmentation of knee thermal image using the regional isotherm-based segmentation (RIBS) algorithm and segmentation of ultrasound image using the image J software; (ii) to implement the RIBS algorithm using computer-aided diagnostic (CAD) tools for classification of rheumatoid arthritis (RA) patients and normal subjects based on feature extraction values; and (iii) to correlate the extracted thermal imaging features and colour Doppler ultrasound (CDUS) features in the knee re...
Source: Biomedizinische Technik/Biomedical Engineering - December 11, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Realisation and assessment of a low-cost LED device for contact lens disinfection by visible violet light.
This study presents a device for efficient, low-cost and eye-friendly overnight disinfection of contact lenses by visible violet light as an alternative to disinfection with biocide-containing solutions. Bacterial solutions with one Pseudomonas and one Staphylococcus strain each were irradiated for up to 8 h in commercial transparent contact lens cases by the presented light-emitting diode (LED) device. Samples were taken at different intervals and distributed on agar plates. The surviving bacteria were determined by counting of colony-forming units and compared to the specific requirements of the stand-alone test for cont...
Source: Biomedizinische Technik/Biomedical Engineering - December 8, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

The effectiveness of the choice of criteria on the stationary and non-stationary noise removal in the phonocardiogram (PCG) signal using discrete wavelet transform.
Authors: Rouis M, Sbaa S, Benhassine NE Abstract The greatest problem with recording heart sounds is parasitic noise effects. A reasonable solution to reduce noise can be carried out by minimization of extraneous noises in the vicinity of the patient during recording, in addition to the methods of signal processing that must be effective in noisy environments. Wavelet transform has become an essential tool for many applications, but its effectiveness is influenced by main parameters. Determination of mother wavelet function and decomposition level (DL) are important key factors to demonstrate the advantages of wave...
Source: Biomedizinische Technik/Biomedical Engineering - December 1, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Wireless power transmission in endoscopy capsules.
Authors: Kühne M, Andrä W, Werner C, Bellemann ME Abstract The operating life of endoscopy capsules is limited by the batteries needed for use. The capacity of corresponding batteries, however, is too short to cover the total period of gastrointestinal transit. To overcome this limitation, a novel kind of wireless power transmission was used. It utilizes a permanent magnetic cylinder located outside the patient's body and is turned by an electric motor, thereby generating a rotating magnetic field. This field in turn causes the motor, by a permanent magnetic sphere, located in a liquid bearing inside the ...
Source: Biomedizinische Technik/Biomedical Engineering - December 1, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Monitoring the dynamics of acute radiofrequency ablation lesion formation in thin-walled atria - a simultaneous optical and electrical mapping study.
Conclusion Aneg and Vpp are excellent parameters to discriminate the growing lesion area from healthy myocardium. The experimental setup opens new opportunities to investigate EGM characteristics of more complex ablation lesions. PMID: 31756159 [PubMed - as supplied by publisher] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - November 24, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Correlational study of the center of pressure measures of postural steadiness on five different standing tasks in overweight adults.
This study applied the posturography framework on five static standing tasks from the Berg Balance Scale (BBS). Thirteen participants were recruited and the trajectory data of the center of pressure (CoP) were collected. To analyze the postural performance, two approaches were taken: the scores from the BBS and statistical analysis. For the statistical analysis, Spearman's method was applied to determine the correlation of CoP parameters. The results revealed the correlations between CoP parameters in the anterior-posterior (AP) and medial-lateral (ML) directions, and on the statokinesgram (SK) plane for all tasks. To obta...
Source: Biomedizinische Technik/Biomedical Engineering - November 24, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Multimodal feature learning and fusion on B-mode ultrasonography and sonoelastography using point-wise gated deep networks for prostate cancer diagnosis.
Authors: Zhang Q, Xiong J, Cai Y, Shi J, Xu S, Zhang B Abstract B-mode ultrasonography and sonoelastography are used in the clinical diagnosis of prostate cancer (PCa). A combination of the two ultrasound (US) modalities using computer aid may be helpful for improving the diagnostic performance. A technique for computer-aided diagnosis (CAD) of PCa is presented based on multimodal US. Firstly, quantitative features are extracted from both B-mode US images and sonoelastograms, including intensity statistics, regional percentile features, gray-level co-occurrence matrix (GLCM) texture features and binary texture feat...
Source: Biomedizinische Technik/Biomedical Engineering - November 21, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Effective segmentation and classification of tumor on liver MRI and CT images using multi-kernel K-means clustering.
Authors: Krishan A, Mittal D Abstract Our proposed research technique intends to provide an effective liver magnetic resonance imaging (MRI) and computed tomography (CT) scan image classification which would play a significant role in medical dataset especially in feature selection and classification. There are a number of existing research works classifying the liver tumor disease. Early detection of liver tumor will help the patients to get cured rapidly. Our proposed research focuses on the classification of medical images with respect to the classification technique artificial neural network (ANN) to classify a...
Source: Biomedizinische Technik/Biomedical Engineering - November 21, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

GPU-enabled design of an adaptable pattern recognition system for discriminating squamous intraepithelial lesions of the cervix.
Authors: Konstandinou C, Kostopoulos S, Glotsos D, Pappa D, Ravazoula P, Michail G, Kalatzis I, Asvestas P, Lavdas E, Cavouras D, Sakellaropoulos G Abstract The aim of the present study was to design an adaptable pattern recognition (PR) system to discriminate low- from high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively) of the cervix using microscopy images of hematoxylin and eosin (H&E)-stained biopsy material from two different medical centers. Clinical material comprised H&E-stained biopsies of 66 patients diagnosed with LSIL (34 cases) or HSIL (32 cases). Regions of interest were ...
Source: Biomedizinische Technik/Biomedical Engineering - November 21, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Dynamic cerebral perfusion parameters and magnetic nanoparticle accumulation assessed by AC biosusceptometry.
Authors: Próspero AG, Soares GA, Moretto GM, Quini CC, Bakuzis AF, de Arruda Miranda JR Abstract Cerebral blood flow (CBF) assessment is mainly performed by scintigraphy, computed tomography (CT) and magnetic resonance imaging (MRI). New approaches to assess the CBF through the passage of magnetic nanoparticles (MNPs) to blood-brain barrier (BBB) are convenient to help decrease the use of ionizing radiation and unleash the required MRI schedule in clinics. The development of nanomedicine and new biomedical devices, such as the magnetic particle imaging (MPI), enabled new approaches to study dynamic brain blo...
Source: Biomedizinische Technik/Biomedical Engineering - November 14, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A robust grey wolf-based deep learning for brain tumour detection in MR images.
This article proposes a new accurate detection model. The model includes certain processes such as preprocessing, segmentation, feature extraction and classification. Particularly, two extreme processes such as contrast enhancement and skull stripping are processed under the initial phase. In the segmentation process, we used the fuzzy means clustering (FCM) algorithm. Both the grey co-occurrence matrix (GLCM) as well as the grey-level run-length matrix (GRLM) features were extracted in the feature extraction phase. Moreover, this paper uses a deep belief network (DBN) for classification. The optimized DBN concept is used ...
Source: Biomedizinische Technik/Biomedical Engineering - November 1, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Sonographic visibility of cannulas using convex ultrasound transducers.
Authors: Rumble S, Schmitz G, Dencks S Abstract The key for safe ultrasound (US)-guided punctures is a good visibility of the cannula. When using convex transducers for deep punctures, the incident angle between US beam and cannula varies along the cannula leading to a complex visibility pattern. Here, we present a method to systematically investigate the visibility throughout the US image. For this, different objective criteria were defined and applied to measurement series with varying puncture angles and depths of the cannula. It is shown that the visibility not only depends on the puncture angle but also on the...
Source: Biomedizinische Technik/Biomedical Engineering - October 31, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Diagnosis of attention-deficit hyperactivity disorder using EOG signals: a new approach.
In this study, a new method is presented to test and diagnose individuals who were attention deficit. PMID: 31661435 [PubMed - as supplied by publisher] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - October 31, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Mussel-inspired polydopamine-mediated surface modification of freeze-cast poly ( ε-caprolactone) scaffolds for bone tissue engineering applications.
In this study, polycaprolactone (PCL) scaffolds were fabricated by freeze-casting technology in order to create porous microstructure with oriented open-pore channels. To induce biomineralization, and to improve hydrophilicity and cell interactions, mussel-inspired polydopamine (PDA) was coated on the surface of the freeze-cast PCL constructs. Then, the synergistic effects of oriented microstructure and deposited layer on efficient reconstruction of injured bone were studied. Microscopic observations demonstrated that, the coated layer did not show any special change in lamellar microstructure of the scaffolds. Water-scaff...
Source: Biomedizinische Technik/Biomedical Engineering - October 30, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Functional and radiographic evaluation of an interspinous device as an adjunct for lumbar interbody fusion procedures.
Authors: Spicher A, Schmoelz W, Schmid R, Stofferin H, Craig NJA Abstract In the last decades, several interspinous process devices were designed as a minimally invasive treatment option for spinal stenosis. In order to minimise surgical trauma, interspinous process devices were recently discussed as an alternative posterior fixation in vertebral interbody fusions. Therefore, the purpose of this study was to evaluate the effect of a newly designed interspinous device with polyester bands (PBs) on range of motion (RoM) and centre of rotation (CoR) of a treated motion segment in comparison with an established intersp...
Source: Biomedizinische Technik/Biomedical Engineering - October 27, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma.
Authors: Xu W, Lou Y, Chen W, Kang Y Abstract Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible ...
Source: Biomedizinische Technik/Biomedical Engineering - October 14, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Computer-aided classification of small airways dysfunction using impulse oscillometric features: a children-focused review.
Conclusion There is still a great opportunity to improve the utility of IOS by developing more computer-aided robust classifiers, specifically for the asthmatic children population as the classification studies performed to date (1) are limited in number, (2) include features derived from tests that are not optimally suitable for children, (3) are solely bi-class (mostly asthma and non-asthma) and therefore fail to include different degrees of peripheral obstruction for disease prevention and control and (4) lack of validation in cases that focus on multi-class classification of the different degrees of peripheral airway o...
Source: Biomedizinische Technik/Biomedical Engineering - October 11, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Mechanomyography-based assessment during repetitive sit-to-stand and stand-to-sit in two incomplete spinal cord-injured individuals.
Authors: Abd Aziz M, Hamzaid NA, Hasnan N, Dzulkifli MA Abstract Standing up and sitting down movements are important prerequisites to achieve functional independence in everyday life of spinal cord injury (SCI) patients. Thus, mechanomyography (MMG) was proposed as a safe monitoring tool to evaluate muscle function performance of these activities. Two incomplete SCI participants performed repetitive sit-to-stand (SitTS) and stand-to-sit (StandTS) until fatigued challenge. Three sets of these activities were completed with MMG sensors attached over the quadriceps muscles of both legs. A 5-min rest was allocated bet...
Source: Biomedizinische Technik/Biomedical Engineering - September 30, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Effective brain connectivity estimation between active brain regions in autism using the dual Kalman-based method.
In this study, a dual Kalman-based method is used for effective connectivity estimation. Because of connectivity changes in autism, the method is applied to autistic signals for effective connectivity estimation. For method validation, the dual Kalman based method is compared with other connectivity estimation methods by estimation error and the dual Kalman-based method gives acceptable results with less estimation errors. Then, connectivities between active brain regions of autistic and normal children in the resting state are estimated and compared. In this simulation, the brain is divided into eight regions and the conn...
Source: Biomedizinische Technik/Biomedical Engineering - September 22, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification.
Authors: Nabil D, Benali R, Bereksi Reguig F Abstract Epileptic seizure (ES) is a neurological brain dysfunction. ES can be detected using the electroencephalogram (EEG) signal. However, visual inspection of ES using long-time EEG recordings is a difficult, time-consuming and a costly procedure. Thus, automatic epilepsy recognition is of primary importance. In this paper, a new method is proposed for automatic ES recognition using short-time EEG recordings. The method is based on first decomposing the EEG signals on sub-signals using discrete wavelet transform. Then, from the obtained sub-signals, different non-lin...
Source: Biomedizinische Technik/Biomedical Engineering - September 21, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Quadriceps mechanomyography reflects muscle fatigue during electrical stimulus-sustained standing in adults with spinal cord injury - a proof of concept.
This study investigates whether mechanomyography (MMG) produced from contracting muscles as a measure of their performance could be a proxy of muscle fatigue during a sustained functional electrical stimulation (FES)-supported standing-to-failure task. Bilateral FES-evoked contractions of quadriceps and glutei muscles, of four adults with motor-complete spinal cord injury (SCI), were used to maintain upright stance using two different FES frequencies: high frequency (HF - 35 Hz) and low frequency (LF - 20 Hz). The time at 30° knee angle reduction was taken as the point of critical "fatigue failure", while the...
Source: Biomedizinische Technik/Biomedical Engineering - September 21, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents.
Authors: Zhou C, Feng X, Shi Z, Song C, Cui X, Zhang J, Li T, Toft ES, Ge J, Wang L, Zhang H Abstract Coronary stents made of zinc (Zn)-0.8 copper (Cu) (in wt%) alloy were developed as biodegradable metal stents (Zn-Cu stents) in this study. The mechanical properties of the Zn-Cu stents and the possible gain effects were characterized by in vitro and in vivo experiments compared with 316L stainless steel stents (316L stents). Young's modulus of the as-extruded Zn-0.8Cu alloy and properties of the stents, including their intrinsic elastic recoil, stent trackability were evaluated compared with 316L stents. In vivo s...
Source: Biomedizinische Technik/Biomedical Engineering - September 20, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A left ventricular phantom for 3D echocardiographic twist measurements.
Authors: Hjertaas JJ, Matre K Abstract Traditional two-dimensional (2D) ultrasound speckle tracking echocardiography (STE) studies have shown a wide range of twist values, also for normal hearts, which is due to the limitations of short-axis 2D ultrasound. The same limitations do not apply to three-dimensional (3D) ultrasound, and several studies have shown 3D ultrasound to be superior to 2D ultrasound, which is unreliable for measuring twist. The aim of this study was to develop a left ventricular twisting phantom and to evaluate the accuracy of 3D STE twist measurements using different acquisition methods and vol...
Source: Biomedizinische Technik/Biomedical Engineering - September 20, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Automatic hypernasality grade assessment in cleft palate speech based on the spectral envelope method.
Authors: Zhang J, Yang S, Wang X, Tang M, Yin H, He L Abstract Due to velopharyngeal incompetence, airflow overflows from the oral cavity to the nasal cavity, which results in hypernasality. Hypernasality greatly reduces speech intelligibility and affects the daily communication of patients with cleft palate. Accurate assessment of hypernasality grades can provide assisted diagnosis for speech-language pathologists (SLPs) in clinical settings. Utilizing a support vector machine (SVM), this paper classifies speech recordings into four grades (normal, mild, moderate and severe hypernasality) based on vocal tract char...
Source: Biomedizinische Technik/Biomedical Engineering - September 18, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Measuring lower limb circumference and volume - introduction of a novel optical 3D volumetric measurement system.
This study comprised two experiments: (1) the reliability of a novel optical three-dimensional (3D) volumetric measurement system (BODYTRONIC® 600) for the assessment of lower limb circumference and volume; (2) the comparison of data obtained from BODYTRONIC® 600 with that provided by computed tomography (CT) for accuracy estimation. Reliability was assessed in 20 healthy subjects. Accuracy was determined by comparing the deviations in the surface topology of two 3D models obtained from BODYTRONIC® 600 and CT. Reliability was very high for leg circumference measures [coefficient of variations (CVs) range 0.3%-1...
Source: Biomedizinische Technik/Biomedical Engineering - September 18, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Automatic analysis of image quality by ETR-1 for the On-Board Imager.
Authors: Ahmed S, Krüger M, Willomitzer C, Abu Zakaria G Abstract The test-plate image of an image quality test tool is processed. The processing is based on quality assurance with the well-established test device ETR-1. A program is developed to analyze the parameters such as contrast, low contrast and resolution automatically. This results in more accurate patient positioning for the On-Board Imager (OBI) system. The contrast and resolution are measured by means of Bresenham's line algorithm. The low contrast is calculated with the help of binary masking. The modulation transfer function (MTF) is also observ...
Source: Biomedizinische Technik/Biomedical Engineering - September 8, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Epileptic seizure detection on EEG signals using machine learning techniques and advanced preprocessing methods.
In this study, a novel automatic seizure-detection approach is proposed. Three different strategies are suggested to the user whereby he/she could choose the appropriate one for a given classification problem. Indeed, the feature extraction step, including both linear and nonlinear measures, is performed either directly from the EEG signals, or from the derived sub-bands of tunable-Q wavelet transform (TQWT), or even from the intrinsic mode functions (IMFs) of multivariate empirical mode decomposition (MEMD). The classification procedure is executed using a support vector machine (SVM). The performance of the proposed meth...
Source: Biomedizinische Technik/Biomedical Engineering - September 1, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Experimental investigation on the effect of drill quality on the performance of bone drilling.
This study suggests that the sharp drill along with controlled drilling speed and feed rate may be used for safe and efficient surgical drilling in bone. PMID: 31437122 [PubMed - as supplied by publisher] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - August 24, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

EOG-based eye movement recognition using GWO-NN optimization.
Authors: Mulam H, Mudigonda M Abstract In recent times, the control of human-computer interface (HCI) systems is triggered by electrooculography (EOG) signals. Eye movements recognized based on the EOG signal pattern are utilized to govern the HCI system and do a specific job based on the type of eye movement. With the knowledge of various related examinations, this paper intends a novel model for eye movement recognition based on EOG signals by utilizing Grey Wolf Optimization (GWO) with neural network (NN). Here, the GWO is used to minimize the error function from the classifier. The performance of the proposed m...
Source: Biomedizinische Technik/Biomedical Engineering - August 9, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A novel approach to the diagnostic assessment of carpal tunnel syndrome based on the frequency domain of the compound muscle action potential.
Authors: Alcan V, Kaya H, Zinnuroğlu M, Karataş GK, Canal MR Abstract Conventional electrophysiological (EP) tests may yield ambiguous or false-negative results in some patients with signs and symptoms of carpal tunnel syndrome (CTS). Therefore, researchers tend to investigate new parameters to improve the sensitivity and specificity of EP tests. We aimed to investigate the mean and maximum power of the compound muscle action potential (CMAP) as a novel diagnostic parameter, by evaluating diagnosis and classification performance using the supervised Kohonen self-organizing map (SOM) network models. The CMAPs were...
Source: Biomedizinische Technik/Biomedical Engineering - August 6, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Pattern recognition of head movement based on mechanomyography and its application.
Authors: Gu X, Wu Q, Zhang Y, Zhong H, Zhang S, Xia C, Yu J Abstract The first part of this study investigated pattern recognition of head movements based on mechanomyography (MMG) signals. Four channel MMG signals were collected from the sternocleidomastoid (SCM) muscles and the splenius capitis (SPL) muscles in the subjects' neck when they bowed the head, raised the head, side-bent to left, side-bent to right, turned to left and turned to right. The MMG signals were then filtered, normalized and divided using an unequal length segmentation algorithm into a single action frame. After extracting the energy features...
Source: Biomedizinische Technik/Biomedical Engineering - July 30, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Radioguided surgery: physical principles and an update on technological developments.
Authors: Pashazadeh A, Friebe M Abstract Radioguided surgery (RGS) is the use of radiation detection probes and handheld gamma cameras in surgery rooms to identify radioactively labeled lesions inside the body with an aim to improve surgical outcome. In today's surgery, application of these devices is a well-established practice, which provides surgeons with real-time information to guide them to the site of a lesion. In recent years, there have been several major improvements in the technology and design of gamma probes and handheld gamma cameras, enhancing their applications in surgical practices. Handheld gamma ...
Source: Biomedizinische Technik/Biomedical Engineering - July 29, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

An improved method to isolate primary human osteocytes from bone.
Authors: Bernhardt A, Wolf S, Weiser E, Vater C, Gelinsky M Abstract Osteocytes are of high importance in bone metabolism as they orchestrate bone remodeling, react to mechanosensory stimuli and have endocrine functions. In vitro investigations with osteocytes are therefore of high relevance for biomaterial and drug testing. The application of primary human cells instead of rodent osteocyte cell lines like MLOY4 and IDG SW3 is desirable but provides the challenge of isolating these cells, which are deeply embedded into the mineralized bone matrix. The present study describes an improved protocol for the isolation o...
Source: Biomedizinische Technik/Biomedical Engineering - July 29, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Mathematical morphology-based imaging of gastrointestinal cancer cell motility and 5-aminolevulinic acid-induced fluorescence.
In conclusions, our study revealed that MKN28 cells derived from the lymph node have higher motility and 5-ALA-induced fluorescence than AGS or HCT116 derived from primary tumors. Moreover, image analysis based on a large amount of processed data is an important tool to study these tumor cell properties. PMID: 31326958 [PubMed - as supplied by publisher] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - July 23, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A step forward in the quest for a mobile EEG-designed epoch for psychophysiological studies.
Authors: Balart-Sánchez SA, Vélez-Pérez H, Rivera-Tello S, Gómez Velázquez FR, González-Garrido AA, Romo-Vázquez R Abstract The aim of this study was to compare a reconfigurable mobile electroencephalography (EEG) system (M-EMOTIV) based on the Emotiv Epoc® (which has the ability to record up to 14 electrode sites in the 10/20 International System) and a commercial, clinical-grade EEG system (Neuronic MEDICID-05®), and then validate the rationale and accuracy of recordings obtained with the prototype proposed. In this approach, an Emotiv Epoc® was modifie...
Source: Biomedizinische Technik/Biomedical Engineering - July 20, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Iris recognition under the influence of diabetes.
In this study, iris recognition under the influence of diabetes was investigated. A new database containing 1318 pictures from 343 irides - 546 images from 162 healthy irides (62% female users, 38% male users, 21%
Source: Biomedizinische Technik/Biomedical Engineering - July 20, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

ESLMT: a new clustering method for biomedical document retrieval.
Authors: Keyvanpour M, Serpush F Abstract MEDLINE is a rapidly growing database; to utilize this resource, practitioners and biomedical researchers have dealt with tedious and time-consuming tasks such as discovering, searching, reading and evaluating of biomedical documents. However, making a label for a group of biomedical documents is expensive and needs a complicated operation. Otherwise, compound words, polysemous and synonymous problems can influence the search in MEDLINE. Therefore, designing an efficient way of sharing knowledge and information organization is essential so that information retrieval systems...
Source: Biomedizinische Technik/Biomedical Engineering - June 16, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Fetal cardiotocography monitoring using Legendre neural networks.
Authors: Alsayyari A Abstract A new technique for electronic fetal monitoring (EFM) using an efficient structure of neural networks based on the Legendre series is presented in this paper. Such a structure is achieved by training a Legendre series-based neural network (LNN) to classify the different fetal states based on recorded cardiotocographic (CTG) data sets given by others. These data sets consist of measurements of fetal heart rate (FHR) and uterine contraction (UC). The applied LNN utilizes a Legendre series expansion for the input vectors and, hence, has the capability to produce explicit equations describ...
Source: Biomedizinische Technik/Biomedical Engineering - June 16, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Regression analysis for detecting epileptic seizure with different feature extracting strategies.
Authors: Hussain L, Saeed S, Idris A, Awan IA, Shah SA, Majid A, Ahmed B, Chaudhary QA Abstract Due to the excitability of neurons in the brain, a neurological disorder is produced known as epilepsy. The brain activity of patients suffering from epilepsy is monitored through electroencephalography (EEG). The multivariate nature of features from time domain, frequency domain, complexity and wavelet entropy based, and the statistical features were extracted from healthy and epileptic subjects using the Bonn University database and seizure and non-seizure intervals using the CHB MIT database. The robust machine learni...
Source: Biomedizinische Technik/Biomedical Engineering - May 31, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A wavelet-based method for MRI liver image denoising.
Authors: Ali MN Abstract Image denoising stays be a standout amongst the primary issues in the field of image processing. Several image denoising algorithms utilizing wavelet transforms have been presented. This paper deals with the use of wavelet transform for magnetic resonance imaging (MRI) liver image denoising using selected wavelet families and thresholding methods with appropriate decomposition levels. Denoised MRI liver images are compared with the original images to conclude the most suitable parameters (wavelet family, level of decomposition and thresholding type) for the denoising process. The performanc...
Source: Biomedizinische Technik/Biomedical Engineering - May 31, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Comparison of bone biomechanical properties after bone marrow mesenchymal stem cell or alendronate treatment in an osteoporotic animal model.
Authors: Piao C, Li Z, Ding J, Kong D Abstract The aim of this study was to explore the effects of bone marrow mesenchymal stem cells (BMMSCs) and alendronate sodium (ALN) intervention on osteoporosis (OP). Sixty-eight 6-month-old healthy female Sprague Dawley (SD) rats were used to generate an OP model by removal of the ovaries. After 12 weeks, rats were treated with BMMSCs (BMMSC group) or ALN (ALN group) for 5 weeks. Serum type I collagen C terminal peptide (CTX_1), procollagen type I N-terminal propeptide (PINP), and bone alkaline phosphatase (BALP) were tested along with the femur bone density and other proper...
Source: Biomedizinische Technik/Biomedical Engineering - May 24, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Assessment of CSP-based two-stage channel selection approach and local transformation-based feature extraction for classification of motor imagery/movement EEG data.
In this study, a two-stage channel selection and local transformation-based feature extraction are proposed for the classification of motor imagery/movement tasks. In the first stage of the channel selection, the channels were combined according to the neurophysiological information about brain functions acquired from the literature, then averaged and a single channel was formed. In the second stage, selective channels were specified with the common spatial pattern-linear discriminant analysis (CSP-LDA)-based sequential channel removal. After the channel selection phase, the feature extraction was carried out with local tr...
Source: Biomedizinische Technik/Biomedical Engineering - May 17, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A review on the pattern detection methods for epilepsy seizure detection from EEG signals.
Authors: Sharmila A, Geethanjali P Abstract Over several years, research had been conducted for the detection of epileptic seizures to support an automatic diagnosis system to comfort the clinicians' encumbrance. In this regard, a number of research papers have been published for the identification of epileptic seizures. A thorough review of all these papers is required. So, an attempt has been made to review on the pattern detection methods for epilepsy seizure detection from EEG signals. More than 150 research papers have been discussed to determine the techniques for detecting epileptic seizures. Further, the li...
Source: Biomedizinische Technik/Biomedical Engineering - April 27, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Optimization of the proposed hybrid denoising technique to overcome over-filtering issue.
Authors: Kushwaha S, Singh RK Abstract Image denoising has become a crucial task in medical ultrasound (US) imaging due to the presence of speckle or multiplicative noise and additive Gaussian noise. Recently, several denoising techniques such as adaptive wavelet thresholding & joint bilateral (AWT + JB) filter, adaptive fuzzy switching weighted mean (AFSWM) filter and median patch-based locally optimal Wiener (MPBLOW) filter have been proposed to remove the speckle noise. However, these denoising techniques were found to remove noise along with the essential parts of the actual image data which i...
Source: Biomedizinische Technik/Biomedical Engineering - April 14, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Obtaining the sGAG distribution profile in articular cartilage color images.
Authors: Iglesias C, Luo L, Martínez J, Kelly DJ, Taboada J, Pérez I Abstract The articular cartilage tissue is an essential component of joints as it reduces the friction between the two bones. Its load-bearing properties depend mostly on proteoglycan distribution, which can be analyzed through the study of the presence of sulfated glycosaminoglycan (sGAG). Currently, sGAG distribution in articular cartilage is not completely known; it is calculated by means of laboratory tests that imply the inherent inaccuracy of a manual procedure. This paper presents an easy-to-use desktop software application fo...
Source: Biomedizinische Technik/Biomedical Engineering - April 7, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

A comparative study of tapped and untapped pilot holes for bicortical orthopedic screws - 3D finite element analysis with an experimental test.
Authors: Ketata H, Affes F, Kharrat M, Dammak M Abstract The aim of this study was to compare the screw-to-bone fixation strength of two insertion techniques: self-tapping screw (STS) and non-self-tapping screw (NSTS). Finite element analysis (FEA) was used for the comparison by featuring three tests (insertion, pull-out and shear) in a human tibia bone model. A non-linear material behavior with ductile damage properties was chosen for the modeling. To validate the numerical models, experimental insertion and pull-out tests were carried out using a synthetic bone. The experimental and numerical results of pull-out ...
Source: Biomedizinische Technik/Biomedical Engineering - April 4, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Developing viscoelastic contact models and selecting suitable creep function for spherical biological cells.
Authors: Korayem MH, Sooha YH, Rastgear Z Abstract In most contact theories, the most popular of which are the three models of Hertz, Derjaguin, Muller and Toporov (DMT) and Johnson, Kendall and Roberts (JKR), biological cells were considered as an elastic material which is not a proper assumption. The elastic assumption in the case of biological cells could lead to neglecting the loading history as a result of which the stresses and strains applied to the material would not be studied accurately. In this paper, developing the three mentioned elastic models into viscoelastic models, simulating and comparing them wi...
Source: Biomedizinische Technik/Biomedical Engineering - March 28, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Invasive and non-invasive point-of-care testing and point-of-care monitoring of the hemoglobin concentration in human blood - how accurate are the data?
Authors: Dietzel F, Dieterich P, Dörries F, Gehring H, Wegerich P Abstract In this review, scientific investigations of point-of-care testing (POCT) and point-of-care monitoring (POCM) devices are summarized with regard to the measurement accuracy of the hemoglobin concentration. As a common basis, information according to the Bland and Altman principle [bias, limits of agreement (LOA)] as well as the measurement accuracy and precision are considered, so that the comparability can be mapped. These collected data are subdivided according to the manufacturers, devices and procedures (invasive and non-invasive). ...
Source: Biomedizinische Technik/Biomedical Engineering - March 28, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

On the feasibility of a liquid crystal polymer pressure sensor for intracranial pressure measurement.
This study aims to develop a wireless ICP monitoring device that is biocompatible, miniature and implantable. Liquid crystal polymer (LCP) was selected to be the main material for the device fabrication. This study considers the design, fabrication and testing of the sensing unit of the proposed wireless ICP monitoring device. A piezoresistive pressure sensor was designed to respond to 0-50 mm Hg applied pressure and fabricated on LCP by standard microelectromechanical systems (MEMS) procedures. The fabricated LCP pressure sensor was studied in a moist environment by means of a hydrostatic pressure test. The results showed...
Source: Biomedizinische Technik/Biomedical Engineering - March 17, 2019 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research