DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps.
Conclusions: These results suggest that the overexpression of DNMT3B may contribute to a role in the genesis of CAPs through the hypomethylation of chromosomes in the whole cell and promoter hypermethylation of RASSF1A. PMID: 33061956 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Risk Factors of Lymph Node Metastasis in Patients with Pancreatic Neuroendocrine Tumors (PNETs).
Authors: Wang Z, Cao F, Zhang Y, Fang Y, Li F Abstract Background: The prognostic value of lymph node metastasis in patients with PNETs is controversial. Understanding the effect of lymph node metastasis on prognosis in pancreatic neuroendocrine tumors is helpful for surgery and follow-up. The purposes of this study are to identify predictors of lymph node metastasis among patients with PNETs and determine its prognostic associations. Methods: A retrospective analysis of the surveillance, epidemiology, and end results (SEER) database was performed. Patients with PNETs that underwent surgery and pathologic nodal...
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Machine Learning Models of Acute Kidney Injury Prediction in Acute Pancreatitis Patients.
Authors: Qu C, Gao L, Yu XQ, Wei M, Fang GQ, He J, Cao LX, Ke L, Tong ZH, Li WQ Abstract Background. Acute kidney injury (AKI) has long been recognized as a common and important complication of acute pancreatitis (AP). In the study, machine learning (ML) techniques were used to establish predictive models for AKI in AP patients during hospitalization. This is a retrospective review of prospectively collected data of AP patients admitted within one week after the onset of abdominal pain to our department from January 2014 to January 2019. Eighty patients developed AKI after admission (AKI group) and 254 patients did...
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinical Analysis of the Curative Effect of a Transnasal Ileus Tube in the Treatment of Small Bowel Obstruction Caused by a Phytobezoar.
Authors: Lin YX, Wang SJ, Liang HS, Lin S, Bian LY, Ding J, Li D Abstract Objective: To investigate the curative effect of a transnasal ileus tube in the treatment of small bowel obstruction caused by a phytobezoar. Methods: Seventy-one patients with small bowel obstruction caused by a phytobezoar who underwent treatment in three provincial tertiary grade A hospitals in Fujian Province from March 2011 to February 2020 were included in this study. Patients were divided into the following two groups according to the treatment received: (1) conservative group, comprising patients who received medical conservative ...
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening.
Conclusions: According to the risk factors of GC, using statistical methods can establish a high-risk scoring model of GC, and the score ≥ 155 is divided into the screening cut-off value for high-risk GC population. Using this model for clinical outpatient GC screening is cost-effective and has high sensitivity and specificity. PMID: 33061960 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Novel Pathologic Factors for Risk Stratification of Gastric "Indefinite for Dysplasia" Lesions.
Conclusions: Structural atypia was more helpful than nuclear atypia and SAA> 25% was the most powerful predictor for the diagnosis of INDs of the stomach. We propose shortening the follow-up period to six months for Category 1, endoscopic resection for Category 2 and 3, postresection follow-up periods of one year for Category 2, and six months for Category 3. PMID: 33061961 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma.
Authors: Tokunaga M, Matsumura T, Ishikawa K, Kaneko T, Oura H, Ishikawa T, Nagashima A, Shiratori W, Okimoto K, Akizue N, Maruoka D, Ohta Y, Saito K, Nakagawa T, Chiba T, Arai M, Kato J, Kato N Abstract Background: The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Methods: A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 (not detectable) were evaluated by three trainees and three experts using white light...
Source: Gastroenterology Research and Practice - October 20, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

A Methodological and Reporting Quality Assessment of Systematic Reviews/Meta-Analyses about Chinese Medical Treatment for Gastroesophageal Reflux Disease.
Conclusion: The methodological and reporting quality of SRs/MAs about Chinese medical treatment for GERD is generally poor. The main problems included incomplete search strategies, risk of bias in individual studies, the lack of protocol registration and excluded study list, and incorrect study selection methods. PMID: 33029131 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis.
Authors: Li M, Guo Z, Zhang D, Xu X, Romeiro FG, Mancuso A, Zhang J, Feng R, Zhou X, Hong C, Qi X Abstract Methods: Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), ...
Source: Gastroenterology Research and Practice - October 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Tufting Enteropathy: A Review of Clinical and Histological Presentation, Etiology, Management, and Outcome.
This article reviews CTE disease based on its clinical and histological presentation, etiology and pathogenesis, and management and outcome. PMID: 33029133 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Corrigendum to "The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery".
Corrigendum to "The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery". Gastroenterol Res Pract. 2020;2020:1848252 Authors: Zheng K, Zheng N, Xin C, Zhou L, Sun G, Wen R, Zhang H, Yu G, Bai C, Zhang W Abstract [This corrects the article DOI: 10.1155/2020/2052561.]. PMID: 33014036 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Previous Intestinal Resection Is Associated with Postoperative Complications in Crohn's Disease: A Cohort Study.
Authors: Duan Y, Liu Y, Li Y Abstract Background: To assess the influence of a previous intestinal resection on postoperative complications for Crohn's disease (CD). Methods: Data on patients with CD undergoing surgery in our department from January 2016 through December 2019 were retrospectively reviewed. Information collected included demographic details, surgical data, and postoperative outcome. A cross-sectional study design was employed. Associations between postoperative complications and preoperative clinical indicators were further analyzed. Results: Of the 129 patients with CD studied, 62 patients ...
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Standardized Surgical Management for Cystic Dilation of the Bile Ducts Based on Clinical and Pathological Studies: A Narrative Review.
Authors: Xia HT Abstract The surgical method of complete/radical cyst excision plus Roux-en-Y hepaticojejunostomy remains the primary therapy and the only effective treatment for cystic dilation of the bile ducts (CDBDs). However, the incidence of long-term postoperative complications is still high, as is the reoperation rate, and the potential for postoperative malignant transformation still exists. In recent years, significant progress has been made in understanding the pathogenic mechanism and pathological changes of adult CDBDs. Based on which, the surgical procedures for CDBDs have been revised to further impr...
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effect of Combined Live Probiotics Alleviating the Gastrointestinal Symptoms of Functional Bowel Disorders.
Authors: Shi J, Gao F, Zhang J Abstract Objective: Changes of the gut microbiota are related to the pathogenesis of functional bowel disorders (FBDs), and probiotic supplementation may be an effective treatment option. Therefore, we aimed to investigate the effect of combined live probiotics on the gastrointestinal symptoms of FBDs via altering the gut microbiota. Methods: Patients with the gastrointestinal symptoms of FBDs attending the Outpatient Department, from July to November 2019, were recruited. After the bowel preparation with polyethylene glycol electrolyte powder and colonoscopy, patients with normal...
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Risk Factors for Mortality in Patients with Aortoesophageal Fistula Related to Aortic Lesions.
Authors: Li S, Gao F, Hu HO, Shi J, Zhang J Abstract Objective: Aortoesophageal fistula (AEF) related to aortic aneurysm and dissection is an uncommon but life-threatening condition. We performed a systematic review of risk factors for mortality and factors associated with the prognosis of AEF. Methods: A systematic search of the PubMed, Embase, and Cochrane Library databases was performed. Clinical characteristics, diagnostic methods, and treatments were assessed in terms of their ability to predict mortality. Results: The systematic review identified 184 eligible articles including 219 patients with AEF. ...
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

P2X3 Receptor in Primary Afferent Neurons Mediates the Relief of Visceral Hypersensitivity by Electroacupuncture in an Irritable Bowel Syndrome Rat Model.
Conclusion: EA can regulate the P2X3 receptor protein and mRNA expression levels in the colon and related DRG of IBS rats with visceral pain and then regulate the excitatory properties of DRG neurons. PMID: 33014041 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 7, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Enteric Nervous System and Its Emerging Role as a Therapeutic Target.
Authors: Fleming MA, Ehsan L, Moore SR, Levin DE Abstract The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS), an extensive neuronal network that traverses along its walls. Due to local reflex circuits, the ENS is capable of functioning with and without input from the central nervous system. The functions of the ENS range from the propulsion of food to nutrient handling, blood flow regulation, and immunological defense. Records of it first being studied emerged in the early 19th century when the submucosal and myenteric plexuses were discovered. This was followed by extensive research ...
Source: Gastroenterology Research and Practice - September 24, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor.
Authors: Chang XY, Wu Y, Jiang Y, Wang PY, Chen J Abstract An intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic precursor lesion, and it often harbors mutations in KRAS, GNAS, and RNF43. To clarify the molecular profiles of IPMNs, we conducted mutation analysis of KRAS, GNAS, and RNF43 in 61 IPMN formalin-fixed, paraffin-embedded (FFPE) specimens. The mutation rates of codons 12, 13, and 61 in KRAS and codon 201 in GNAS were detected by Sanger sequencing. Next-generation sequencing was performed on RNF43, and the results were further verified by Sanger sequencing. We identified KRAS and GNAS mut...
Source: Gastroenterology Research and Practice - September 17, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms.
Authors: Duan C, Zhang S, Wang J, Qian W, Han C, Hou X Abstract Aim: The outbreak of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic, with the main manifestations being of respiratory nature, including pneumonia. It is noteworthy that digestive symptoms are also observed in COVID-19 patients. In this article, we describe the immuno-inflammatory characteristics of low severity COVID-19 patients with digestive symptoms. Methods: Patients with mild symptoms of COVID-19 were split into three groups based on the patients' symptoms. The first group displayed digestive symptoms only, the second g...
Source: Gastroenterology Research and Practice - September 13, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis.
Authors: Oktem-Okullu S, Cekic-Kipritci Z, Kilic E, Seymen N, Mansur-Ozen N, Sezerman U, Gurol Y Abstract The aim of this study is to evaluate the association between seven important H. pylori virulence factors and antibiotic resistance in patients with gastritis. H. pylori strains isolated from 33 patients with gastritis were examined. Antimicrobial susceptibilities were tested by GenoType® HelicoDR (Hain Life Science, Germany) test kit and RT-PCR. The virulence-factors were determined using conventional PCR. 39% of patients were resistant for clarithromycin and 27% of patients were resistant for fluoroquinolo...
Source: Gastroenterology Research and Practice - September 13, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Randomized Controlled Trial of Polyethylene Glycol versus Oral Sodium Phosphate for Bowel Preparation in Unsedated Colonoscopy.
Authors: Yang D, Tao K, Chen G, Zhang L, He Q, Xu H Abstract Aim: To identify the most effective laxative for bowel preparation in unsedated colonoscopy. Methods: Between April 2019 and April 2020, a total of 586 outpatients scheduled for unsedated colonoscopy at the First Hospital of Jilin University (Changchun, China) were randomized into one of two groups, namely, the polyethylene glycol (PEG) group or the oral sodium phosphate solution (OSP) group. The cleaning efficiency and other relevant clinical parameters were compared between the two groups. Results: Each group consisted of 293 patients. There wer...
Source: Gastroenterology Research and Practice - September 13, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/ β-Cateninsignaling Pathway.
MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway. Gastroenterol Res Pract. 2020;2020:6358685 Authors: Wu X, Zhang Y, Guo J, Yan X, Shen L, Zhou J, Zhao J, Zhuang M, Cao Z Abstract Gastric cancer is one of the most frequently diagnosed cancer and poses a serious threat to health system in the world. Upregulation of meningioma-associated protein (MAC30) has been found in many solid tumors and can regulate the proliferation, differentiation, and apoptosis of different tumor cells. Quantitative polymerase chain reaction (qPCR)...
Source: Gastroenterology Research and Practice - September 11, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Tumor Size as a Critical Prognostic Factor in T1-2 Stage Esophageal Cancer.
Conclusion: The current study identified tumor size as a critical clinical prognostic signature for esophageal cancer with considerable discriminatory ability and prognostic value. Therefore, tumor size should be included in the American Joint Committee on Cancer (AJCC) TNM staging of T1-2 esophagus cancer patients. PMID: 32879626 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - September 4, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Silencing of Long Noncoding RNA LINC00324 Interacts with MicroRNA-3200-5p to Attenuate the Tumorigenesis of Gastric Cancer via Regulating BCAT1.
Conclusion: Silencing of LINC00324 inhibited the proliferation, migration, and invasion of GC cells through regulating the miR-3200-5p/BCAT1 axis. PMID: 32855634 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Claudin-1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta-Analysis.
Authors: Zuo D, Zhang J, Liu T, Li C, Ning G Abstract Background: Claudin-1 plays an important part in maintaining the mucosal structures and physiological functions. Several studies showed a relationship between claudin-1 and colorectal cancer (CRC), but its prognostic significance is inconsistent. This meta-analysis assessed the prognostic value and clinical significance of claudin-1 in CRC. Materials and Methods: We retrieved eligible studies from PubMed, Cochrane Library, Embase, and Web of Science databases before February 10, 2020. The hazard ratio (HR) with 95% confidence interval (CI) was applied to ass...
Source: Gastroenterology Research and Practice - August 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy.
Conclusion: Many patients taking DOACs had small-bowel lesions; however, most lesions were relatively mild. Observing small-bowel lesions over longer periods may be necessary in patients taking DOACs. This trial is registered with UMIN000011527. PMID: 32849868 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 28, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Acute-on-Chronic Liver Failure in Pregnant Patients with Chronic Hepatitis B: A Retrospective Observational Case Series Study.
Conclusion: Asthenia, anorexia, and jaundice during mid-late pregnancy should be immediately investigated. Before and during the pregnancy, hepatologists or obstetricians should actively screen pregnant women with CHB for HBV DNA status and alanine aminotransferase levels. Reactivation of HBV replication in pregnant women with CHB may lead to ACLF, especially in multiparous women. Once ACLF is diagnosed, antiviral therapy should be considered as soon as possible to protect maternal and fetal health. PMID: 32849869 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 28, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Peritoneal Metastatic Cancer Stem Cells of Gastric Cancer with Partial Mesenchymal-Epithelial Transition and Enhanced Invasiveness in an Intraperitoneal Transplantation Model.
Conclusions: pMCSCs might be a specific subpopulation that can be sequentially enriched by intraperitoneal transplantation. pMCSCs exhibited a tendency towards partial mesenchymal-epithelial transition, enhancing their invasiveness during homing and the formation of peritoneal tumors. However, these preliminary findings require validation in further experiments. PMID: 32831823 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Carcinoma of Pancreatobiliary Origin.
Authors: Kohoutová D, Bureš J, Zar S, Urban O PMID: 32831824 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Feasibility and Safely of Oral Rehydration Therapy before Upper Gastrointestinal Endoscopic Submucosal Dissection.
Conclusion: PORT up to two hours before upper gastrointestinal ESD is feasible. PMID: 32831825 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer.
Conclusion: The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC. PMID: 32831826 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Half-Elemental Diet Shifts the Human Intestinal Bacterial Compositions and Metabolites: A Pilot Study with Healthy Individuals.
Conclusions: Half-ED shifts the gut bacterial compositions and metabolites. The changes varied with each individual, while some microbes and metabolites change commonly across individuals. The impact of half-ED may persist even after the withdrawal. This trial is registered with UMIN ID: 000031920. PMID: 32831827 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients.
Authors: Matsuda H, Nosaka T, Akazawa Y, Saito Y, Ozaki Y, Takahashi K, Naito T, Ofuji K, Ohtani M, Hiramatsu K, Nakamoto Y Abstract Introduction: We retrospectively examined the relationship between daily proton pump inhibitor (PPI) use and severity of upper gastrointestinal bleeding (UGIB), mainly in the elderly. Methods: We included 97 patients with nonvariceal UGIB diagnosed at our hospital from January 2012 to October 2017. Bleeding severity was assessed using the shock index (SI) and estimated bleeding volume; 49 patients met the criterion for the mild group and 48 for the moderate/severe group. The effec...
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review.
Authors: Li P, Chen K, Mao Z, Luo Y, Xue Y, Zhang Y, Wang X, Zhang L, Gu S, Dou D Abstract Methods: MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance. Results: Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28; P
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis.
Conclusion: The meta-analysis showed that aspirin users with diabetes were more likely to have GI hemorrhage. Hence, when treating diabetics with aspirin, the increased risk of GI bleeding should be taken in consideration. PMID: 32831830 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effect of Ghrelin Hormone as a Diagnostic Factor on Appendicitis.
Conclusion: This conclusion may be due to the small number of cases introduced into the study, which suggests that further investigation is warranted with a larger sample size. PMID: 32802044 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy.
Authors: Topkan E, Mertsoylu H, Kucuk A, Besen AA, Sezer A, Sezen D, Bolukbasi Y, Selek U, Pehlivan B Abstract Background: We investigated the prognostic significance of pretreatment systemic inflammation response index (SIRI) in locally advanced pancreatic carcinoma (LAPC) patients treated with concurrent chemoradiotherapy (CRT). Methods: Present retrospective cohort analysis investigated consecutive 154 LAPC patients who received radical CRT. The SIRI was defined as: SIRI = neutrophil × monocyte/lymphocyte counts. Ideal SIRI cutoff(s) influencing overall survival (OS) and progression-free surviva...
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Expression of Tripartite Motif Protein 36 and β-Catenin Correlates with the Prognosis of Esophageal Cancer.
Conclusions: Our study provides evidence for the prognostic value of TRIM36 in ESCA. PMID: 32802046 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy.
Conclusions: The IOF rate significantly affects the incidence of POPF and respiratory complications after PD. Careful patient-oriented fluid therapy may help to prevent these complications. PMID: 32802047 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study.
Authors: Zhao Y, Ren M, Wang X, Lu G, Lu X, Zhang D, He S Abstract Poor adherence to treatment instructions may play an important role in the failure of Helicobacter pylori eradication. The aim of this study was to evaluate the effects of telephone-based reeducation on 14-day quadruple H. pylori eradication therapy. In total, 162 patients were randomly assigned (1 : 1) to either the intervention group (patients received telephone-based reeducation on the 4th, 7th, and 10th days of the course) or the control group (patients received instructions only at the time of getting the prescriptions). All patie...
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Nomograms Predicting the Occurrence of Sepsis in Patients following Major Hepatobiliary and Pancreatic Surgery.
Conclusion: The nomogram achieved good performances for predicting postoperative sepsis in patients by combining clinical and inflammation risk factors. This model can provide the early risk estimation of sepsis for patients following major hepatobiliary and pancreatic surgery. PMID: 32802049 [PubMed - as supplied by publisher] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat.
Conclusions: Rifaximin could improve visceral hyperalgesia via TRPV1 channels of peripheral and central neurons by modulating intestinal flora in rats. PMID: 32765600 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare.
Authors: Kroh A, Ivanova V, Drescher H, Andruszkow J, Longerich T, Nolting J, Eickhoff R, Heise D, Rheinwalt KP, Neumann UP, Ulmer FT Abstract A variety of dietary nonalcoholic steatohepatitis (NASH) mouse models are available, and choosing the appropriate mouse model is one of the most important steps in the design of NASH studies. In addition to the histopathological and metabolic findings of NASH, a sufficient mouse model should guarantee a robust clinical status and good animal welfare. Three different NASH diets, a high-fat diet (HFD60), a western diet (WD), and a cafeteria diet (CAFD), were fed for 12 or 16 w...
Source: Gastroenterology Research and Practice - August 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Gastric Carcinoma in Young Patients and Its Clinicopathological Characteristics and Prognosis.
Authors: Sandeep B, Huang X, Li Y, Mao L, Gao K, Xiao Z Abstract Background: Gastric cancer is usually an age-related disease and mostly diagnosed after the sixth decade of life, though it may also be diagnosed earlier. Objective: The aim of this study is to explore the clinicopathological characteristics and prognosis of gastric carcinoma in young patients. Methods: A total of 1379 patients younger than 75 years histologically diagnosed with primary gastric carcinoma underwent gastrectomy. Patients were categorized into three groups based on their age which included young age group (≤40 years), middle-a...
Source: Gastroenterology Research and Practice - August 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Latest Advances in Intersphincteric Resection for Low Rectal Cancer.
Conclusions: The ISR technique seems feasible for selected patients with low rectal cancer. However, the postoperative QoL as a result of functional disorder should be fully discussed with patients before surgery. PMID: 32765603 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction.
Conclusions: Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. The gastric outlet status should be considered in the selection of surgical treatment methods for patients with gastric cancer. PMID: 32774358 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis.
Conclusions: TRG was not an independent predictor for survival, but the system regained its predicting significance in patients with lymph node metastasis. PMID: 32733550 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 1, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges.
Conclusions: Using the current understanding of SARS-CoV-2 as well as other pathogenic coronaviruses immunopathology, we showed why IBD patients should not be considered at an increased risk of infection or more severe outcomes. Whether our findings are entirely applicable to the pathogenesis, disease susceptibility, and treatment management of SARS-CoV-2 infection in IBD must be further explored. PMID: 32714386 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - July 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Mean Platelet Volume/Lymphocyte Ratio as a Prognostic Indicator for HBV-Related Decompensated Cirrhosis.
Conclusions: Increased MPVLR is associated with poor outcomes in patients with HBV-DeCi and might be a useful component of future prognostic scores. PMID: 32714387 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - July 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review.
Conclusions: This is the first report of PMP originating from a transverse colonic mucinous adenocarcinoma. It was diagnosed during resective surgery, involved ovarian metastasis, and survival was short. We did an extensive literature review in order to describe the clinical characteristics, histopathological findings, genetic profile, and potential treatments of PMP caused by nonappendiceal mucinous adenocarcinoma. PMID: 32714388 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - July 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research