Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Authors: Li C, Zuo D, Liu T, Yin L, Li C, Wang L Abstract Objective: To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics. Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used ...
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Colonic Wall Thickening Reported in Abdominal CT: Does It Always Imply Malignancy?
Conclusion: A combined evaluation of Hb, NLR, and MPV values in patients with CWT in abdominal CT examination may contribute to the separation of benign and malignant pathologies. PMID: 31933628 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Conclusions: The results suggested that EP administration could effectively inhibit the liver fibrosis induced by BDL in rat, which may be associated with the enhanced activity of Nrf2 to mediate antioxidant enzyme system and downregulate the inflammatory genes. PMID: 31933629 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Changes in the Management of Patients with Crohn's Disease Based on Magnetic Resonance Enterography Patterns.
Conclusion: MRE discloses disease activity and complications not apparent with other modalities and results in changes in therapeutic decisions. In addition to being used for diagnosis, MRE should be routinely used in the follow-up of CD patients. PMID: 31933630 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Liver Stiffness, Not Fat Liver Content, Predicts the Length of QTc Interval in Patients with Chronic Liver Disease.
Authors: Bellan M, Rigamonti C, Giacomini GM, Makmur G, Marconi C, Nicosia F, Panero A, De Benedittis C, Burlone ME, Minisini R, Pirisi M Abstract The severity of fatty liver at ultrasound has been associated with QT length, a finding invoked to explain the excess cardiovascular risk of patients with fatty liver. However, the ability of ultrasound to stage accurately the severity of fatty liver is limited, with fibrosis a major confounder. Here, we aimed to verify the alleged relationship between fat liver content and QT length using a technique apt at discriminating steatosis from fibrosis noninvasively, i.e., tra...
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Factors Affecting the Accuracy of Endoscopic Ultrasonography in the Diagnosis of Early Gastric Cancer Invasion Depth: A Meta-analysis.
This study is aimed at systematically evaluating the accuracy of EUS in diagnosing the invasion depth of EGC and its affecting factors. Methods: The literatures were identified by searching PubMed, SpringerLink, Cochrane Library, Web of Science, Nature, and Karger knowledge databases. Two researchers extracted the data from the literature and reconstructed these in 2 × 2 tables. The Meta-DiSc software was used to evaluate the overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic advantage ratio, and 95% confidence interval (CI). The SROC was drawn, and the area under t...
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding in Chinese Patients on Antithrombotic Therapy.
Conclusion: Compared to the controls, patients in the antithrombotic group had a significantly higher incidence of critical and active bleeding. Patients with hemodynamic instability should be examined and treated via upper gastrointestinal endoscopy under anesthesia with tracheal intubation and ventilator support. PMID: 31933633 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Application of Minocycline-Containing Bismuth Quadruple Therapies as First-Line Regimens in the Treatment of Helicobacter pylori.
Authors: Zhang L, Lan Y, Wang Q, Zhang Y, Si X Abstract Aim: To evaluate the eradication rate, safety, and compliance of minocycline-containing bismuth quadruple regimens in patients with an untreated Helicobacter pylori (H. pylori) infection. Methods: A total of 360 patients with an untreated H. pylori infection were enrolled in this study between June 2017 and October 2018. Patients were randomly divided into a minocycline/amoxicillin (RMAB) group, a minocycline/metronidazole (RMMB) group, or an amoxicillin/clarithromycin (RACB) group, and all groups received a combined treatment approach with rabeprazole and...
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Endoscopic Perspective in Cholangiocarcinoma Diagnostic Process.
This article focuses on the diagnostic role of advanced biliary endoscopy, including endoscopic retrograde cholangiopancreatography, cholangioscopy, endoscopic ultrasonography, and intraductal sonography. PMID: 31933635 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 16, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study.
Authors: Rejchrt S, Hroch M, Repak R, Fejfar T, Douda T, Kohoutova D, Peterova E, Bures J Abstract Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin> 75 μmol/L, carbohydrate antigen 19-9> 400 U/mL) and the length of stenosis (>15 mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of ...
Source: Gastroenterology Research and Practice - January 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Multicenter Study of the Hemorrhage Risk after Endoscopic Mucosal Resection Associated with Direct Oral Anticoagulants.
This study was a multicenter retrospective cohort study conducted at 8 Japanese institutions. A total of 2062 cases that underwent EMR for colorectal lesions at these 8 institutions from October 2016 to September 2017 were analyzed. The cases were divided into 4 groups: the DOAC group (63 cases), warfarin group (34 cases), antiplatelet group (185 cases), and no antithrombotics group (1780 cases). In all lesions of the DOAC and warfarin groups, endoscopic clipping was performed after EMR. The rate of POH in the DOAC group, patients' clinical characteristics, the risk factors of POH, and the rate of thromboembolism due to st...
Source: Gastroenterology Research and Practice - January 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Association between Helicobacter pylori Infection and Colorectal Adenomatous Polyps.
Authors: Yang W, Yang X Abstract Background: Helicobacter pylori infection is a common chronic infection worldwide. At the same time, the incidence of colorectal adenomatous polyps is also at high levels. In order to assess the relationship between Helicobacter pylori infection and the occurrence of colorectal adenomatous polyps, we observed 166 patients who had undergone an electronic colonoscopy and 13C urea breath test in the outpatient clinic. Method: A total of 166 (87 males and 79 females, aged 53.85 ± 9.18 years) patients who had colonoscopy examination and 13C urea breath test were divided into a...
Source: Gastroenterology Research and Practice - January 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Contemporary Tailored Oncology Treatment of Biliary Tract Cancers.
Authors: Turkes F, Carmichael J, Cunningham D, Starling N Abstract Biliary tract cancers (BTCs) are poor prognosis malignancies with limited treatment options. Capecitabine has recently emerged as an effective agent in the adjuvant setting; however, treatment of advanced disease is still limited to first-line cisplatin and gemcitabine chemotherapy. Recent global efforts in genomic profiling and molecular subtyping of BTCs have uncovered a wealth of genomic aberrations which may carry prognostic significance and/or predict response to treatment, and several targeted agents have shown promising results in clinical tr...
Source: Gastroenterology Research and Practice - January 14, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Effectiveness, Tolerability, and Safety of Different 1-Day Bowel Preparation Regimens for Pediatric Colonoscopy.
Conclusion: All bowel cleansing methods show similar efficacy. However, because of the higher tolerability and acceptability profile, the NaPico+MgCit-based regimen appears to be the most proper for colonoscopy preparation in children. PMID: 31915433 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Laparoscopic and Endoscopic Cooperative Dissection for Small Gastric Gastrointestinal Stromal Tumor without Causing Injury to the Mucosa.
Authors: Cao L, Zheng K, Wang H, Zhao Y, Yang Z, Li W Abstract Objective: To investigate the feasibility of laparoscopic and endoscopic cooperative dissection (LECD) for small gastric gastrointestinal stromal tumors (GISTs) without causing injury to the mucosa, compared with ESD surgery which is widely used now. Methods: A total of 25 patients with small gastric GISTs who underwent LECD and 20 patients with small gastric GISTs who underwent ESD between October 2014 and June 2016 were included in this study. All patients underwent curative resection for pathologically diagnosed small gastric GISTs. Patients' cli...
Source: Gastroenterology Research and Practice - January 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Systematic Review with Meta-Analysis: The Effects of Probiotics in Nonalcoholic Fatty Liver Disease.
Conclusion: The systematic review and meta-analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach. PMID: 31885541 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinical Utility of Emergency Capsule Endoscopy for Diagnosing the Source and Nature of Ongoing Overt Obscure Gastrointestinal Bleeding.
Conclusions: Emergency CE represents a useful diagnostic modality in patients with ongoing overt OGIB, potentially improving detection rates and reducing rebleeding risk. PMID: 31885542 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prevalance of Celiac Disease in Patients with Inflammatory Bowel Disease in Turkish Population.
Conclusions: We did not find an increased prevalance of celiac disease in Turkish IBD patients in this study. In the presence of refractory iron deficiency anemia without any other cause in IBD patients, investigations for celiac disease should be considered. PMID: 31885543 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

HAVCR1 Affects the MEK/ERK Pathway in Gastric Adenocarcinomas and Influences Tumor Progression and Patient Outcome.
Authors: Xue J, Li Y, Yi J, Jiang H Abstract The hepatitis A virus cellular receptor 1 (HAVCR1) gene as a sensitive and specific biomarker has been reported in various diseases. Especially, HAVCR1 overexpression promotes the development and progression of several human cancers. Hence, we aimed to detect the effects of HAVCR1 on gastric adenocarcinoma (GAC). We first determined the expression of HAVCR1 in GAC tissues compared with normal gastric tissues based on the Cancer Genome Atlas (TCGA) database using bioinformatics analysis methods. Then, we assessed the biological function of HAVCR1 in GAC cells using quanti...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice.
Authors: Fokam Tagne MA, Akaou H, Noubissi PA, Foyet Fondjo A, Rékabi Y, Wambe H, Kamgang R, Essame Oyono JL Abstract Objective: The treatment of diarrheal diseases is a serious problem in developing countries, where population generally uses medicinal plants. The leaves of Bixa orellana have been reported to be traditionally used in the treatment of diarrhea by local people in the district of Khulna in Bangladesh. The aim of this study was to investigate the effects of the hydroethanolic extract of Bixa orellana leaves on castor oil-induced diarrhea in mice. Methods: The powder of the leaves of Bixa ore...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Attachment and Mentalizing Abilities in Patients with Inflammatory Bowel Disease.
Conclusion: These findings have suggested a plausible impact of IBD on mentalization abilities and have provided new insights into the interplay between IBD, deficits in mentalization, and attachment insecurity. IBD patients are highly vulnerable to disease-related stress that may promote impairments in mentalization. Low mentalization might play a central role in the development of attachment insecurity and emotional disturbances in IBD. The present study's results might open new scenarios for psychodynamic approaches to the treatment of the emotional disturbances in IBD based on attachment and mentalization theory. P...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection.
Authors: Tsai MY, Yen YH, Huang PY, Sou FM, Lin CC, Cho WR, Wang HM, Chen DW, Chang KC, Wu CK, Hu TH, Tsai MC Abstract Background and Aim: Liver fibrosis is associated with the prognosis of patients with hepatocellular carcinoma (HCC) after resection. The fibrosis-4 (FIB-4) index is an accurate and noninvasive marker to determine the degree of liver fibrosis. Here, we evaluated the effect of pre- and postoperative FIB-4 index in predicting the outcomes after resection of HCC in patients who have chronic hepatitis B (CHB) infection. Methods: A total of 534 CHB patients with HCC who received curative hepatectomy ...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study.
Authors: Gong Y, Wang P, Zhu Z, Zhang J, Huang J, Xu H Abstract Purpose: Upper or proximal gastric cancer occurs in the upper third of the stomach between the cardia and a line connecting the greater and lesser curvatures. As it differs from other gastric cancers in pathology and prognosis, we evaluated patient and disease characteristics that might guide improved treatment and survival of upper gastric cancer. Methods: We conducted a retrospective analysis of 649 patients with upper gastric cancer and 1551 patients with lower gastric cancer and R0 radical surgery at our institution between January 1980 and Dec...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Research Progress in Fecal Microbiota Transplantation as Treatment for Irritable Bowel Syndrome.
Authors: Wang Y, Zheng F, Liu S, Luo H Abstract Irritable bowel syndrome is a functional disorder characterized by abdominal pain or discomfort associated with altered bowel habits. Due to the uncertainty of the pathogenesis of IBS and the diversity of its clinical manifestations, IBS cannot be completely cured. Increasing evidence suggests the key role of altered intestinal microbiota in the pathogenesis of IBS. Therefore, attention is being shifted to adjusting the changes in intestinal microbiota to control IBS symptoms. Fecal microbiota transplantation (FMT), antibiotics, probiotics, and synbiotics are currentl...
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Interventional Protocol for Treatment of Complications after Esophagojejunostomy for Esophagogastric Carcinoma.
Conclusion: Interventional protocol is safe, feasible, and efficacious for treatment of complications after esophagojejunostomy. PMID: 31871443 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer.
Conclusion: In the general populations, no significant association was found between Helicobacter pylori infection and the risk of esophageal squamous cell carcinoma. However, lower risk was found in the Middle East. Helicobacter pylori infection may reduce the risk of esophageal adenocarcinoma, but such "protection effect" may be overestimated. PMID: 31871444 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases.
Conclusions: The incidence of LI, LM, and ATH does not differ among children with IBD from the population. PMID: 31871445 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Colorectal Cancer and Polyps in Diverticulosis Patients: A 10-Year Retrospective Study in 13680 Patients.
Authors: Abu Baker F, Z'cruz De La Garza JA, Mari A, Zeina AR, Bishara A, Gal O, Kopelman Y Abstract Introduction: Shared by certain epidemiological and etiological characteristics, diverticulosis and colorectal cancer (CRC) as well as colonic polyps has long been linked. This association was studied in several heterogeneous studies but has reported inconsistent results. Clarifying the association is clinically relevant for endoscopist awareness and potential modification of screening and surveillance intervals for diverticulosis patients. Methods: In this retrospective single-center study, patients diagnosed w...
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions.
Authors: Shi J, Xu X, Du J, Cui H, Luo Q Abstract Objective: To detect the expression of the Oncostatin M (OSM) gene and encoded protein in the mucosal epithelium of chronic gastritis, intestinal metaplasia (IM), low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), early gastric cancer (EGC), and advanced gastric cancer (AGC) samples and to explore the correlation and clinicopathological significance of OSM expression in the process of gastric carcinogenesis. Methods: The expression levels of OSM in chronic gastritis, IM, LGIN, HGIN, EGC, and AGC samples were detected by gene...
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Impact of Resected Gastric Volume on Postoperative Weight Loss after Laparoscopic Sleeve Gastrectomy.
Authors: D'Ugo S, Bellato V, Bianciardi E, Gentileschi P Abstract Among the bariatric surgery community, it has recently emerged the idea of a possible association between resected gastric volume (RGV) and weight loss after laparoscopic sleeve gastrectomy (LSG). If the size of the sleeve depends on the bougie caliber, the resected volume of the stomach remains something which is not possible to standardize. The aim of the study was to investigate a possible relationship between RGV and weight loss after LSG. We developed a mathematical method to calculate the RGV, based on the specimen size removed during LSG. Nine...
Source: Gastroenterology Research and Practice - December 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Increased Serum Angiotensin II Is a Risk Factor of Nonalcoholic Fatty Liver Disease: A Prospective Pilot Study.
Conclusion: Ang II levels of NAFLD patients significantly increased, and elevated Ang II level is an independent risk factor of NAFLD. Our preliminary results also indicate that Ang II may promote the development of NAFLD by activating NLRP3 inflammasome. PMID: 31827504 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 14, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Association between Lifestyle and Gastroesophageal Reflux Disease Questionnaire Scores: A Cross-Sectional Study of 37 442 Chinese Adults.
Authors: Gong Y, Zeng Q, Yan Y, Han C, Zheng Y Abstract The aim of this study was to investigate the distribution characteristics of GerdQ results in a Chinese population and the association between lifestyle and GerdQ scores. Among the 37 442 individuals enrolled from September 2009 to March 2016, 7 449 (19.89%) had a GerdQ score of ≥8 points and 29 993 (80.11%) had a GerdQ score of
Source: Gastroenterology Research and Practice - December 14, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Use of Biopsy and "No-Biopsy" Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region.
The Use of Biopsy and "No-Biopsy" Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region. Gastroenterol Res Pract. 2019;2019:9370397 Authors: Riznik P, Balogh M, Bódi P, De Leo L, Dolinsek J, Guthy I, Gyimesi J, Horváth Á, Kis I, Klemenak M, Koletzko B, Koletzko S, Korponay-Szabó IR, Krencnik T, Not T, Palcevski G, Pollák É, Sblattero D, Tokodi I, Vogrincic M, Werkstetter KJ, Dolinsek J Abstract Objectives: The current European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines introduced...
Source: Gastroenterology Research and Practice - December 14, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Precursors to Cholangiocarcinoma.
Authors: Hucl T Abstract Cancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses. In recent years, several lesions have been described as precursors that precede biliary cancers. They include flat and microscopic lesions known as biliary intraepithelial neoplasia, macroscopic and tumor-forming intraductal papillary biliary neoplasia, intraductal tubular neoplasia, and mucinous cystic neoplasm of the bile duct. These conditions are rarely diagnosed, while their natural history and progression to cancer have...
Source: Gastroenterology Research and Practice - December 11, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer.
Conclusions: Increased FA score after NCRT was an independent negative prognostic factor for DFS and OS in patients with NCRT-treated LARC. PMID: 31814824 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 11, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prevalence of Gastric and Small-Intestinal Mucosal Injury in Elderly Patients Taking Enteric-Coated Aspirin by Magnetically Controlled Capsule Endoscopy.
Authors: Gao F, Chen X, Zhang J Abstract Objective: To investigate aspirin-related gastric and small-intestinal mucosal injury in elderly patients by magnetically controlled capsule endoscopy (MCCE). Methods: Patients taking enteric-coated aspirin attending the outpatient department of Beijing Anzhen Hospital, Capital Medical University, from September 2017 to July 2019 underwent MCCE to assess injury to the gastric and small-intestinal mucosa. The patients were divided into the elderly group (age ≥ 60 years) and middle-aged group (45 years ≤ age
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Mutation Profiling of Premalignant Colorectal Neoplasia.
Authors: Karczmarski J, Goryca K, Pachlewski J, Dabrowska M, Pysniak K, Paziewska A, Kulecka M, Lenarcik M, Mroz A, Mikula M, Ostrowski J Abstract Accumulation of allelic variants in genes that regulate cellular proliferation, differentiation, and apoptosis may result in expansion of the aberrant intestinal epithelium, generating adenomas. Herein, we compared the mutation profiles of conventional colorectal adenomas (CNADs) across stages of progression towards early carcinoma. DNA was isolated from 17 invasive adenocarcinomas (ACs) and 58 large CNADs, including 19 with low-grade dysplasia (LGD), 21 with LGD adjacen...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Usefulness of 3-Dimensional Flexible Endoscopy in Esophageal Endoscopic Submucosal Dissection in an Ex Vivo Animal Model.
Conclusions: 3D vision improves the sense of security during ESD and may reduce technical errors, especially in trainees, indicating the feasibility of a clinical trial of ESD under 3D vision. PMID: 31781187 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia.
Conclusions: VD deficiency was common and inversely correlated with liver fibrosis in BA patients. Furthermore, VD was not correlated with liver function except alkaline phosphatase. PMID: 31781188 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Lactate Level Predicts Mortality in Patients with Upper Gastrointestinal Bleeding.
Conclusions: The venous blood lactate value of a patient who was admitted to the emergency department with UGI bleeding might be helpful in predicting the transfusion needs of the patient and predicting the mortality. PMID: 31781189 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Endoscopic Stenting in Hilar Cholangiocarcinoma: When, How, and How Much to Drain?
Authors: Tringali A, Boškoski I, Costamagna G Abstract Hilar cholangiocarcinoma (HCCA) involves a complex anatomical region where bile ducts, arteries, and veins create a complex network. HCCA can lead to biliary strictures at the main hepatic confluence, involving the right and left radicles. Endoscopic drainage of jaundiced patients with HCCA is challenging and carries a high risk of infective complications. HCCA needs a careful multidisciplinary evaluation to assess the indication and purposes (preoperative/palliative) of the biliary drainage. Biliary drainage in HCCA needs to be planned by magnetic reson...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis.
Conclusion: In a systematic review of the literature, we found that disease extent, disease duration, and geography were strong, independent risk factors in UC-associated CRC development. PMID: 31781191 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Feasibility and Histological Diagnostic Accuracy of Novel Menghini Needle (EUS Sonopsy CY ™) for Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy of Solid Pancreatic Masses: A Prospective Crossover Study Comparing Standard Biopsy Needles.
Conclusions: EUS Sonopsy CY™ is a reliable device for EUS-FNAB of solid pancreatic masses. PMID: 31781192 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
Authors: Xu Y, Zhao Z, Liu S, Xiao Y, Miao M, Dong Q, Xin Y Abstract Background: Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphism and serum FADS2 level with NAFLD and CAD in Chinese Han population. Materials and Methods: The serum level of FADS2 was detected by enzyme-linked immunosorbent assay (ELISA) in healthy people, NAFLD patients, and NAFLD patients combined with CAD (...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Preoperative Serum IL6, IL8, and TNF- α May Predict the Recurrence of Hepatocellular Cancer.
Conclusions: The present study confirmed that high preoperative serum IL6, IL8, and TNF-α levels were distinctly correlated with the postoperative tumor recurrence risk of HCC patients. PMID: 31781194 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases.
Conclusions: Compared with CRC patients without metastases, PDW is reduced in CRC patients with liver metastases. Moreover, PDW was independently associated with the presence of CRC liver metastases. PMID: 31781195 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy.
Conclusions: Contrast-enhanced CT might be a diagnostic alternative for EVNTs in cirrhotic patients, but its diagnostic performance was slightly weakened in secondary prophylaxis population. Additionally, contrast-enhanced CT may be considered for diagnosis of GVNTs in primary prophylaxis population without previous endoscopic variceal therapy and secondary prophylaxis population. PMID: 31781196 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Development of a Novel Gastrointestinal Endoscopic Robot Enabling Complete Remote Control of All Operations: Endoscopic Therapeutic Robot System (ETRS).
Conclusion: We successfully used the ETRS to perform completely remote-controlled ESD in porcine stomachs. PMID: 31781197 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

QuantiFERON-TB Gold Test Conversion Is Associated with Active Tuberculosis Development in Inflammatory Bowel Disease Patients Treated with Biological Agents: An Experience of a Medical Center in Taiwan.
Authors: Lai HC, Chang CH, Cheng KS, Chen TW, Tsai YY, Chou JW Abstract Taiwan has a lower prevalence of inflammatory bowel disease (IBD) and a higher prevalence of tuberculosis (TB) infection than Western countries. The aim of this study was to investigate the prevalence of latent TB (LTB) and active TB infection in IBD patients treated with biological agents. From January 2000 to September 2018, we retrospectively collected data from IBD patients treated with biological agents at a tertiary referral center. Patients underwent a QuantiFERON-TB Gold test (QFT) to screen for TB infection before and after biological ...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Does Tumour Contrast Retention on CT Immediately Post Chemoembolization Predict Tumour Metabolic Response on FDG-PET in Patients with Hepatic Metastases from Colorectal Cancer?
This study is aimed at assessing if metabolic response on PET-CT can be related to posttreatment tumour contrast retention. Materials and Methods: In this retrospective study, a total of 17 patients with a total of 55 marker lesions were recruited. Results: The area of tumour contrast retention can be matched to a hypometabolic area on subsequent PET-CT in over 36 lesions (65.5%). Out of the 55 lesions, a total of 38 marker lesions in 11 patients who also had pre-DEBIRI PET-CT were analyzed for disease response. 10 out of 10 lesions that had a complete response on PET-CT were found to demonstrate contrast retention...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research