Clinical Features of False-Negative Early Gastric Cancers: A Retrospective Study of Endoscopic Submucosal Dissection Cases
Gastroenterol Res Pract. 2021 Feb 8;2021:6635704. doi: 10.1155/2021/6635704. eCollection 2021.ABSTRACTBACKGROUND: We frequently encounter early gastric cancer (EGC) that could not be detected in the previous esophagogastroduodenoscopy even if the procedure was annually performed. However, little evidence exists regarding the characteristics of false-negative EGCs. Our aim was to reveal the clinical features of false-negative EGCs.METHODS: We retrospectively reviewed cases of endoscopic submucosal dissection (ESD) for EGCs in Fukuchiyama City Hospital between January 2013 and May 2019. False-negative EGCs were defined as EG...
Source: Gastroenterology Research and Practice - February 25, 2021 Category: Gastroenterology Authors: Kohei Oka Naoto Iwai Takashi Okuda Tasuku Hara Yutaka Inada Toshifumi Tsuji Toshiyuki Komaki Junichi Sakagami Yuji Naito Keizo Kagawa Yoshito Itoh Source Type: research

The Clinical Manifestation Variety and Management Choice of Meckel's Diverticulum with Complication: A Single Center Experience
CONCLUSION: The clinical characteristics of Meckel's diverticulum varied. Children with hematochezia, peritonitis, and intestinal obstruction without history of prior abdominal operation should be suspected with this disease until proven otherwise. Hematochezia is often associated with ectopic gastric mucosa in the diverticulum. Laparoscopic surgery should be one of the choices for the diagnosis and treatment of Meckel's diverticulum with complications.PMID:33628226 | PMC:PMC7886519 | DOI:10.1155/2021/6640660 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 25, 2021 Category: Gastroenterology Authors: Tingliang Fu Xiaoliang Xu Lei Geng Yanli Huang Guojian Ding Hong Ji Source Type: research

A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract
Gastroenterol Res Pract. 2021 Feb 6;2021:8167149. doi: 10.1155/2021/8167149. eCollection 2021.ABSTRACTA granuloma is defined as a localized inflammatory reaction or a hypersensitive response to a nondegradable product leading to an organized collection of epithelioid histiocytes. Etiologies of granulomatous disorders can be divided into two broad categories: infectious and noninfectious (autoimmune conditions, toxins, etc.) causes. The endless list of causalities may prove challenging for gastroenterologists and pathologists to formulate a list of clearly defined differentials. This is true when distinguishing these etiolo...
Source: Gastroenterology Research and Practice - February 25, 2021 Category: Gastroenterology Authors: Shivantha Amarnath Liliane Deeb Jobin Philipose Xiaomin Zheng Vivek Gumaste Source Type: research

Coexistence of Takayasu's Arteritis in Patients with Inflammatory Bowel Diseases
CONCLUSION: Although the coexistence of TA and IBD is uncommon, both seem to be strongly associated through pathophysiological pathways.PMID:33628228 | PMC:PMC7895552 | DOI:10.1155/2021/8831867 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 25, 2021 Category: Gastroenterology Authors: Camilla de Almeida Martins Ana Elisa Rabe Caon Carolina Bortolozzo Graciolli Facanali Carlos Walter Sobrado Sergio Carlos Nahas Rosa Maria Rodrigues Pereira Reuma Margalit-Yehuda Uri Kopylov Natalia Sousa Freitas Queiroz Source Type: research

Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases.
Authors: Touzani S, El Bouazzaoui A, Bouyarmane F, Faraj K, Houari N, Boukatta B, Kanjaa N Abstract Background: Severe acute cholangitis is a life-threatening biliary infection, leading to organ dysfunction, septic shock, and naturally death. Mortality has dropped significantly in the past years through improving resuscitation and biliary drainage techniques. The aim of our study is to analyze our daily practice and the factors associated with mortality. Methods: A retrospective study including severe acute cholangitis patients admitted to our unit from January 2009 to December 2018. Variables analyzed (univari...
Source: Gastroenterology Research and Practice - February 14, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

A Novel Method of Natural Orifice Specimen Extraction Surgery (NOSES) during Laparoscopic Anterior Resection for Rectal Cancer.
Authors: Wang J, Hong J, Wang Q, Luo F, Guo F Abstract We propose a modification to the reconstruction method of natural orifice specimen extraction surgery (NOSES) during laparoscopic anterior resection (LAR) for rectal cancer (RC) and evaluated its feasibility and short-term safety by comparing surgical and postoperative outcomes with those of conventional LAR. Twenty patients with RC underwent "double-purse" NOSES-LAR from October 2017 to June 2018. Data of clinicopathological characteristics, surgical and postoperative outcomes, and follow-up findings in NOSES-LAR cases were collected and retrospectiv...
Source: Gastroenterology Research and Practice - February 14, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model.
Conclusions: Our results showed that 5-FU caused intestinal inflammation mainly via Th1 and Th17 responses. 5-FU could stimulate stem cells and proliferation cells in a mouse model. We demonstrate chemotherapy could decrease immune competence. Probiotics were shown to modulate the immune response. This is the first study to analyze the immune modulation effects and safety of Lactobacillus strain on enterocytes and intestinal stem cells in a mouse model. PMID: 33564301 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 11, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Does Intraperitoneal Chemotherapy Increase the Incidence of Anastomotic Leakage after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis.
Conclusions: This meta-analysis provides some evidence to suggest ICwh may increase the incidence of postoperative AL in colorectal cancer. However, fluorouracil implantation for ICwh does not increase the risk of AL, which seems to be a relatively safe method of ICwh. PMID: 33564302 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 11, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinical Characteristics and Manifestations of Fungal Esophagitis: A Single-Center Experience in South China.
In conclusion, fungal esophagitis primarily affects men and elderly individuals; it develops in the setting of malignancy, smoking, and certain previous medication use. Candida albicans is the most common pathogen and is sensitive to antifungal agents. Fluconazole has a good therapeutic effect. PMID: 33531895 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 4, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Colonic Transendoscopic Enteral Tubing: Route for a Novel, Safe, and Convenient Delivery of Washed Microbiota Transplantation in Children.
This study is aimed at evaluating the safety, feasibility, and value of colonic TET in 3-7 years old children. Methods: All patients aged 3-7 years who underwent colonic TET in our center for WMT or medication were prospectively evaluated. The feasibility and safety of TET were evaluated. A questionnaire was completed by the children's parents to evaluate the children's response to the colonic TET as well as the parent's satisfaction. Results: Forty-seven children were included (mean age 5 years). TET was implemented into the colon of all the patients, and the success rate of the procedure was 100%. The median rete...
Source: Gastroenterology Research and Practice - January 31, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain.
Authors: Xu HM, Huang HL, Zhou YL, Zhao HL, Xu J, Shou DW, Liu YD, Zhou YJ, Nie YQ Abstract Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through t...
Source: Gastroenterology Research and Practice - January 31, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

An External Validation Study of the Oakland and Glasgow-Blatchford Scores for Predicting Adverse Outcomes of Acute Lower Gastrointestinal Bleeding in an Asian Population.
Conclusions: The Oakland and SALGIB scores had excellent and comparable performance and outperformed the GBS score for predicting adverse outcomes of ALGIB in Vietnamese. PMID: 33505461 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 29, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Long-Term Functional Results of a Modified Caudal-to-Cranial Approach in Laparoscopic Segmental Left Colectomy for Diverticular Disease.
Authors: Manigrasso M, Pesce M, Milone M, Anoldo P, D'Amore A, Galasso G, Gennarelli N, Maione F, Vertaldi S, Sarnelli G, De Palma GD Abstract A modified caudal-to-cranial approach to perform laparoscopic left colectomy for benign diseases has been recently designed to facilitate the low-tie mesenteric dissection. A chart review has been performed including all consecutive patients with uncomplicated diverticulitis who have been treated by segmental left colectomy with a caudal-to-cranial approach. A total of 34 patients were included in the study. 21 patients were male, mean age was 54.1 ± 11.3, and mean BM...
Source: Gastroenterology Research and Practice - January 29, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Diagnosis of Biliary Strictures Using Probe-Based Confocal Laser Endomicroscopy under the Direct View of Peroral Cholangioscopy: Results of a Prospective Study (with Video).
Conclusions: pCLE under the direct view of POCS provided highly accurate and sensitive characterization of biliary strictures and showed the potential for more diagnostic reliability and reduction of delays in diagnosis. This trial was registered at UMIN (registration number: UMIN000033801). PMID: 33488697 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 27, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Practical Experience of Endoscope Reprocessing and Working-Platform Disinfection in COVID-19 Patients: A Report from Guangdong China during the Pandemic.
Conclusions: For endoscopic preprocessing at the bedside, a key disinfection step is using a multienzyme stock solution. The nucleic acid tests for endoscopists, washers, endoscopes, and working platforms were all negative. Based on our experience with the 11 COVID-19 patients who had undergone endoscopy, we provide an endoscopic reprocessing method for the bedside endoscopic diagnosis and treatment of COVID-19 patients for reference. PMID: 33488698 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 27, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Lifestyle and Chronic Constipation in Medical Students.
Conclusion: The results of our study showed that medical education did not curb constipation frequency. We believe that stress is significant in constipation. The data we collected indicate that regular eating habits and excess liquid intake are not as effective as suggested in the treatment of constipation. PMID: 33488699 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 27, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation.
Authors: Ma H, Li Z, Yuan J, Zhang L, Xie X, Yin X, Chen R, Ren Z Abstract Objective: Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Our aim was to assess the prognostic significance of primary curative resection factors in recurrent HCC patients undergoing radiofrequency ablation therapy (RFA). Methods: In this retrospective study, we assessed 235 patients who underwent limited RFA of HCC recurrences (tumors ≤ 5 cm; nodules &le...
Source: Gastroenterology Research and Practice - January 27, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Role of Active Inflammation and Surgical Therapy in Crohn's Disease Recurrence.
Authors: Ingallinella S, Campanelli M, Antonelli A, Arcudi C, Bellato V, Divizia A, Franceschilli M, Petagna L, Sensi B, Sibio S, Siragusa L, Sica GS Abstract An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn's disease (CD) patients has a high surgical recurrence rate. In this review, we examined the IBD inflammatory pathways, the current surgical treatment...
Source: Gastroenterology Research and Practice - January 21, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Preeclampsia and the Risk of Pancreatitis: A Nationwide, Population-Based Cohort Study.
Conclusion: Compared with patients without preeclampsia, the risk of pancreatitis in patients with preeclampsia is significantly increased after adjusting for demographics and comorbidities. The risk of pancreatitis is greatly increased when preeclampsia is accompanied by alcohol-related diseases, hepatitis C, gallstones, diabetes, or age of 26-35 years. Early identification and effective control of preeclampsia and the associated comorbidities can reduce the risk of pancreatitis and the associated morbidity and mortality. PMID: 33456459 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 21, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Retracted: Influence of Gastrectomy on Cortical and Cancellous Bones in Rats.
Authors: Research And Practice G Abstract [This retracts the article DOI: 10.1155/2013/381616.]. PMID: 33456460 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 21, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Routine Multiple Duodenal Biopsy during Endoscopy of Dyspeptic Patients Seems Unnecessary for Screening of Celiac Disease.
This study is aimed at investigating the prevalence of CD in dyspeptic patients based on serology and biopsy, determining the associated factors, and assessing the necessity of regular duodenal biopsies from normal mucosa in diagnosis of CD among dyspeptic patients. Methods: This cross-sectional study was performed on 530 adult dyspeptic patients who underwent gastroduodenoscopy in Imam Reza hospital, Mashhad, during 2016-2018. Demographic characteristics, clinical data, and laboratory analyses were extracted from hospital records. CD was diagnosed based on intestinal biopsy and serum antitissue transglutaminase (anti-...
Source: Gastroenterology Research and Practice - January 12, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Impact of Sedation on Adenoma Detection Rate and Cecal Intubation Rate in Colonoscopy.
Authors: Zhang Q, Dong Z, Jiang Y, Zhan T, Wang J, Xu S Abstract Purpose: To explore the effect of sedation on the quality of colonoscopy. Methods: The data collected from the Digestive Endoscopy Center of Shanghai Tongji Hospital from March 2012 to June 2019 were retrospectively analyzed. The rate of sedation and quality metrics of colonoscopy such as adenoma detection rate (ADR) and cecal intubation rate (CIR) were calculated. The logistic regression model was used to explore the relationship between sedation and quality metrics of colonoscopy. The interaction effects between experience of endoscopists and se...
Source: Gastroenterology Research and Practice - January 2, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer.
Authors: Zou Q, Ren D, Wang X, Bai L, Tang G, Huang M, Luo Y, Yu H Abstract Background: The interventions for hemorrhoid increase access to rectal cancer screening and thus might reduce cancer death. We aimed to examine the impact of hemorrhoid on survival outcomes in rectal cancer. Methods: We identified 510 patients with stage I to III rectal cancer from a prospectively collected database. Patients were divided into hemorrhoid and non-hemorrhoid group. The primary endpoints were disease-free survival (DFS) and overall survival (OS). Results: Hemorrhoid group had significantly more stage I-II diseases in c...
Source: Gastroenterology Research and Practice - January 2, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Helicobacter pylori Prevalence in Laparoscopic Sleeve Gastrectomy Specimen.
Conclusion: Routine histopathologic examination of LSG specimens may detect H. pylori in a significant proportion of patients, and increasing the number of sections for histology from LSG specimens improves the rate of detection of this bacterium and identifies individuals who may benefit from treatment. PMID: 33381168 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 2, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF- κB Pathway.
Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF-κB Pathway. Gastroenterol Res Pract. 2020;2020:2549486 Authors: Xu X, Zhu Q, Li G, Ma J, Pan Z, Wu W Abstract Somatostatin (SST) has a protective role in intestinal injury, inflammatory response, and intestinal mucosal barrier in rats with acute pancreatitis. However, its function in sepsis-induced intestinal barrier dysfunction remains largely unknown. A mouse sepsis model was constructed, and SST was injected into the tail vein. Then, hematoxylin and eosin staining (HE) was u...
Source: Gastroenterology Research and Practice - January 1, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Validation and Refinement of the Baveno VI Criteria for Ruling Out High-Risk Varices.
Authors: Zhou H, Hu H, Tian M, Chu J, Tian C, Yang Y, Lin S Abstract In the past decade, numerous studies have evaluated the roles of noninvasive methods for diagnosing or excluding varices and high-risk varices in patients with liver cirrhosis. The Baveno VI criteria recommend the use of a simple algorithm based on a liver stiffness measurement 150 × 109/L for ruling out high-risk varices in patients with compensated advanced chronic liver disease. A large number of studies have validated the clinical usefulness of Baveno VI criteria for excluding high-risk varices. Several strategies have been...
Source: Gastroenterology Research and Practice - January 1, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

VSNL1 Promotes Gastric Cancer Cell Proliferation and Migration by Regulating P2X3/P2Y2 Receptors and Is a Clinical Indicator of Poor Prognosis in Gastric Cancer Patients.
Conclusion: VSNL1 may promote the proliferation and migration of GC cells by regulating P2X3 and P2Y2 expression. VSNL1 plays important roles in GC development and metastasis and may be correlated with patient prognosis. PMID: 33376484 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 1, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer.
Authors: Hao Q, Zhang Z Abstract Circular RNAs (circRNAs) belong to noncoding RNAs and are widely expressed in a variety of cell species, including cancers. However, the function and mechanism of circRNAs in colorectal cancer (CRC) has not been well investigated. Here, we firstly downloaded and analyzed the circRNA expression profile of CRC from the Gene Expression Omnibus (GEO) database. And we identified 181 differentially expressed circRNAs between 10 pairs of CRC and adjacent normal tissues. Interestingly, we observed that the expression of hsa_circRNA_000166 was the top increased among these circRNAs. Then, we...
Source: Gastroenterology Research and Practice - January 1, 2021 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Acupuncture for the Treatment of Liver Cirrhosis: A Meta-analysis.
Authors: Qi L, Li S, Xu J, Xu J, Lou W, Cheng L, Zhang C Abstract Acupuncture is widely used in the clinical treatment of liver cirrhosis (LC) in China. However, the efficacy of acupuncture on LC has not been fully confirmed by systematic analysis. This current meta-analysis evaluated the impact effect of acupuncture on patients with LC. We conducted a systematic literature search of the China National Knowledge Infrastructure, the Chinese Biomedical Database (SinoMed), VIP medicine information system, Wanfang Data, PubMed, Cochrane Library, Web of Science, and Embase. Further, we used Review Manager 5.3 software f...
Source: Gastroenterology Research and Practice - December 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.
Authors: Matah Marte VM, Ateufack G, Mbiantcha M, Atsamo AD, Adjouzem CF, Djuichou Nguemnang SF, Tsafack EG, Yousseu Nana W, Madjo Kouam YK, Ngoufack Azanze E Abstract Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus benthamianus and its mechanisms of action. The healing properties of gastric ulcers (chronic ulcer model induced by ethanol and indometh...
Source: Gastroenterology Research and Practice - December 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Gastroenterologists Reveal More Digestive Symptoms in COVID-19 Patients than Nongastroenterologists in Fever Clinic.
Authors: Jiang Y, Han C, Bai T, Zhang S, Song J, Hou X Abstract The incidence of digestive symptoms may vary depending on doctors' professional backgrounds when they inquired suspected COVID-19 patients in a fever clinic. We sought to understand the characteristics of inquiries about digestive symptoms by doctors in different specialties; therefore, inquiry records of 2 gastroenterologists and 6 nongastroenterologists were reviewed. We compared the difference in inquiry of digestive symptoms (diarrhea, vomit, distension, anorexia, and abdominal pain) between these two groups among identified COVID-19 patients. And ...
Source: Gastroenterology Research and Practice - December 29, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma.
Conclusion: GCLS comprised 6.2% of overall GC and more frequent in the proximal portion of the stomach. Since GCLS was associated with better prognosis, the histologic finding can be useful for predicting the patient's prognosis. PMID: 33343655 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 23, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis.
Conclusion: Factors that impair histologic remission in patients with ulcerative colitis were treatment with steroids and reduced mucin production; meanwhile, less than 10 eosinophils per high power showed a predictive value for histologic remission. PMID: 33343656 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 23, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis.
Conclusion: circRNAs might be a promising biomarker for diagnosis, prognosis, and clinicopathological features of EC. PMID: 33335548 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 19, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Presence of Ascites Affects the Predictive Value of HVPG on Early Rebleeding in Patients with Cirrhosis.
Conclusion: The predictive value of HVPG for early rebleeding in patients with cirrhosis that developed acute variceal bleeding is hindered by the presence of ascites. PMID: 33299405 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 12, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis.
Conclusions: This study identified independent predictors and prognostic factors for SCLLM based on a large database of the United States. The predictors and prognostic factors can provide supporting evidence for the prevention and treatment of SCLLM. PMID: 33299406 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 12, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Efficacy of Short-Duration Polyethylene Glycol plus Electrolytes for Improving Bowel Preparation of Colonoscopy in Patients with Chronic Constipation.
Authors: Yoshida N, Inagaki Y, Fukumoto K, Yoriki H, Inada Y, Murakami T, Tomita Y, Hashimoto H, Sugino S, Hirose R, Dohi O, Inoue K, Itoh Y Abstract Materials and Methods: This multicenter retrospective study was conducted from September 2019 to September 2020 at 5 related institutions among patients ≥ 20 years old diagnosed with chronic constipation whose previous colonoscopic BP had had a fair or poor Aronchick score. Two or four sachets of PEG+E (13.7 or 27.4 g/day) were prescribed for 1 week before colonoscopy. We analyzed the rate of improvement in BP, effect-related factors, spontaneous bowel movem...
Source: Gastroenterology Research and Practice - December 12, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Utilization of an Intraoperative Grading Scale in Laparoscopic Cholecystectomy: A Nepalese Perspective.
Authors: Baral S, Chhetri RK, Thapa N Abstract Introduction: Difficult geographic diversity and late presentation to medical attention often make the laparoscopic cholecystectomy difficult and chances of conversion and complication remains. Various preoperative grading scales have been developed for predicting the difficulty of surgery in cholecystitis patients; however, intraoperative assessment of anatomical status and inflammation of the gall bladder has not been assessed till date except for some guidelines like the Parkland grading scale (PGS). We aimed to utilise this guideline in patients undergoing laparosc...
Source: Gastroenterology Research and Practice - December 12, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Retracted: Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis.
Authors: Research And Practice G Abstract [This retracts the article DOI: 10.1155/2014/827989.]. PMID: 33299409 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 12, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer.
Conclusions: SII may be a noninvasive and powerful tool for predicting survival outcomes in CRC patients. However, more well-designed studies are needed to validate our findings. PMID: 33293949 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Corrigendum to "Acute-on-Chronic Liver Failure in Pregnant Patients with Chronic Hepatitis B: A Retrospective Observational Case Series Study".
Corrigendum to "Acute-on-Chronic Liver Failure in Pregnant Patients with Chronic Hepatitis B: A Retrospective Observational Case Series Study". Gastroenterol Res Pract. 2020;2020:2603491 Authors: Wang S, Xiong H, Luo C, Zhao H, Fan Y, Zhang T, Wang L, Wang Q, Xie W Abstract [This corrects the article DOI: 10.1155/2020/9831687.]. PMID: 33273913 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 6, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comparison of a Novel Herbal Medicine and Omeprazole in the Treatment of Functional Dyspepsia: A Randomized Double-Blinded Clinical Trial.
This study was designed to appraise the efficacy and safety of a novel herbal medicine consisting of ZM, AG, and TA essential oils compared to omeprazole in FD treatment. Methods: The present study was a randomized double-blind clinical trial with parallel groups in Iran. Patients in control and intervention arms received omeprazole 20 mg once a day and 250 mg soft-gel capsules containing 180 mg of essential oils of ZM, AG, and TA twice a day for two weeks, respectively. The primary outcome was the sufficient response rate in the postprandial distress syndrome (PDS) and/or epigastric pain syndrome ...
Source: Gastroenterology Research and Practice - December 6, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinical Characterization of Ulcerative Colitis in Patients with Primary Sclerosing Cholangitis.
Authors: Murasugi S, Ito A, Omori T, Nakamura S, Tokushige K Abstract Objectives: The clinical/colonoscopic features of ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC), the prognostic impact of UC, and the utility of UC screening in PSC patients are unknown. We characterized UC associated with PSC and assessed UC's impact on the prognosis of PSC and the importance of colonoscopic UC screening in PSC patients. Methods: We retrospectively analyzed the cases of 77 patients treated for PSC at a single center (April 2000-July 2019). We reviewed the clinical/colonoscopic profiles of the c...
Source: Gastroenterology Research and Practice - November 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Circulating Irisin Levels in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Authors: Hu J, Ke Y, Wu F, Liu S, Ji C, Zhu X, Zhang Y Abstract Background and Aims: Previous studies have revealed the close relation of irisin with the occurrence and development of nonalcoholic fatty liver disease (NAFLD). A systematic review and meta-analysis were conducted to evaluate the association of circulating irisin levels and NAFLD. Methods: A systematic literature search of PubMed, Embase, Cochrane Library, Clinicaltrials.gov, WANFANG, CNKI, and CBM databases was performed for relevant articles till August 2020. The weighted mean difference (WMD) values and 95% confidence intervals (CIs) were estim...
Source: Gastroenterology Research and Practice - November 25, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
This study was aimed at evaluating the anti-inflammatory, antioxidant, and anticolitis effects of these compounds. In vitro anti-inflammatory properties were evaluated by inhibition of cyclooxygenase, 5-lipoxygenase, and denaturation of the protein; antioxidant properties were assessed by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)) ABTS•+, capacity tests ferric reducing antioxidant (FRAP), and trapping nitric oxide. For in vivo analysis, we used the model of ulcerative colitis induced by Dextran Sulfate Sodium (DSS). Studies of the anti-inflammatory activity sho...
Source: Gastroenterology Research and Practice - November 21, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Psychosocial Burden of HCV Infection and the Impact of Antiviral Therapy on the Quality of Life in Liver and Kidney Transplant Recipients: A Pilot Study.
Authors: Santonicola A, Bilancio G, Zingone F, Donnarumma L, Caputo C, Ciacci C Abstract Background: Therapy with direct-acting antivirals (DAA) for HCV is safe and effective in the liver (LT) and kidney transplant (KT) recipients; however, data on the quality of life (QoL) of patients are scanty. This pilot study is aimed at prospectively evaluating the QoL in LT and KT recipients before and after DAA treatment. Methods: We prospectively enrolled 17 LT and 11 KT recipients with HCV infection starting a sofosbuvir-based antiviral therapy for 12 weeks. All participants before (T0), 12 (T12), and 24 (T24) weeks a...
Source: Gastroenterology Research and Practice - November 21, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients.
Conclusion: A large proportion of these Thai chronic hepatitis C patients (26.9%) had hepatic steatosis, which was strongly associated with host metabolic factors, e.g., obesity (BMI ≥ 25) and diabetes mellitus. These cofactors contributed to the progression of liver disease to cirrhosis and required concurrent management with antiviral therapy. PMID: 33204256 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - November 21, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

miR-21 Overexpression Promotes Esophageal Squamous Cell Carcinoma Invasion and Migration by Repressing Tropomyosin 1.
In conclusion, the aberrant overexpression of miR-21 is common in cancer and promotes the migration and invasion of ESCC through inhibiting the TPM1 expression. These results suggest that miR-21 may be a novel predictive marker and therapeutic target for treatment of ESCC. PMID: 33193757 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - November 18, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Colonoscopy Quality and Adherence to Postpolypectomy Surveillance Guidelines in an Underinsured Clinic System.
Conclusions: Overall, the quality of screening colonoscopy was high, but reporting was incomplete. We found fair adherence to evidence-based surveillance guidelines, with significant opportunities to extend surveillance intervals and improve adherence to best practices. PMID: 33178263 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - November 13, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects.
Conclusion: Preexisting adenoma and GC with MSI are more common in patients with FHx of GC than in those without. There were no significant differences in the survival rate according to FHx. PMID: 33144855 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - November 6, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research