Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme.
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps & TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps & TSAs. Methods: We identified all colorectal serrated polyps...
Source: Gastroenterology Research and Practice - March 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Electroacupuncture and Moxibustion Improved Anxiety Behavior in DSS-Induced Colitis Mice.
Conclusion: EA and MB were able to regulate the concentration of CRH in serum and protein expression in the peripheral and central at different levels and promote the recovery of the HPA axis that may be the basis for EA and MB to improve colonic pathology and alleviate anxiety behavior in DSS-induced colitis. PMID: 30881446 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

MHC Class 1 and PDL-1 Status of Primary Tumor and Lymph Node Metastatic Tumor Tissue in Gastric Cancers.
In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - March 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis.
Conclusion: H. pylori-induced follicular gastritis is considered as an additional risk factor for bleeding from gastric varices. PMID: 30881448 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis.
Conclusions: B cells and NK cells closely correlate with patients' condition and may help to diagnose AP more accurately and reflect treatment effect of AP in time, affecting the recovery speed of patients with M-AP, which may help physicians to better understand the pathophysiology of pancreatitis. PMID: 30881449 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prior Esophagogastric Devascularization Followed by Splenectomy for Liver Cirrhosis with Portal Hypertension: A Modified Laparoscopic Technique.
This study was conducted to introduce a novel modified surgical technique for laparoscopic splenectomy and esophagogastric devascularization (LSED) and its safety and efficiency. Methods: From June 2016 to November 2017, 86 patients were diagnosed with portal hypertension and serious gastroesophageal varices in our center. Of them, 32 patients underwent LSED and 54 received the modified LSED. Results and outcomes were compared retrospectively. Results: There were no significant differences in preoperative patient characteristics of the two groups. No intraoperative deaths took place in both groups. The intraoperati...
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Noninvasive Evaluation of Liver Function in Morbidly Obese Patients.
Authors: Alizai PH, Lurje I, Kroh A, Schmitz S, Luedde T, Andruszkow J, Neumann UP, Ulmer F Abstract Background: More than half of the obese patients develop nonalcoholic fatty liver disease (NAFLD), which may further progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. The aim of this study was to assess alterations in liver function in obese patients with a noninvasive liver function test. Methods: In a prospective cohort study 102 morbidly obese patients undergoing bariatric surgery were evaluated for their liver function. Liver function capacity was determined by the LiMAx® test (enzymatic cap...
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma.
Authors: Liang Y, Zheng G, Yin W, Song H, Li C, Tian L, Yang D Abstract Objective: The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods: 33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. We analyzed the relationships of these marker...
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Do Self-Expanding Metal Stents as a Bridge to Surgery Benefit All Patients with Obstructive Left-Side Colorectal Cancers?
Conclusion: SEMS might be preferred for patients of obstructive left-sided colorectal cancer in the "high-operative risk group" with existing comorbidities or those without locally advanced invasion, such as the non-pT4-stage status. PMID: 30863441 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Advances in Translational Research and Clinical Care in Pancreatic Cancer: Where Are We Headed?
We present a brief summary of key areas of laboratory research and its translation to clinical care. PMID: 30863442 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comparing PET/MRI with PET/CT for Pretreatment Staging of Gastric Cancer.
Authors: Liu Y, Zheng D, Liu JJ, Cui JX, Xi HQ, Zhang KC, Huang XH, Wei B, Wang XX, Xu BX, Li K, Gao YH, Liang WQ, Tian JH, Chen L Abstract 18F-FDG PET/MRI has been applied to the diagnosis and preoperative staging in various tumor types; however, reports using PET/MRI in gastric cancer are rare because of motion artifacts. We investigated the value of PET/MRI for preoperative staging compared with PET/CT in gastric cancer (GC). Thirty patients with confirmed GC underwent PET/CT and PET/MRI. TNM staging for each patient was determined from the PET/MRI and PET/CT images. The diagnostic performance of PET/MRI and PET...
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Application of Extraperitoneal Ostomy Combined with Pelvic Peritoneal Reconstruction in Laparoscopic Abdominoperineal Resection for Rectal Cancer.
Conclusion: We consider LAPR with our two techniques feasible and safe, which can be accepted quickly to improve the life quality of patients. Therefore, we suggest our procedures as the first choice during LAPR surgery. This trial is registered with trial registration number 2014028. PMID: 30867662 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Pneumo-PET-CT: Initial Results of This Novel Technique on the Evaluation of Esophageal and Gastric Tumors with Anatomic-Surgical Correlation.
We present the initial results of a novel hybrid scanning-based technique that combines pneumo-computed tomography (PNCT) with positron emission tomography (PET) using 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG). We denominate it pneumo-PET-CT. The focus of our discussion will be on the description of the pneumo-PET-CT technique and the interpretation criteria with emphasis on its benefits and applications in the presurgical and postneoadjuvant therapy evaluation of esophageal, esophagogastric junction (EGJ), and gastric tumors. PMID: 30867663 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Magnetic-Resonance-Imaging Texture Analysis Predicts Early Progression in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiation.
Authors: Nardone V, Reginelli A, Scala F, Carbone SF, Mazzei MA, Sebaste L, Carfagno T, Battaglia G, Pastina P, Correale P, Tini P, Pellino G, Cappabianca S, Pirtoli L Abstract Background: We hypothesized that texture analysis (TA) from the preoperative MRI can predict early disease progression (ePD), defined as the percentage of patients who relapsed or showed distant metastasis within three months from the radical surgery, in patients with locally advanced rectal cancer (LARC, stage II and III, AJCC) undergoing neoadjuvant chemoradiotherapy (C-RT). Methods: This retrospective monoinstitutional cohort study in...
Source: Gastroenterology Research and Practice - March 9, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Quantitative Analysis of HER2 Amplification by Droplet Digital PCR in the Follow-Up of Gastric Cancer Patients Being Treated with Trastuzumab after Surgery.
Authors: Liu Y, Yang M, Jiang T, Lan C, Yuan H, Li G, Jia G, Wang K, Zhao G Abstract Background: Circulating tumor DNA (ctDNA) derived from tumors is a promising biomarker for monitoring tumor status and evaluating therapeutic effects and prognosis. We studied the plasma human epidermal growth factor receptor 2 (HER2) amplification in gastric cancer (GC) patients by droplet digital PCR (ddPCR) during therapy with trastuzumab. Methods: A total of 12 patients were recruited after surgery. All patients received FOLFOX chemotherapy combined with trastuzumab as a treatment regimen. During the 12 months of the follow...
Source: Gastroenterology Research and Practice - March 8, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effect of a Novel Patient Garment on Perceived Privacy during Colonoscopy: A Simple Approach to Minimize Embarrassment.
Conclusion: All participants, particularly women and nonwhite participants, reported high rates of respect and satisfaction and decrease in embarrassment utilizing the novel gown during colonoscopy. Patients who had prior colonoscopy with a traditional gown preferred the novel garment. A novel procedure gown may enhance colonoscopy acceptance by minimizing embarrassment. PMID: 30833965 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 7, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Diagnosis and Treatment of Atraumatic Splenic Rupture: Experience of 8 Cases.
In this study, we retrospectively described our experience on the diagnosis and treatment of 8 patients (male: 6; female: 2; mean age: 49.6) with ASR. ASR accounted for 3.2% (8/251) of the splenic ruptures. The clinical presentation of ASR was similar to traumatic splenic rupture (TSR). The sensitivity of ultrasound and contrast-enhanced computed tomography (CECT) in ASR diagnosis was 57.1% and 85.7%, respectively. According to the classification of the American Association for the Surgery of Trauma (AAST), 2 cases were classified as grade II splenic ruptures, 4 cases were classified as grade III ruptures, 1 case was class...
Source: Gastroenterology Research and Practice - March 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Preoperative Serum Platelet-Lymphocyte Ratio as a Prognostic Factor in Cholangiocarcinoma Patients after Radical Resection: A Retrospective Analysis of 119 Patients.
Conclusions: The preoperative serum PLR is an independent prognostic factor for OS and PFS in CCA patients after radical resection, including patients requiring adjuvant therapy. PMID: 30809257 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives.
Authors: Assadsangabi A, Evans CA, Corfe BM, Lobo A Abstract Inflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. Despite their important contribution to a better delineation of the disease process in IBD, these genetic ...
Source: Gastroenterology Research and Practice - February 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management.
Authors: Cassese G, Amendola A, Maione F, Giglio MC, Pagano G, Milone M, Aprea G, Luglio G, De Palma GD Abstract Prompt diagnosis and correct management of the so called "serrated lesions" (SLs) of the colon-rectum are generally considered of crucial importance in the past years, mainly due to their histological heterogeneity and peculiar clinical and molecular patterns; sometimes, they are missed at conventional endoscopy and are possibly implicated in the genesis of interval cancers. The aim of this review is to focus on the diagnostic challenges of serrated lesions, underlying the role of both conventi...
Source: Gastroenterology Research and Practice - February 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Endoscopic Sphincterotomy before Fully Covered Metal Stent Placement Is Not Required for Distal Malignant Biliary Stricture due to a Pancreatic Head Tumor.
Conclusions: EST before FCSEMS placement for distal malignant biliary stricture due to a pancreatic head tumor does not affect the successful drainage and incidence of adverse events. The necessity of EST to prevent pancreatitis before FCSEMS placement was deemed low. PMID: 30774655 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 19, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults.
Authors: Ridolo E, Martignago I, Pellicelli I, Incorvaia C Abstract Background: Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE. Methods: Medical charts of patients affected by EoE were retrospectively evaluated. Phenotyping of patients was conducted according to demographic, clinical, histo...
Source: Gastroenterology Research and Practice - February 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors.
Authors: Abe K, Tominaga K, Kanamori A, Suzuki T, Kino H, Nakano M, Sugaya T, Tsuchida K, Majima Y, Murohisa T, Iijima M, Goda K, Irisawa A Abstract Objective: There is no consensus regarding administration of propofol for performing endoscopic submucosal dissection (ESD) in patients with comorbidities. The aim of this study was to evaluate the safety and efficacy of propofol-induced sedation administered by nonanesthesiologists during ESD of gastric cancer in patients with comorbidities classified according to the American Society of Anesthesiologists (ASA) physical status. Methods: Five hundred and twenty-two...
Source: Gastroenterology Research and Practice - February 15, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Effect of Puncture Sites of Portal Vein in TIPS with ePTFE-Covered Stents on Postoperative Long-Term Clinical Efficacy.
Conclusion: Choosing the left branch of the portal vein as the puncture site to create the shunt in TIPS with ePTFE-covered stents may decrease the incident of primary restenosis and HE significantly. PMID: 30728835 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 9, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Assessment of Patients' Future Outlook after Bowel Resection in Crohn's Disease.
Conclusion: From this survey, it is clear that most patients who underwent an elective bowel resection for CD are satisfied with their timing of surgery. Patients who have clinical recurrence carry a significant negative outlook for their future life. Postoperative management which focuses on preventing clinical recurrence may enhance patients' outlook for the future. PMID: 30728836 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 9, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies.
Authors: Bunu DM, Timofte CE, Ciocoiu M, Floria M, Tarniceriu CC, Barboi OB, Tanase DM Abstract Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that targets mainly the gastrointestinal tract. The clinical presentation of IBD includes both gastrointestinal manifestations and extraintestinal manifestations (EIM). The reported cardiovascular manifestations in IBD patients include pericarditis, myocarditis, venous and arterial thromboembolism, arrhythmias, atrioventricular block, heart failure, endocarditis, valvulopathies, and Takayasu arteritis. The aim of this article is to review...
Source: Gastroenterology Research and Practice - February 9, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Synchronous Gastrointestinal Tumor and Abdominal Aortic Aneurysm or Dissection Treated with Endovascular Aneurysm Repair Followed by Tumor Resection.
Conclusion: Our results demonstrate that EVAR could significantly shorten the delay between AAA and gastrointestinal procedure with an excellent postoperative outcome. If the anatomical criteria are satisfied, EVAR followed by tumor resection might be an effective treatment for concomitant AAA and gastrointestinal tumor. PMID: 30723497 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 8, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Ambulatory Surgery for Perianal Crohn's Disease: Study of Feasibility.
Conclusions: This preliminary study indicates that OE in CD patients with symptomatic perianal fistulas is safe and feasible in a high-volume referral center. It might provide several benefits, including patients' logistics, reduce or remove patients' symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications. PMID: 30671093 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 25, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches.
Authors: Parente P, Parcesepe P, Covelli C, Olivieri N, Remo A, Pancione M, Latiano TP, Graziano P, Maiello E, Giordano G Abstract Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients. Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor. A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy. The continued crosstalk...
Source: Gastroenterology Research and Practice - January 23, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla.
Authors: Ding L, Xiao L, Lin X, Xiong C, Lin L, Chen S Abstract Background: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis). Material and Methods: This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016. IVIM DWI (seven differ...
Source: Gastroenterology Research and Practice - January 17, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comment #2 on "First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin".
Comment #2 on "First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin". Gastroenterol Res Pract. 2018;2018:5260358 Authors: Ribaldone DG, Astegiano M PMID: 30647734 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 17, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Is Combination Antiviral Therapy Mandatory for Maintenance Therapy in Fully Suppressed Multidrug-Resistant Hepatitis B Patients?
Conclusions: For patients with suppressed HBV DNA, the efficacy of TDF monotherapy as maintenance therapy is comparable to that of entecavir plus TDF combination therapy. PMID: 30647735 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 17, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comment on "Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study".
Comment on "Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study". Gastroenterol Res Pract. 2018;2018:8356948 Authors: Ribaldone DG, Pellicano R PMID: 30647736 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 17, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Prevalence and Risk Factors of Gastric Polyp in Asymptomatic Patients Receiving Health Examination.
Conclusions: In Taiwan, asymptomatic gastric polyps have a prevalence of 29.8%. Age range of 45-60 years and current smoking may increase the risk of asymptomatic gastric polyps. PMID: 30647737 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 17, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Submucosal Tunnel Endoscopic Resection for Esophageal Submucosal Tumors: A Multicenter Study.
Conclusions: STER is a safe and feasible technique for treating esophageal SMTs originating from the muscularis propria layer. PMID: 30622559 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 10, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

T and N Staging of Gastric Cancer Using Dual-Source Computed Tomography.
Conclusions: T3 and T4 nIC values of the extraserosal adipose tissue showed statistically significant differences. Hence, dual-source CT may be helpful in the differential diagnosis between T3 and T4. PMID: 30622560 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 10, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Therapeutic Effect of a Multistrain Probiotic on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study.
Conclusion: Treatment with a multistrain probiotic for 8 weeks led to significant increases in beneficial bacteria in the gut as well as the improvement of gastrointestinal symptoms. This study is registered at the Clinical Research Information Service (KCT0002906). PMID: 30622561 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 10, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma.
Authors: Wang Y, Pang Q, Jin H, Zhou L, Hu X, Qian Z, Man Z, Yang S, Liu H Abstract Aim: Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms. The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC). Methods: A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department,...
Source: Gastroenterology Research and Practice - January 10, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Interaction of lncRNA-HEIH and lncRNA-HULC with HBXIP in Hepatitis B Patients.
In this study, reverse transcription and quantitative PCR were used to detect the expression of lncRNA-HEIH and lncRNA-HULC and western blot analysis to detect the expression of hepatitis B X-interacting protein (HBXIP). RNA immunoprecipitation was used to detect the interaction of HBXIP with lncRNA-HULC and lncRNA-HEIH. The results showed that lncRNA-HEIH, lncRNA-HULC, and HBXIP were upregulated in hepatitis B patients, particularly those with hepatitis B-related HCC. Both lncRNA-HEIH and lncRNA-HULC interacted with HBXIP. These results suggest that lncRNA-HEIH and lncRNA-HULC interact with HBXIP in hepatitis B-related di...
Source: Gastroenterology Research and Practice - January 10, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique.
Authors: Fani B, Bertani L, Paglianiti I, Fantechi L, De Bortoli N, Costa F, Volterrani D, Marchi S, Bellini M Abstract Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to diffe...
Source: Gastroenterology Research and Practice - January 3, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications.
Authors: Bond CE, Whitehall VLJ Abstract The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and the BRAF V600E has been commonly associated with the CpG island methylator phenotype, microsatellite instability (MSI), and a consistent clinical presentation including a proximal location and predilection for elderly females. A proportion of the BRAF mutant lesions remain as microsatellite stable (MSS), and in contrast to the MSI cancers, they have an aggressive phen...
Source: Gastroenterology Research and Practice - January 3, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Pancreatoduodenectomy without Vascular Resection in Patients with Primary Resectable Adenocarcinoma and Unilateral Venous Contact: A Matched Case Study.
Conclusions. PD without vascular resection can be considered safe and oncologically acceptable in selected patients with preoperative diagnosis of prVC-PDAC. The poor prognosis of PDAC is related to the aggressive biology and systemic spread of the tumor, rather than the local control of the disease. PMID: 30595690 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - January 2, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Novel Approaches to Ileocolic and Perianal Fistulising Crohn's Disease.
Authors: Luglio G, Cassese G, Amendola A, Rispo A, Maione F, De Palma GD Abstract Crohn's disease (CD) is a well-known idiopathic inflammatory bowel disease characterised by transmural inflammation which can ordinarily affect all the gastrointestinal tract. Its true aetiology is unknown, and a causal therapy is not available to date. The most peculiar aspect of CD lies in its absolute heterogeneity, as we might face various scenarios, locations of the disease, pathologic behaviours, and severity of the disease itself. For these reasons, the cornerstone for the treatment of CD lies in a complex multimodal management...
Source: Gastroenterology Research and Practice - December 27, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis.
Authors: Xing H, Wang J, Wang Y, Tong M, Hu H, Huang C, Li D Abstract Background: CA 19-9 and carcinoembryonic antigen (CEA) are widely used for the diagnosis of pancreatic cancer. The purpose of the present study was to compare the diagnostic value of CA 19-9 with CEA for pancreatic cancer. Methods: The studies were obtained from electronic searches conducted in PubMed, Embase, and Cochrane Library databases until December 2017. The keywords included diagnosis of pancreatic cancer, CA 19-9, and CEA. The ratio of sensitivity, the specificity, the diagnostic odds ratio (DOR), and the summary of the receiver oper...
Source: Gastroenterology Research and Practice - December 27, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Screening for Gastric and Small Intestinal Mucosal Injury with Magnetically Controlled Capsule Endoscopy in Asymptomatic Patients Taking Enteric-Coated Aspirin.
Authors: Chen X, Gao F, Zhang J Abstract Objective: To investigate gastric and small intestinal mucosal injury in asymptomatic patients taking enteric-coated aspirin using magnetically controlled capsule endoscopy. Methods: Patients taking enteric-coated aspirin (aspirin group) and healthy controls (control group) were recruited from Beijing Anzhen Hospital, Capital Medical University, between September 2017 and May 2018, and undertook magnetically controlled capsule endoscopy. Results: Twenty-six subjects were recruited to the aspirin group and twenty-six to the control group; the median Gastrointestinal S...
Source: Gastroenterology Research and Practice - December 26, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comprehensive Complication Index Predicts Cancer-Specific Survival of Patients with Postoperative Complications after Curative Resection of Gastric Cancer.
Authors: Tu RH, Lin JX, Li P, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Zheng CH, Huang CM Abstract Objective: To investigate the prognostic impact of postoperative complications for patients with gastric cancer. Methods: Postoperative complications of patients undergoing radical gastrectomy for gastric cancer were reviewed. The severity of complications was graded by the CCI and C-D classification. Results: A total of 5327 patients were included in the study. Complications were observed in 767 patients. When the C-D classification system was applied, for patients with grade I-II complications, the len...
Source: Gastroenterology Research and Practice - December 26, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Prediction of the Clinical Outcomes of Sigmoid Volvulus by Abdominal X-Ray: AXIS Classification System.
Conclusions: We developed the AXIS classification system to predict the severity of sigmoid volvulus. This new classification system may facilitate triage and therapeutic decision-making for sigmoid volvulus patients. PMID: 30581464 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 26, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Pure Well-Differentiated Adenocarcinoma Is a Safe Factor for Lymph Node Metastasis in T1 and T2 Colorectal Cancer: A Pilot Study.
Authors: Yoshida N, Nakanishi M, Inoue K, Yasuda R, Hirose R, Naito Y, Itoh Y, Arita T, Murayama Y, Kuriu Y, Otsuji E, Yanagisawa A, Ogiso K, Murakami T, Morinaga Y, Konishi E, Inada Y, Kishimoto M Abstract Background and Aims: Various risk factors for lymph node metastasis (LNM) have been reported in colorectal T1 cancers. However, the factors available are insufficient for predicting LNM. We therefore investigated the utility of the new histological factor "pure well-differentiated adenocarcinoma" (PWDA) as a safe factor for predicting LNM in T1 and T2 cancers. Materials and Methods: We reviewed 115...
Source: Gastroenterology Research and Practice - December 26, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis.
Conclusion: Polymorphisms at PRSS1-PRSS2 and MORC4 are not associated with the risk or severity of post-ERCP pancreatitis. PMID: 30524475 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 16, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Effects of Appendectomy on the Onset and Course of Ulcerative Colitis in Chinese Patients.
This study examined the associations between appendectomy performed before UC diagnosis and the occurrence and clinical course of UC in Chinese patients. Methods: A case control study was conducted to compare the rate of appendectomy between UC patients and controls matched for age and sex at two Chinese hospitals. Clinical course of UC was compared between UC patients who underwent appendectomies before UC diagnosis and who did not. Results: 402 UC patients and 402 controls were included. The percentage of appendectomy performed before UC diagnosis in UC patients did not differ significantly from controls (2.74% v...
Source: Gastroenterology Research and Practice - December 16, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research