Nursing Value Analysis and Risk Assessment of Acute Gastrointestinal Bleeding Using Multiagent Reinforcement Learning Algorithm
Gastroenterol Res Pract. 2022 Jan 6;2022:7874751. doi: 10.1155/2022/7874751. eCollection 2022.ABSTRACTGastrointestinal bleeding (GIB) indicates an issue in the digestive system. Blood can be found in feces or vomiting; however, it is not always visible, even if it makes the stool appear darkish or muddy. The bleeding can range in harshness from light to severe and can be dangerous. It is advised that nursing value analysis and risk assessment of patients with GIB is essential, but existing risk assessment techniques function inconsistently. Machine learning (ML) has the potential to increase risk evaluation. For evaluating...
Source: Gastroenterology Research and Practice - January 17, 2022 Category: Gastroenterology Authors: Fang Liu Xiaoli Liu Changyou Yin Hongrong Wang Source Type: research

Development and Application of Magnetically Controlled Capsule Endoscopy in Detecting Gastric Lesions
Gastroenterol Res Pract. 2021 Dec 30;2021:2716559. doi: 10.1155/2021/2716559. eCollection 2021.ABSTRACTIn the past 20 years, several magnetically controlled capsule endoscopes (MCCE) have been developed for the evaluation of gastric lesions, including NaviCam (ANKON), MiroCam-Navi (Intromedic), Endocapsule MGCE (Olympus and Siemens), SMCE (JIFU), and FAMCE (Jinshan). Although limited to observing esophageal and duodenal lesions and lacking the ability of biopsy, MCCE has the advantages of comfort, safety, no anesthesia, no risk of cross-infection, and high acceptability. Several high-quality RCTs showed that the diagnostic...
Source: Gastroenterology Research and Practice - January 10, 2022 Category: Gastroenterology Authors: Yaoping Zhang Yanning Zhang Xiaojun Huang Source Type: research

Exploration of the Potential Mechanisms of Wumei Pill for the Treatment of Ulcerative Colitis by Network Pharmacology
CONCLUSIONS: The approach of network pharmacology reveals the key ingredients, potential core targets, and biological process of WMP in the treatment of UC. The mechanisms of action of WMP involve anti-inflammation, antioxidation, and modulation of immunity, which provides evidence for the therapeutic role of WMP in UC.PMID:34970312 | PMC:PMC8714398 | DOI:10.1155/2021/4227668 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 31, 2021 Category: Gastroenterology Authors: Jinke Huang Yijun Zheng Jinxin Ma Jing Ma Mengxiong Lu Xiangxue Ma Fengyun Wang Xudong Tang Source Type: research

TAS-102 Monotherapy and Combination Therapy with Bevacizumab for Metastatic Colorectal Cancer
CONCLUSION: TAS-102 monotherapy and combination therapy with bevacizumab can significantly improve the survival of patients and prevent specific adverse events from happening.PMID:34966426 | PMC:PMC8712127 | DOI:10.1155/2021/4014601 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 30, 2021 Category: Gastroenterology Authors: Cheng-Jiang Liu Ting Hu Ping Shao Wu-Yang Chu Yu Cao Feng Zhang Source Type: research

p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for < em > TP53 < /em > Mutations in Gastrointestinal Neuroendocrine Neoplasms
CONCLUSIONS: p53 IHC patterns may be used as predictors of TP53 gene mutations and therefore could be potential surrogate markers for TP53 mutations in GI-NENs and could distinguish between well-differentiated NETs and poorly differentiated NECs.PMID:34956360 | PMC:PMC8695011 | DOI:10.1155/2021/2510195 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Junjie Li Jing Wang Dan Su Xiu Nie Yueping Liu Lianghong Teng Junyi Pang Huanwen Wu Zhiyong Liang Source Type: research

Endoscopic Delivery Method Using a Retrieval Net for Patients with Small-Bowel Capsule Endoscopy Stagnation in the Stomach
This study included 16 male (55%) and 13 female (45%) patients with a mean age of 69.2 ± 13.2 years. 11 patients (38%) had a history of gastrointestinal surgical resection. The entire small bowel could be observed in 19 patients (66%), and CE reached the terminal ileum in the remaining patients. A history of gastrointestinal surgical resection was significantly more frequent in the group where the entire small bowel could not be observed. The rate of small-bowel lesion detection was 55% (16/29). There were no adverse events associated with our endoscopic delivery method. Thus, the endoscopic delivery method using a ...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Akihiko Sumioka Shiro Oka Akiyoshi Tsuboi Issei Hirata Sumio Iio Hidenori Tanaka Ken Yamashita Takahiro Kotachi Ryo Yuge Yuji Urabe Shinji Tanaka Source Type: research

Risk of Bleeding after Colorectal Endoscopic Resection in Patients with Continued Warfarin Use Compared to Heparin Replacement: A Propensity Score Matching Analysis
Gastroenterol Res Pract. 2021 Dec 17;2021:9415387. doi: 10.1155/2021/9415387. eCollection 2021.ABSTRACTThe Japan Gastroenterological Endoscopy Society (JGES) guidelines recommend continued warfarin treatment during gastroenterological endoscopic procedures with a high risk of bleeding as an alternative to heparin replacement in patients on warfarin therapy. However, there is insufficient evidence to support the use of warfarin in colorectal endoscopic resection (ER). The present study is aimed at verifying the risk of bleeding after ER for colorectal neoplasia (CRN) in patients with continued warfarin use. This was a singl...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Katsuaki Inagaki Ken Yamashita Shiro Oka Fumiaki Tanino Noriko Yamamoto Yuki Kamigaichi Hirosato Tamari Yasutsugu Shimohara Tomoyuki Nishimura Yuki Okamoto Hidenori Tanaka Takahiro Kotachi Ryo Yuge Yuji Urabe Yasuhiko Kitadai Kenichi Yoshimura Shinji Tana Source Type: research

p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for < em > TP53 < /em > Mutations in Gastrointestinal Neuroendocrine Neoplasms
CONCLUSIONS: p53 IHC patterns may be used as predictors of TP53 gene mutations and therefore could be potential surrogate markers for TP53 mutations in GI-NENs and could distinguish between well-differentiated NETs and poorly differentiated NECs.PMID:34956360 | PMC:PMC8695011 | DOI:10.1155/2021/2510195 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Junjie Li Jing Wang Dan Su Xiu Nie Yueping Liu Lianghong Teng Junyi Pang Huanwen Wu Zhiyong Liang Source Type: research

Endoscopic Delivery Method Using a Retrieval Net for Patients with Small-Bowel Capsule Endoscopy Stagnation in the Stomach
This study included 16 male (55%) and 13 female (45%) patients with a mean age of 69.2 ± 13.2 years. 11 patients (38%) had a history of gastrointestinal surgical resection. The entire small bowel could be observed in 19 patients (66%), and CE reached the terminal ileum in the remaining patients. A history of gastrointestinal surgical resection was significantly more frequent in the group where the entire small bowel could not be observed. The rate of small-bowel lesion detection was 55% (16/29). There were no adverse events associated with our endoscopic delivery method. Thus, the endoscopic delivery method using a ...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Akihiko Sumioka Shiro Oka Akiyoshi Tsuboi Issei Hirata Sumio Iio Hidenori Tanaka Ken Yamashita Takahiro Kotachi Ryo Yuge Yuji Urabe Shinji Tanaka Source Type: research

Risk of Bleeding after Colorectal Endoscopic Resection in Patients with Continued Warfarin Use Compared to Heparin Replacement: A Propensity Score Matching Analysis
Gastroenterol Res Pract. 2021 Dec 17;2021:9415387. doi: 10.1155/2021/9415387. eCollection 2021.ABSTRACTThe Japan Gastroenterological Endoscopy Society (JGES) guidelines recommend continued warfarin treatment during gastroenterological endoscopic procedures with a high risk of bleeding as an alternative to heparin replacement in patients on warfarin therapy. However, there is insufficient evidence to support the use of warfarin in colorectal endoscopic resection (ER). The present study is aimed at verifying the risk of bleeding after ER for colorectal neoplasia (CRN) in patients with continued warfarin use. This was a singl...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Katsuaki Inagaki Ken Yamashita Shiro Oka Fumiaki Tanino Noriko Yamamoto Yuki Kamigaichi Hirosato Tamari Yasutsugu Shimohara Tomoyuki Nishimura Yuki Okamoto Hidenori Tanaka Takahiro Kotachi Ryo Yuge Yuji Urabe Yasuhiko Kitadai Kenichi Yoshimura Shinji Tana Source Type: research

p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for < em > TP53 < /em > Mutations in Gastrointestinal Neuroendocrine Neoplasms
CONCLUSIONS: p53 IHC patterns may be used as predictors of TP53 gene mutations and therefore could be potential surrogate markers for TP53 mutations in GI-NENs and could distinguish between well-differentiated NETs and poorly differentiated NECs.PMID:34956360 | PMC:PMC8695011 | DOI:10.1155/2021/2510195 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Junjie Li Jing Wang Dan Su Xiu Nie Yueping Liu Lianghong Teng Junyi Pang Huanwen Wu Zhiyong Liang Source Type: research

Endoscopic Delivery Method Using a Retrieval Net for Patients with Small-Bowel Capsule Endoscopy Stagnation in the Stomach
This study included 16 male (55%) and 13 female (45%) patients with a mean age of 69.2 ± 13.2 years. 11 patients (38%) had a history of gastrointestinal surgical resection. The entire small bowel could be observed in 19 patients (66%), and CE reached the terminal ileum in the remaining patients. A history of gastrointestinal surgical resection was significantly more frequent in the group where the entire small bowel could not be observed. The rate of small-bowel lesion detection was 55% (16/29). There were no adverse events associated with our endoscopic delivery method. Thus, the endoscopic delivery method using a ...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Akihiko Sumioka Shiro Oka Akiyoshi Tsuboi Issei Hirata Sumio Iio Hidenori Tanaka Ken Yamashita Takahiro Kotachi Ryo Yuge Yuji Urabe Shinji Tanaka Source Type: research

Risk of Bleeding after Colorectal Endoscopic Resection in Patients with Continued Warfarin Use Compared to Heparin Replacement: A Propensity Score Matching Analysis
Gastroenterol Res Pract. 2021 Dec 17;2021:9415387. doi: 10.1155/2021/9415387. eCollection 2021.ABSTRACTThe Japan Gastroenterological Endoscopy Society (JGES) guidelines recommend continued warfarin treatment during gastroenterological endoscopic procedures with a high risk of bleeding as an alternative to heparin replacement in patients on warfarin therapy. However, there is insufficient evidence to support the use of warfarin in colorectal endoscopic resection (ER). The present study is aimed at verifying the risk of bleeding after ER for colorectal neoplasia (CRN) in patients with continued warfarin use. This was a singl...
Source: Gastroenterology Research and Practice - December 27, 2021 Category: Gastroenterology Authors: Katsuaki Inagaki Ken Yamashita Shiro Oka Fumiaki Tanino Noriko Yamamoto Yuki Kamigaichi Hirosato Tamari Yasutsugu Shimohara Tomoyuki Nishimura Yuki Okamoto Hidenori Tanaka Takahiro Kotachi Ryo Yuge Yuji Urabe Yasuhiko Kitadai Kenichi Yoshimura Shinji Tana Source Type: research

Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer
In this study, it was aimed at investigating the effect of TRPM7 expression on prognosis in GC patients. Additionally, for the first time, it was investigated whether the density of Factor XIIIa-expressing tumor-associated macrophages (TAMs) in GC has an effect on the biological behaviour of the tumor.METHODS: TRPM7 expression and Factor XIIIa-expressing TAM density were immunohistochemically evaluated in paraffin-embedded tumor tissues of 204 GC patients undergoing surgery at a single institution.RESULTS: Tumor size was clearly higher in cases with high TRPM7 expression than those with low expression (p
Source: Gastroenterology Research and Practice - December 23, 2021 Category: Gastroenterology Authors: Muhammet Calik Ilknur Calik Gokhan Artas Ibrahim Hanifi Ozercan Source Type: research

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis
CONCLUSION: Metabolomic analysis and functional analysis of 3 key genes demonstrated that abnormal serum metabolites affected the pancreatic transcriptome and induced a sensitive state of inflammation in the pancreas. These metabolites may represent important targets for future research on the pathogenesis, clinical diagnosis, and treatment of noncalculous biliary pancreatitis.PMID:34925503 | PMC:PMC8674085 | DOI:10.1155/2021/2368571 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Yuanyuan Sun Qiang Wang Chenjun Hao Dongbo Xue Source Type: research

The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients
Gastroenterol Res Pract. 2021 Dec 9;2021:4269781. doi: 10.1155/2021/4269781. eCollection 2021.ABSTRACTBACKGROUND: Few studies on the clinicopathological features and prognosis of DNA mismatch repair deficiency (dMMR) gastric cancer (GC) have been reported, and no clear conclusions have been drawn about the factors affecting the prognosis of dMMR GC. The aim of this study was to explore the clinicopathological characteristics and prognoses of dMMR GC patients.METHODS: From May 2011 to November 2020, GC patients who underwent surgery with dMMR confirmed by immunohistochemistry (IHC) at the Affiliated Cancer Hospital of Shanx...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Jie Wang Yanfeng Xi Jian Zhao Xuetong Rong Weidong Lu Yusheng Wang Source Type: research

Comparison of the Development and Prognosis in Patients of Hypertriglyceridemic Pancreatitis with and without Diabetes
Gastroenterol Res Pract. 2021 Dec 9;2021:8895268. doi: 10.1155/2021/8895268. eCollection 2021.ABSTRACTAIM: To investigate the clinical features and prognosis in patients of hyperlipidemic acute pancreatitis with or without diabetes.METHODS: 157 patients with hypertriglyceridemic pancreatitis (HTGP) were included in this study. Patients with a previous history of diabetes were identified in the group of HTGP with diabetes (HTGPD), while patients without a history of diabetes were identified in the group of HTGP. The clinical characteristics and prognosis data of these patients in the two groups were analyzed.RESULTS: Multiv...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Wenjian Liao Xiuxiu Niu Wei Zhang Xiaobing Liu Source Type: research

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis
CONCLUSION: Metabolomic analysis and functional analysis of 3 key genes demonstrated that abnormal serum metabolites affected the pancreatic transcriptome and induced a sensitive state of inflammation in the pancreas. These metabolites may represent important targets for future research on the pathogenesis, clinical diagnosis, and treatment of noncalculous biliary pancreatitis.PMID:34925503 | PMC:PMC8674085 | DOI:10.1155/2021/2368571 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Yuanyuan Sun Qiang Wang Chenjun Hao Dongbo Xue Source Type: research

The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients
Gastroenterol Res Pract. 2021 Dec 9;2021:4269781. doi: 10.1155/2021/4269781. eCollection 2021.ABSTRACTBACKGROUND: Few studies on the clinicopathological features and prognosis of DNA mismatch repair deficiency (dMMR) gastric cancer (GC) have been reported, and no clear conclusions have been drawn about the factors affecting the prognosis of dMMR GC. The aim of this study was to explore the clinicopathological characteristics and prognoses of dMMR GC patients.METHODS: From May 2011 to November 2020, GC patients who underwent surgery with dMMR confirmed by immunohistochemistry (IHC) at the Affiliated Cancer Hospital of Shanx...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Jie Wang Yanfeng Xi Jian Zhao Xuetong Rong Weidong Lu Yusheng Wang Source Type: research

Comparison of the Development and Prognosis in Patients of Hypertriglyceridemic Pancreatitis with and without Diabetes
Gastroenterol Res Pract. 2021 Dec 9;2021:8895268. doi: 10.1155/2021/8895268. eCollection 2021.ABSTRACTAIM: To investigate the clinical features and prognosis in patients of hyperlipidemic acute pancreatitis with or without diabetes.METHODS: 157 patients with hypertriglyceridemic pancreatitis (HTGP) were included in this study. Patients with a previous history of diabetes were identified in the group of HTGP with diabetes (HTGPD), while patients without a history of diabetes were identified in the group of HTGP. The clinical characteristics and prognosis data of these patients in the two groups were analyzed.RESULTS: Multiv...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Wenjian Liao Xiuxiu Niu Wei Zhang Xiaobing Liu Source Type: research

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis
CONCLUSION: Metabolomic analysis and functional analysis of 3 key genes demonstrated that abnormal serum metabolites affected the pancreatic transcriptome and induced a sensitive state of inflammation in the pancreas. These metabolites may represent important targets for future research on the pathogenesis, clinical diagnosis, and treatment of noncalculous biliary pancreatitis.PMID:34925503 | PMC:PMC8674085 | DOI:10.1155/2021/2368571 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Yuanyuan Sun Qiang Wang Chenjun Hao Dongbo Xue Source Type: research

The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients
Gastroenterol Res Pract. 2021 Dec 9;2021:4269781. doi: 10.1155/2021/4269781. eCollection 2021.ABSTRACTBACKGROUND: Few studies on the clinicopathological features and prognosis of DNA mismatch repair deficiency (dMMR) gastric cancer (GC) have been reported, and no clear conclusions have been drawn about the factors affecting the prognosis of dMMR GC. The aim of this study was to explore the clinicopathological characteristics and prognoses of dMMR GC patients.METHODS: From May 2011 to November 2020, GC patients who underwent surgery with dMMR confirmed by immunohistochemistry (IHC) at the Affiliated Cancer Hospital of Shanx...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Jie Wang Yanfeng Xi Jian Zhao Xuetong Rong Weidong Lu Yusheng Wang Source Type: research

Comparison of the Development and Prognosis in Patients of Hypertriglyceridemic Pancreatitis with and without Diabetes
Gastroenterol Res Pract. 2021 Dec 9;2021:8895268. doi: 10.1155/2021/8895268. eCollection 2021.ABSTRACTAIM: To investigate the clinical features and prognosis in patients of hyperlipidemic acute pancreatitis with or without diabetes.METHODS: 157 patients with hypertriglyceridemic pancreatitis (HTGP) were included in this study. Patients with a previous history of diabetes were identified in the group of HTGP with diabetes (HTGPD), while patients without a history of diabetes were identified in the group of HTGP. The clinical characteristics and prognosis data of these patients in the two groups were analyzed.RESULTS: Multiv...
Source: Gastroenterology Research and Practice - December 20, 2021 Category: Gastroenterology Authors: Wenjian Liao Xiuxiu Niu Wei Zhang Xiaobing Liu Source Type: research

A Systematic Review and Network Meta-Analysis on the Efficacy of Medications in the Treatment of Chronic Idiopathic Constipation in Japan
CONCLUSION: Our direct and indirect meta-analyses revealed that the new CIC medications available in Japan have equal efficacy but that elobixibat and lubiprostone are highly likely to be more efficacious.PMID:34887919 | PMC:PMC8651382 | DOI:10.1155/2021/5534687 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 10, 2021 Category: Gastroenterology Authors: Atsushi Nakajima Ayako Shoji Kinya Kokubo Ataru Igarashi Source Type: research

< em > Enterococcus faecium < /em > Alleviates Gut Barrier Injury in C57BL/6 Mice with Dextran Sulfate Sodium-Induced Ulcerative Colitis
In this study, a dextran sulphate sodium-induced (DSS-induced) colitis model was used to detect the underlying mechanism of E. faecium in maintaining gut homeostasis. ELISA was performed to detect the levels of cytokines (TNF-α, IL-1β, IL-6, and IL-10). Furthermore, 454 pyrosequencing was used to investigate the microbiota composition in fecal samples. The results illustrate that E. faecium administration could prevent DSS-induced gut inflammation and intestinal flora imbalance. At the same time, the damage to intestinal mucosal barrier and tight junctions was partially repaired. These results demonstrate the pr...
Source: Gastroenterology Research and Practice - December 6, 2021 Category: Gastroenterology Authors: Wei He Weijie Ni Junning Zhao Source Type: research

Therapeutic Effect of Biejiaxiaozheng Pills on Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats through the NF- < em > κ < /em > B/Nrf2 Pathway
CONCLUSION: Biejiaxiaozheng pills improved hepatic fibrosis symptoms and lesions in rats, likely by inhibiting the NF-κB pathway and promoting the Nrf2 pathway.PMID:34868305 | PMC:PMC8635903 | DOI:10.1155/2021/3954244 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 6, 2021 Category: Gastroenterology Authors: Weibin Wu Liqiang Li Jian Yang Pinyu Li Yuying Hu Guifeng Zhang Xiaozhong Zhu Source Type: research

Automatic Detection of Small Intestinal Hookworms in Capsule Endoscopy Images Based on a Convolutional Neural Network
Gastroenterol Res Pract. 2021 Nov 24;2021:5682288. doi: 10.1155/2021/5682288. eCollection 2021.ABSTRACTAncylostomiasis is a fairly common small bowel parasite disease identified by capsule endoscopy (CE) for which a computer-aided clinical detection method has not been established. We sought to develop an artificial intelligence system with a convolutional neural network (CNN) to automatically detect hookworms in CE images. We trained a deep CNN system based on a YOLO-V4 (You Look Only Once-Version4) detector using 11236 CE images of hookworms. We assessed its performance by calculating the area under the receiver operatin...
Source: Gastroenterology Research and Practice - December 6, 2021 Category: Gastroenterology Authors: Tao Gan Yulin Yang Shuaicheng Liu Bing Zeng Jinlin Yang Kai Deng Junchao Wu Li Yang Source Type: research