Comparative analysis of sorafenib and lenvatinib on HepG2 cells and human umbilical vein endothelial cells: Involvement of transforming growth factor- β signaling in their molecular effects
CONCLUSIONS: Our findings indicate that both sorafenib and lenvatinib possess anticancer abilities by inducing the cytotoxicity of hepatocellular carcinoma cells. Furthermore, they show opposing effects on TGF-β-induced cell invasion and angiogenesis, thereby enhancing the understanding of the multifaceted functions of molecular targeted drugs in treating hepatocellular carcinoma.PMID:38666637 | DOI:10.1111/hepr.14045 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Ting Wang Yasuhiro Takikawa Kazuyuki Suzuki Hidekatsu Kuroda Keisuke Kakisaka Toshimi Chiba Source Type: research
TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis
EMBO Mol Med. 2024 Apr 26. doi: 10.1038/s44321-024-00068-4. Online ahead of print.ABSTRACTRadiotherapy (RT) has been reported to induce abscopal effect in advanced hepatocellular carcinoma (HCC), but such phenomenon was only observed in sporadic cases. Here, we demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during RT through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1. Moreover, poly(I:C) could pro...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liman Qiu Hongbing Ji Kai Wang Wenhan Liu Qizhen Huang Xinting Pan Honghao Ye Zhenli Li Geng Chen Xiaohua Xing Xiuqing Dong Ruijing Tang Haipo Xu Jingfeng Liu Zhixiong Cai Xiaolong Liu Source Type: research
Epithelial-Mesenchymal Transformation Promotes the Progression of Hepatocellular Carcinoma through NF- κB/MMP9 Axis
CONCLUSIONS: The NF-κB/MMP9 signaling axis serves as a pivotal regulator that fosters proliferation and impedes apoptosis in Huh7 cells by modulating the process of EMT.PMID:38665016 | DOI:10.24976/Discov.Med.202436183.63 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Jinsen Li Qingbin Cai Ziyue Wang Liangshi Wang Guangrun Yang Zhilong Zhang Na Ge Shunxin Hu Tian Bai Source Type: research
Metabolome Profiling of Malignant Ascites Identifies Candidate Metabolic Biomarkers of Hepatocellular Carcinoma
CONCLUSION: Our results suggest that the key factors associated with pathways, such as arachidonic acid, phenylalanine, and glutamic acid pathways, are potential ascitic fluidbased biomarkers for differentiating hepatocellular carcinoma with cirrhosis ascites; the results also provide a clinical pathophysiological interpretation of biomarkers and metabolic pathways relevant to disease status.PMID:38666505 | DOI:10.2174/0929867330666230324153552 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 26, 2024 Category: Chemistry Authors: Weijia Wang Yue Wu Qinsheng Zhang Peilin Cui Source Type: research
Unmet needs in the post-DAA era: the risk and molecular mechanisms of hepatocellular carcinoma after HCV eradication
Clin Mol Hepatol. 2024 Apr 26. doi: 10.3350/cmh.2024.0155. Online ahead of print.ABSTRACTHepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus int...
Source: Clinical and molecular hepatology - April 26, 2024 Category: Gastroenterology Authors: Chung-Feng Huang Manar Hijaze Awad Meital Gal-Tanamy Ming-Lung Yu Source Type: research
Biomarkers in Detection of Hepatitis C Virus Infection
Pathogens. 2024 Apr 17;13(4):331. doi: 10.3390/pathogens13040331.ABSTRACTThe hepatitis C virus (HCV) infection affects 58 million people worldwide. In the United States, the incidence rate of acute hepatitis C has doubled since 2014; during 2021, this increased to 5% from 2020. Acute hepatitis C is defined by any symptom of acute viral hepatitis plus either jaundice or elevated serum alanine aminotransferase (ALT) activity with the detection of HCV RNA, the anti-HCV antibody, or hepatitis C virus antigen(s). However, most patients with acute infection are asymptomatic. In addition, ALT activity and HCV RNA levels can fluct...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jungreem Woo Youkyung Choi Source Type: research
Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)
Oncol Rep. 2024 Jun;51(6):84. doi: 10.3892/or.2024.8743. Epub 2024 Apr 26.ABSTRACTEven under aerobic conditions, tumor cells can reprogram their metabolism to preferentially metabolize glucose into lactic acid. This abnormal metabolic pattern, known as the 'Warburg' effect or aerobic glycolysis, promotes cancer progression. Long non‑coding RNAs (lncRNAs) are RNAs that are >200 nucleotides in length and do not have protein‑coding capabilities. However, these RNAs play a key role in tumor development. There is increasing evidence to indicate that lncRNAs regulate glucose metabolism in tumor cells by affecting metaboli...
Source: Oncology Reports - April 26, 2024 Category: Cancer & Oncology Authors: Qiongqing Huang Zhengui Liang Qiqi Huang Xueyu Li Jingjing Xia Lining Huang Lin Bing Huang Chao Ou Source Type: research
A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature
In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication.PMID:38668050 | DOI:10.3390/curroncol31040147 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Monika P éčová Jakub Benko Martin Jozef P éč Jakub Jurica Simona Horn á Tom áš Bolek Tatiana Hurtov á J án Sýkora Kamil Zele ňák Matej Samo š Juraj Sokol Source Type: research
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma
Through bioinformatic analysis of transcriptomes in the cancer genome atlas (TCGA), we identified a new role for the transcription factor THAP domain-containing 3 (THAP3) in the expression of oxidative phosphorylation (OXPHOS) genes and mitochondrial respiration. Mechanistically, THAP3 cooperated with the histone methyltransferase SET and MYND domain-containing protein 3 (SMYD3) to upregulate H3K4me3 and promote OXPHOS gene expression. These actions of THAP3 support liver cancer cell proliferation and contribute to tumor development. Mitochondria harbor the oxidative phosphorylation (OXPHOS) system to sustain cellular resp...
Source: FEBS Letters - April 26, 2024 Category: Biochemistry Authors: Zi ‐Hao Wang,
Jingyi Wang,
Fuchen Liu,
Sijun Sun,
Quan Zheng,
Xiaotian Hu,
Zihan Yin,
Chengmei Xie,
Haiyan Wang,
Tianshi Wang,
Shengjie Zhang,
Yi‐Ping Wang Tags: Research Article Source Type: research
Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma
In this study, we conducted an integrated single-cell analysis of four cohorts (GSE140228, GSE125449, GSE149614 and GSE156625) to elucidate the TAM landscape in HCC. We identified 284 gene markers, termed Panmyeloid markers, that characterize myeloid cells within this context. Our analysis distinguished six clusters of monocyte-derived macrophages (Macro1-Macro6) and four clusters of Kupffer cells (Kupffer1-Kupffer4). Notably, CXCL10 + macrophages and MT1G + Kupffer cells, predominantly located within tumor tissues, exhibited distinct functional characteristics relevant to HCC. We also explored cellular communicat...
Source: Inflammation - April 26, 2024 Category: Allergy & Immunology Source Type: research
Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors Versus Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma with First- or Lower-Order Portal Vein Tumor Thrombosis
ConclusionTACE-TKI-ICI therapy contributed to better tumor control, PFS and OS than TKI-ICI therapy in unresectable HCC patients with first- or lower-order PVTT.Graphical Abstract (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - April 26, 2024 Category: Radiology Source Type: research
Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma
In this study, we conducted an integrated single-cell analysis of four cohorts (GSE140228, GSE125449, GSE149614 and GSE156625) to elucidate the TAM landscape in HCC. We identified 284 gene markers, termed Panmyeloid markers, that characterize myeloid cells within this context. Our analysis distinguished six clusters of monocyte-derived macrophages (Macro1-Macro6) and four clusters of Kupffer cells (Kupffer1-Kupffer4). Notably, CXCL10 + macrophages and MT1G + Kupffer cells, predominantly located within tumor tissues, exhibited distinct functional characteristics relevant to HCC. We also explored cellular communicat...
Source: Inflammation - April 26, 2024 Category: Allergy & Immunology Source Type: research
Primary squamous cell carcinoma of the pancreas causing regional portal hypertension
A female patient presented with epigastric pain with black stools and laboratory results suggesting positive fecal occult blood and higher than normal CA199. Upper abdominal CT (Fig. 1a,b) and magnetic resonance (Fig. 1c) suggested the possibility of pancreatic cervical body occupying lesions, involving the portal vein, splenic vein and superior mesenteric vein. Ultrasound-guided puncture biopsy of pancreatic mass was performed, and invasive carcinoma was detected (Fig. 1d). Immunohistochemistry results: P40 (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Jingzhi Zhang, Daocong Ren, Qingshun Meng Tags: Image of the Month Source Type: research
Exploring Hepatocellular Carcinoma Risks in Sub-Saharan African and Afro-Surinamese Individuals with Chronic Hepatitis B living in Europe
We read with great interest the article by Lesley A. Patmore et al., published in the Journal of Hepatology, titled “Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe [1].” The study highlights that, among chronic hepatitis B (CHB) patients of Sub-Saharan African and Afro-Surinamese descent residing in Europe, the cumulative incidenc e rates of hepatocellular carcinoma (HCC) over 5 and 10 years are 1% and 2.4%, respectively. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Mo-Yao Tan, Jun-Hua Su Tags: Letter to the Editor Source Type: research
Cancers, Vol. 16, Pages 1675: Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular Carcinoma
In this study, we analyzed fecal samples collected before treatment to investigate the relationship between the intestinal microbiome and the efficacy of atezolizumab and bevacizumab. A total of 37 patients with advanced HCC who were treated with atezolizumab and bevacizumab were enrolled. Fecal samples were collected from the patients, and they were divided into responder (n = 28) and non-responder (n = 9) groups. We compared the intestinal microbiota of the two groups and analyzed the intestinal bacteria associated with prognosis using QIIME2. The alpha and beta diversities were not significantly different between both g...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Yosuke Inukai Kenta Yamamoto Takashi Honda Shinya Yokoyama Takanori Ito Norihiro Imai Yoji Ishizu Masanao Nakamura Masatoshi Ishigami Hiroki Kawashima Tags: Article Source Type: research
