Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma
CONCLUSION: CircSMARCA5 has the potential to be a more sensitive predictor of HCC disease compared to AFP.PMID:38680002 | DOI:10.31557/APJCP.2024.25.4.1411 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hanan M Bedair Elaf A El-Banna Elhamy A Ahmed Mostafa G Elhelbawy Ahmed Abdelfattah Fatma A Khalaf Mohamed Abdel-Samiee Amal El Sharnoby Source Type: research
Clinical Utility of Cytokeratins for Accurate Diagnosis of Hepatocellular Carcinoma Among Hepatitis C Virus High-Risk Patients
CONCLUSION: CK-HCC score could replace AFP during screening of HCV patients and early detection of HCC.PMID:38679993 | DOI:10.31557/APJCP.2024.25.4.1325 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Mahdi Al Haddad Hatem A El-Mezayen Mohamed El-Kassas Fateheya Metwally Aml El-Sharkawy Source Type: research
Mitochondrial dynamics, quality control and mtDNA in Alcohol-associated liver disease and liver cancer
Hepatology. 2024 Apr 29. doi: 10.1097/HEP.0000000000000910. Online ahead of print.ABSTRACTMitochondria are intracellular organelles responsible for energy production, glucose and lipid metabolism, cell death, cell proliferation, and innate immune response. Mitochondria are highly dynamic organelles that constantly undergo fission, fusion, and intracellular trafficking, as well as degradation and biogenesis. Mitochondrial dysfunction has been implicated in a variety of chronic liver diseases including alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinom...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Xiaowen Ma Mengwei Niu Hong-Min Ni Wen-Xing Ding Source Type: research
Construction of an Immunogenic Cell Death-Related Gene Signature and Genetic Subtypes for Predicting Prognosis, Immune Microenvironments, and Drug Sensitivity in Hepatocellular Carcinoma
CONCLUSION: In this study, we developed an ICDRG risk model and demonstrated its applicability in predicting survival outcomes, immune and chemotherapeutic responses in HCC patients. ICDRGs are expected to be used as novel biomarkers in the medical decision-making of HCC.PMID:38681068 | PMC:PMC11049185 | DOI:10.2147/JIR.S451800 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Shuo Li Tingyu Zhang Xin Sun Xiaoke Li Source Type: research
Treatment of Moderate-to-Severe Pain in Hepatocellular Carcinoma with Transcutaneous Electrical Acupoint Stimulation: A Randomized Controlled Trial
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 29, 2024 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
ConclusionThis case exemplifies the unfortunate course of a rapidly progressive NET G3 and highlights the limited number of effective therapies for some tumors within the relatively new cohort of NET G3 with a yet unsatisfactory understanding of its underlying tumor biology and behavioral spectrum. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
Regarding the role of post-transplant inflammatory cytokine signature on predicting tumor recurrence after liver transplantation for hepatocellular carcinoma
(Source: Hepatology International)
Source: Hepatology International - April 29, 2024 Category: Infectious Diseases Source Type: research
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made g... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2024 Category: Hematology Authors: Ke-Yu Shen, Ying Zhu, Sun-Zhe Xie and Lun-Xiu Qin Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1746: Bovine Meat and Milk Factor-like Sequences Are Frequently Detected in Renal Cell Carcinoma Tissues
ah
Axel zur Hausen
Previous studies have indicated a potential role of diet in the pathogenesis of renal cell carcinoma (RCC). Recently, circular bovine meat and milk factor (BMMF) DNAs have been identified in peritumoral tissues of human colon and breast cancers. Here, we investigated the prevalence of the DNA of these novel human pathogenic infectious agents in RCC and adjacent peritumoral renal tissues. DNA was extracted from formalin-fixed and paraffin-embedded (FFPE) RCC and peritumoral kidney tissues, including a test (n = 11) and a validation (n = 152) collection. BMMF1 and BMMF2 consensus primers were designe...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Ghalib Mobaraki Shuai Shi Kim M. Smits Kim Severens Kim Lommen Dorit Rennspiess Emil Chteinberg V éronique Winnepenninckx Iryna Samarska Faisal Klufah Axel zur Hausen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1739: Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma
Juei Jeng
HCC remains one of the leading causes of cancer-related death globally. The main challenges in treatments of hepatocellular carcinoma (HCC) primarily arise from high rates of postoperative recurrence and the limited efficacy in treating advanced-stage patients. Various signaling pathways involved in HCC have been reported. Among them, the Sonic hedgehog (SHH) signaling pathway is crucial. The presence of SHH ligands is identified in approximately 60% of HCC tumor tissues, including tumor nests. PTCH-1 and GLI-1 are detected in more than half of HCC tissues, while GLI-2 is found in over 84% of HCC tissues. The...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Kuo-Shyang Jeng Chiung-Fang Chang Yuk-Ming Tsang I-Shyan Sheen Chi-Juei Jeng Tags: Review Source Type: research
Viruses, Vol. 16, Pages 707: The Adaptive Immune Response in Hepatitis B Virus-Associated Hepatocellular Carcinoma Is Characterized by Dysfunctional and Exhausted HBV-Specific T Cells
na Weis
This systematic review investigates the immunosuppressive environment in HBV-associated hepatocellular carcinoma (HCC), characterized by dysfunctional and exhausted HBV-specific T cells alongside an increased infiltration of HBV-specific CD4+ T cells, particularly regulatory T cells (Tregs). Heightened expression of checkpoint inhibitors, notably PD-1, is linked with disease progression and recurrence, indicating its potential as both a prognostic indicator and a target for immunotherapy. Nevertheless, using PD-1 inhibitors has shown limited effectiveness. In a future perspective, understanding the intricate in...
Source: Viruses - April 29, 2024 Category: Virology Authors: Malene Broholm Anne-Sofie Mathiasen Ása Didriksen Apol Nina Weis Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2053: Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract
asela Elena Gîrd
Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount of 3.3886 ± 0.3481 mg Eq chlorogenic acid/100 g extract and 78.95 µg/g berberine. The dried hydro-ethanolic extract (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chrom...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Ionu ț Mădălin Ivan Octavian Tudorel Olaru Violeta Popovici Carmen Lidia Chi țescu Liliana Popescu Emanuela Alice Lu ță Elena Iuliana Ilie Lorelei Irina Bra șoveanu Camelia Mia Hotnog George Mihai Ni țulescu Rica Boscencu Cerasela Elena G îrd Tags: Article Source Type: research
Screening for exclusion of high-risk bleeding features of esophageal varices in cirrhosis through CT and MRI
This study assessed the efficacy of imaging in ruling out EVs and their high-risk features associated with bleeding in patients with cirrhosis and with HCC. (Source: Clinical Imaging)
Source: Clinical Imaging - April 29, 2024 Category: Radiology Authors: Ali Borhani, Harry Luu, Alireza Mohseni, Ziyi Xu, Mohammadreza Shaghaghi, Celestina Tolosa, Mohammad Mirza Aghazadeh Attari, Seyedeh Panid Madani, Haneyeh Shahbazian, Pegah Khoshpouri, Shadi Afyouni, Ghazal Zandieh, Ihab Kamel, Amy K. Kim Tags: Body Imaging Source Type: research
Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma
Cell Death & Disease, Published online: 29 April 2024; doi:10.1038/s41419-024-06685-8Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma (Source: Cell death and disease)
Source: Cell death and disease - April 29, 2024 Category: Internal Medicine Authors: Xin Li Yu-Fei Pan Yi-Bin Chen Qian-Qian Wan Yun-Kai Lin Tai-Yu Shang Meng-You Xu Tian-Yi Jiang Meng-Miao Pei Ye-Xiong Tan Li-Wei Dong Xu-Ying Wan Source Type: research
Association of GLP-1 receptor agonists and hepatocellular carcinoma incidence and hepatic decompensation in patients with type 2 diabetes
Hepatocellular carcinoma (HCC) is a leading cause of cancer death. HCC is preventable with about 70 percent of HCC attributable to modifiable risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), FDA-approved medications for treating type 2 diabetes mellitus (T2DM), have pleiotropic effects on counteracting risk factors for HCC. Here we evaluate the association of GLP-1RAs with incident HCC risk in a real-world population. (Source: Gastroenterology)
Source: Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Lindsey Wang, Nathan A. Berger, David C. Kaelber, Rong Xu Tags: Clinical - Liver Source Type: research
