Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01223-0. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechanisms that lead to the upregulation of PLAGL2 in HCC remain unclear. The present study revealed that stress-induced epinephrine increased the expression of PLAGL2, thereby promoting the progression of HCC. Furthermore, PLAGL2 knockdown inhibited epinephrine-induced HCC development. Mechanistically, epinephrine upregulated ubiquitin-s...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1 α to induce the polarization of tumor-associated macrophages
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01214-1. Online ahead of print.ABSTRACTTumor-associated macrophages (TAMs) are vital contributors to the growth, metastasis, and therapeutic resistance of various cancers, including hepatocellular carcinoma (HCC). However, the exact phenotype of TAMs and the mechanisms underlying their modulation for therapeutic purposes have not been determined. Here, we present compelling evidence that glutamine-derived aspartate in TAMs stimulates spermidine production through the polyamine synthesis pathway, thereby increasing the translation efficiency of HIF-1α via eIF5A hypusination....
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Dong-Ho Kim Yoo Na Kang Jonghwa Jin Mihyang Park Daehoon Kim Ghilsuk Yoon Jae Won Yun Jaebon Lee Soo Young Park Yu Rim Lee Jun-Kyu Byun Yeon-Kyung Choi Keun-Gyu Park Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
Effectiveness of Semecarpus anacardium fruits in cancer and inflammatory diseases: A mini review
CONCLUSION: The findings will provide more support for investigating SCA fruits in cancer treatment and will furnish thorough reference data and recommendations for future studies on this botanical medication.PMID:38685508 | DOI:10.1016/j.fitote.2024.105978 (Source: Fitoterapia)
Source: Fitoterapia - April 30, 2024 Category: Biochemistry Authors: Ashwini Kumar Mishra S L Neha Ankit Jain Chandrashekhar Y Jagtap Ganesh Dane Shweta Paroha Pravat Kumar Sahoo Source Type: research
Preparation, evaluation and application of MRI detectable sunitinib-loaded calcium alginate/poly(acrylic acid) hydrogel microspheres
In conclusion, CA/PAA-MDMs showed outstanding drug loading capability, excellent imaging property and embolization effect, which would be expected to be used as a potential biodegradable embolic agent in the clinical interventional therapy.PMID:38688794 | DOI:10.1016/j.ijbiomac.2024.131730 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Jijun Fu Guanli Lin Chenchen Fang Baiqi Chen Xingmei Deng Junhong Chen Weiqi Yang Yugang Huang Aiping Qin Xufeng Li Caifang Zeng Xin Li Lingran Du Source Type: research
Pre-diagnostic plasma proteomics profile for hepatocellular carcinoma
CONCLUSION: However, the limited number of HCC cases in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.PMID:38688524 | DOI:10.1093/jnci/djae079 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 30, 2024 Category: Genetics & Stem Cells Authors: Xinyuan Zhang Longgang Zhao Long H Ngo Simon T Dillon Xuesong Gu Michelle Lai Tracey G Simon Andrew T Chan Edward L Giovannucci Towia A Libermann Xuehong Zhang Source Type: research
No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | DOI:10.3348/kjr.2023.1225 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Cholangiocarcinoma and Occupational Exposure to Asbestos: Insights From the Italian Pooled Cohort Study
CONCLUSION: Further studies are needed to explore the association between occupational exposure to asbestos and CC. Record linkage was hampered due to incomplete coverage of the study areas and periods by Cancer Registries. The identification of CC among unspecific histology cases is fundamental to establish more effective and targeted liver cancer screening strategies.PMID:38686579 | DOI:10.23749/mdl.v115i2.14649 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Stefania Curti Mena Gallo Daniela Ferrante Francesca Bella Lorenza Boschetti Veronica Casotto Marcello Ceppi Daniela Cervino Lucia Fazzo Ugo Fedeli Paolo Giorgi Rossi Lucia Giovannetti Paolo Girardi Cecilia Lando Enrica Migliore Lucia Miligi Enrico Oddone Source Type: research
No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | DOI:10.3348/kjr.2023.1225 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
CONCLUSIONS: Toripalimab plus bevacizumab showed a favorable efficacy and safety profile, supporting further studies of this combination regimen as a first-line treatment of advanced HCC.PMID:38687583 | DOI:10.1158/1078-0432.CCR-24-0006 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Yajin Chen Cheng-You Du Shunli Shen Wu Zhang Yunfeng Shan Ang Lyu Jianhui Wu Changzhen Shang Xuan Luo Jinxing Wei Heng Xiao Jianguo Qiu Yunpeng Hua Shutong Wang Ting Wang Shengjie Dai Shuhao Zhang Bingying Xie Yinghao Wu Chunyi Hao Source Type: research
Efficacy of microwave ablation with parallel acupuncture guided by ultrasound in treating single hepatocellular carcinoma in high-risk areas: A retrospective analysis of 155 patients
CONCLUSION: Microwave ablation with parallel acupuncture guided by ultrasound is a safe and effective treatment for single hepatocellular carcinoma in high-risk areas.PMID:38687924 | DOI:10.4103/jcrt.jcrt_1246_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Sheng Liu Pingsheng Zhou Qiang Shen Guojun Qian Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein-1 inhibitors: A promising treatment approach for high-burden hepatocellular carcinoma
CONCLUSION: The combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC.PMID:38686567 | DOI:10.1002/cam4.7105 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu Yongkang Xu Ye Mao Mengting He Zhimeng Chen Shenglan Huang Dan Li Yaqin Lv Jianbing Wu Source Type: research
Protective effect of higher free thyroxine levels within the reference range on biliary tract cancer risk: a multivariable mendelian randomization and mediation analysis
CONCLUSION: The findings suggest that higher FT4-RR may have a protective effect against BTC, which is partially mediated by decreased risk of MetS and a reduction in WC. This study highlights the potential role of FT4 in the pathogenesis of BTC and underscores that MetS and WC may play mediation effects as two mediators in this process.PMID:38686204 | PMC:PMC11056546 | DOI:10.3389/fendo.2024.1379607 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Yuxian Chen Hao Dong Baozhen Qu Xuezhen Ma LinLin Lu Source Type: research
Improving Tamoxifen Performance in Inducing Apoptosis and Hepatoprotection by Loading on a Dual Nanomagnetic Targeting System
CONCLUSION: All the results showed that MNPs-DPN-HA-FA-TMX can show good affinity to cancer cells using targeting agents and induce apoptosis in metastatic breast ductal carcinoma T-47D cell lines. Also, the protective effects of MNPs on hepatocytes are quite evident, and they can reduce the side effects of TMX.PMID:38685808 | DOI:10.2174/0118715206289666240423091244 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Yanfang Zhao Wanbao Ding Peixian Zhang Lei Deng Yi Long Jiuqin Lu Fereshteh Shiri Mostafa Heidari Majd Source Type: research
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research
