Lenvatinib ‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis
Oncol Lett. 2024 Apr 12;27(6):265. doi: 10.3892/ol.2024.14398. eCollection 2024 Jun.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long-term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain. Lenvatinib (LEN) has shown efficacy and tolerable rates of adverse events (AEs) when applied in combination with immune checkpoint inhibitors (ICIs) or l...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Saixin Li Zeyu Zhang Zheng Wang Kenan Wang Minghao Sui Dongbin Liu Kuo Liang Source Type: research
Feasibility Study of Computed Tomographic Radiomics Model for the Prediction of Early and Intermediate Stage Hepatocellular Carcinoma Using BCLC Staging
CONCLUSION: The CT radiomic model can be used to predict the BCLC stage of early-stage and intermediate-stage HCC.PMID:38660703 | DOI:10.1177/15330338241245943 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 25, 2024 Category: Cancer & Oncology Authors: Han Dong Lu Yang Duan Shaofeng Guo Lili Source Type: research
Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review
CONCLUSION: Although, studies have shown that HCV genotype-3 infection is an independent risk factor for end-stage liver disease, HCC, and liver-related death, there is a lack of evidence for specific risk factors for HCC secondary to HCV genotype-3. Only cirrhosis and age have demonstrated an association; however, the number of studies is very small, and more research is required to investigate risk factors for HCC secondary to HCV genotype-3.PMID:38660636 | PMC:PMC11037048 | DOI:10.4251/wjgo.v16.i4.1596 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Hamzah Z Farooq Michael James Jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry Graham R Foster Source Type: research
Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma
CONCLUSION: This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable HCC. The patients with BCLC B-stage disease with early NLR response (decrease) and early AFP response (decrease > 20%) may achieve better clinical outcomes with this triple therapy.PMID:38660650 | PMC:PMC11037041 | DOI:10.4251/wjgo.v16.i4.1236 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Kun-Peng Ma Jin-Xin Fu Feng Duan Mao-Qiang Wang Source Type: research
Anesthetic management during laparoscopic liver resection in a patient with Fontan physiology and high central venous pressure
The Fontan procedure was developed in 1971 for the surgical palliation of patients with single ventricle physiology [1]. In patients with Fontan physiology, pulmonary perfusion depends on pulmonary vascular resistance and systemic venous pressure. Long-term survival after the Fontan procedure has improved [2]. However, chronically high venous pressure may cause liver congestion and lead to the development of hepatocellular carcinoma (HCC) [3]. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 25, 2024 Category: Anesthesiology Authors: Kousuke Kikuchi, Akira Iura, Naohiro Hara, Takeshi Iritakenishi, Daisuke Hiramatsu, Yuji Fujino Tags: Case Report Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study
ConclusionMetastasectomy in patients with metastatic non-ccRCC may provide clinical benefits in terms of improved PFS and OS, especially in patients without liver metastasis and those with metachronous metastasis. (Source: World Journal of Urology)
Source: World Journal of Urology - April 25, 2024 Category: Urology & Nephrology Source Type: research
A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
ConclusionsThe NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NOTA...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Negative Impact of Intra-Operative Blood Transfusion on Survival Outcomes of Hepatocellular Carcinoma Patients
(Source: Cancer Management and Research)
Source: Cancer Management and Research - April 24, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Correction to “The adverse characteristics of hepatocellular carcinoma in the non‐cirrhotic liver disproportionately disadvantage black patients”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 24, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma
This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.PMID:38658380 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Xiao-Feng Hu Qing Zhang Mei-Lv Liang Qing-Niao Zhou Rui-Qiang Zhao Zu-Kang Gong Wen-Zhen Lin Source Type: research
GSE261938 Potential utility of L-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis
We examined the potential utility of L-carnitine for alleviating metabolic dysfunction-associated steatohepatitis (MASH) and preventing the development of hepatocellular carcinoma.Short-term L-carnitine administration ameliorated MASH through its anti-inflammatory effects. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Incidentally found parotid gland lesion in 18F-FDG PET/CT for staging evaluation of patients with hepatocellular carcinoma: remote possibility of metastatic tumor or second primary salivary gland malignancy
We primarily aimed to evaluate whether parotid incidental lesion (PIL) in 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging evaluation of patients with hepatocel... (Source: BMC Surgery)
Source: BMC Surgery - April 24, 2024 Category: Surgery Authors: Jin Hyung Jung, Yoon Se Lee, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam, Hyo Jung Cho and Minsu Kwon Tags: Research Source Type: research
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC).... (Source: Biology Direct)
Source: Biology Direct - April 24, 2024 Category: Biology Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu Tags: Research Source Type: research
