Primary squamous cell carcinoma of the pancreas causing regional portal hypertension
A female patient presented with epigastric pain with black stools and laboratory results suggesting positive fecal occult blood and higher than normal CA199. Upper abdominal CT (Fig. 1a,b) and magnetic resonance (Fig. 1c) suggested the possibility of pancreatic cervical body occupying lesions, involving the portal vein, splenic vein and superior mesenteric vein. Ultrasound-guided puncture biopsy of pancreatic mass was performed, and invasive carcinoma was detected (Fig. 1d). Immunohistochemistry results: P40 (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Jingzhi Zhang, Daocong Ren, Qingshun Meng Tags: Image of the Month Source Type: research
Exploring Hepatocellular Carcinoma Risks in Sub-Saharan African and Afro-Surinamese Individuals with Chronic Hepatitis B living in Europe
We read with great interest the article by Lesley A. Patmore et al., published in the Journal of Hepatology, titled “Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe [1].” The study highlights that, among chronic hepatitis B (CHB) patients of Sub-Saharan African and Afro-Surinamese descent residing in Europe, the cumulative incidenc e rates of hepatocellular carcinoma (HCC) over 5 and 10 years are 1% and 2.4%, respectively. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Mo-Yao Tan, Jun-Hua Su Tags: Letter to the Editor Source Type: research
Cancers, Vol. 16, Pages 1675: Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular Carcinoma
In this study, we analyzed fecal samples collected before treatment to investigate the relationship between the intestinal microbiome and the efficacy of atezolizumab and bevacizumab. A total of 37 patients with advanced HCC who were treated with atezolizumab and bevacizumab were enrolled. Fecal samples were collected from the patients, and they were divided into responder (n = 28) and non-responder (n = 9) groups. We compared the intestinal microbiota of the two groups and analyzed the intestinal bacteria associated with prognosis using QIIME2. The alpha and beta diversities were not significantly different between both g...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Yosuke Inukai Kenta Yamamoto Takashi Honda Shinya Yokoyama Takanori Ito Norihiro Imai Yoji Ishizu Masanao Nakamura Masatoshi Ishigami Hiroki Kawashima Tags: Article Source Type: research
Viruses, Vol. 16, Pages 682: Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV)
unetto
Anna Linda Zignego
Carmine Coppola
Andrea Iannone
Elisa Biliotti
Elena Rosselli Del Turco
Marco Massari
Anna Licata
Francesco Barbaro
Marcello Persico
Filomena Morisco
Maurizio Pompili
Federica Cerini
Massimo Puoti
Teresa Santantonio
Antonio Craxì
Loreta A. Kondili
Liliana Chemello Investigators
on behalf of PITER Collaborating Investigators on behalf of PITER Collaborating Investigators
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in peop...
Source: Viruses - April 26, 2024 Category: Virology Authors: Maria Giovanna Quaranta Luisa Cavalletto Francesco Paolo Russo Vincenza Calvaruso Luigina Ferrigno Alberto Zanetto Benedetta Mattioli Roberta D ’Ambrosio Valentina Panetta Giuseppina Brancaccio Giovanni Raimondo Maurizia Rossana Brunetto Anna Linda Zign Tags: Article Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Lenvatinib ‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis
Oncol Lett. 2024 Apr 12;27(6):265. doi: 10.3892/ol.2024.14398. eCollection 2024 Jun.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long-term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain. Lenvatinib (LEN) has shown efficacy and tolerable rates of adverse events (AEs) when applied in combination with immune checkpoint inhibitors (ICIs) or l...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Saixin Li Zeyu Zhang Zheng Wang Kenan Wang Minghao Sui Dongbin Liu Kuo Liang Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Lenvatinib ‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis
Oncol Lett. 2024 Apr 12;27(6):265. doi: 10.3892/ol.2024.14398. eCollection 2024 Jun.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long-term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain. Lenvatinib (LEN) has shown efficacy and tolerable rates of adverse events (AEs) when applied in combination with immune checkpoint inhibitors (ICIs) or l...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Saixin Li Zeyu Zhang Zheng Wang Kenan Wang Minghao Sui Dongbin Liu Kuo Liang Source Type: research
Feasibility Study of Computed Tomographic Radiomics Model for the Prediction of Early and Intermediate Stage Hepatocellular Carcinoma Using BCLC Staging
CONCLUSION: The CT radiomic model can be used to predict the BCLC stage of early-stage and intermediate-stage HCC.PMID:38660703 | PMC:PMC11044781 | DOI:10.1177/15330338241245943 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 25, 2024 Category: Cancer & Oncology Authors: Han Dong Lu Yang Duan Shaofeng Guo Lili Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Interim analysis of the PARADISE study: Benefits of add-on peginterferon- α in NA-treated patients with CHB
This study aimed to investigate whether peginterferon-α (IFN) add-on nucleos(t)ide analogs(NAs) can further reduce hepatocellular carcinoma(HCC) risk compared with NAs monotherapy in NA-treated patients with chronic hepatitis B(CHB). In this multi-center randomized controlled trial "PARADISE study" (NCT05671315), CHB patients with intermediate to high risk of HCC after more than 24-week NAs pretreatment were recruited, randomized to two groups at a ratio of 1:2 and followed up for 240 weeks. NAs group maintained NAs monotherapy, while IFN + NAs group received IFN add-on NAs therapy for 48 weeks, then switched to NAs monot...
Source: Antiviral Research - April 25, 2024 Category: Virology Authors: Shaowen Jiang Simin Guo Yan Huang Jie Xu Yi Li Yilan Zeng Yuan Guo Lijuan Ouyang Chuanwu Zhu Weifeng Zhao Qin Zhang Qing Guo Haiguang Xin Qing Xie Source Type: research
Aflatoxin B < sub > 1 < /sub > -exposed hepatocyte-derived extracellular vesicles: Initiating hepatic stellate cell-mediated liver fibrosis through a p53-Parkin-dependent mitophagy pathway
This study further revealed that the hepatic fibrogenesis of AFB1 exposure was rescued by genetic intervention with siPARK2 or p53's Pifithrin-α (PFTα) inhibitors. Furthermore, AFB1-EVs-induced HSCs activation was relieved by GW4869 pharmaceutic inhibition of EVs secretion. These results revealed a novel mechanism that AFB1 exposure-induced p53-Parkin signal axis regulated mitophagy-dependent hepatocyte-derived EVs to mediate the mitochondria-trafficking intercellular communication between hepatocytes and HSCs in the local hepatotoxic microenvironment to promote the activated HSCs-associated liver fibrogenesis. Our study...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Lei Yang Yun-Lu Gao Shan Jiang Bo Qian Lin Che Jia-Shen Wu Ze-Bang Du Ming-Zhu Wang Yun Yang Yu-Chun Lin Gang Liu Zhong-Ning Lin Source Type: research
FDG PET/CT Imaging of Sarcomatoid Hepatocellular Carcinoma ：A case report
Asian J Surg. 2024 Apr 24:S1015-9584(24)00721-8. doi: 10.1016/j.asjsur.2024.04.061. Online ahead of print.NO ABSTRACTPMID:38664188 | DOI:10.1016/j.asjsur.2024.04.061 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 25, 2024 Category: Surgery Authors: Zhiyan Chen He Wang Xiangrong Yu Source Type: research
