Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Hepatic artery infusion chemotherapy combined with the FOLFOX regimen for the treatment of hepatocellular carcinoma: recent advances and literature review
Expert Rev Anticancer Ther. 2024 Apr 24:1-12. doi: 10.1080/14737140.2024.2346624. Online ahead of print.ABSTRACTINTRODUCTION: The incidence of primary liver cancer (PLC) has experienced a significant global increase, primarily attributed to the rise in hepatocellular carcinoma (HCC). Unfortunately, HCC is often diagnosed in advanced stages, leaving patients with limited treatment options. Therefore, transformation therapy is a crucial approach for long-term survival and radical resection in patients with advanced HCC. Conversion therapy has demonstrated promise in the treatment of advanced HCC. When integrated with the FOL...
Source: Expert Review of Anticancer Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Suqi Zhu Yahan Yu Mingqi Yang Xin Liu Mingkai Lai Jieren Zhong Xiaoguang Zhao Ligong Lu Yanyan Liu Source Type: research
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf
In this study, we aimed to explore the interplay among quercetin, mitochondrial dynamics and mitophagy and whether mitophagy-inhibition synergistically enhances the anti-tumor effects of quercetin. Huh7 and Hep3B cells were utilized for in vitro and in vivo studies. Results showed that quercetin treatment significantly increased the expression of mitochondrial fusion genes (MFN1 and MFN2) and decreased the expression of fission genes (DRP1 and FIS1) in Huh7 and Hep3B cells, leading to a more fused and elongated mitochondrial network. Quercetin upregulated the expression of key mitophagy regulators, PINK1 and PARK2, and enh...
Source: Biochemical and Biophysical Research communications - April 23, 2024 Category: Biochemistry Authors: Fang Chen Source Type: research
LAGE3 promotes angiogenesis on hepatocellular carcinoma by stabilizing VEGFA mRNA
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167196. doi: 10.1016/j.bbadis.2024.167196. Online ahead of print.ABSTRACTRNA modification plays important roles in various physiological and pathological process. LAGE3 is a component of EKC/KEOPS complex, which is probably involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs, but its exact role in HCC is less studied. Our study reveals that LAGE3 exhibits upregulated expression in HCC compared with normal hepatocellular tissue. High expression of LAGE3 promotes hepatocellular cell proliferation and migration. Further i...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Zhuangzhi Cong Huan Zhao Shuyu Zhang Tiangeng You Yanting Xie Source Type: research
Laparoscopic liver resection versus radiofrequency ablation for small hepatocellular carcinoma: randomized clinical trial
CONCLUSION: For small hepatocellular carcinoma, percutaneous radiofrequency ablation provides therapeutic effects similar to those of laparoscopic liver resection.REGISTRATION NUMBER: NCT02243384 (http://www.clinicaltrials.gov).PMID:38650579 | DOI:10.1093/bjs/znae099 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 23, 2024 Category: Surgery Authors: Juxian Song Li Cao Kuansheng Ma Jianwei Li Xiaojun Wang Jian Chen Shuguo Zheng Source Type: research
Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway
J Cell Mol Med. 2024 Apr;28(8):e18335. doi: 10.1111/jcmm.18335.ABSTRACTManagement of hepatocellular carcinoma (HCC) remains challenging due to population growth, frequent recurrence and drug resistance. Targeting of genes involved with the ferroptosis is a promising alternative treatment strategy for HCC. The present study aimed to investigate the effect of dihydroartemisinin (DHA) against HCC and explore the underlying mechanisms. The effects of DHA on induction of ferroptosis were investigated with the measurement of malondialdehyde concentrations, oxidised C11 BODIPY 581/591 staining, as well as subcutaneous xenograft e...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Jie Ji Ziqi Cheng Jie Zhang Jianye Wu Xuanfu Xu Chuanyong Guo Jiao Feng Source Type: research
Identification of PPAR-related differentially expressed genes liver hepatocellular carcinoma and construction of a prognostic model based on data analysis and molecular docking
In this study, single-cell RNA sequencing (scRNA-seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy. The expression of peroxisome proliferator-activated receptors (PPAR)-related genes was analysed in LIHC samples, and primary cell populations, including natural killer cells, T cells, B cells, myeloid cells, endothelial cells, fibroblasts and hepatocytes, were identified. Analysis of the differentially expressed genes (DEGs) between normal and tumour tissues revealed significant changes in gene expression in various cell populations. PPAR activity was evalu...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Yumeng Wang Shuqiang Li Zihang Liu Xuanzheng Li Yifan Yu Hao Liu Source Type: research
Hepatic artery infusion chemotherapy combined with the FOLFOX regimen for the treatment of hepatocellular carcinoma: recent advances and literature review
Expert Rev Anticancer Ther. 2024 Apr 24:1-12. doi: 10.1080/14737140.2024.2346624. Online ahead of print.ABSTRACTINTRODUCTION: The incidence of primary liver cancer (PLC) has experienced a significant global increase, primarily attributed to the rise in hepatocellular carcinoma (HCC). Unfortunately, HCC is often diagnosed in advanced stages, leaving patients with limited treatment options. Therefore, transformation therapy is a crucial approach for long-term survival and radical resection in patients with advanced HCC. Conversion therapy has demonstrated promise in the treatment of advanced HCC. When integrated with the FOL...
Source: Expert Review of Anticancer Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Suqi Zhu Yahan Yu Mingqi Yang Xin Liu Mingkai Lai Jieren Zhong Xiaoguang Zhao Ligong Lu Yanyan Liu Source Type: research
Identification of PPAR-related differentially expressed genes liver hepatocellular carcinoma and construction of a prognostic model based on data analysis and molecular docking
In this study, single-cell RNA sequencing (scRNA-seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy. The expression of peroxisome proliferator-activated receptors (PPAR)-related genes was analysed in LIHC samples, and primary cell populations, including natural killer cells, T cells, B cells, myeloid cells, endothelial cells, fibroblasts and hepatocytes, were identified. Analysis of the differentially expressed genes (DEGs) between normal and tumour tissues revealed significant changes in gene expression in various cell populations. PPAR activity was evalu...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Yumeng Wang Shuqiang Li Zihang Liu Xuanzheng Li Yifan Yu Hao Liu Source Type: research
Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway
J Cell Mol Med. 2024 Apr;28(8):e18335. doi: 10.1111/jcmm.18335.ABSTRACTManagement of hepatocellular carcinoma (HCC) remains challenging due to population growth, frequent recurrence and drug resistance. Targeting of genes involved with the ferroptosis is a promising alternative treatment strategy for HCC. The present study aimed to investigate the effect of dihydroartemisinin (DHA) against HCC and explore the underlying mechanisms. The effects of DHA on induction of ferroptosis were investigated with the measurement of malondialdehyde concentrations, oxidised C11 BODIPY 581/591 staining, as well as subcutaneous xenograft e...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Jie Ji Ziqi Cheng Jie Zhang Jianye Wu Xuanfu Xu Chuanyong Guo Jiao Feng Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
LAGE3 promotes angiogenesis on hepatocellular carcinoma by stabilizing VEGFA mRNA
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167196. doi: 10.1016/j.bbadis.2024.167196. Online ahead of print.ABSTRACTRNA modification plays important roles in various physiological and pathological process. LAGE3 is a component of EKC/KEOPS complex, which is probably involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs, but its exact role in HCC is less studied. Our study reveals that LAGE3 exhibits upregulated expression in HCC compared with normal hepatocellular tissue. High expression of LAGE3 promotes hepatocellular cell proliferation and migration. Further investiga...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Zhuangzhi Cong Huan Zhao Shuyu Zhang Tiangeng You Yanting Xie Source Type: research
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf
In this study, we aimed to explore the interplay among quercetin, mitochondrial dynamics and mitophagy and whether mitophagy-inhibition synergistically enhances the anti-tumor effects of quercetin. Huh7 and Hep3B cells were utilized for in vitro and in vivo studies. Results showed that quercetin treatment significantly increased the expression of mitochondrial fusion genes (MFN1 and MFN2) and decreased the expression of fission genes (DRP1 and FIS1) in Huh7 and Hep3B cells, leading to a more fused and elongated mitochondrial network. Quercetin upregulated the expression of key mitophagy regulators, PINK1 and PARK2, and enh...
Source: Biochemical and Biophysical Research communications - April 23, 2024 Category: Biochemistry Authors: Fang Chen Source Type: research
Laparoscopic liver resection versus radiofrequency ablation for small hepatocellular carcinoma: randomized clinical trial
CONCLUSION: For small hepatocellular carcinoma, percutaneous radiofrequency ablation provides therapeutic effects similar to those of laparoscopic liver resection.REGISTRATION NUMBER: NCT02243384 (http://www.clinicaltrials.gov).PMID:38650579 | DOI:10.1093/bjs/znae099 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 23, 2024 Category: Surgery Authors: Juxian Song Li Cao Kuansheng Ma Jianwei Li Xiaojun Wang Jian Chen Shuguo Zheng Source Type: research
