Liver biopsy in the post-hepatitis C virus era in Japan
In conclusion, pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.PMID:38681127 | PMC:PMC11045496 | DOI:10.3748/wjg.v30.i14.1949 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Yoshihiro Ikura Takako Okubo Yasuhiro Sakai Source Type: research
Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma
CONCLUSION: CircSMARCA5 has the potential to be a more sensitive predictor of HCC disease compared to AFP.PMID:38680002 | DOI:10.31557/APJCP.2024.25.4.1411 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hanan M Bedair Elaf A El-Banna Elhamy A Ahmed Mostafa G Elhelbawy Ahmed Abdelfattah Fatma A Khalaf Mohamed Abdel-Samiee Amal El Sharnoby Source Type: research
Clinical Utility of Cytokeratins for Accurate Diagnosis of Hepatocellular Carcinoma Among Hepatitis C Virus High-Risk Patients
CONCLUSION: CK-HCC score could replace AFP during screening of HCV patients and early detection of HCC.PMID:38679993 | DOI:10.31557/APJCP.2024.25.4.1325 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Mahdi Al Haddad Hatem A El-Mezayen Mohamed El-Kassas Fateheya Metwally Aml El-Sharkawy Source Type: research
Onco-therapeutic Effect of Novel Triterpenoid Compound Oleanolic Acid Isolated and Characterized from the Methanolic Extract of Coldenia procumbens (Linn.)
Appl Biochem Biotechnol. 2024 Apr 29. doi: 10.1007/s12010-024-04959-7. Online ahead of print.ABSTRACTIndia is considered a hub for a wide range of phytochemicals due to its rich biodiversity, which indeed flourished with many folk medicines and treatments. Phytochemicals are secondary metabolites synthesized in plants to protect themselves from deteriorating environmental stress and defense against pathogens. In the present study, we aimed to explore the strong anticancer potential of the bioactive compound present in the leaf extract of Coldenia procumbens (L.). The bioactive compound oleanolic acid was first time reporte...
Source: Applied Biochemistry and Biotechnology - April 29, 2024 Category: Biochemistry Authors: Banupriya Ravichandran Elumalai Sanniyasi Saravanan Govindasamy Kuppusamy Parthasarathi Perumal Source Type: research
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1 ‑autophagy axis
In conclusion, GDF11 may exert tumor-suppressive properties in HCC cells through inactivating the mTORC1 signaling pathway to strengthen autophagy.PMID:38682112 | PMC:PMC11046183 | DOI:10.3892/etm.2024.12540 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Qingyi Wu Chan Fan Kebo Liu Jiefu Tang Source Type: research
Hepatocellular carcinoma and musculoskeletal system: A narrative literature review
World J Gastroenterol. 2024 Apr 21;30(15):2109-2117. doi: 10.3748/wjg.v30.i15.2109.ABSTRACTMusculoskeletal alterations in hepatocellular carcinoma (HCC) are less common than liver-related complications. However, they can significantly impact the quality of life and overall prognosis of patients with HCC. The main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asymptomatic and unapparent during routine clinical evaluations. This narrative literature review aimed to provide a comprehensive overview of the contem...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jelena Jadzic Danijela Djonic Source Type: research
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
CONCLUSION: Taurine exerts therapeutic effects on liver fibrosis via mechanisms that involve inhibition of autophagy and trigger of ferroptosis and ferritinophagy in HSCs to eliminate aHSCs.PMID:38681990 | PMC:PMC11045481 | DOI:10.3748/wjg.v30.i15.2143 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Source Type: research
Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis
CONCLUSION: The combined model, integrating both radiomics and clinical-radiologic characteristics, exhibited excellent performance in HCC with cirrhosis. The K-M curves assessing OS revealed statistically significant differences.PMID:38681988 | PMC:PMC11045480 | DOI:10.3748/wjg.v30.i15.2128 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Gui-Xiang Qian Zi-Ling Xu Yong-Hai Li Jian-Lin Lu Xiang-Yi Bu Ming-Tong Wei Wei-Dong Jia Source Type: research
Liver biopsy in the post-hepatitis C virus era in Japan
In conclusion, pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.PMID:38681127 | PMC:PMC11045496 | DOI:10.3748/wjg.v30.i14.1949 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Yoshihiro Ikura Takako Okubo Yasuhiro Sakai Source Type: research
Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma
This study utilized data from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases to identify basement membrane-related genes differentially expressed in HCC. Through gene co-expression analysis, BM-associated long non-coding RNAs (lncRNAs) were discovered. LncRNAs related to HCC survival were selected via univariate analysis, and a prognostic model was constructed using LASSO regression and multivariate analysis. This model effectively classified HCC patients into high and low-risk groups, uncovering significant differences in prognosis, immune response, mutation, and drug sensitivity. Six BM-related l...
Source: Biochemical Genetics - April 29, 2024 Category: Genetics & Stem Cells Authors: Xuyang Liu Chao Lv Jian Zheng Jingjing Xiao Nan He Jun Du Xianwu Yang Huajian Gu Source Type: research
Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Biochem Genet. 2024 Apr 29. doi: 10.1007/s10528-024-10803-8. Online ahead of print.ABSTRACTLiver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes and progression of LIHC and to provided potential prognostic markers and therapy targets for LIHC. Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues. The differential co-expression genes were extracted by Weig...
Source: Biochemical Genetics - April 29, 2024 Category: Genetics & Stem Cells Authors: Jiawei Sun Zizhen Zhang Jiaru Cai Xiaoping Li Xiaoling Xu Source Type: research
Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis
CONCLUSION: The combined model, integrating both radiomics and clinical-radiologic characteristics, exhibited excellent performance in HCC with cirrhosis. The K-M curves assessing OS revealed statistically significant differences.PMID:38681988 | PMC:PMC11045480 | DOI:10.3748/wjg.v30.i15.2128 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Gui-Xiang Qian Zi-Ling Xu Yong-Hai Li Jian-Lin Lu Xiang-Yi Bu Ming-Tong Wei Wei-Dong Jia Source Type: research
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
CONCLUSION: Taurine exerts therapeutic effects on liver fibrosis via mechanisms that involve inhibition of autophagy and trigger of ferroptosis and ferritinophagy in HSCs to eliminate aHSCs.PMID:38681990 | PMC:PMC11045481 | DOI:10.3748/wjg.v30.i15.2143 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Source Type: research
Hepatocellular carcinoma and musculoskeletal system: A narrative literature review
World J Gastroenterol. 2024 Apr 21;30(15):2109-2117. doi: 10.3748/wjg.v30.i15.2109.ABSTRACTMusculoskeletal alterations in hepatocellular carcinoma (HCC) are less common than liver-related complications. However, they can significantly impact the quality of life and overall prognosis of patients with HCC. The main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asymptomatic and unapparent during routine clinical evaluations. This narrative literature review aimed to provide a comprehensive overview of the contem...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jelena Jadzic Danijela Djonic Source Type: research
Liver biopsy in the post-hepatitis C virus era in Japan
In conclusion, pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.PMID:38681127 | PMC:PMC11045496 | DOI:10.3748/wjg.v30.i14.1949 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Yoshihiro Ikura Takako Okubo Yasuhiro Sakai Source Type: research
