The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
Effectiveness of Semecarpus anacardium fruits in cancer and inflammatory diseases: A mini review
CONCLUSION: The findings will provide more support for investigating SCA fruits in cancer treatment and will furnish thorough reference data and recommendations for future studies on this botanical medication.PMID:38685508 | DOI:10.1016/j.fitote.2024.105978 (Source: Fitoterapia)
Source: Fitoterapia - April 30, 2024 Category: Biochemistry Authors: Ashwini Kumar Mishra S L Neha Ankit Jain Chandrashekhar Y Jagtap Ganesh Dane Shweta Paroha Pravat Kumar Sahoo Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein ‐1 inhibitors: A promising treatment approach for high‐burden hepatocellular carcinoma
ConclusionThe combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu,
Yongkang Xu,
Ye Mao,
Mengting He,
Zhimeng Chen,
Shenglan Huang,
Dan Li,
Yaqin Lv,
Jianbing Wu Tags: RESEARCH ARTICLE Source Type: research
GSE264010 The effects of knock-out PARP1 on HepG2.
Contributors : Qingtian Huang ; Jie Yang ; Yanfen Wang ; Ling QiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGiven the critical role of PARP1 in liver cancer cells, our aim was to find evidence of PARP1-mediated gene regulation in the HepG2 hepatoma cell line. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Hepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy
Hepatitis B virus (HBV) reactivation (HBVr) is a major concern for hepatocellular carcinoma (HCC) patients undergoing hepatic arterial infusion chemotherapy (HAIC) using mFOLFOX6 regimen. There is insufficient... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Lijie Zhang, Yiming Liu, Songlin Song, Joyman Makamure, Heshui Shi, Chuansheng Zheng and Bin Liang Tags: Research Source Type: research
Correlation of pathological examination with indocyanine green (ICG) intensity gradients: a prospective study in patients with liver tumor
ConclusionThe use of ICG fluorescence can be helpful in determining resection margins. Resection of tumor should include complete resection of the green zone shown in the fluorescence image. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 30, 2024 Category: Surgery Source Type: research
Managing hepatocellular carcinoma across the stages: efficacy and outcomes of stereotactic body radiotherapy
ConclusionSBRT offers a compelling option for achieving high local control and promising survival outcomes in HCC. The study supports a radiation dose range of 61–73.1 Gy, coupled with a mean liver dose under 12.6–12.8 Gy as EQD2, to achieve favorable FFLP rates, with acceptable toxicity rates. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 30, 2024 Category: Cancer & Oncology Source Type: research
Adverse Events as Potential Predictive Factors of Activity in Patients with Advanced HCC Treated with Atezolizumab Plus Bevacizumab
ConclusionsAs demonstrated for other therapies, there is also a correlation between the occurrence of AEs and outcomes for patients with HCC for the combination of atezolizumab plus bevacizumab. (Source: Targeted Oncology)
Source: Targeted Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression
. (Source: Cell Cycle)
Source: Cell Cycle - April 30, 2024 Category: Cytology Authors: Yicun LiuLuo XiWeiJie ChenZhixing DongTiaochun ChengLin ChenLinling JuWeihua CaiZhaolian Biana Nantong University Medical School, Nantong, Jiangsu, Chinab Department of Clinical Laboratory, Nantong Third People ’s Hospital, Affiliated Nantong Hospital 3 Source Type: research
A Closer Look at the Innovative PAGED-B Score
I wish to express my thoughts regarding the recent publication titled “PAGE-B incorporating moderate HBV DNA levels predicts risk of HCC among patients entering into HBeAg-positive chronic hepatitis B” 1. Chun et al. developed a new hepatocellular carcinoma (HCC) risk prediction score (PAGED-B score) in non-cirrhotic treatment-naïve adult patients who started ant iviral therapy upon entering into hepatitis B e antigen (HBeAg)-positive chronic hepatitis B from chronic infection which was found to have a high accuracy of predicting the 5-year risk of HCC. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 30, 2024 Category: Gastroenterology Authors: Hanyun Tu Source Type: research
Genes, Vol. 15, Pages 577: Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
ynski
P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), head and neck squamou...
Source: Genes - April 30, 2024 Category: Genetics & Stem Cells Authors: Ruby Khan Bakht Pari Krzysztof Puszynski Tags: Article Source Type: research
Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression
. (Source: Cell Cycle)
Source: Cell Cycle - April 30, 2024 Category: Cytology Authors: Yicun LiuLuo XiWeiJie ChenZhixing DongTiaochun ChengLin ChenLinling JuWeihua CaiZhaolian Biana Nantong University Medical School, Nantong, Jiangsu, Chinab Department of Clinical Laboratory, Nantong Third People ’s Hospital, Affiliated Nantong Hospital 3 Source Type: research
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1 ‑autophagy axis
In conclusion, GDF11 may exert tumor-suppressive properties in HCC cells through inactivating the mTORC1 signaling pathway to strengthen autophagy.PMID:38682112 | PMC:PMC11046183 | DOI:10.3892/etm.2024.12540 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Qingyi Wu Chan Fan Kebo Liu Jiefu Tang Source Type: research
Effectiveness and Safety of Radiofrequency Ablation versus Liver Resection in the Treatment of Early-stage Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
CONCLUSION: During the treatment of hepatocellular carcinoma, hepatectomy demonstrates superior clinical efficacy compared to radiofrequency ablation, particularly in its ability to control tumor recurrence. However, radiofrequency ablation presents with fewer complications and a higher level of safety. These findings can serve as a valuable foundation for clinicians when selecting the most suitable treatment approaches for liver cancer.PMID:38684504 | DOI:10.62713/aic.3155 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Zhifeng Xu Yiren Hu Lidong Huang Source Type: research
Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma
CONCLUSION: CircSMARCA5 has the potential to be a more sensitive predictor of HCC disease compared to AFP.PMID:38680002 | DOI:10.31557/APJCP.2024.25.4.1411 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hanan M Bedair Elaf A El-Banna Elhamy A Ahmed Mostafa G Elhelbawy Ahmed Abdelfattah Fatma A Khalaf Mohamed Abdel-Samiee Amal El Sharnoby Source Type: research
