Platelet, Antiplatelet Therapy and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
Life (Basel). 2024 Apr 4;14(4):473. doi: 10.3390/life14040473.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also an independent risk factor for the development of cardiovascular disease. MASLD has been shown to be independently related to endothelial dysfunction and atherosclerosis. MASLD is characterized by a chronic proinflammatory response that, in turn, may induce a prothrombotic state. Several mechanisms such as endothelial and platelet dysfunction, changes in the coagulative f...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Andrea Boccatonda Lorenza Del Cane Lara Marola Damiano D'Ardes Gianfranco Lessiani Nicoletta di Gregorio Claudio Ferri Francesco Cipollone Carla Serra Francesca Santilli Fabio Piscaglia Source Type: research
Association between ascites Gustave Roussy immune score and the intratumoural microbiome in malignant ascites secondary to hepatocellular carcinoma
CONCLUSIONS: Our present study identified a novel scoring system (aGRIm score) that can predict the survival outcome of patients with malignant ascites secondary to HCC.PMID:38677092 | DOI:10.1016/j.intimp.2024.112097 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 27, 2024 Category: Allergy & Immunology Authors: None ShanTian Yingyun Guo Qingzhi Lan Jiao Li Jiaming Hu Meiqi Qiu Chunxia Guo Weiguo Dong Source Type: research
Incidence of cirrhosis in Iceland-impact of the TraP HepC nationwide HCV elimination program
CONCLUSION: During the past two decades, the incidence of cirrhosis has increased extraordinarily in Iceland, associated with increased alcohol consumption, obesity, and HCV. ALD and MASLD now collectively make up two thirds of cases in Iceland. Following a nationwide elimination program, incidence of HCV cirrhosis has dropped rapidly in Iceland.PMID:38676467 | DOI:10.1080/00365521.2024.2345384 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Authors: Halldor A Haraldsson Sigurdur Olafsson Magnus Gottfredsson Ubaldo Benitez Hernandez Einar S Bjornsson Source Type: research
Investigation of folate-modified EGCG-loaded thermosensitive nanospheres inducing immunogenic cell death and damage-associated molecular patterns in hepatocellular carcinoma
CONCLUSION: EGCG not only hinders the proliferation, migration, and invasion of hepatocellular carcinoma cells and induces apoptosis, but also holds significant clinical promise in the treatment of malignant tumors by promoting ICD and DAMPs secretion.PMID:38677007 | DOI:10.1016/j.bbrc.2024.149976 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 27, 2024 Category: Biochemistry Authors: Li He Lisheng Peng Lianan Wang Xiaoyan Jiang Xinfeng Sun Haiwen Li Tong Lin Zhulin Wu Sen Lin Source Type: research
Construction of an immunosensor based on Cys/Au@TiO < sub > 2 < /sub > modification for the detection of liver cancer marker PIVKA-II
Talanta. 2024 Apr 16;275:126082. doi: 10.1016/j.talanta.2024.126082. Online ahead of print.ABSTRACTAn ultrasensitive immunosensor of Cys/Au@TiO2 based on disposable screen-printed electrodes (SPE) for PIVKA-II detection for hepatocellular carcinoma (HCC) diagnosis was developed by utilizing Cystine (Cys) and nanocomposite Au@TiO2. Firstly, HAuCl4 underwent a reduction reaction with NaBH4, then Au nanoparticles were coated onto TiO2 nanoparticles. Followed, Cys/Au@TiO2 was formed through self-assembly of cysteine to allow the monoclonal antibody of abnormal thrombospondin to bound to the amino group on the surface of the co...
Source: Talanta - April 27, 2024 Category: Chemistry Authors: Lvhong Gong Shengxi Wu Junjie Liu Mingjun Zhang Jinghao Zhuang Doudou Xu Source Type: research
Hypoxia-induced TRPM7 Promotes Glycolytic Metabolism and Progression in Hepatocellular Carcinoma
CONCLUSIONS: TRPM7 was directly transcriptionally regulated by HIF-1α, leading to glycolytic metabolic reprogramming and the promotion of HCC proliferation and metastasis in vitro and in vivo. Our findings suggest that TRPM7 might be a potential diagnostic indicator and therapeutic target for HCC.PMID:38677534 | DOI:10.1016/j.ejphar.2024.176601 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Fengbo Zhao Weili Yu Jingyan Hu Yi Xia YuXuan Li Siqi Liu Aifen Liu Chengniu Wang Hong Zhang Lei Zhang Jianwu Shi Source Type: research
Platelet, Antiplatelet Therapy and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
Life (Basel). 2024 Apr 4;14(4):473. doi: 10.3390/life14040473.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also an independent risk factor for the development of cardiovascular disease. MASLD has been shown to be independently related to endothelial dysfunction and atherosclerosis. MASLD is characterized by a chronic proinflammatory response that, in turn, may induce a prothrombotic state. Several mechanisms such as endothelial and platelet dysfunction, changes in the coagulative f...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Andrea Boccatonda Lorenza Del Cane Lara Marola Damiano D'Ardes Gianfranco Lessiani Nicoletta di Gregorio Claudio Ferri Francesco Cipollone Carla Serra Francesca Santilli Fabio Piscaglia Source Type: research
Potential Antitumor Activity of Combined Lycopene and Sorafenib against Solid Ehrlich Carcinoma via Targeting Autophagy and Apoptosis and Suppressing Proliferation
Pharmaceuticals (Basel). 2024 Apr 19;17(4):527. doi: 10.3390/ph17040527.ABSTRACTAn FDA-approved kinase inhibitor called sorafenib (SOR) is used to treat primary kidney and liver cancer as well as to stop the spread of advanced breast cancer. Side effects from SOR, such as palmar-plantar erythrodysesthesia syndrome, can negatively impact an individual's quality of life. There are a lot of data supporting the importance of lycopene (LYC) in preventing cancer. The antitumor properties of the combination of sorafenib and lycopene were examined in this study. A viability test against MDA-MB-231 was used to assess the anticancer...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Thanaa A El-Masry Maysa M F El-Nagar Nageh A El Mahdy Fatemah A Alherz Reham Taher Enass Y Osman Source Type: research
Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma
In conclusion, PD-1 gene expression is associated with OS and PFS and CTLA-4 gene expression is associated with OS, whereas the serum biomarkers analyzed in this study show no significant correlation with survival in HCC. Hence, PD-1 and CTLA-4 expressed in PBMCs are considered potential prognostic biomarkers for patients with HCC that can facilitate prediction of malignancy, response to currently available HCC treatments, and overall survival.PMID:38672574 | DOI:10.3390/cancers16081493 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Ji Ah Lee Hei-Gwon Choi Hyuk Soo Eun Jiyoon Bu Tae Min Jang Jeongdong Lee Chae Yeon Son Min Seok Kim Woo Sun Rou Seok Hyun Kim Byung Seok Lee Ha Neul Kim Tae Hee Lee Hong Jae Jeon Source Type: research
Recommencement of atezolizumab with associated pulmonary sarcoid ‐like reaction
An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab was identified as the likely culprit. He was treated with prednisolone, resul ting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab. AbstractAn 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atez...
Source: Respirology Case Reports - April 27, 2024 Category: Respiratory Medicine Authors: Khai Tam,
Michael Wallace,
Siobhain Mulrennan Tags: CASE REPORT Source Type: research
GSE216716 Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma [WES]
Contributors : Christel F Ramirez ; Serena Vegna ; Daniel de GrootSeries Type : OtherOrganism : Mus musculusHepatocellular carcinoma (HCC) is a highly heterogenous disease associated with an equally dynamic tumor microenvironment (TME). We generated somatic HCC mouse models bearing clinically-relevant oncogenic driver combinations that faithfully recapitulated different human HCC subclasses. Using WES data, we explored the tumor mutation frequencies between models and compared them with human datasets. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 27, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)
AbstractNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease worldwide, consisting of a broad spectrum of diseases such as simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatic inflammation plays a key role in the pathophysiology of NAFLD. Inflammatory mediators such as cytokines and chemokines are considered as contributing factors to NAFLD development and progression. In the present study, we aimed to investigate the inflammatory protein signatures as predictive disease-specific markers for non-alcoholic fatty liver disease (NA...
Source: Inflammation - April 27, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Circular RNA circ_0000517 regulates hepatocellular carcinoma development via miR-326/IGF1R axis
(Source: Cancer Cell International)
Source: Cancer Cell International - April 27, 2024 Category: Cancer & Oncology Authors: Shuwei He, Jianzeng Yang, Shitao Jiang, Yuan Li and Xingmin Han Tags: Retraction Note Source Type: research
Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)
AbstractNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease worldwide, consisting of a broad spectrum of diseases such as simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatic inflammation plays a key role in the pathophysiology of NAFLD. Inflammatory mediators such as cytokines and chemokines are considered as contributing factors to NAFLD development and progression. In the present study, we aimed to investigate the inflammatory protein signatures as predictive disease-specific markers for non-alcoholic fatty liver disease (NA...
Source: Inflammation - April 27, 2024 Category: Allergy & Immunology Source Type: research
Cancers, Vol. 16, Pages 1706: Dissecting the Puzzling Roles of FAM46C: A Multifaceted Pan-Cancer Tumour Suppressor with Increasing Clinical Relevance
Manfrini
FAM46C is a well-established tumour suppressor with a role that is not completely defined or universally accepted. Although FAM46C expression is down-modulated in several tumours, significant mutations in the FAM46C gene are only found in multiple myeloma (MM). Consequently, its tumour suppressor activity has primarily been studied in the MM context. However, emerging evidence suggests that FAM46C is involved also in other cancer types, namely colorectal, prostate and gastric cancer and squamous cell and hepatocellular carcinoma, where FAM46C expression was found to be significantly reduced in tumoural versus...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Giancarlo Lai Federica De Grossi Ilaria Catusi Elisa Pesce Nicola Manfrini Tags: Review Source Type: research
