Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma

In conclusion, PD-1 gene expression is associated with OS and PFS and CTLA-4 gene expression is associated with OS, whereas the serum biomarkers analyzed in this study show no significant correlation with survival in HCC. Hence, PD-1 and CTLA-4 expressed in PBMCs are considered potential prognostic biomarkers for patients with HCC that can facilitate prediction of malignancy, response to currently available HCC treatments, and overall survival.PMID:38672574 | DOI:10.3390/cancers16081493

Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Ji Ah Lee Hei-Gwon Choi Hyuk Soo Eun Jiyoon Bu Tae Min Jang Jeongdong Lee Chae Yeon Son Min Seok Kim Woo Sun Rou Seok Hyun Kim Byung Seok Lee Ha Neul Kim Tae Hee Lee Hong Jae Jeon Source Type: research