No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | PMC:PMC11058422 | DOI:10.3348/kjr.2023.1225 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Effectiveness of Semecarpus anacardium fruits in cancer and inflammatory diseases: A mini review
CONCLUSION: The findings will provide more support for investigating SCA fruits in cancer treatment and will furnish thorough reference data and recommendations for future studies on this botanical medication.PMID:38685508 | DOI:10.1016/j.fitote.2024.105978 (Source: Fitoterapia)
Source: Fitoterapia - April 30, 2024 Category: Biochemistry Authors: Ashwini Kumar Mishra S L Neha Ankit Jain Chandrashekhar Y Jagtap Ganesh Dane Shweta Paroha Pravat Kumar Sahoo Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
Cholangiocarcinoma and Occupational Exposure to Asbestos: Insights From the Italian Pooled Cohort Study
CONCLUSION: Further studies are needed to explore the association between occupational exposure to asbestos and CC. Record linkage was hampered due to incomplete coverage of the study areas and periods by Cancer Registries. The identification of CC among unspecific histology cases is fundamental to establish more effective and targeted liver cancer screening strategies.PMID:38686579 | DOI:10.23749/mdl.v115i2.14649 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Stefania Curti Mena Gallo Daniela Ferrante Francesca Bella Lorenza Boschetti Veronica Casotto Marcello Ceppi Daniela Cervino Lucia Fazzo Ugo Fedeli Paolo Giorgi Rossi Lucia Giovannetti Paolo Girardi Cecilia Lando Enrica Migliore Lucia Miligi Enrico Oddone Source Type: research
No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | PMC:PMC11058422 | DOI:10.3348/kjr.2023.1225 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Pre-diagnostic plasma proteomics profile for hepatocellular carcinoma
CONCLUSION: However, the limited number of HCC cases in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.PMID:38688524 | DOI:10.1093/jnci/djae079 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 30, 2024 Category: Genetics & Stem Cells Authors: Xinyuan Zhang Longgang Zhao Long H Ngo Simon T Dillon Xuesong Gu Michelle Lai Tracey G Simon Andrew T Chan Edward L Giovannucci Towia A Libermann Xuehong Zhang Source Type: research
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research
YBX1 as a prognostic biomarker and potential therapeutic target in hepatocellular carcinoma: A comprehensive investigation through bioinformatics analysis and in vitro study
CONCLUSIONS: YBX-1 serves as a favorable prognostic indicator in various cancers, particularly in liver hepatocellular carcinoma. Targeting YBX1 in HCC offers potential therapeutic strategies. This work paves the way for fresh insights into targeted therapeutic approaches for cancers, especially benefiting liver hepatocellular carcinoma patients.PMID:38688048 | DOI:10.1016/j.tranon.2024.101965 (Source: Translational Oncology)
Source: Translational Oncology - April 30, 2024 Category: Cancer & Oncology Authors: Zizhen Li Wenhua Lu Feng Yin Amin Huang Source Type: research
Effect of stability of PTEN on hepatocellular carcinoma
CONCLUSIONS: On the one hand, our study revealed that CRISPR-Cas12a might play an important role in the screening and prognosis of HCC as a new clinical method to detect PTEN mutation.PMID:38687946 | DOI:10.4103/jcrt.jcrt_349_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yilin Hu Hongliang Mei Tianji Luan Huiling Sun Qiping Lu Rong Liu Source Type: research
No-Touch Radiofrequency Ablation Using Twin Cooled Wet Electrodes for Recurrent Hepatocellular Carcinoma Following Locoregional Treatments
CONCLUSION: NT-RFA using TCW electrodes is a safe and effective treatment for recurrent HCC, with 6.0% (ITT analysis) and 1.3% (PP analysis) cumulative incidence of LTP at 2 and 3-year follow-ups.PMID:38685734 | PMC:PMC11058422 | DOI:10.3348/kjr.2023.1225 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Seong Jun Hong Jae Hyun Kim Jeong Hee Yoon Jeong Hoan Park Jung-Hwan Yoon Yoon Jun Kim Su Jong Yu Eun Ju Cho Jeong Min Lee Source Type: research
Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
CONCLUSIONS: Toripalimab plus bevacizumab showed a favorable efficacy and safety profile, supporting further studies of this combination regimen as a first-line treatment of advanced HCC.PMID:38687583 | DOI:10.1158/1078-0432.CCR-24-0006 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Yajin Chen Cheng-You Du Shunli Shen Wu Zhang Yunfeng Shan Ang Lyu Jianhui Wu Changzhen Shang Xuan Luo Jinxing Wei Heng Xiao Jianguo Qiu Yunpeng Hua Shutong Wang Ting Wang Shengjie Dai Shuhao Zhang Bingying Xie Yinghao Wu Chunyi Hao Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01224-z. Online ahead of print.ABSTRACTRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression. The molecular mechanistic interplay between miRNAs and their regulatory factors, RNA-binding proteins (RBPs) and exoribonucleases, has been revealed to play a critical role in tumorigenesis. Moreover, recent studies have shown that the proliferation of hepatocellular carcinoma (HCC)-causing hepatitis C virus (HCV) is also characterized by close ...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Yoona Seo Jiho Rhim Jong Heon Kim Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01223-0. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechanisms that lead to the upregulation of PLAGL2 in HCC remain unclear. The present study revealed that stress-induced epinephrine increased the expression of PLAGL2, thereby promoting the progression of HCC. Furthermore, PLAGL2 knockdown inhibited epinephrine-induced HCC development. Mechanistically, epinephrine upregulated ubiquitin-s...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1 α to induce the polarization of tumor-associated macrophages
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01214-1. Online ahead of print.ABSTRACTTumor-associated macrophages (TAMs) are vital contributors to the growth, metastasis, and therapeutic resistance of various cancers, including hepatocellular carcinoma (HCC). However, the exact phenotype of TAMs and the mechanisms underlying their modulation for therapeutic purposes have not been determined. Here, we present compelling evidence that glutamine-derived aspartate in TAMs stimulates spermidine production through the polyamine synthesis pathway, thereby increasing the translation efficiency of HIF-1α via eIF5A hypusination....
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Dong-Ho Kim Yoo Na Kang Jonghwa Jin Mihyang Park Daehoon Kim Ghilsuk Yoon Jae Won Yun Jaebon Lee Soo Young Park Yu Rim Lee Jun-Kyu Byun Yeon-Kyung Choi Keun-Gyu Park Source Type: research
