Hypoxia-induced TRPM7 Promotes Glycolytic Metabolism and Progression in Hepatocellular Carcinoma

CONCLUSIONS: TRPM7 was directly transcriptionally regulated by HIF-1α, leading to glycolytic metabolic reprogramming and the promotion of HCC proliferation and metastasis in vitro and in vivo. Our findings suggest that TRPM7 might be a potential diagnostic indicator and therapeutic target for HCC.PMID:38677534 | DOI:10.1016/j.ejphar.2024.176601

Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Fengbo Zhao Weili Yu Jingyan Hu Yi Xia YuXuan Li Siqi Liu Aifen Liu Chengniu Wang Hong Zhang Lei Zhang Jianwu Shi Source Type: research