Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Aug 2:PHARMREV-AR-2022-000799. doi: 10.1124/pharmrev.122.000799. Online ahead of print.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic not a hydrostatic gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplifiy the proposal and indicate both paracellular and transcellular water flow into h...
Source: Pharmacological Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Aug 2:PHARMREV-AR-2022-000799. doi: 10.1124/pharmrev.122.000799. Online ahead of print.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic not a hydrostatic gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplifiy the proposal and indicate both paracellular and transcellular water flow into h...
Source: Pharmacological Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Aug 2:PHARMREV-AR-2022-000799. doi: 10.1124/pharmrev.122.000799. Online ahead of print.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic not a hydrostatic gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplifiy the proposal and indicate both paracellular and transcellular water flow into h...
Source: Pharmacological Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Sep;75(5):1036-1042. doi: 10.1124/pharmrev.122.000799. Epub 2023 Aug 2.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic, not a hydrostatic, gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplify the initial proposal and indicate both paracellular and transcellular water flow into hepatic ...
Source: Pharmacognosy Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Interpretation of the structure-function relationships in synthetic HDL nanodiscs
The objectives of the research are the study of: sHDL with different compositions; apoA-I mimetic peptides in sHDL with/without LCAT; location, orientation and positioning of LCAT on sHDL; how apoA-I mimetic peptides modulate LCAT activity. (Source: Atherosclerosis)
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: L. Giorgi, A. Niemel ä, E.-P. Kumpula, P. Parkkila, O. Natri, J. Huiskonen, A. Koivuniemi Source Type: research
Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
Int J Biol Macromol. 2023 Jul 26:125980. doi: 10.1016/j.ijbiomac.2023.125980. Online ahead of print.ABSTRACTA nanostructured device based on poly(vinyl alcohol) (PVA) loaded with a cross-linked chitosan (CH) emulsion, soy lecithin, and peppermint essential oil (Mentha piperita) was designed for topical applications using an electrospinning instrument coupled to a rotary drum collector. Different suspensions were obtained by varying the PVA to emulsion ratio (PVA:Em) 87.5:12.5, 82:18, and 75:25, using a PVA solution as a control. ATR-FTIR spectra confirmed the interactions among the components of the system. Scanning electr...
Source: International Journal of Biological Macromolecules - July 28, 2023 Category: Biochemistry Authors: Javier Lamarra Sandra Rivero Adriana Pinotti Daniel Lopez Source Type: research
Self ‐Assembly of Selenium‐Doped Carbon Quantum Dots as Antioxidants for Hepatic Ischemia‐Reperfusion Injury Management (Small 30/2023)
Hepatic Ischemia-Reperfusion Injury ManagementSelenium-doped carbon quantum dots (Se-CQDs) with excellent anti-oxidation capability protect hepatocytes from apoptosis by limiting damage from oxidative stress. Se-CQDs-lecithin nanoparticles are developed through a supramolecular self-assembly mainly driven by noncovalent interactions, which effectively scavenge reactive oxygen species and inhibit the release of inflammatory cytokines, thus exerting beneficial therapeutic efficacy on hepatic ischemia-reperfusion injury. More details can be found in article number2300217 by Yu Xia, Huaping Xu, Guocan Yu, Zuobing Chen, and co-...
Source: Small - July 26, 2023 Category: Nanotechnology Authors: Bing Bai,
Shaolong Qi,
Kai Yang,
Xinyang Yu,
Ruijun Jian,
Tianfang Zhang,
Daming Wang,
Hongbo Meng,
Yifan Zhao,
Yu Xia,
Huaping Xu,
Guocan Yu,
Zuobing Chen Tags: Frontispiece Source Type: research
Purification and Characterization of the Lecithin-Dependent Thermolabile Hemolysin Vhe1 from the Vibrio sp. Strain MA3 Associated with Mass Mortality of Pearl Oyster (Pinctada fucata)
Curr Microbiol. 2023 Jul 17;80(9):288. doi: 10.1007/s00284-023-03409-7.ABSTRACTIn a previous study, we isolated a Vibrio sp. strain MA3 and its virulence factor, a hemolysin encoded by vhe1. This strain is associated with mass mortalities of the pearl oyster Pinctada fucata. In the present study, the vhe1 gene from strain MA3 was cloned and its encoded product was purified and characterized. Our results show that the vhe1 gene encodes a protein of 417 amino acids with an estimated molecular mass of 47.2 kDa and a pI of 5.14. The deduced protein, Vhe1, was found to contain the conserved amino acid sequence (GDSL motif) of t...
Source: Current Microbiology - July 17, 2023 Category: Microbiology Authors: Akihiro Sakatoku Kaito Hatano Kosei Takada Ryota Shimizu Takaya Suzuki Makoto Seki Nobuo Suzuki Daisuke Tanaka Shogo Nakamura Tadashi Isshiki Source Type: research
Lecithin-amended montmorillonite clays enhance the antibacterial effect of barrier creams
The objective of this study was to assess in vitro antibacterial activity of barrier cream (EVB) formulations containing either calcium montmorillonite (CM) or lecithin-amended montmorillonite (CML). All ingredients were generally recognized as safe (GRAS), and clay minerals were specifically studied due to their known ability to adsorb numerous toxins of human clinical relevance. Characterization of the EVB formulations showed good spreadability, pH, appearance, unity, viscosity, and no evidence of phase separation. Colony forming, disk diffusion susceptibility, and agar dilution assays were used to determine the minimal ...
Source: Colloids and Surfaces - July 14, 2023 Category: Biotechnology Authors: Meichen Wang Timothy D Phillips Source Type: research
Soybean lecithin and cholesterol-loaded cyclodextrin in combination to enhances the cryosurvival of dairy goat semen
The objective of the study was to examine the effect of soy lecithin (SL) and cholesterol loaded cryclodestrin (CLC) on cryo-survival of sperm cryopreserved in the presence or absence of seminal plasma in Saanen dairy goats. Tris-based dilutions containing various concentrations of SL (0, 0.5%, 1.0% or 2.0%) and CLC (0, 2.0 g/L, 4.0 g/L or 6.0 g/L CLC) were used to cryopreserve Saanen dairy goat sperm. The quality of frozen-thawed sperm, including progressive motility, viability, acrosome and plasma membrane integrity, as well as fertility were detected. Results found that the optimal combination of the two cryoprotectants...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Rong Li Hubei Zhao Bowen Li Siqi Wang Song Hua Source Type: research
Lecithin-amended montmorillonite clays enhance the antibacterial effect of barrier creams
The objective of this study was to assess in vitro antibacterial activity of barrier cream (EVB) formulations containing either calcium montmorillonite (CM) or lecithin-amended montmorillonite (CML). All ingredients were generally recognized as safe (GRAS), and clay minerals were specifically studied due to their known ability to adsorb numerous toxins of human clinical relevance. Characterization of the EVB formulations showed good spreadability, pH, appearance, unity, viscosity, and no evidence of phase separation. Colony forming, disk diffusion susceptibility, and agar dilution assays were used to determine the minimal ...
Source: Colloids and Surfaces - July 14, 2023 Category: Biotechnology Authors: Meichen Wang Timothy D Phillips Source Type: research
Soybean lecithin and cholesterol-loaded cyclodextrin in combination to enhances the cryosurvival of dairy goat semen
The objective of the study was to examine the effect of soy lecithin (SL) and cholesterol loaded cryclodestrin (CLC) on cryo-survival of sperm cryopreserved in the presence or absence of seminal plasma in Saanen dairy goats. Tris-based dilutions containing various concentrations of SL (0, 0.5%, 1.0% or 2.0%) and CLC (0, 2.0 g/L, 4.0 g/L or 6.0 g/L CLC) were used to cryopreserve Saanen dairy goat sperm. The quality of frozen-thawed sperm, including progressive motility, viability, acrosome and plasma membrane integrity, as well as fertility were detected. Results found that the optimal combination of the two cryoprotectants...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Rong Li Hubei Zhao Bowen Li Siqi Wang Song Hua Source Type: research
Soybean lecithin and cholesterol-loaded cyclodextrin in combination to enhances the cryosurvival of dairy goat semen
The objective of the study was to examine the effect of soy lecithin (SL) and cholesterol loaded cryclodestrin (CLC) on cryo-survival of sperm cryopreserved in the presence or absence of seminal plasma in Saanen dairy goats. Tris-based dilutions containing various concentrations of SL (0, 0.5%, 1.0% or 2.0%) and CLC (0, 2.0 g/L, 4.0 g/L or 6.0 g/L CLC) were used to cryopreserve Saanen dairy goat sperm. The quality of frozen-thawed sperm, including progressive motility, viability, acrosome and plasma membrane integrity, as well as fertility were detected. Results found that the optimal combination of the two cryoprotectants...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Rong Li Hubei Zhao Bowen Li Siqi Wang Song Hua Source Type: research
Soybean lecithin and cholesterol-loaded cyclodextrin in combination to enhances the cryosurvival of dairy goat semen
The objective of the study was to examine the effect of soy lecithin (SL) and cholesterol loaded cryclodestrin (CLC) on cryo-survival of sperm cryopreserved in the presence or absence of seminal plasma in Saanen dairy goats. Tris-based dilutions containing various concentrations of SL (0, 0.5%, 1.0% or 2.0%) and CLC (0, 2.0 g/L, 4.0 g/L or 6.0 g/L CLC) were used to cryopreserve Saanen dairy goat sperm. The quality of frozen-thawed sperm, including progressive motility, viability, acrosome and plasma membrane integrity, as well as fertility were detected. Results found that the optimal combination of the two cryoprotectants...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Rong Li Hubei Zhao Bowen Li Siqi Wang Song Hua Source Type: research
Soybean lecithin and cholesterol-loaded cyclodextrin in combination to enhances the cryosurvival of dairy goat semen
The objective of the study was to examine the effect of soy lecithin (SL) and cholesterol loaded cryclodestrin (CLC) on cryo-survival of sperm cryopreserved in the presence or absence of seminal plasma in Saanen dairy goats. Tris-based dilutions containing various concentrations of SL (0, 0.5%, 1.0% or 2.0%) and CLC (0, 2.0 g/L, 4.0 g/L or 6.0 g/L CLC) were used to cryopreserve Saanen dairy goat sperm. The quality of frozen-thawed sperm, including progressive motility, viability, acrosome and plasma membrane integrity, as well as fertility were detected. Results found that the optimal combination of the two cryoprotectants...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Rong Li Hubei Zhao Bowen Li Siqi Wang Song Hua Source Type: research
