Comparative assessment of emulsifiers for in vitro ruminal gas production and fermentation measurements: Tween 80 is a suitable emulsifier
This study aimed to evaluate seven emulsifiers ’ impact on in vitro ruminal fermentation using the Hohenheim Gas Test in order to identify the most inert emulsifier. Rumen fluids were collected from three non-lactating Original Brown-Swiss cannulated cows before morning feeding and incubated for 24 h with a basal diet in triplicates. The em ulsifiers tested were ethanol, ethyl acetate, propylene glycol, glycerol, ethylene glycol, soy lecithin, and Tween® 80, each in two dosages (0.5% or 1% v/v). The untreated basal diet served as control. Compared to control, in vitro organic matter digestibility was enhanced by ethy...
Source: Journal of Animal Physiology and Animal Nutrition - January 15, 2024 Category: Zoology Authors: Xiaoge Sun,
Yang Li,
Katrin Giller,
Carmen Kunz,
Melissa Terranova,
Mutian Niu Tags: ORIGINAL ARTICLE Source Type: research
Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation
This study aims to investigate potential mechanism(s) of oxygen delivery and in particular the possible use of oxygen-loaded nanobubbles in preventing bone metastasis via effects on osteoclasts. Lecithin-based nanobubbles preferentially interacted with phagocytic cells (monocytes, osteoclasts) via a combination of lipid transfer, clathrin-dependent endocytosis and phagocytosis. This interaction caused general suppression of osteoclast differentiation via inhibition of cell fusion. Additionally, repeat exposure to oxygen-loaded nanobubbles inhibited osteoclast formation to a greater extent than nitrogen-loaded nanobubbles. ...
Source: Biomaterials - January 13, 2024 Category: Materials Science Authors: Helen J Knowles Alexandra Vasilyeva Mihir Sheth Oliver Pattinson Jonathan May Robin M H Rumney Philippa A Hulley Duncan B Richards Dario Carugo Nicholas D Evans Eleanor Stride Source Type: research
Maternal supplementation of DHA does not cause fetal ductus arteriosus constriction: randomized controlled trial
CONCLUSIONS: Even though complete safety of DHA has not been tested, this randomized clinical trial shows that third trimester maternal supplementation of DHA, at the doses and period used, does not result in inhibition of PGE2 and does not cause ductus arteriosus constriction, providing the basis for post-market surveillance studies with larger numbers, to allow the best clinical reassurance. This article is protected by copyright. All rights reserved.PMID:38214544 | DOI:10.1002/uog.27584 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - January 12, 2024 Category: Radiology Authors: P Zielinsky D R Alves J D Á Foresti D B Guimar ães K P Zucatti I Vian Source Type: research
TPGS-modified Chitosan Nanoparticles of EGFR Inhibitor: Physicochemical and In vitro Evaluation against HepG2 Cell Lines
CONCLUSION: It was observed that the optimized GFN-NP1 formulation successfully internalized and inhibited the growth of HepG2 cells. Hence, it can be concluded that the prepared NPs can be a new therapeutic option for treating liver cancer.PMID:38204256 | DOI:10.2174/0115672018268315231206045504 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 11, 2024 Category: Drugs & Pharmacology Authors: Mahendra Singh None Alka Prashant Shukla Zhi-Hong Wen Chou-Yuan Ko Ramachandran Vinayagam Source Type: research
Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin
This study aimed to develop a nanosuspension to deliver THP to tumor tissues more efficiently. Fatty-acid-modified THPs (FA-THPs; octanoic acid, dodecanoic acid, palmitic acid-THPs) were synthesized to increase the hydrophobicity of THP. Nanosuspensions of these FA-THPs were then prepared using an antisolvent precipitation technique. Among the FA-THPs, the most efficiently drug-loaded nanosuspension was obtained from palmitic acid-THP (pal-THP) using an aqueous antisolvent containing bovine serum albumin as a stabilizer. The pal-THP nanoparticles in the nanosuspension were confirmed to be of optimal size (100-125 nm) for d...
Source: Chemical and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takashi Hasegawa Kenji Tsukigawa Kindness Commey Mina Sakuragi Shuhei Imoto Kazuaki Taguchi Koji Nishi Masaki Otagiri Keishi Yamasaki Source Type: research
Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations
Yakugaku Zasshi. 2024;144(1):87-97. doi: 10.1248/yakushi.23-00155.ABSTRACTI have been studying the improvement of drug solubility using solid dispersion and skin-applied formulations. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hyadrogenated lecithin; this facilitates drug permeation through the skin. The promoting effect differs with the nature of the oil used...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Makiko Fujii Source Type: research
Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin
This study aimed to develop a nanosuspension to deliver THP to tumor tissues more efficiently. Fatty-acid-modified THPs (FA-THPs; octanoic acid, dodecanoic acid, palmitic acid-THPs) were synthesized to increase the hydrophobicity of THP. Nanosuspensions of these FA-THPs were then prepared using an antisolvent precipitation technique. Among the FA-THPs, the most efficiently drug-loaded nanosuspension was obtained from palmitic acid-THP (pal-THP) using an aqueous antisolvent containing bovine serum albumin as a stabilizer. The pal-THP nanoparticles in the nanosuspension were confirmed to be of optimal size (100-125 nm) for d...
Source: Chemical and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takashi Hasegawa Kenji Tsukigawa Kindness Commey Mina Sakuragi Shuhei Imoto Kazuaki Taguchi Koji Nishi Masaki Otagiri Keishi Yamasaki Source Type: research
Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations
Yakugaku Zasshi. 2024;144(1):87-97. doi: 10.1248/yakushi.23-00155.ABSTRACTI have been studying the improvement of drug solubility using solid dispersion and skin-applied formulations. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hyadrogenated lecithin; this facilitates drug permeation through the skin. The promoting effect differs with the nature of the oil used...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Makiko Fujii Source Type: research
Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin
This study aimed to develop a nanosuspension to deliver THP to tumor tissues more efficiently. Fatty-acid-modified THPs (FA-THPs; octanoic acid, dodecanoic acid, palmitic acid-THPs) were synthesized to increase the hydrophobicity of THP. Nanosuspensions of these FA-THPs were then prepared using an antisolvent precipitation technique. Among the FA-THPs, the most efficiently drug-loaded nanosuspension was obtained from palmitic acid-THP (pal-THP) using an aqueous antisolvent containing bovine serum albumin as a stabilizer. The pal-THP nanoparticles in the nanosuspension were confirmed to be of optimal size (100-125 nm) for d...
Source: Chemical and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takashi Hasegawa Kenji Tsukigawa Kindness Commey Mina Sakuragi Shuhei Imoto Kazuaki Taguchi Koji Nishi Masaki Otagiri Keishi Yamasaki Source Type: research
Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations
Yakugaku Zasshi. 2024;144(1):87-97. doi: 10.1248/yakushi.23-00155.ABSTRACTI have been studying the improvement of drug solubility using solid dispersion and skin-applied formulations. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hyadrogenated lecithin; this facilitates drug permeation through the skin. The promoting effect differs with the nature of the oil used...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Makiko Fujii Source Type: research
Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin
This study aimed to develop a nanosuspension to deliver THP to tumor tissues more efficiently. Fatty-acid-modified THPs (FA-THPs; octanoic acid, dodecanoic acid, palmitic acid-THPs) were synthesized to increase the hydrophobicity of THP. Nanosuspensions of these FA-THPs were then prepared using an antisolvent precipitation technique. Among the FA-THPs, the most efficiently drug-loaded nanosuspension was obtained from palmitic acid-THP (pal-THP) using an aqueous antisolvent containing bovine serum albumin as a stabilizer. The pal-THP nanoparticles in the nanosuspension were confirmed to be of optimal size (100-125 nm) for d...
Source: Chemical and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takashi Hasegawa Kenji Tsukigawa Kindness Commey Mina Sakuragi Shuhei Imoto Kazuaki Taguchi Koji Nishi Masaki Otagiri Keishi Yamasaki Source Type: research
Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations
Yakugaku Zasshi. 2024;144(1):87-97. doi: 10.1248/yakushi.23-00155.ABSTRACTI have been studying the improvement of drug solubility using solid dispersion and skin-applied formulations. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hyadrogenated lecithin; this facilitates drug permeation through the skin. The promoting effect differs with the nature of the oil used...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Makiko Fujii Source Type: research
Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin
This study aimed to develop a nanosuspension to deliver THP to tumor tissues more efficiently. Fatty-acid-modified THPs (FA-THPs; octanoic acid, dodecanoic acid, palmitic acid-THPs) were synthesized to increase the hydrophobicity of THP. Nanosuspensions of these FA-THPs were then prepared using an antisolvent precipitation technique. Among the FA-THPs, the most efficiently drug-loaded nanosuspension was obtained from palmitic acid-THP (pal-THP) using an aqueous antisolvent containing bovine serum albumin as a stabilizer. The pal-THP nanoparticles in the nanosuspension were confirmed to be of optimal size (100-125 nm) for d...
Source: Chemical and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takashi Hasegawa Kenji Tsukigawa Kindness Commey Mina Sakuragi Shuhei Imoto Kazuaki Taguchi Koji Nishi Masaki Otagiri Keishi Yamasaki Source Type: research
Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations
Yakugaku Zasshi. 2024;144(1):87-97. doi: 10.1248/yakushi.23-00155.ABSTRACTI have been studying the improvement of drug solubility using solid dispersion and skin-applied formulations. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hyadrogenated lecithin; this facilitates drug permeation through the skin. The promoting effect differs with the nature of the oil used...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Makiko Fujii Source Type: research
