Effects of adding antioxidant nanoparticles on sperm parameters of non-human species after the freezing and thawing process: A systematic review and meta-analysis
In conclusion, our results indicated the positive effects of nanoparticles as cryoprotectant agents on post-thawed sperm motility, viability, and membrane integrity.PMID:37666048 | DOI:10.1016/j.anireprosci.2023.107323 (Source: Animal Reproduction Science)
Source: Animal Reproduction Science - September 4, 2023 Category: Zoology Authors: Zahra Asadi Roya Safari-Faramani Faranak Aghaz Source Type: research
Effects of adding antioxidant nanoparticles on sperm parameters of non-human species after the freezing and thawing process: A systematic review and meta-analysis
In conclusion, our results indicated the positive effects of nanoparticles as cryoprotectant agents on post-thawed sperm motility, viability, and membrane integrity.PMID:37666048 | DOI:10.1016/j.anireprosci.2023.107323 (Source: Animal Reproduction Science)
Source: Animal Reproduction Science - September 4, 2023 Category: Zoology Authors: Zahra Asadi Roya Safari-Faramani Faranak Aghaz Source Type: research
Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis
Acta Biochim Biophys Sin (Shanghai). 2023 Aug 31. doi: 10.3724/abbs.2023222. Online ahead of print.ABSTRACTAging is a pressing global health issue that is linked to various diseases, such as diabetes and Alzheimer's disease. It is well known that glycation plays a pathological role in the aging process and age-related diseases. Thus, it is of great significance to discover protein glycation at an early stage for monitoring and intervention in the aging process. However, the endogenous age-related early-stage glycated proteome remains insufficiently profiled. To address this research gap, our study focuses on assessing glyc...
Source: Acta Biochimica et Biophysica Sinica - September 1, 2023 Category: Biochemistry Authors: Xinyue Ren Linlin Wu Lei Zhang Yang Liu Guoli Wang Haojie Lu Source Type: research
Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis
Acta Biochim Biophys Sin (Shanghai). 2023 Aug 31. doi: 10.3724/abbs.2023222. Online ahead of print.ABSTRACTAging is a pressing global health issue that is linked to various diseases, such as diabetes and Alzheimer's disease. It is well known that glycation plays a pathological role in the aging process and age-related diseases. Thus, it is of great significance to discover protein glycation at an early stage for monitoring and intervention in the aging process. However, the endogenous age-related early-stage glycated proteome remains insufficiently profiled. To address this research gap, our study focuses on assessing glyc...
Source: Acta Biochimica et Biophysica Sinica - September 1, 2023 Category: Biochemistry Authors: Xinyue Ren Linlin Wu Lei Zhang Yang Liu Guoli Wang Haojie Lu Source Type: research
Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis
Acta Biochim Biophys Sin (Shanghai). 2023 Aug 31. doi: 10.3724/abbs.2023222. Online ahead of print.ABSTRACTAging is a pressing global health issue that is linked to various diseases, such as diabetes and Alzheimer's disease. It is well known that glycation plays a pathological role in the aging process and age-related diseases. Thus, it is of great significance to discover protein glycation at an early stage for monitoring and intervention in the aging process. However, the endogenous age-related early-stage glycated proteome remains insufficiently profiled. To address this research gap, our study focuses on assessing glyc...
Source: Acta Biochimica et Biophysica Sinica - September 1, 2023 Category: Biochemistry Authors: Xinyue Ren Linlin Wu Lei Zhang Yang Liu Guoli Wang Haojie Lu Source Type: research
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
AbstractWhile low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascular risk factor, HDL-C-rising therapies largely failed, suggesting the importance of both HDL functions and individual subspecies. Indeed HDL particles are highly heterogeneous, with small, dense pre-beta-HDLs being considered highly biologically active but remaining poorly studied, largely reflecting difficulties for their purification. We developed an original experimental approach allowing the isolation of sufficient amounts of human pre-beta-HDLs and revealing the specificity of their proteo...
Source: Basic Research in Cardiology - August 28, 2023 Category: Cardiology Source Type: research
Analysis of the Macular Region Following Panretinal Photocoagulation for the Treatment of Diabetic Retinopathy Using Optical Coherence Tomography
CONCLUSIONS: PRP emerges as a highly valuable approach in the management of DR. It contributes to retinal thickness improvement within the macular region and inflammation reduction, and also enhances therapeutic outcomes, minimizes adverse reactions, and optimizes patients' quality of life. These findings warrant further clinical adoption and widespread promotion.PMID:37632956 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Haijing Cao Kai Wang Qing Pan Chaopeng Li Source Type: research
Analysis of the Macular Region Following Panretinal Photocoagulation for the Treatment of Diabetic Retinopathy Using Optical Coherence Tomography
CONCLUSIONS: PRP emerges as a highly valuable approach in the management of DR. It contributes to retinal thickness improvement within the macular region and inflammation reduction, and also enhances therapeutic outcomes, minimizes adverse reactions, and optimizes patients' quality of life. These findings warrant further clinical adoption and widespread promotion.PMID:37632956 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Haijing Cao Kai Wang Qing Pan Chaopeng Li Source Type: research
Analysis of the Macular Region Following Panretinal Photocoagulation for the Treatment of Diabetic Retinopathy Using Optical Coherence Tomography
CONCLUSIONS: PRP emerges as a highly valuable approach in the management of DR. It contributes to retinal thickness improvement within the macular region and inflammation reduction, and also enhances therapeutic outcomes, minimizes adverse reactions, and optimizes patients' quality of life. These findings warrant further clinical adoption and widespread promotion.PMID:37632956 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Haijing Cao Kai Wang Qing Pan Chaopeng Li Source Type: research
Analysis of the Macular Region Following Panretinal Photocoagulation for the Treatment of Diabetic Retinopathy Using Optical Coherence Tomography
CONCLUSIONS: PRP emerges as a highly valuable approach in the management of DR. It contributes to retinal thickness improvement within the macular region and inflammation reduction, and also enhances therapeutic outcomes, minimizes adverse reactions, and optimizes patients' quality of life. These findings warrant further clinical adoption and widespread promotion.PMID:37632956 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Haijing Cao Kai Wang Qing Pan Chaopeng Li Source Type: research
Integrating Artificial Intelligence with Quality by Design in the Formulation of Lecithin/Chitosan Nanoparticles of a Poorly Water-Soluble Drug
AAPS PharmSciTech. 2023 Aug 8;24(6):169. doi: 10.1208/s12249-023-02609-5.ABSTRACTThe aim of the current study is to explore the potential of artificial intelligence (AI) when integrated with Quality by Design (QbD) approach in the formulation of a poorly water-soluble drug, for its potential use in carcinoma. Silymarin is used as a model drug for its potential effectiveness in liver cancer. A detailed QbD approach was applied. The effect of the critical process parameters was studied on each of the particle size, size distribution, and entrapment efficiency. Response surface designs were applied in the screening and optimi...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Marwa H S Dawoud Islam S Mannaa Amira Abdel-Daim Nabila M Sweed Source Type: research
Integrating Artificial Intelligence with Quality by Design in the Formulation of Lecithin/Chitosan Nanoparticles of a Poorly Water-Soluble Drug
AAPS PharmSciTech. 2023 Aug 8;24(6):169. doi: 10.1208/s12249-023-02609-5.ABSTRACTThe aim of the current study is to explore the potential of artificial intelligence (AI) when integrated with Quality by Design (QbD) approach in the formulation of a poorly water-soluble drug, for its potential use in carcinoma. Silymarin is used as a model drug for its potential effectiveness in liver cancer. A detailed QbD approach was applied. The effect of the critical process parameters was studied on each of the particle size, size distribution, and entrapment efficiency. Response surface designs were applied in the screening and optimi...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Marwa H S Dawoud Islam S Mannaa Amira Abdel-Daim Nabila M Sweed Source Type: research
Integrating Artificial Intelligence with Quality by Design in the Formulation of Lecithin/Chitosan Nanoparticles of a Poorly Water-Soluble Drug
AAPS PharmSciTech. 2023 Aug 8;24(6):169. doi: 10.1208/s12249-023-02609-5.ABSTRACTThe aim of the current study is to explore the potential of artificial intelligence (AI) when integrated with Quality by Design (QbD) approach in the formulation of a poorly water-soluble drug, for its potential use in carcinoma. Silymarin is used as a model drug for its potential effectiveness in liver cancer. A detailed QbD approach was applied. The effect of the critical process parameters was studied on each of the particle size, size distribution, and entrapment efficiency. Response surface designs were applied in the screening and optimi...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Marwa H S Dawoud Islam S Mannaa Amira Abdel-Daim Nabila M Sweed Source Type: research
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Aug 2:PHARMREV-AR-2022-000799. doi: 10.1124/pharmrev.122.000799. Online ahead of print.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic not a hydrostatic gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplifiy the proposal and indicate both paracellular and transcellular water flow into h...
Source: Pharmacological Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
