The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research

The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research

Towards quantifying biomarkers for respiratory distress in preterm infants: Machine learning on mid infrared spectroscopy of lipid mixtures
This study presents a lung lipid model of five lipids present in lung surfactant and varies each in a systematic approach to evaluate the ability of machine learning models to predict the lipid concentrations, the L/S ratio and to quantify the uncertainty in the predictions using the jackknife + -after-bootstrap and variant bootstrap methods. We establish the L/S ratio can be determined with an uncertainty of approximately ±0.3 mol/mol and we further identify the 5 most prominent wavenumbers associated with each machine learning model.PMID:38615457 | DOI:10.1016/j.talanta.2024.126062 (Source: Talanta)
Source: Talanta - April 14, 2024 Category: Chemistry Authors: Waseem Ahmed Aneesh Vincent Veluthandath Jens Madsen Howard W Clark Ahilanandan Dushianthan Anthony D Postle James S Wilkinson Ganapathy Senthil Murugan Source Type: research

Ultrasound modification on milk fat globule membrane and soy lecithin to improve the physicochemical properties, microstructure and stability of mimicking human milk fat emulsions
This study can provide a reference for the screening of milk fat globules mimicking membrane materials and the further utilization and development of ultrasound in infant formula.PMID:38608436 | DOI:10.1016/j.ultsonch.2024.106873 (Source: Ultrasonics Sonochemistry)
Source: Ultrasonics Sonochemistry - April 12, 2024 Category: Chemistry Authors: Qian Ma Tao Zhou Zhong Wang Yanjie Zhao Xiaodong Li Lu Liu Xiuxiu Zhang Kouadio Jean Eric-Parfait Kouame Shuo Chen Source Type: research

Chitosan lecithin nanocomposite based electrochemical biosensor for glycine detection in biological matrices
Colloids Surf B Biointerfaces. 2024 Apr 10;238:113901. doi: 10.1016/j.colsurfb.2024.113901. Online ahead of print.ABSTRACTIncreased glycine concentrations are associated with altered metabolism of cancer cells and is reflected in the bodily fluids of the brain cancer patients. Various studies have been conducted in past to detect glycine as an imaging biomarker via NMR Spectroscopy tools. However, the use is limited because of the low concentration and different in vivo detection due to overlapping of peaks with myo-inositol in same spectral position. Alongside, little is known about the electrochemical potential of Glycin...
Source: Colloids and Surfaces - April 12, 2024 Category: Biotechnology Authors: Neha Saini Deepak Yadav Mandar Shirolkar Sivasubramanian Murugappan Nanasaheb Thorat Atul Kulkarni Source Type: research

Chitosan lecithin nanocomposite based electrochemical biosensor for glycine detection in biological matrices
Colloids Surf B Biointerfaces. 2024 Apr 10;238:113901. doi: 10.1016/j.colsurfb.2024.113901. Online ahead of print.ABSTRACTIncreased glycine concentrations are associated with altered metabolism of cancer cells and is reflected in the bodily fluids of the brain cancer patients. Various studies have been conducted in past to detect glycine as an imaging biomarker via NMR Spectroscopy tools. However, the use is limited because of the low concentration and different in vivo detection due to overlapping of peaks with myo-inositol in same spectral position. Alongside, little is known about the electrochemical potential of Glycin...
Source: Colloids and Surfaces - April 12, 2024 Category: Biotechnology Authors: Neha Saini Deepak Yadav Mandar Shirolkar Sivasubramanian Murugappan Nanasaheb Thorat Atul Kulkarni Source Type: research

Subcritical water-assisted fish gelatin hydrolysis for astaxanthin-loaded fish oil emulsion stability
In this study, subcritical water hydrolysis (SWH)-modified LMW fish gelatin (SWHG) was produced from 110 °C to 180 °C and used to enhance the AST steadiness in oil/water emulsions in the presence of an emulsifier, lecithin. In the prepared emulsions, the surface charge increased while droplet size decreased with the decrease in gelatin MW due to the reduced thickness of the adsorbed gelatin membrane. LMW gelatin and lecithin could form a firm-absorbed layer on the droplet surface by electrostatic interaction between amide groups of gelatin molecules and phosphate groups of lecithin, thus stabilizing the emulsions. SWHG i...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Truc Cong Ho Vikash Chandra Roy Weerathunga Arachchige Shran Chamika Md Sadek Ali Ahmed Redwan Haque Jin-Seok Park Hee-Jeong Lee Byun-Soo Chun Source Type: research

Subcritical water-assisted fish gelatin hydrolysis for astaxanthin-loaded fish oil emulsion stability
In this study, subcritical water hydrolysis (SWH)-modified LMW fish gelatin (SWHG) was produced from 110 °C to 180 °C and used to enhance the AST steadiness in oil/water emulsions in the presence of an emulsifier, lecithin. In the prepared emulsions, the surface charge increased while droplet size decreased with the decrease in gelatin MW due to the reduced thickness of the adsorbed gelatin membrane. LMW gelatin and lecithin could form a firm-absorbed layer on the droplet surface by electrostatic interaction between amide groups of gelatin molecules and phosphate groups of lecithin, thus stabilizing the emulsions. SWHG i...
Source: International Journal of Biological Macromolecules - March 30, 2024 Category: Biochemistry Authors: Truc Cong Ho Vikash Chandra Roy Weerathunga Arachchige Shran Chamika Md Sadek Ali Ahmed Redwan Haque Jin-Seok Park Hee-Jeong Lee Byun-Soo Chun Source Type: research

Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform
Colloids Surf B Biointerfaces. 2024 Mar 19;237:113858. doi: 10.1016/j.colsurfb.2024.113858. Online ahead of print.ABSTRACTHerein, lipid-polymer core-shell hybrid nanoparticles composed of poly(D,L-lactic-co-glycolic acid) (PLGA)/lecithin (PLNs) were synthesized through lipid-based surface engineering. Lipids were absorbed onto the surface of the PLGA core to enhance the advantages of polymeric nanoparticles and liposomes. The amounts of lipids and encapsulation of the drug nicardipine hydrochloride (NCH) in the PLNs were studied. NCH-loaded PLNs (NCH-PLNs) were produced in high yield (66%) with a high encapsulation efficie...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Nopparuj Soomherun Narumol Kreua-Ongarjnukool Saowapa Thumsing Niyomthai Sorayouth Chumnanvej Source Type: research

Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform
Colloids Surf B Biointerfaces. 2024 Mar 19;237:113858. doi: 10.1016/j.colsurfb.2024.113858. Online ahead of print.ABSTRACTHerein, lipid-polymer core-shell hybrid nanoparticles composed of poly(D,L-lactic-co-glycolic acid) (PLGA)/lecithin (PLNs) were synthesized through lipid-based surface engineering. Lipids were absorbed onto the surface of the PLGA core to enhance the advantages of polymeric nanoparticles and liposomes. The amounts of lipids and encapsulation of the drug nicardipine hydrochloride (NCH) in the PLNs were studied. NCH-loaded PLNs (NCH-PLNs) were produced in high yield (66%) with a high encapsulation efficie...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Nopparuj Soomherun Narumol Kreua-Ongarjnukool Saowapa Thumsing Niyomthai Sorayouth Chumnanvej Source Type: research

Optimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies
Fungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations. Soya lecithin and Span 80 were chosen as independent variables, and the effect of these v...
Source: Frontiers in Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 19, 2024 Category: Physiology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 19, 2024 Category: Physiology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research