< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 19, 2024 Category: Physiology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 19, 2024 Category: Physiology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research

Bioremediation of trichloroethylene-contaminated groundwater using green carbon-releasing substrate with pH control capability
Environ Pollut. 2024 Mar 15:123768. doi: 10.1016/j.envpol.2024.123768. Online ahead of print.ABSTRACTIn this research, a sustainable substrate, termed green and long-lasting substrate (GLS), featuring a blend of emulsified substrate (ES) and modified rice husk ash (m-RHA) was devised. The primary objective was to facilitate the bioremediation of groundwater contaminated with trichloroethylene (TCE) using innovative GLS for slow carbon release and pH control. The GLS was concocted by homogenizing a mixture of soybean oil, surfactants (Simple Green™ and soya lecithin), and m-RHA, ensuring a gradual release of carbon source...
Source: Environmental Pollution - March 17, 2024 Category: Environmental Health Authors: Hsin-Chia Lee Ssu-Ching Chen Yih-Terng Sheu Chao-Ling Yao Kai-Hung Lo Chih-Ming Kao Source Type: research

Bioremediation of trichloroethylene-contaminated groundwater using green carbon-releasing substrate with pH control capability
Environ Pollut. 2024 Mar 15:123768. doi: 10.1016/j.envpol.2024.123768. Online ahead of print.ABSTRACTIn this research, a sustainable substrate, termed green and long-lasting substrate (GLS), featuring a blend of emulsified substrate (ES) and modified rice husk ash (m-RHA) was devised. The primary objective was to facilitate the bioremediation of groundwater contaminated with trichloroethylene (TCE) using innovative GLS for slow carbon release and pH control. The GLS was concocted by homogenizing a mixture of soybean oil, surfactants (Simple Green™ and soya lecithin), and m-RHA, ensuring a gradual release of carbon source...
Source: Environmental Pollution - March 17, 2024 Category: Environmental Health Authors: Hsin-Chia Lee Ssu-Ching Chen Yih-Terng Sheu Chao-Ling Yao Kai-Hung Lo Chih-Ming Kao Source Type: research

The soybean lecithin-cyclodextrin-vitamin E complex nanoparticles stabilized Pickering emulsions for the delivery of β-carotene: Physicochemical properties and in vitro digestion
Int J Biol Macromol. 2024 Mar 14:130742. doi: 10.1016/j.ijbiomac.2024.130742. Online ahead of print.ABSTRACTIn this work, soybean lecithin (LC) was used to modify β-cyclodextrin (β-CD) by esterifying with hydrophobic fat chains to become amphiphilic (LC-CD), and vitamin E (VE) was encapsulated in former modified β-CD complexes (LC-CD-VE), the new Pickering emulsions stabilized by LC-CD-VE and LC-CD complexes for the delivery of β-carotene (BC) were created. The surface tension, contact angle, zeta potential, and particle size were used to assess the changes in complexes nanoparticles at various pH values. Furthermore, ...
Source: International Journal of Biological Macromolecules - March 16, 2024 Category: Biochemistry Authors: Lei Hao Junjiao Li Jin Mao Qi Zhou Qianchun Deng Zhaofei Chai Lei Zheng Jie Shi Source Type: research

The soybean lecithin-cyclodextrin-vitamin E complex nanoparticles stabilized Pickering emulsions for the delivery of β-carotene: Physicochemical properties and in vitro digestion
Int J Biol Macromol. 2024 Mar 14:130742. doi: 10.1016/j.ijbiomac.2024.130742. Online ahead of print.ABSTRACTIn this work, soybean lecithin (LC) was used to modify β-cyclodextrin (β-CD) by esterifying with hydrophobic fat chains to become amphiphilic (LC-CD), and vitamin E (VE) was encapsulated in former modified β-CD complexes (LC-CD-VE), the new Pickering emulsions stabilized by LC-CD-VE and LC-CD complexes for the delivery of β-carotene (BC) were created. The surface tension, contact angle, zeta potential, and particle size were used to assess the changes in complexes nanoparticles at various pH values. Furthermore, ...
Source: International Journal of Biological Macromolecules - March 16, 2024 Category: Biochemistry Authors: Lei Hao Junjiao Li Jin Mao Qi Zhou Qianchun Deng Zhaofei Chai Lei Zheng Jie Shi Source Type: research

Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis
AAPS PharmSciTech. 2024 Mar 12;25(3):57. doi: 10.1208/s12249-024-02774-1.ABSTRACTPsoriasis is a complex and persistent autoimmune skin disease. The present research focused on the therapeutic evaluation of betulin-loaded nanostructured lipid carriers (BE-NLCs) towards managing psoriasis. The BE-NLCs were synthesized using the emulsification cum solidification method, exhibiting a spherical shape with a particle size of 183.5±1.82nm and a narrow size distribution window (PDI: 0.142±0.05). A high zeta potential -38.64±0.05mV signifies the relative stability of the nano-dispersion system. BE-NLCs show a drug loading and en...
Source: AAPS PharmSciTech - March 13, 2024 Category: Drugs & Pharmacology Authors: Prativa Biswasroy Deepak Pradhan Dilip Kumar Pradhan Goutam Ghosh Goutam Rath Source Type: research

Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis
AAPS PharmSciTech. 2024 Mar 12;25(3):57. doi: 10.1208/s12249-024-02774-1.ABSTRACTPsoriasis is a complex and persistent autoimmune skin disease. The present research focused on the therapeutic evaluation of betulin-loaded nanostructured lipid carriers (BE-NLCs) towards managing psoriasis. The BE-NLCs were synthesized using the emulsification cum solidification method, exhibiting a spherical shape with a particle size of 183.5±1.82nm and a narrow size distribution window (PDI: 0.142±0.05). A high zeta potential -38.64±0.05mV signifies the relative stability of the nano-dispersion system. BE-NLCs show a drug loading and en...
Source: AAPS PharmSciTech - March 13, 2024 Category: Drugs & Pharmacology Authors: Prativa Biswasroy Deepak Pradhan Dilip Kumar Pradhan Goutam Ghosh Goutam Rath Source Type: research

Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis
AAPS PharmSciTech. 2024 Mar 12;25(3):57. doi: 10.1208/s12249-024-02774-1.ABSTRACTPsoriasis is a complex and persistent autoimmune skin disease. The present research focused on the therapeutic evaluation of betulin-loaded nanostructured lipid carriers (BE-NLCs) towards managing psoriasis. The BE-NLCs were synthesized using the emulsification cum solidification method, exhibiting a spherical shape with a particle size of 183.5±1.82nm and a narrow size distribution window (PDI: 0.142±0.05). A high zeta potential -38.64±0.05mV signifies the relative stability of the nano-dispersion system. BE-NLCs show a drug loading and en...
Source: AAPS PharmSciTech - March 13, 2024 Category: Drugs & Pharmacology Authors: Prativa Biswasroy Deepak Pradhan Dilip Kumar Pradhan Goutam Ghosh Goutam Rath Source Type: research

Longitudinal analysis of clinical and laboratory biomarkers in a patient with Familial Lecithin: Cholesterol acyltransferase deficiency (FLD) and accelerated eGFR decline: a case study.
Familial LCAT Deficiency (FLD) is an ultra-rare autosomal recessive disorder caused by complete loss of function variants in the gene encoding for lecithin:cholesterol acyltransferase (LCAT).1FLD is characterized by very low HDL-Cholesterol (HDL-C) levels, often reduced LDL-Cholesterol (LDL-C) levels, elevated and variable triglycerides (TG), and the presence of abnormal lipoproteins such as lipoprotein X (LpX), which is believed to be nephrotoxic.1 Despite having significantly reduced HDL-C levels, FLD patients are not higher risk of atherosclerotic cardiovascular disease. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 13, 2024 Category: Lipidology Authors: Gregory Alfaro, Jay Pendyala, Michael Sulewski, Michael Miller, Cecilia Vitali, Marina Cuchel Tags: Case Study Source Type: research

Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles
Int J Biol Macromol. 2024 Mar 5:130649. doi: 10.1016/j.ijbiomac.2024.130649. Online ahead of print.ABSTRACTBone Morphogenetic Protein 4 (BMP4) is crucial for bone and cartilage tissue regeneration, essential in medical tissue engineering, cosmetology, and aerospace. However, its cost and degradation susceptibility pose significant clinical challenges. To enhance its osteogenic activity while reducing dosage and administration frequency, we developed a novel long-acting BMP4 delivery system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PBVHx) nanoparticles with soybean lecithin-modified BMP4 (sBP...
Source: International Journal of Biological Macromolecules - March 7, 2024 Category: Biochemistry Authors: Xiao-Yun Huang Xiao-Xiang Zhou Hui Yang Tao Xu Jin-Wei Dao Li Bian Dai-Xu Wei Source Type: research

Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles
Int J Biol Macromol. 2024 Mar 5:130649. doi: 10.1016/j.ijbiomac.2024.130649. Online ahead of print.ABSTRACTBone Morphogenetic Protein 4 (BMP4) is crucial for bone and cartilage tissue regeneration, essential in medical tissue engineering, cosmetology, and aerospace. However, its cost and degradation susceptibility pose significant clinical challenges. To enhance its osteogenic activity while reducing dosage and administration frequency, we developed a novel long-acting BMP4 delivery system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PBVHx) nanoparticles with soybean lecithin-modified BMP4 (sBP...
Source: International Journal of Biological Macromolecules - March 7, 2024 Category: Biochemistry Authors: Xiao-Yun Huang Xiao-Xiang Zhou Hui Yang Tao Xu Jin-Wei Dao Li Bian Dai-Xu Wei Source Type: research

Construction of nanoparticles from blueberry anthocyanins-lecithin/gum Arabic improves lipid droplet accumulation and gut microbiota disturbance in HFD-induced obese mice
Int J Biol Macromol. 2024 Mar 2:130595. doi: 10.1016/j.ijbiomac.2024.130595. Online ahead of print.ABSTRACTThe digestive instability of anthocyanins (ACNs) limits their application in food nutrition, especially precision nutrition. Blueberry ACNs-loaded nanoparticles (Lipo/GA-ACNs NPs) were prepared using gum arabic (GA) as the delivery carrier and liposomal vesicles (Lipo) prepared from soy lecithin as the targeting scaffold. The average particle size of the NPs was 99.4 nm, and the polydispersion index (PDI) was 0.46. The results showed that the presence of the Lipo-GA matrix enhanced the NPs' in vitro stability and anti...
Source: International Journal of Biological Macromolecules - March 4, 2024 Category: Biochemistry Authors: Zhen Cheng Wenwen Wei Yi Chen Aihua Xu Yuehua Wang Bin Li Source Type: research