Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
Biol Pharm Bull. 2023 Dec 14. doi: 10.1248/bpb.b23-00704. Online ahead of print.ABSTRACTWe investigated the effect of the rheological properties and composition of lecithin reverse wormlike micelles (LRWs) on the skin permeation of a model of a hydrophilic drug to determine whether LRWs support uniform hydrophilic drug/oil-based formulations and good drug penetrate into skin. Here, we prepared LRWs with D (-)-ribose (RI) or glycerol (GL) as polar compounds, liquid paraffin (LP) or isopropyl myristate (IPM) as oils, and 6-carboxyfluorescein (CF) as a model for a hydrophilic drug, and evaluated the rheological properties and...
Source: Biological and Pharmaceutical Bulletin - December 13, 2023 Category: Drugs & Pharmacology Authors: Yoshiyuki Miyasaka Kaname Hashizaki Kohsuke Shibasaki Makiko Fujii Hiroyuki Taguchi Source Type: research
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: < em > In-vitro < /em > characterization and < em > In-vivo < /em > pharmacokinetic investigations
CONCLUSION: The CAND-PFLC mixed micelle formulation demonstrated improved performance compared to pure CAND, indicating its potential as a promising oral drug delivery system for the effective treatment of hypertension.PMID:38079333 | DOI:10.1080/03639045.2023.2293122 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - December 11, 2023 Category: Drugs & Pharmacology Authors: Homraj Mahajan Hemil S Patel Debes Ray Vinod K Aswal Rakesh K Sharma Hemal Tandel Source Type: research
Enhancement of antimicrobial and antibiofilm activities of liposomal fatty acids
In this study, soy lecithin liposomes loaded with lauric acid (LA) and myristoleic acid (MA) were formulated using an emulsification method, and their antibiofilm properties were evaluated. The physio-chemical properties of the most potent liposome were characterized using a zeta sizer, transmission electron microscopy (TEM), fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy. TEM and zeta sizer analysis of the liposome revealed a homogeneous spherical structure with an average size of 159.2 nm and zeta potential of - 5.4 mV. The unilamellar liposomes loaded with LA at 0.1-0.5 µg/mL achie...
Source: Colloids and Surfaces - December 9, 2023 Category: Biotechnology Authors: Devaraj Bharathi Jin-Hyung Lee Jintae Lee Source Type: research
Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice
CONCLUSIONS: α-Asarone in PPE inhibited inflammation-associated atheroma formation and promoted hepatic HDL-C trafficking in dyslipidemic mice.PMID:38053825 | PMC:PMC10694419 | DOI:10.4162/nrp.2023.17.6.1099 (Source: Atherosclerosis)
Source: Atherosclerosis - December 6, 2023 Category: Cardiology Authors: Sin-Hye Park Young Eun Sim Min-Kyung Kang Dong Yeon Kim Il-Jun Kang Soon Sung Lim Young-Hee Kang Source Type: research
A Case Report Of Tangier Disease Presents With Acute Sensorimotor Polyneuropathy And Its Treatment Approach
Tangier disease (TD) is a very rare disorder, inherited autosomal recessively due to mutations in encoding ATP-binding cassette transporter 1 (ABCA1) gene on chromosome 9q311,2,3. In lipid metabolism, apolipoprotein (Apo) A-1 takes cholesterol esters from peripheral tissues via ABCA1 receptors and then transfers them to HDL-3 with the help of lecithin-cholesterol acyltransferase1,2,3. HDL-3 density range is predominantly comprised of particles containing apoA-1 and apoA-2 (small HDL, very small HDL). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - December 1, 2023 Category: Lipidology Authors: Saniye Karabudak, Vildan G üzel, Beril Güler, Bülent Uyanık, Azize Esra Gürsoy Tags: Case Study Source Type: research
Flipped C-Terminal Ends of apoA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs
CONCLUSIONS: We present a mechanism for the enhanced CEC of small HDLs. In smaller particles, the C-termini of the 2 antiparallel molecules of apoA1 are "flipped" off the lipid surface of HDL. This extended conformation allows them to engage with ABCA1. In contrast, the C-termini of larger HDLs are unable to interact productively with ABCA1 because they form a helical bundle that strongly adheres to the lipid on the particle. Enhanced CEC, as seen with the smaller particles, predicts decreased cardiovascular disease risk. Thus, extra-small and small HDLs may be key mediators and indicators of the cardioprotective effects o...
Source: Circulation - November 29, 2023 Category: Cardiology Authors: Yi He Chiara Pavanello Patrick M Hutchins Chongren Tang Mohsen Pourmousa Tomas Vaisar Hyun D Song Richard W Pastor Alan T Remaley Ira J Goldberg Tina Costacou W Sean Davidson Karin E Bornfeldt Laura Calabresi Jere P Segrest Jay W Heinecke Source Type: research
Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
Study on the Nasal Drug Delivery System of NMD Liposomes In Situ Thermosensitive Gel
AAPS PharmSciTech. 2023 Nov 16;24(8):234. doi: 10.1208/s12249-023-02679-5.ABSTRACTNimodipine (NMD) is a 1,4-dihydropyridine calcium antagonist that is effective in the prevention and treatment of cerebral arterial vasospasm and cerebral ischemic injury caused by subarachnoid hemorrhage. Since the drug itself is highly insoluble in water and has low oral bioavailability, while injectable formulations may cause pain and inflammation, the blood-brain barrier (BBB) prevents the effective delivery of therapeutic agents to the brain tissue. Therefore, in the present study, NMD liposomes were prepared by ethanol injection and inn...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Lin Ma HeYing Mao Jing Xu Jingshu Piao Mingguan Piao Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
Study on the Nasal Drug Delivery System of NMD Liposomes In Situ Thermosensitive Gel
AAPS PharmSciTech. 2023 Nov 16;24(8):234. doi: 10.1208/s12249-023-02679-5.ABSTRACTNimodipine (NMD) is a 1,4-dihydropyridine calcium antagonist that is effective in the prevention and treatment of cerebral arterial vasospasm and cerebral ischemic injury caused by subarachnoid hemorrhage. Since the drug itself is highly insoluble in water and has low oral bioavailability, while injectable formulations may cause pain and inflammation, the blood-brain barrier (BBB) prevents the effective delivery of therapeutic agents to the brain tissue. Therefore, in the present study, NMD liposomes were prepared by ethanol injection and inn...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Lin Ma HeYing Mao Jing Xu Jingshu Piao Mingguan Piao Source Type: research
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
AAPS PharmSciTech. 2023 Nov 16;24(8):235. doi: 10.1208/s12249-023-02690-w.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary administration can make the drug directly reach the lung lesion location and reduce systemic toxic and side effects. The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonary fibrosis was investigated. Len liposomes (Len-Lip) were prepared from soybean lecithin, cholesterol (Chol), and medicine in different weight ratios by thin film hydration method. The Len-Lip were...
Source: AAPS PharmSciTech - November 16, 2023 Category: Drugs & Pharmacology Authors: Zhilin Luo Liyuan Ji Hongting Liu Yao Sun Conglu Zhao Xiang Xu Xiaoting Gu Xiaoyu Ai Cheng Yang Source Type: research
