Interdigitation of lipids for vesosomal formulation of ergotamine tartrate with caffeine: a futuristic trend of intranasal route
CONCLUSIONS: The stable vesosomes prepared using interdigitation of saturated phospholipids proved to be a viable option for ERG when administered intranasally for better absorption and bioavailability coupled with ease of administration gaining wider patient acceptance.PMID:38158799 | DOI:10.1080/03639045.2023.2301018 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - December 30, 2023 Category: Drugs & Pharmacology Authors: Preeti Dali Pravin Shende Source Type: research
Transferosomes stabilized hydrogel incorporated rhodomyrtone-rich extract from Rhodomyrtus tomentosa leaf fortified with phosphatidylcholine for the management of skin and soft-tissue infections
Biotechnol Lett. 2023 Dec 27. doi: 10.1007/s10529-023-03452-1. Online ahead of print.ABSTRACTRhodomyrtus tomentosa leaf (RT)-incorporated transferosomes were developed with lecithin and cholesterol blends with edge activators at different ratios. RT-transferosomes were characterized and employed in transferosomal gel formulations for the management of skin and soft-tissue infections. The optimized formulation entrapped up to 81.90 ± 0.31% of RT with spherical vesicles (405.3 ± 2.0 nm), polydispersity index value of 0.16 ± 0.08, and zeta potential of - 61.62 ± 0.86 mV. Total phenolic and flavonoid contents of RT-transfe...
Source: Biotechnology Letters - December 27, 2023 Category: Biotechnology Authors: Julalak Chorachoo Ontong Sudarshan Singh Thanyaluck Siriyong Supayang P Voravuthikunchai Source Type: research
Transferosomes stabilized hydrogel incorporated rhodomyrtone-rich extract from Rhodomyrtus tomentosa leaf fortified with phosphatidylcholine for the management of skin and soft-tissue infections
Biotechnol Lett. 2023 Dec 27. doi: 10.1007/s10529-023-03452-1. Online ahead of print.ABSTRACTRhodomyrtus tomentosa leaf (RT)-incorporated transferosomes were developed with lecithin and cholesterol blends with edge activators at different ratios. RT-transferosomes were characterized and employed in transferosomal gel formulations for the management of skin and soft-tissue infections. The optimized formulation entrapped up to 81.90 ± 0.31% of RT with spherical vesicles (405.3 ± 2.0 nm), polydispersity index value of 0.16 ± 0.08, and zeta potential of - 61.62 ± 0.86 mV. Total phenolic and flavonoid contents of RT-transfe...
Source: Biotechnology Letters - December 27, 2023 Category: Biotechnology Authors: Julalak Chorachoo Ontong Sudarshan Singh Thanyaluck Siriyong Supayang P Voravuthikunchai Source Type: research
Enhancing oral bioavailability of Ca-DTPA by Self Double Emulsifying Drug Delivery System (SDEDDS)
CONCLUSION: The present studies have clearly demonstrated that SDEDDS could readily form w/o/w double emulsions in vivo with enhanced in vitro and in vivo oral bioavailability. Therefore considerable augmentation in the rate and extent of oral drug absorption ratified the better performance of the SDEDDS in enhancing the bioavailability of Ca-DTPA.PMID:38145420 | DOI:10.1080/03639045.2023.2298881 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - December 25, 2023 Category: Drugs & Pharmacology Authors: Vaishali Agrawal Anjali Priyadarshani Dharam Pal Pathak Nidhi Sandal Source Type: research
Enhancing the physicochemical stability and antioxidant activity of cape gooseberry calyx extract through nanoencapsulation in soy lecithin liposomes
Colloids Surf B Biointerfaces. 2023 Nov 23;234:113662. doi: 10.1016/j.colsurfb.2023.113662. Online ahead of print.ABSTRACTThe focus of this study was on the development, physicochemical characterisation and evaluation of the antioxidant activity of cape gooseberry calyx extract loaded into nanoliposomal systems. Various nanoliposomes were prepared and optimised using the ethanol injection method and characterised based on particle size, polydispersity and zeta potential measurements. Subsequently, the encapsulation efficiency and in vitro release profile of the natural antioxidant extract (NAE) were evaluated, and its anti...
Source: Colloids and Surfaces - December 21, 2023 Category: Biotechnology Authors: Elizabeth Tobar-Delgado Oswaldo Osorio-Mora Alvaro Barrera-Ocampo Liliana Serna-Cock Constain H Salamanca Source Type: research
Enhancing the physicochemical stability and antioxidant activity of cape gooseberry calyx extract through nanoencapsulation in soy lecithin liposomes
Colloids Surf B Biointerfaces. 2023 Nov 23;234:113662. doi: 10.1016/j.colsurfb.2023.113662. Online ahead of print.ABSTRACTThe focus of this study was on the development, physicochemical characterisation and evaluation of the antioxidant activity of cape gooseberry calyx extract loaded into nanoliposomal systems. Various nanoliposomes were prepared and optimised using the ethanol injection method and characterised based on particle size, polydispersity and zeta potential measurements. Subsequently, the encapsulation efficiency and in vitro release profile of the natural antioxidant extract (NAE) were evaluated, and its anti...
Source: Colloids and Surfaces - December 21, 2023 Category: Biotechnology Authors: Elizabeth Tobar-Delgado Oswaldo Osorio-Mora Alvaro Barrera-Ocampo Liliana Serna-Cock Constain H Salamanca Source Type: research
Design, development, and evaluation of CDK-4/6 inhibitor loaded 4-carboxy phenyl boronic acid conjugated pH-sensitive chitosan lecithin nanoparticles in the management of breast cancer
Int J Biol Macromol. 2023 Dec 16:128821. doi: 10.1016/j.ijbiomac.2023.128821. Online ahead of print.ABSTRACTOur main aim to design and develop a novel 4-carboxy phenyl boronic acid (4-CPBA) conjugated Palbociclib (PALB) loaded pH-sensitive chitosan lipid nanoparticles (PPCL) to enhance the anti-cancer efficacy of the PALB in in-vitro cell line studies by loading into 4-CPBA conjugated chitosan lipid nanoparticles. 4-CPBA was conjugated to chitosan by carbodiimide chemistry and formation of conjugate was confirmed by 1HNMR, ATR-FTIR spectroscopic techniques. Ionic-gelation method was used for the fabrication of PPCL and par...
Source: International Journal of Biological Macromolecules - December 18, 2023 Category: Biochemistry Authors: Yeruva Sri Pooja Naveen Rajana Rati Yadav Lakshmi Tulasi Naraharisetti Chandraiah Godugu Neelesh Kumar Mehra Source Type: research
Design, development, and evaluation of CDK-4/6 inhibitor loaded 4-carboxy phenyl boronic acid conjugated pH-sensitive chitosan lecithin nanoparticles in the management of breast cancer
Int J Biol Macromol. 2023 Dec 16;258(Pt 1):128821. doi: 10.1016/j.ijbiomac.2023.128821. Online ahead of print.ABSTRACTOur main aim to design and develop a novel 4-carboxy phenyl boronic acid (4-CPBA) conjugated Palbociclib (PALB) loaded pH-sensitive chitosan lipid nanoparticles (PPCL) to enhance the anti-cancer efficacy of the PALB in in-vitro cell line studies by loading into 4-CPBA conjugated chitosan lipid nanoparticles. 4-CPBA was conjugated to chitosan by carbodiimide chemistry and formation of conjugate was confirmed by 1HNMR, ATR-FTIR spectroscopic techniques. Ionic-gelation method was used for the fabrication of PP...
Source: International Journal of Biological Macromolecules - December 18, 2023 Category: Biochemistry Authors: Yeruva Sri Pooja Naveen Rajana Rati Yadav Lakshmi Tulasi Naraharisetti Chandraiah Godugu Neelesh Kumar Mehra Source Type: research
Environmental Cadmium Exposure Exacerbated Bone Loss in NAFLD Mice
Biol Trace Elem Res. 2023 Dec 15. doi: 10.1007/s12011-023-04016-0. Online ahead of print.ABSTRACTDue to rapid urbanization and industrialization, Cadmium (Cd) contamination is widespread. Meanwhile, the prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. Cd is linked to bone damage. However, the osteotoxicity of environmental Cd exposure in NAFLD remains unclear. Therefore, this study aimed to investigate the effects and potential mechanisms of Cd on bone metabolism in NAFLD mice. NAFLD mice were treated with 50 mg/L cadmium chloride in drinking water for 12 weeks. Bone microstructures were scanned ...
Source: Biological Trace Element Research - December 15, 2023 Category: Biology Authors: Changhao Li Nana Wang Yuting Li Hui Yang Jiafu Li Zengli Zhang Source Type: research
Dietary hydrolyzed soya lecithin affects feed intake, abundance of bacteria in the caecum, fatty acid composition and area of adipocytes in pre ‐mating primiparous V‐line female rabbit
In conclusion, soya lecithin at a dose of 0.5% increased feed intake and energy storage in adipocytes and improved the fatty acid profile of periovarian fat. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - December 13, 2023 Category: Zoology Authors: M. I. Mandouh,
I. B. Shaheed,
M. Bionaz,
A. A. Elolimy,
H. A. Mansour,
Shereen A. Mohamed,
Mahmoud M. El ‐Attrouny,
O. A. A. Farid,
M. R. Mousa,
A. M. Abdelatty Tags: ORIGINAL ARTICLE Source Type: research
Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
Biol Pharm Bull. 2023 Dec 14. doi: 10.1248/bpb.b23-00704. Online ahead of print.ABSTRACTWe investigated the effect of the rheological properties and composition of lecithin reverse wormlike micelles (LRWs) on the skin permeation of a model of a hydrophilic drug to determine whether LRWs support uniform hydrophilic drug/oil-based formulations and good drug penetrate into skin. Here, we prepared LRWs with D (-)-ribose (RI) or glycerol (GL) as polar compounds, liquid paraffin (LP) or isopropyl myristate (IPM) as oils, and 6-carboxyfluorescein (CF) as a model for a hydrophilic drug, and evaluated the rheological properties and...
Source: Biological and Pharmaceutical Bulletin - December 13, 2023 Category: Drugs & Pharmacology Authors: Yoshiyuki Miyasaka Kaname Hashizaki Kohsuke Shibasaki Makiko Fujii Hiroyuki Taguchi Source Type: research
Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
Biol Pharm Bull. 2023 Dec 14. doi: 10.1248/bpb.b23-00704. Online ahead of print.ABSTRACTWe investigated the effect of the rheological properties and composition of lecithin reverse wormlike micelles (LRWs) on the skin permeation of a model of a hydrophilic drug to determine whether LRWs support uniform hydrophilic drug/oil-based formulations and good drug penetrate into skin. Here, we prepared LRWs with D (-)-ribose (RI) or glycerol (GL) as polar compounds, liquid paraffin (LP) or isopropyl myristate (IPM) as oils, and 6-carboxyfluorescein (CF) as a model for a hydrophilic drug, and evaluated the rheological properties and...
Source: Biological and Pharmaceutical Bulletin - December 13, 2023 Category: Drugs & Pharmacology Authors: Yoshiyuki Miyasaka Kaname Hashizaki Kohsuke Shibasaki Makiko Fujii Hiroyuki Taguchi Source Type: research
Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
Biol Pharm Bull. 2023 Dec 14. doi: 10.1248/bpb.b23-00704. Online ahead of print.ABSTRACTWe investigated the effect of the rheological properties and composition of lecithin reverse wormlike micelles (LRWs) on the skin permeation of a model of a hydrophilic drug to determine whether LRWs support uniform hydrophilic drug/oil-based formulations and good drug penetrate into skin. Here, we prepared LRWs with D (-)-ribose (RI) or glycerol (GL) as polar compounds, liquid paraffin (LP) or isopropyl myristate (IPM) as oils, and 6-carboxyfluorescein (CF) as a model for a hydrophilic drug, and evaluated the rheological properties and...
Source: Biological and Pharmaceutical Bulletin - December 13, 2023 Category: Drugs & Pharmacology Authors: Yoshiyuki Miyasaka Kaname Hashizaki Kohsuke Shibasaki Makiko Fujii Hiroyuki Taguchi Source Type: research
