Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer
This study developed an irinotecan/rapamycin-loaded oral lecithin-based self-nanoemulsifying nanoemulsion preconcentrate (LBSNENPir/ra) and evaluated its synergistic combination effects on pancreatic cancer. LBSNENP loaded with irinotecan and rapamycin at a ratio of 1:1 (LBSNENPir10/ra10) had a better drug release profile and smaller particle size (<200 nm) than the drug powder. Moreover, LBSNENPir10/ra10 exhibited a strong synergistic effect (combination index [CI] < 1.0) in cell viability and combination effect studies. In the tumor inhibition study, the antitumor activity of LBSNENPir10/ra10/sily20 against MIA PaC...
Source: Cancer Control - February 25, 2023 Category: Cancer & Oncology Authors: Yu-Hsuan Liu Ling-Chun Chen Wen-Ting Cheng Pu-Sheng Wei Chien-Ming Hsieh Ming-Thau Sheu Shyr-Yi Lin Hsiu-O Ho Hong-Liang Lin Source Type: research
Soy Lecithin in High ‐Fat Diets Exerts Dual Effects on Adipose Tissue Versus Ileum
ConclusionThe incorporation of SPL in a diet with rapeseed oil exerts differential effect on WAT and ileum, with respectively an inflammation of WAT and an antimicrobial activity in ileum, associated with specific microbiota changes. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 17, 2023 Category: Food Science Authors: Charline Buisson,
Valentin Leuzy,
Emmanuelle Loizon,
Emmanuelle Meugnier,
Magali Monnoye,
Catherine Philippe,
Philippe G érard,
Marie‐Caroline Michalski,
Fabienne Laugerette Tags: Research Article Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Cell Research - February 14, 2023 Category: Cytology Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Biochem Cell Biol. 2023 Feb 14. doi: 10.1139/bcb-2022-0266. Online ahead of print.ABSTRACTA surfeit of mitochondrial ROS and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of Lecithin: Retinol Acyl Transferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier, however its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in HFD-fed rats and palmi...
Source: Biochemistry and Cell Biology - February 14, 2023 Category: Biochemistry Authors: Eshani Karmakar Nabanita Das Bidisha Mukherjee Prosenjit Das Satinath Mukhopadhyay Sib Sankar Roy Source Type: research
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle
Cell Rep. 2023 Feb 8;42(2):112091. doi: 10.1016/j.celrep.2023.112091. Online ahead of print.ABSTRACTRetinosomes are intracellular lipid bodies found in the retinal pigment epithelium (RPE). They contain retinyl esters (REs) and are thought to be involved in visual chromophore regeneration during dark adaptation and in case of chromophore depletion. However, key enzymes in chromophore regeneration, retinoid isomerase (RPE65), and lecithin:retinol acyltransferase (LRAT) are located in the endoplasmic reticulum (ER). The mechanism and the enzyme responsible for mobilizing REs from retinosomes remained unknown. Our study demon...
Source: Cell Research - February 10, 2023 Category: Cytology Authors: Miwa Hara Wenjing Wu Volha V Malechka Yusuke Takahashi Jian-Xing Ma Gennadiy Moiseyev Source Type: research
Insight into application of phosphate-solubilizing bacteria promoting phosphorus availability during chicken manure composting
Bioresour Technol. 2023 Feb 4:128707. doi: 10.1016/j.biortech.2023.128707. Online ahead of print.ABSTRACTUnderstanding ecological roles of phosphate-solubilizing bacteria (PSB) is important to optimize composting systems. Illumina MiSeq sequencing, gene quantitation, and statistical analyses were employed to explore ecological mechanisms underlying available phosphorus (AP) facilitation during composting with the inoculation of PSB Pseudomonas sp. WWJ-22. Results displayed that the inoculation of PSB significantly increased AP from 0.83 to 1.23 g kg-1, and notably increased abundances of phosphorus-cycling genes as well as...
Source: Bioresource Technology - February 6, 2023 Category: Biotechnology Authors: Qiusheng Wu Wenjie Wan Source Type: research
Insight into application of phosphate-solubilizing bacteria promoting phosphorus availability during chicken manure composting
Bioresour Technol. 2023 Feb 4:128707. doi: 10.1016/j.biortech.2023.128707. Online ahead of print.ABSTRACTUnderstanding ecological roles of phosphate-solubilizing bacteria (PSB) is important to optimize composting systems. Illumina MiSeq sequencing, gene quantitation, and statistical analyses were employed to explore ecological mechanisms underlying available phosphorus (AP) facilitation during composting with the inoculation of PSB Pseudomonas sp. WWJ-22. Results displayed that the inoculation of PSB significantly increased AP from 0.83 to 1.23 g kg-1, and notably increased abundances of phosphorus-cycling genes as well as...
Source: Bioresource Technology - February 6, 2023 Category: Biotechnology Authors: Qiusheng Wu Wenjie Wan Source Type: research
Structural and functional characterization of a thermostable secretory phospholipase A2 from Sciscionella marina and its application in liposome biotransformation
Secretory phospholipase A2 (sPLA2), which hydrolyzes the sn-2 acyl bond of lecithin in a Ca2+-dependent manner, is an important enzyme in the oil and oleochemical industries. However, most sPLA2s are not stable under process conditions. Therefore, a thermostable sPLA2 was investigated in this study. A marine bacterial sPLA2 isolated from Sciscionella marina (Sm-sPLA2) was catalytically active even after 5 h of incubation at high temperatures of up to 50 ° C, which is outstanding compared with a representative bacterial sPLA2 (i.e. sPLA2 from Streptomyces violaceoruber; Sv-sPLA2). Consistent with this, the melting temp...
Source: Acta Crystallographica Section D - February 6, 2023 Category: Biochemistry Authors: Kang, B.-G. Kwon, S.-Y. Lee, H.-R. Hwang, Y. Youn, S.-Y. Oh, C. Park, J.-B. Cha, S.-S. Tags: phospholipase A2 Sciscionella marina thermostability crystal structure loop anchoring liposome biotransformation research papers Source Type: research
Soy Lecithin in High ‐Fat Diets Exerts Dual Effects on Adipose Tissue vs Ileum
ConclusionThe incorporation of SPL in a diet with rapeseed oil exerts differential effect on WAT and ileum, with respectively an inflammation of WAT and an antimicrobial activity in ileum, associated with specific microbiota changes.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - January 29, 2023 Category: Food Science Authors: Charline Buisson,
Valentin Leuzy,
Emmanuelle Loizon,
Emmanuelle Meugnier,
Magali Monnoye,
Catherine Philippe,
Philippe G érard,
Marie‐Caroline Michalski,
Fabienne Laugerette Tags: Research Article Source Type: research
Effect of the Emulsifier used in Dunaliella Salina ‐based Nanoemulsions Formulation on the β‐Carotene Absorption and Metabolism in Rats
ConclusionsNanoemulsions, especially those formulated with protein emulsifiers, are effective systems for increasing β-carotene absorption, as well as retinol concentration in different rat tissues.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - January 28, 2023 Category: Food Science Authors: J úlia Teixé‐Roig,
Gemma Oms‐Oliu,
Isabel Odriozola‐Serrano,
Olga Martín‐Belloso Tags: Research Article Source Type: research
