Construction of nanoparticles from blueberry anthocyanins-lecithin/gum Arabic improves lipid droplet accumulation and gut microbiota disturbance in HFD-induced obese mice
Int J Biol Macromol. 2024 Mar 2;264(Pt 1):130595. doi: 10.1016/j.ijbiomac.2024.130595. Online ahead of print.ABSTRACTThe digestive instability of anthocyanins (ACNs) limits their application in food nutrition, especially precision nutrition. Blueberry ACNs-loaded nanoparticles (Lipo/GA-ACNs NPs) were prepared using gum arabic (GA) as the delivery carrier and liposomal vesicles (Lipo) prepared from soy lecithin as the targeting scaffold. The average particle size of the NPs was 99.4 nm, and the polydispersion index (PDI) was 0.46. The results showed that the presence of the Lipo-GA matrix enhanced the NPs' in vitro stabilit...
Source: International Journal of Biological Macromolecules - March 4, 2024 Category: Biochemistry Authors: Zhen Cheng Wenwen Wei Yi Chen Aihua Xu Yuehua Wang Bin Li Source Type: research
Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
In this study, ritonavir loaded solid LBFs (sLBFs) were prepared using solid lipid excipients to investigate whether sLBFs are also capable of improving solubility and permeability. Additionally, the influence of polymeric precipitation inhibitors (PVP-VA and HPMC-AS) on lipolysis triggered supersaturation and precipitation was investigated. One step intestinal digestion and bicompartmental permeation studies using an artificial lecithin-in-dodecane (LiDo) membrane were performed for each formulation. All formulations presented significantly higher solubility (5 to >20-fold higher) during lipolysis and permeation studie...
Source: European Journal of Pharmaceutical Sciences - February 26, 2024 Category: Drugs & Pharmacology Authors: Arne Schulzen Ioannis I Andreadis Christel A S Bergstr öm Julian Quodbach Source Type: research
Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
In this study, ritonavir loaded solid LBFs (sLBFs) were prepared using solid lipid excipients to investigate whether sLBFs are also capable of improving solubility and permeability. Additionally, the influence of polymeric precipitation inhibitors (PVP-VA and HPMC-AS) on lipolysis triggered supersaturation and precipitation was investigated. One step intestinal digestion and bicompartmental permeation studies using an artificial lecithin-in-dodecane (LiDo) membrane were performed for each formulation. All formulations presented significantly higher solubility (5 to >20-fold higher) during lipolysis and permeation studie...
Source: European Journal of Pharmaceutical Sciences - February 26, 2024 Category: Drugs & Pharmacology Authors: Arne Schulzen Ioannis I Andreadis Christel A S Bergstr öm Julian Quodbach Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
Effects of different extenders, storage temperatures, and antioxidant supplementation on chilled semen quality: a review
AbstractThe successful preservation of ram semen is essential to promote genetic variability, ensure semen transportation, and inseminate multiple ewes. Currently, either animal or plant-based lipoprotein-based extenders are used for semen preservation. Animal product-based extenders include milk and egg yolk, while soybean lecithin is a plant-based extender. Although extenders containing products of animal origin better preserve the quality of chilled semen, the in vivo efficacy after 24 h of storage is still of great concern. Storage temperature is another important and effective factor in preserving sperm quality, whe...
Source: Tropical Animal Health and Production - February 22, 2024 Category: Veterinary Research Source Type: research
Ultrasound-induced structural changes of different milk fat globule membrane protein-phospholipids complexes and their effects on physicochemical and functional properties of emulsions
This study investigated the effects of ultrasonic time (5 min, 10 min, 15 min) and power (150 W,300 W,500 W) on the structural properties of three types of phospholipids composed of different fatty acids (milk fat globule membrane phospholipid (MPL), egg yolk lecithin (EYL), soybean lecithin (SL)) and milk fat globule membrane protein (MFGMP). We found that the ultrasound treatment changed the conformation of the protein, and the emulsions prepared by the pretreatment showed better emulsification and stability, the lipid droplets were also more evenly distributed. Meanwhile, the flocculation phenomenon of the lipid droplet...
Source: Ultrasonics Sonochemistry - February 16, 2024 Category: Chemistry Authors: Yanjie Zhao Qian Ma Tao Zhou Lu Liu Yuxin Wang Xiaodong Li Xiuxiu Zhang Xiaoqing Dang Kouadio Jean Eric-Parfait Kouame Source Type: research
Ultrasound-induced structural changes of different milk fat globule membrane protein-phospholipids complexes and their effects on physicochemical and functional properties of emulsions
This study investigated the effects of ultrasonic time (5 min, 10 min, 15 min) and power (150 W,300 W,500 W) on the structural properties of three types of phospholipids composed of different fatty acids (milk fat globule membrane phospholipid (MPL), egg yolk lecithin (EYL), soybean lecithin (SL)) and milk fat globule membrane protein (MFGMP). We found that the ultrasound treatment changed the conformation of the protein, and the emulsions prepared by the pretreatment showed better emulsification and stability, the lipid droplets were also more evenly distributed. Meanwhile, the flocculation phenomenon of the lipid droplet...
Source: Ultrasonics Sonochemistry - February 16, 2024 Category: Chemistry Authors: Yanjie Zhao Qian Ma Tao Zhou Lu Liu Yuxin Wang Xiaodong Li Xiuxiu Zhang Xiaoqing Dang Kouadio Jean Eric-Parfait Kouame Source Type: research
Hybrid Nanoparticle for Co-delivering Paclitaxel and Dihydroartemisinin to Exhibit Synergic Anticancer Therapeutics
CONCLUSION: Dual-drug-loaded hybrid PLGA-lecithin NP is a potential system to minimize severe side effects while enhancing antitumor efficacy, in which lyophilization is a key process to increase stability.</p>.PMID:38321897 | DOI:10.2174/0115680096283208231229103822 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 7, 2024 Category: Cancer & Oncology Authors: Bao Ngoc Tran Thu Thi Kim Ninh Thao Thi Do Phuong Thi Do Chien Ngoc Nguyen Source Type: research
A high fat to vitamin E ratio in the feed protects and improves uptake of the natural form of vitamin E in postweaning calves
AbstractIn postweaning calves, it is a challenge to maintain the plasma vitamin E level at or above the recommended level (3 µg/mL), which is linked to a good immune response. It has been unclear until now why the provision of solid feed with concentrations below 200 mg/kg feed of vitamin E is ineffective in maintaining the plasma vitamin E level of calves above the recommended plasma level postweaning. The present study was conducted to investigate if a high fat to vitamin E ratio in the concentrate could protect and improve the delivery of the natural form of vitamin E (RRR-α-tocopherol) to calves postweaning. Thi...
Source: Journal of Animal Physiology and Animal Nutrition - January 25, 2024 Category: Zoology Authors: Saman Lashkari,
S øren K. Jensen,
Leslie Foldager,
Torben Larsen,
Mogens Vestergaard Tags: ORIGINAL ARTICLE Source Type: research
Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation
AAPS PharmSciTech. 2024 Jan 23;25(1):18. doi: 10.1208/s12249-024-02742-9.ABSTRACTDue to tenoxicam (TX)'s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe GIT disturbances. Topical administration of TX can help in bypassing the GIT adverse effects. Therefore, in the present work, we constructed different pluronic/lecithin organogels (PLOs) for topical delivery of TX. PLO was constructed simply via direct mixing of an aqueous pluronic solution with lecithin solution. The prepared PLO formulations were characterized for their physicochemica...
Source: AAPS PharmSciTech - January 23, 2024 Category: Drugs & Pharmacology Authors: Shaaban K Osman Taher M Yassin Arafat Abdelzaher Fatma Ahmed Ahmed M Mohammed Ahmed A H Abdellatif Khalid I Saleh Wael A Mahdi Sultan Alshehri Mohamed A El Hamd Hatem Sarhan Source Type: research
Molecules, Vol. 29, Pages 564: A High-Throughput NMR Method for Lipoprotein-X Quantification
Margery A. Connelly
Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin&ndash;cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnostic tests for its detection, a proton nuclear magnetic resonance (NMR) spectroscopy-based method was developed for use on a clinical NMR analyzer commonly used for the quantification of lipoproteins and other cardiovascular biomarkers. The LP-X assay was linear from 89 to 1615 mg/dL (cholesterol units) and had a functional sensitivity of 44 mg...
Source: Molecules - January 23, 2024 Category: Chemistry Authors: Erwin Garcia Irina Shalaurova Steven P. Matyus Lita A. Freeman Edward B. Neufeld Maureen L. Sampson Rafael Zubir án Anna Wolska Alan T. Remaley James D. Otvos Margery A. Connelly Tags: Article Source Type: research
Comparative assessment of emulsifiers for in vitro ruminal gas production and fermentation measurements: Tween 80 is a suitable emulsifier
This study aimed to evaluate seven emulsifiers ’ impact on in vitro ruminal fermentation using the Hohenheim Gas Test in order to identify the most inert emulsifier. Rumen fluids were collected from three non-lactating Original Brown-Swiss cannulated cows before morning feeding and incubated for 24 h with a basal diet in triplicates. The em ulsifiers tested were ethanol, ethyl acetate, propylene glycol, glycerol, ethylene glycol, soy lecithin, and Tween® 80, each in two dosages (0.5% or 1% v/v). The untreated basal diet served as control. Compared to control, in vitro organic matter digestibility was enhanced by ethy...
Source: Journal of Animal Physiology and Animal Nutrition - January 15, 2024 Category: Zoology Authors: Xiaoge Sun,
Yang Li,
Katrin Giller,
Carmen Kunz,
Melissa Terranova,
Mutian Niu Tags: ORIGINAL ARTICLE Source Type: research
