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NDRG2 inhibits tumorigenesis of hepatocellular carcinoma by regulating metabolism of phospholipids and triglyceride: a metabonomic analysis
CONCLUSION: NDRG2 regulates tumorigenesis of hepatocellular carcinoma by modulating the metabolism of phospholipids and triglyceride.PMID:36651243 | PMC:PMC9878422 | DOI:10.12122/j.issn.1673-4254.2022.12.03 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 18, 2023 Category: Universities & Medical Training Authors: J Wang Y Yuan K Zhang X Sun X Bu J Dong Y Wu H Tian L Shen Source Type: research

Perfluorocarbon emulsion enhances MR-ARFI displacement and temperature in vitro: Evaluating the response with MRI, NMR, and hydrophone
Sonosensitive perfluorocarbon F8TAC18-PFOB emulsion is under development to enhance heating, increase thermal contrast, and reduce treatment times during focused ultrasound tumor ablation of highly perfused tissue. The emulsion previously showed enhanced heating during ex vivo and in vitro studies. Experiments were designed to observe the response in additional scenarios by varying focused ultrasound conditions, emulsion concentrations, and surfactants. Most notably, changes in acoustic absorption were assessed with MR-ARFI. Phantoms were developed to have thermal, elastic, and relaxometry properties similar to those of ex...
Source: Frontiers in Oncology - January 13, 2023 Category: Cancer & Oncology Source Type: research

EGFR-Targeted Hybrid Lipid Nanoparticles for Chemo-Photothermal Therapy Against Colorectal Cancer Cells
Chem Phys Lipids. 2023 Jan 9:105280. doi: 10.1016/j.chemphyslip.2023.105280. Online ahead of print.ABSTRACTAntibody-functionalized targeted nanocarriers have shown great potential for minimizing the chemoresistance and systemic toxicity of cancer chemotherapies. The combination of chemotherapy and photothermal therapy has great potential in improving therapeutic effect. However, cetuximab-modified nanoparticles based lipids for chemo-phototherapy of EGFR overexpressing colorectal carcinoma (CRC) have seldom been investigated. Hence, this study aimed to fabricate cetuximab-conjugated and near infrared (NIR) light-responsive...
Source: Chemistry and Physics of Lipids - January 12, 2023 Category: Lipidology Authors: Fang Fang Xinming Zhang Jin Tang Yu Wang Jinchen Xu Yu Sun Source Type: research

EGFR-targeted hybrid lipid nanoparticles for chemo-photothermal therapy against colorectal cancer cells
Chem Phys Lipids. 2023 Jan 10;251:105280. doi: 10.1016/j.chemphyslip.2023.105280. Online ahead of print.ABSTRACTAntibody-functionalized targeted nanocarriers have shown great-potential for minimizing the chemoresistance and systemic toxicity of cancer chemotherapies. The combination of chemotherapy and photothermal therapy has great potential in improving therapeutic effect. However, cetuximab-modified nanoparticles based lipids for chemo-phototherapy of EGFR overexpressing colorectal carcinoma (CRC) have seldom been investigated. Hence, this study aimed to fabricate cetuximab-conjugated and near infrared (NIR) light-respo...
Source: Chemistry and Physics of Lipids - January 12, 2023 Category: Lipidology Authors: Fang Fang Xinming Zhang Jin Tang Yu Wang Jinchen Xu Yu Sun Source Type: research