Regulation of pain perception by microbiota in Parkinson's Disease
Pharmacol Rev. 2023 Oct 20:PHARMREV-AR-2022-000674. doi: 10.1124/pharmrev.122.000674. Online ahead of print.ABSTRACTPain perception involves current stimulation in peripheral nociceptive nerves and the subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in chronic pain, the neural activity of both peripheral nociceptors and postsynaptic neurons in the central nervous system is influenced by several inflammatory mediators produced by the immune system. Growing evidence has indicated that the commensal microbiota plays an active role in regulating pain perception by either acting direct...
Source: Pharmacognosy Reviews - October 20, 2023 Category: Drugs & Pharmacology Authors: Zulmary Manjarres Margarita Calvo Rodrigo Pacheco Source Type: research
Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens
Pharmacol Rev. 2023 Oct 16:PHARMREV-AR-2023-000863. doi: 10.1124/pharmrev.123.000863. Online ahead of print.ABSTRACTAntimicrobial resistance presents us with a potential global crisis as it undermines the abilities of conventional antibiotics to combat pathogenic microbes. The history of antimicrobial agents is replete with examples of scaffolds containing halogens. In this review, we discuss the impacts of halogen atoms in various antibiotic types and antimicrobial scaffolds and their modes of action, structure-activity relationships, and the contributions of halogen atoms in antimicrobial activity and drug resistance. Ot...
Source: Pharmacognosy Reviews - October 16, 2023 Category: Drugs & Pharmacology Authors: Olajide Sunday Faleye Bharath Reddy Boya Jin Hyung Lee Inho Choi Jintae Lee Source Type: research
Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin
This article aims to provide the most updated information on targeting the liver with ASO and siRNA drugs. The generated knowledge may stimulate further investigations in this growing field of new therapeutic entities for the treatment of some human systemic diseases, which currently have no or limited options for treatment.PMID:37696583 | DOI:10.1124/pharmrev.123.000815 (Source: Pharmacognosy Reviews)
Source: Pharmacognosy Reviews - September 11, 2023 Category: Drugs & Pharmacology Authors: Anagha Gogate Jordyn Belcourt Milan Shah Alicia Zongxun Wang Alexis Frankel Holly Kolmel Matthew Chalon Prajith Stephen Aarush Kolli Sherouk M Tawfik Jing Jin Raman Bahal Theodore P Rasmussen Jose E Manautou Xiao-Bo Zhong Source Type: research
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. SIGNIFICANCE STATEMENT: This review provides an in-depth v...
Source: Pharmacognosy Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremi ć Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023
Pharmacol Rev. 2023 Nov;75(6):1233-1318. doi: 10.1124/pharmrev.121.000436. Epub 2023 Aug 16.ABSTRACTThe NR superfamily comprises 48 transcription factors in humans that control a plethora of gene network programs involved in a wide range of physiologic processes. This review will summarize and discuss recent progress in NR biology and drug development derived from integrating various approaches, including biophysical techniques, structural studies, and translational investigation. We also highlight how defective NR signaling results in various diseases and disorders and how NRs can be targeted for therapeutic intervention ...
Source: Pharmacognosy Reviews - August 16, 2023 Category: Drugs & Pharmacology Authors: Thomas P Burris Ian Mitchelle S de Vera Isabelle Cote Colin A Flaveny Udayanga S Wanninayake Arindam Chatterjee John K Walker Nickolas Steinauer Jinsong Zhang Laurel A Coons Kenneth S Korach Derek W Cain Anthony N Hollenberg Paul Webb Douglas Forrest Anto Source Type: research
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Sep;75(5):1036-1042. doi: 10.1124/pharmrev.122.000799. Epub 2023 Aug 2.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic, not a hydrostatic, gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplify the initial proposal and indicate both paracellular and transcellular water flow into hepatic ...
Source: Pharmacognosy Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Optical Approaches for Investigating Neuromodulation and G Protein-Coupled Receptor Signaling
Pharmacol Rev. 2023 Nov;75(6):1119-1139. doi: 10.1124/pharmrev.122.000584. Epub 2023 Jul 10.ABSTRACTDespite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved pharmacological therapeutics target G protein-coupled receptors (GPCRs), there remains a gap in our understanding of the physiologic and functional role of these receptors at the systems level. Although heterologous expression systems and in vitro assays have revealed a tremendous amount about GPCR signaling cascades, how these cascades interact across cell types, tissues, and organ systems remains obscure. Classic behavioral pharmacology...
Source: Pharmacognosy Reviews - July 10, 2023 Category: Drugs & Pharmacology Authors: David J Marcus Michael R Bruchas Source Type: research
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor
This article reviews the cancer biology of EGFR as well as the mechanisms of actions and the therapeutic efficacies of current and emerging EGFR inhibitors. The findings could potentially lead to development of more effective treatments for EGFR-positive cancers.PMID:37339882 | PMC:PMC10595022 | DOI:10.1124/pharmrev.123.000906 (Source: Pharmacognosy Reviews)
Source: Pharmacognosy Reviews - June 20, 2023 Category: Drugs & Pharmacology Authors: Yuesheng Zhang Source Type: research
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming
Pharmacol Rev. 2023 Nov;75(6):1140-1166. doi: 10.1124/pharmrev.122.000782. Epub 2023 Jun 16.ABSTRACTPharmacological agents used to treat or manage diseases can modify the level of heat strain experienced by chronically ill and elderly patients via different mechanistic pathways. Human thermoregulation is a crucial homeostatic process that maintains body temperature within a narrow range during heat stress through dry (i.e., increasing skin blood flow) and evaporative (i.e., sweating) heat loss, as well as active inhibition of thermogenesis, which is crucial to avoid overheating. Medications can independently and synergisti...
Source: Pharmacognosy Reviews - June 16, 2023 Category: Drugs & Pharmacology Authors: Jericho Wee Xiang Ren Tan Samuel H Gunther Mohammed Ihsan Melvin Khee Shing Leow Doreen Su-Yin Tan Johan G Eriksson Jason Kai Wei Lee Source Type: research
Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments
This article brings together an integrated, detailed review of the pharmacology of oxycodone, preclinical and clinical studies of pain and abuse, and recent advances to identify potential opioid analgesics without abuse liability.PMID:37321860 | PMC:PMC10595024 | DOI:10.1124/pharmrev.121.000506 (Source: Pharmacognosy Reviews)
Source: Pharmacognosy Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: James E Barrett Aryan Shekarabi Saadet Inan Source Type: research
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction
Pharmacol Rev. 2023 Nov;75(6):1200-1217. doi: 10.1124/pharmrev.123.000834. Epub 2023 Jun 9.ABSTRACTChronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the major hurdle limiting long-term survival after lung transplantation, and limited therapeutic options are available to slow the progressive decline in lung function. Most interventions are only temporarily effective in stabilizing the loss of or modestly improving lung function, with disease progression resuming over time in the majority of patients. Therefore, identification of effective treatments that prevent the onset or halt progres...
Source: Pharmacognosy Reviews - June 9, 2023 Category: Drugs & Pharmacology Authors: Saskia Bos Pauline Prad ère Hanne Beeckmans Andrea Zajacova Bart M Vanaudenaerde Andrew J Fisher Robin Vos Source Type: research
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications
Pharmacol Rev. 2023 Sep;75(5):1043-1061. doi: 10.1124/pharmrev.123.000841. Epub 2023 Jun 6.ABSTRACTExtracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic applications in the field of regenerative medicine. Therapeutic application of stem cell-derived EVs has shown great potential to stimulate tissue repair. However, the exact mechanisms through which they induce this effect have not been fully clarified. This may to a large extent be attributed to a lack of knowledge on EV heterogeneity. Recent s...
Source: Pharmacognosy Reviews - June 6, 2023 Category: Drugs & Pharmacology Authors: Simonides Immanuel van de Wakker Fleur Michelle Meijers Joost Petrus Gerardus Sluijter Pieter Vader Source Type: research
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics
Pharmacol Rev. 2023 Sep;75(5):1007-1035. doi: 10.1124/pharmrev.122.000795. Epub 2023 Jun 6.ABSTRACTCancer is a leading cause of death worldwide, resulting in ∼10 million deaths in 2020. Major oncogenic effectors are the Myc proto-oncogene family, which consists of three members including c-Myc, N-Myc, and L-Myc. As a pertinent example of the role of the Myc family in tumorigenesis, amplification of MYCN in childhood neuroblastoma strongly correlates with poor patient prognosis. Complexes between Myc oncoproteins and their partners such as hypoxia-inducible factor-1α and Myc-associated protein X (MAX) result in prolifera...
Source: Pharmacognosy Reviews - June 6, 2023 Category: Drugs & Pharmacology Authors: Zhao Deng Des R Richardson Source Type: research
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years
Pharmacol Rev. 2023 Sep;75(5):885-958. doi: 10.1124/pharmrev.122.000600. Epub 2023 May 10.ABSTRACTThe cannabis derivative marijuana is the most widely used recreational drug in the Western world and is consumed by an estimated 83 million individuals (∼3% of the world population). In recent years, there has been a marked transformation in society regarding the risk perception of cannabis, driven by its legalization and medical use in many states in the United States and worldwide. Compelling research evidence and the Food and Drug Administration cannabis-derived cannabidiol approval for severe childhood epilepsy have conf...
Source: Pharmacognosy Reviews - May 10, 2023 Category: Drugs & Pharmacology Authors: Mauro Maccarrone Vincenzo Di Marzo J ürg Gertsch Uwe Grether Allyn C Howlett Tian Hua Alexandros Makriyannis Daniele Piomelli Natsuo Ueda Mario van der Stelt Source Type: research
Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?
Pharmacol Rev. 2023 Sep;75(5):979-1006. doi: 10.1124/pharmrev.122.000784. Epub 2023 May 3.ABSTRACTProtein SUMOylation is a major post-translational modification essential for maintaining cellular homeostasis. SUMOylation has long been associated with stress responses as a diverse array of cellular stress signals are known to trigger rapid alternations in global protein SUMOylation. In addition, while there are large families of ubiquitination enzymes, all small ubiquitin-like modifiers (SUMOs) are conjugated by a set of enzymatic machinery comprising one heterodimeric SUMO-activating enzyme, a single SUMO-conjugating enzym...
Source: Pharmacognosy Reviews - May 3, 2023 Category: Drugs & Pharmacology Authors: Xiaodong Cheng Wenli Yang Wei Lin Fang Mei Source Type: research
