Trends and sex differences in atrial fibrillation among patients hospitalized due to asthma: Insights from a nationwide population-based discharge database in Spain, 2016-2021
CONCLUSIONS: AF is highly prevalent among subjects hospitalized due to asthma, with this prevalence having increased significantly in Spain over time. The presence of AF in patients with asthma was associated significantly with a higher LOHS and IHM. Sex was not associated with IHM in these patients.PMID:38135195 | DOI:10.1016/j.rmed.2023.107508 (Source: Respiratory Care)
Source: Respiratory Care - December 22, 2023 Category: Respiratory Medicine Authors: Javier de-Miguel-Diez Natalia Gutierrez-Albaladejo Francisco J Caballero-Segura Ana Lopez-de-Andres Rodrigo Jimenez-Garcia Jos é J Zamorano-Leon David Carabantes-Alarcon Ricardo Oma ña-Palanco Valent ín Hernández-Barrera Natividad Cuadrado-Corrales Source Type: research
Trends and sex differences in atrial fibrillation among patients hospitalized due to asthma: Insights from a nationwide population-based discharge database in Spain, 2016-2021
CONCLUSIONS: AF is highly prevalent among subjects hospitalized due to asthma, with this prevalence having increased significantly in Spain over time. The presence of AF in patients with asthma was associated significantly with a higher LOHS and IHM. Sex was not associated with IHM in these patients.PMID:38135195 | DOI:10.1016/j.rmed.2023.107508 (Source: Respiratory Care)
Source: Respiratory Care - December 22, 2023 Category: Respiratory Medicine Authors: Javier de-Miguel-Diez Natalia Gutierrez-Albaladejo Francisco J Caballero-Segura Ana Lopez-de-Andres Rodrigo Jimenez-Garcia Jos é J Zamorano-Leon David Carabantes-Alarcon Ricardo Oma ña-Palanco Valent ín Hernández-Barrera Natividad Cuadrado-Corrales Source Type: research
Randomized Double-blind Placebo-controlled Trial on Levothyroxine and Liothyronine Combination Therapy in Totally Thyroidectomized Subjects: the Levolio Study
CONCLUSIONS: Six months of combination therapy with twice daily LT3 dose adapted according to TSH-level do not significantly change peripheral tissue response or quality of life, despite an increase in the fT3/fT4 ratio.PMID:38124252 | DOI:10.1093/ejendo/lvad172 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 21, 2023 Category: Endocrinology Authors: Brigante Giulia Santi Daniele Boselli Gisella Margiotta Gianluca Corleto Rossella Monzani Maria Laura Craparo Andrea Locaso Michela Sperduti Samantha Roy Neena Casarini Livio Trenti Tommaso Tagliavini Simonetta De Santis Maria Cristina Roli Laura Rochira Source Type: research
Randomized Double-blind Placebo-controlled Trial on Levothyroxine and Liothyronine Combination Therapy in Totally Thyroidectomized Subjects: the Levolio Study
CONCLUSIONS: Six months of combination therapy with twice daily LT3 dose adapted according to TSH-level do not significantly change peripheral tissue response or quality of life, despite an increase in the fT3/fT4 ratio.PMID:38124252 | DOI:10.1093/ejendo/lvad172 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 21, 2023 Category: Endocrinology Authors: Brigante Giulia Santi Daniele Boselli Gisella Margiotta Gianluca Corleto Rossella Monzani Maria Laura Craparo Andrea Locaso Michela Sperduti Samantha Roy Neena Casarini Livio Trenti Tommaso Tagliavini Simonetta De Santis Maria Cristina Roli Laura Rochira Source Type: research
Single-cell RNA sequencing reveals transdifferentiation of parathyroid chief cells into oxyphil cells in patients with uremic secondary hyperthyroidism.
The parathyroid gland is one of the main organs that regulate calcium and phosphorus metabolism. It is mainly composed of chief cells and oxyphil cells. Oxyphil cell counts are low in the parathyroid glands of healthy adults but are dramatically increased in patients with uremia and secondary hyperparathyroidism (SHPT). Increased oxyphil cell counts are related to drug treatment resistance, but the origin of oxyphil cells and the mechanism of proliferation remain unknown. Herein, three types of parathyroid nodules (chief cell nodules, oxyphil cell nodules and mixed nodules, respectively) excised from parathyroid glands of ...
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Jianping Mao, Huaizhou You, Mengjing Wang, Yongbing Ba, Jing Qian, Ping Cheng, Chuhan Lu, Jing Chen Tags: clinical investigation Source Type: research
Transition from Hashimoto thyroiditis to Graves ’s Disease: an unpredictable change?
ConclusionsConversion of Hashimoto Thyroiditis towards Graves ’ disease is a rare phenomenon which can occur almost at any time after the development of autoimmune hypothyroidism. Our findings suggest active surveillance of hypothyroid patients who require frequent reduction of levothyroxine during follow up and testing for TSHR antibodies in these patients. (Source: Endocrine)
Source: Endocrine - December 20, 2023 Category: Endocrinology Source Type: research
The Presence of Anti-TPO Antibodies Increase the Likelihood of
Post-I131 Hypothyroidism
Horm Metab Res DOI: 10.1055/a-2205-2052The use of radioactive iodine in the treatment of hyperthyroidism is common
practice. However, a standardized treatment protocol with regard to radioactive
iodine treatment (RAI) remains subject to discussion. We retrospectively
analyzed 100 patient records. Patient diagnosis, age, gender, body mass index
(BMI), dose of radioactive iodine, thyroid size, the 24 h radioiodine
uptake (24 h RAIU) and protein bound iodine (PBI) were deducted, as well
as the use of antithyroid drugs prior to RAI. Biochemical parameters were
...
Source: Hormone and Metabolic Research - December 19, 2023 Category: Endocrinology Authors: Quataert, Felix Bravenboer, Bert Keyaerts, Marleen Andreescu, Corina Emilia Tags: Original Article: Endocrine Care Source Type: research
The genetics of Graves' disease
Rev Endocr Metab Disord. 2023 Dec 18. doi: 10.1007/s11154-023-09848-8. Online ahead of print.ABSTRACTGraves' disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors account for 60-80% of risk of developing GD. In this review, we collate numerous genetic studies and outline the discoveries over the years, starting with historic candidate gene studies and then exploring more recent genome-wide linkage and association studies, which have involved substantial cohorts of ...
Source: ENDOCR REV - December 18, 2023 Category: Endocrinology Authors: Lydia Grixti Laura C Lane Simon H Pearce Source Type: research
The genetics of Graves' disease
Rev Endocr Metab Disord. 2023 Dec 18. doi: 10.1007/s11154-023-09848-8. Online ahead of print.ABSTRACTGraves' disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors account for 60-80% of risk of developing GD. In this review, we collate numerous genetic studies and outline the discoveries over the years, starting with historic candidate gene studies and then exploring more recent genome-wide linkage and association studies, which have involved substantial cohorts of ...
Source: ENDOCR REV - December 18, 2023 Category: Endocrinology Authors: Lydia Grixti Laura C Lane Simon H Pearce Source Type: research
The genetics of Graves ’ disease
AbstractGraves ’ disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors account for 60-80% of risk of developing GD. In this review, we collate numerous genetic studies and outline the discoveries over the years, starting with historic candidate gene studies and then exploring more recent genome-wide linkage and association studies, which have involved substantial cohorts of East Asian patients as well as those of European descent. Variants in genes includingHLA,C...
Source: Reviews in Endocrine and Metabolic Disorders - December 18, 2023 Category: Endocrinology Source Type: research
Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease
ConclusionOur study offers a step-by-step evaluation algorithm for DTD diagnosis, with a very good overall diagnostic performance (AUC of 0.946). (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 18, 2023 Category: Endocrinology Source Type: research
Cardiometabolic-related dietary patterns and thyroid function: a population-based cross-sectional study
ConclusionsA diet high in fast foods, soft drinks, and legumes and low in confectionery, potatoes, butter, and jam and honey was associated with higher TSH levels in euthyroidism and higher odds of subclinical hypothyroidism. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 18, 2023 Category: Research Source Type: research
Pulmonary and systemic hemodynamics in patients with hyperthyroidism
There is an association between hyperthyroidism and pulmonary hypertension. However, the prevalence of pulmonary hypertension in hyperthyroidism and the underlying mechanisms are incompletely defined. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - December 15, 2023 Category: General Medicine Authors: Roman Brenner, Tilman Drescher, Rebecca Locher, Stefan Bilz, Hans Rickli, Michael Br ändle, Daniel Nobel, Daniel Weilenmann, Peter Ammann, Micha T. Maeder Tags: Clinical Research Study Source Type: research
Endocrine-disrupting chemicals and neurodevelopment in children
The endocrine system plays a crucial role in the neurodevelopment of children. Starting from the prenatal period, maternal hormones, particularly thyroid hormones and glucocorticoids, significantly influence fetal brain development and psychomotor development following birth.1 Thyroid hormones are critical for normal neurogenesis, neuronal migration, differentiation of neuronal and glial cells, myelination, and synaptogenesis.1 Their deficiency can impair central nervous system development. Maternal hyperthyroidism poses a risk for attention deficit/hyperactivity disorder in the fetus, whereas maternal hypothyroidism incre...
Source: Pediatrics and Neonatology - December 15, 2023 Category: Perinatology & Neonatology Authors: Ming-Tao Yang Tags: Editorial Source Type: research
