Prevalence of thyroid dysfunction and associated factors among adult type 2 diabetes mellitus patients, 2000 –2022: a systematic review and meta-analysis
ConclusionThe current systematic review and meta-analysis showed that the TD ’s pooled prevalence was relatively higher than the general population. Therefore, regular screening of TD should be done for T2DM patients. (Source: Systematic Reviews)
Source: Systematic Reviews - April 30, 2024 Category: International Medicine & Public Health Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu < sup > 2+ < /sup > -PPi interaction using bimetallic Au-Ag nanoclusters
Anal Chim Acta. 2024 May 29;1305:342584. doi: 10.1016/j.aca.2024.342584. Epub 2024 Apr 10.ABSTRACTBACKGROUND: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic p...
Source: Analytica Chimica Acta - April 27, 2024 Category: Chemistry Authors: Deepika Sharma Nishima Wangoo Rohit K Sharma Source Type: research
Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu < sup > 2+ < /sup > -PPi interaction using bimetallic Au-Ag nanoclusters
Anal Chim Acta. 2024 May 29;1305:342584. doi: 10.1016/j.aca.2024.342584. Epub 2024 Apr 10.ABSTRACTBACKGROUND: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic p...
Source: Analytica Chimica Acta - April 27, 2024 Category: Chemistry Authors: Deepika Sharma Nishima Wangoo Rohit K Sharma Source Type: research
Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu < sup > 2+ < /sup > -PPi interaction using bimetallic Au-Ag nanoclusters
Anal Chim Acta. 2024 May 29;1305:342584. doi: 10.1016/j.aca.2024.342584. Epub 2024 Apr 10.ABSTRACTBACKGROUND: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic p...
Source: Analytica Chimica Acta - April 27, 2024 Category: Chemistry Authors: Deepika Sharma Nishima Wangoo Rohit K Sharma Source Type: research
Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu < sup > 2+ < /sup > -PPi interaction using bimetallic Au-Ag nanoclusters
Anal Chim Acta. 2024 May 29;1305:342584. doi: 10.1016/j.aca.2024.342584. Epub 2024 Apr 10.ABSTRACTBACKGROUND: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic p...
Source: Analytica Chimica Acta - April 27, 2024 Category: Chemistry Authors: Deepika Sharma Nishima Wangoo Rohit K Sharma Source Type: research
A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report
We describe a case of a young man who presented with progressive cough, increased abdominal girth and ankle swelling for a few months. On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti-thyrotropin receptor antibodies. Also, the patient had pancytopenia, coagulopathy and cholestatic pattern of elevated liver enzymes. Echocardiography demonstrated mildly reduced left ventricular function with diastolic dysfunction, but electrocardiogram did...
Source: Clinical Case Reports - April 25, 2024 Category: General Medicine Authors: Mohamed Kamal Sabra,
Anwar Joudeh,
Mahmoud Al Niserat,
Riyadh Hammamy Tags: CASE REPORT Source Type: research
Thyroid dysfunction in nonvalvular atrial fibrillation and clinical outcomes
ConclusionLow T3 syndrome are linked to an increased risk of heart failure and all-cause death in individuals with NVAF. And Patients with NVAF and low TT3 levels have a higher risk of thromboembolism. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was ...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Ramadan S Hussein Moustafa M Eyada Rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Source Type: research
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was ...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Ramadan S Hussein Moustafa M Eyada Rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Source Type: research
