Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats
This study was designed to evaluate the ther... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 1, 2024 Category: Complementary Medicine Authors: Ragaa SM Kawara, Fatma SM Moawed, Yakout Elsenosi, Hussein Abd Elmaksoud, Esraa S. A. Ahmed and Omayma AR Abo-Zaid Tags: Research Source Type: research
Thyroid Hormone Differentially Regulates Gene Expression in Asthmatic vs Non-Asthmatic Primary Bronchial Epithelium
The thyroid hormone triiodothyronine (T3) has a wide array of effects on gene expression and metabolism in multiple tissue types. Previous studies have suggested a relationship between asthma, chronic rhinosinusitis, and dysregulated T3 levels in circulation, including evidence that hyperthyroidism contributes to status asthmaticus. Further, asthma strongly correlates with obesity, pointing to a possible role for metabolic dysregulation in the pathogenesis of asthma in which T3 signaling may play a role. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: James McAuley, Sergejs Berdnikovs, Lucas Loffredo, Grace Miklaszewski Source Type: research
Maternal thyroid function and free beta human chorionic gonadotrophin level in triploid pregnancies of paternal origin
Introduction and objectives of the study: Triploidy is a frequent life-limiting genetic defect resulting from an extra haploid set of chromosomes. The course of pregnancy is affected by the parental origin of these extra chromosomes. Paternal triploidy is associated with a cystic appearance of placenta and high levels of maternal serum human chorionic gonadotrophin (hCG). As hCG unit can bind to the thyroid stimulating hormone (TSH) receptor, TSH levels are usually below normal values raising suspicion of hyperthyroidism. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Diana Massalska, Ma łgorzata Bińkowska, Julia Bijok, Anna Kucińska-Chahwan, Tomasz Roszkowski, Katarzyna Ozdarska, Janusz Grzegorz Zimowski Source Type: research
The genetics of Graves ’ disease
AbstractGraves ’ disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors account for 60-80% of risk of developing GD. In this review, we collate numerous genetic studies and outline the discoveries over the years, starting with historic candidate gene studies and then exploring more recent genome-wide linkage and association studies, which have involved substantial cohorts of East Asian patients as well as those of European descent. Variants in genes includingHLA,C...
Source: Reviews in Endocrine and Metabolic Disorders - February 1, 2024 Category: Endocrinology Source Type: research
Comparison of pathophysiology in subclinical hyperthyroidism with different etiologies
Endocr J. 2024 Jan 31. doi: 10.1507/endocrj.EJ23-0497. Online ahead of print.ABSTRACTSubclinical hyperthyroidism (SHyper) is defined as normal levels of free thyroxine (fT4) and free triiodothyronine (fT3) with suppressed levels of TSH. Previous studies have reported the individual pathophysiology of endogenous SHyper patients and athyreotic patients receiving TSH suppression therapy with levothyroxine; however, apparently no studies have compared the two conditions. Five-hundred-forty untreated endogenous SHyper patients and 1,024 patients receiving TSH suppression therapy who underwent total thyroidectomy for papillary t...
Source: Endocrine Journal - January 31, 2024 Category: Endocrinology Authors: Hanna Deguchi-Horiuchi Mitsuru Ito Sawako Takahashi Kazuyoshi Kousaka Mako Hisakado Shuji Fukata Takumi Kudo Eijun Nishihara Mitsushige Nishikawa Akira Miyauchi Takashi Akamizu Source Type: research
Association between skeletal muscle and left ventricular mass in patients with hyperthyroidism
ConclusionPatients with hyperthyroidism may exhibit simultaneous decreases in LVM, SMM, and SMI. The LVM in patients is correlated with SMM and hand grip strength, highlighting the need for further exploration of the causal relationship and underlying mechanisms. These findings provide a basis for the prevention and treatment of secondary sarcopenia and cardiac pathology in patients with hyperthyroidism. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 31, 2024 Category: Endocrinology Source Type: research
Association between thymic hyperplasia and serum calcium level in Graves ’ disease
Graves' disease increases bone resorption in hyperthyroidism, leading to elevated serum calcium levels and a negative bone balance. Thymic hyperplasia is observed in some Graves' disease patients. What's more,... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - January 29, 2024 Category: Endocrinology Authors: Jing Zeng, Lan Li and Dong Wei Tags: Research Source Type: research
Thyroid Inflammation and Immunity During the COVID-19 Pandemic: A
Comprehensive Review and Case Study
Horm Metab Res 2024; 56: 111-117 DOI: 10.1055/a-2222-6300The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the development of
various vaccines. Reports have emerged suggesting a possible association between
SARS-CoV-2 vaccination and the onset of thyroid diseases. This review explores
the clinical aspects of thyroid disorders following SARS-CoV-2 vaccination,
including a case report of a patient with concomitant subacute thyroiditis (SAT)
and Graves’ disease (GD) with blocking thyro...
Source: Hormone and Metabolic Research - January 29, 2024 Category: Endocrinology Authors: Lampropoulou, Eleni Benz, Claus Kahaly, George J. F ührer, Dagmar Tags: Review Source Type: research
Factors predicting remission in hyperthyroid patients after low-dose I-131 therapy: 20 years retrospective study from a tertiary care hospital
ConclusionHigh therapeutic outcome was observed with a single dose of LDT while on iodine-free diet. Remission with single dose of LDT occurred in 90% patients by 5th month. Of them 56% patients were treatment naive prior to LDT. LDT is thus a safe and effective therapy in hyperthyroid patients and can be recommended as a primary modality of management. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 26, 2024 Category: Nuclear Medicine Source Type: research
Long-term Outcomes of Combined Revascularization Surgery for Moyamoya Disease in the Elderly: A Single Institute Experience
Neurol Med Chir (Tokyo). 2024 Jan 24. doi: 10.2176/jns-nmc.2023-0219. Online ahead of print.ABSTRACTThe opportunity to treat older patients with Moyamoya disease (MMD) is increasing. However, the surgical outcomes after combined direct and indirect revascularization for elderly patients with MMD are not fully understood, especially for those ≥60 years old. This retrospective study examined 232 consecutive hemispheres of 165 adults with MMD who underwent combined revascularization. Clinical features and surgical outcomes were compared between the elderly (≥60 years) and nonelderly group (<60 years). Thirteen (5.6%, 6...
Source: Neurologia Medico-Chirurgica - January 24, 2024 Category: Neurosurgery Authors: Kota Kurisu Masaki Ito Haruto Uchino Taku Sugiyama Miki Fujimura Source Type: research
Retracting the thyroid matters: Who develops asymptomatic transient thyrotoxicosis after parathyroidectomy
Hyperthyroidism after parathyroidectomy is not a well-understood complication. We sought to determine the incidence and risk factors of hyperthyroidism after parathyroidectomy. (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 24, 2024 Category: Surgery Authors: Rongzhi Wang, Gabe Stidham, Kelly Lovell, Jessica Liu McMullin, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Herbert Chen Tags: Featured Article Source Type: research
Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study
CONCLUSION: Patients with subclinical hyperthyroidism improve both biochemically and in their QoL after RIT, compared to controls. QoL assessment should have a wider role in clinical practice to complement biochemical tests and help with treatment decisions.PMID:38262472 | DOI:10.1055/a-2240-8087 (Source: Nuklearmedizin)
Source: Nuklearmedizin - January 23, 2024 Category: Radiology Authors: Rolf Larisch John E M Midgley Johannes W Dietrich Rudolf Hoermann Source Type: research
Autoimmune Implications in a Patient with Graves' Hyperthyroidism, Pre-eclampsia with Severe Features, and Primary Aldosteronism
Conclusions: This patient manifested severe GD with antibodies undetectable by conventional TSI and TSH receptor assays and accelerated hypertension from PA simultaneously. These conditions were successfully treated separately by spironolactone and thyroidectomy. Autoimmune PA was considered likely given the clinical picture. The diagnosis of PA should be considered in hypertension with GD.PMID:38256430 | PMC:PMC10820415 | DOI:10.3390/medicina60010170 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 23, 2024 Category: Universities & Medical Training Authors: Benjamin Lin Lauren Robinson Basem Soliman Jill Gulizia Stephen Usala Source Type: research
Amiodarone-induced thyrotoxicosis: Should surgery be considered?
Ann Endocrinol (Paris). 2024 Jan 19:S0003-4266(24)00006-4. doi: 10.1016/j.ando.2024.01.006. Online ahead of print.ABSTRACTAmiodarone is the most widely prescribed antiarrhythmic drug worldwide, but induces thyrotoxicosis or hypothyroidism in 15 to 20% of patients. Hyperthyroidism is less frequent than hypothyroidism, and two types of thyrotoxicosis are distinguished according to presence of underlying thyroid disease. Diagnosis is made in case of low TSH and high levels of T3 and T4. Initial treatment is based on anti-thyroid drugs and/or glucocorticoids. Some patients do not respond to medication, which increases the time...
Source: Annales d'Endocrinologie - January 21, 2024 Category: Endocrinology Authors: Samuel Frey C écile Caillard Pascale Mahot Delphine Drui Eric Miralli é Source Type: research
Gamma knife radiosurgery is effective in patients with thyrotropin-secreting pituitary adenomas
ConclusionOur study shows that GKRS is an effective and safe adjuvant treatment for selected patients with residual or recurring TSHoma. The option of GKRS as an alternative treatment to lifelong medical treatment with somatostatin analogs should be thoroughly discussed with the patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 20, 2024 Category: Endocrinology Source Type: research
