Thyroid Hormone Differentially Regulates Gene Expression in Asthmatic vs Non-Asthmatic Primary Bronchial Epithelium

The thyroid hormone triiodothyronine (T3) has a wide array of effects on gene expression and metabolism in multiple tissue types. Previous studies have suggested a relationship between asthma, chronic rhinosinusitis, and dysregulated T3 levels in circulation, including evidence that hyperthyroidism contributes to status asthmaticus. Further, asthma strongly correlates with obesity, pointing to a possible role for metabolic dysregulation in the pathogenesis of asthma in which T3 signaling may play a role.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research