GRADE-ADOLOPMENT of hyperthyroidism treatment guidelines for a Pakistani context
The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate ... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 21, 2024 Category: Endocrinology Authors: Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub and Muhammad Qamar Masood Tags: Research Source Type: research
Is thyroid function associated with polycystic ovary syndrome? A bidirectional Mendelian randomization study
ConclusionAlthough the MR analysis didn ’t indicate genetic causal association between thyroid function and PCOS after Bonferroni correction. Further efforts are needed to interpret the potential causal relationship between thyroid function and PCOS in different age and BMI subgroup. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Unusual imaging findings associated with abdominal pediatric germ cell tumors
AbstractGerm cell tumors of childhood are tumors arising from germline cells in gonadal or extragonadal locations. Extragonadal germ cell tumors are characteristically located in the midline, arising intracranially or in the mediastinum, retroperitoneum, or pelvis. These tumors are generally easily diagnosed due to typical sites of origin, characteristic imaging findings, and laboratory markers. However, germ cell tumors can be associated with unusual clinical syndromes or imaging features that can perplex the radiologist. This review will illustrate atypical imaging/clinical manifestations and complications of abdominal g...
Source: Pediatric Radiology - March 11, 2024 Category: Radiology Source Type: research
Central hyperthyroidism due to an ectopic TSH-secreting pituitary tumor: a case report and literature review
Ectopic thyroid-stimulating hormone (TSH)-secreting tumors are extremely rare, with only 15 reported cases in the literature. Herein, we described a 60-year-old female patient with thyrotoxicosis and elevated or unsuppressed levels of TSH. Family history and laboratory and genetic tests did not support a diagnosis of resistance to thyroid hormone (RTH). Given the unsuppressed TSH, TSH-secreting tumor was suspected, and magnetic resonance imaging (MRI) of the pituitary gland was performed. Surprisingly, the MRI scans revealed a nodule in the nasopharynx rather than a pituitary tumor in the sella region. Further evaluation u...
Source: Frontiers in Endocrinology - March 7, 2024 Category: Endocrinology Source Type: research
Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor
J Immunol Methods. 2024 Mar 4:113655. doi: 10.1016/j.jim.2024.113655. Online ahead of print.ABSTRACTGraves' disease is a type of autoimmune hyperthyroidism caused by thyroid-stimulating antibodies (TSAb).1 The combination of a porcine thyroid cell bioassay and cyclic adenosine monophosphate (cAMP) immunoassay (TSAb-enzyme immunoassay; EIA) is a clinically approved TSAb measurement method. Due to the requirement of multiple procedures and a long assay time of 6 h in the TSAb-EIA, a simplified and rapid assay is desired. Herein, we developed a rapid homogeneous TSAb bioassay (rapid-TSAb assay) using the human embryonic kidne...
Source: Journal of Immunological Methods - March 6, 2024 Category: Allergy & Immunology Authors: Motoki Hoshina Shiomi Ojima Atsushi Kawasaki Kosuke Doi Satoshi Ohta Asuka Inoue Hiroshi Murayama Source Type: research
Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor
J Immunol Methods. 2024 Mar 4:113655. doi: 10.1016/j.jim.2024.113655. Online ahead of print.ABSTRACTGraves' disease is a type of autoimmune hyperthyroidism caused by thyroid-stimulating antibodies (TSAb).1 The combination of a porcine thyroid cell bioassay and cyclic adenosine monophosphate (cAMP) immunoassay (TSAb-enzyme immunoassay; EIA) is a clinically approved TSAb measurement method. Due to the requirement of multiple procedures and a long assay time of 6 h in the TSAb-EIA, a simplified and rapid assay is desired. Herein, we developed a rapid homogeneous TSAb bioassay (rapid-TSAb assay) using the human embryonic kidne...
Source: Journal of Immunological Methods - March 6, 2024 Category: Allergy & Immunology Authors: Motoki Hoshina Shiomi Ojima Atsushi Kawasaki Kosuke Doi Satoshi Ohta Asuka Inoue Hiroshi Murayama Source Type: research
Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor
J Immunol Methods. 2024 Mar 4:113655. doi: 10.1016/j.jim.2024.113655. Online ahead of print.ABSTRACTGraves' disease is a type of autoimmune hyperthyroidism caused by thyroid-stimulating antibodies (TSAb).1 The combination of a porcine thyroid cell bioassay and cyclic adenosine monophosphate (cAMP) immunoassay (TSAb-enzyme immunoassay; EIA) is a clinically approved TSAb measurement method. Due to the requirement of multiple procedures and a long assay time of 6 h in the TSAb-EIA, a simplified and rapid assay is desired. Herein, we developed a rapid homogeneous TSAb bioassay (rapid-TSAb assay) using the human embryonic kidne...
Source: Journal of Immunological Methods - March 6, 2024 Category: Allergy & Immunology Authors: Motoki Hoshina Shiomi Ojima Atsushi Kawasaki Kosuke Doi Satoshi Ohta Asuka Inoue Hiroshi Murayama Source Type: research
Treatment for Hyperthyroidism During Pregnancy
To the Editor Although the recent review of hyperthyroidism by Lee and Pearce was comprehensive, as specialists in maternal-fetal medicine, we have concerns regarding the authors ’ overview of antithyroid medications during pregnancy. (Source: JAMA)
Source: JAMA - March 5, 2024 Category: General Medicine Source Type: research
