Changes in metabolic acidosis following birth in intensive care unit neonates
Acidosis in the fetus-neonate is often measured at the time of delivery from samples of arterial and venous umbilical cord blood. The cord blood arterial pH and base excess (BE) in particular, reflecting the degree of metabolic acidosis present in the fetus just prior to birth, may be used retrospectively to assess the impact of intrapartum events, timeliness of interventions, and prospectively to guide newborn treatment (e.g., therapeutic hypothermia) [1 –3]. Severe acidosis (pH ≤ 7.1 and especially ≤ 7.0) in the umbilical cord artery is commonly used to assess the risk of fetal neurologic injury attributabl...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 20, 2024 Category: OBGYN Authors: Natalie T Simon, Patricia M Hagan, Karilynn M Rockhill, Kent D Heyborne Tags: Full length article Source Type: research

How does maternal anemia affect the levels of umb ılıcal cord braın-derıved neurotrophıc factor?
Iron deficiency anemia affects billions of people worldwide, and without anemia, iron deficiency is even the most common nutritional deficiency [1,2] Anemia is a global health problem which children and pregnant women throughout the world. World Health Organization estimates that 42% of children who are younger than 5 years of age and 40% of pregnant women have anemia [1]. Enlargement of the maternal red blood cell mass during pregnancy and the Growing placenta and the fetus triples the amount of iron needed [2]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 18, 2024 Category: OBGYN Authors: G ökçe İpek Aytok, Asuman Akkaya Fırat, İlke Mungan Akın, Ayşegül Özel Tags: Full length article Source Type: research

Evaluation of serum CA125, HE4 and CA724 and the risk of ovarian malignancy algorithm score in the diagnosis of high-grade serous ovarian cancer
Over the last 20  years, there has been a continuous increase in the number of cases of ovarian cancer, which is the most lethal gynaecological cancer. In 2020, there were approximately 300,000 new cases and 200,000 deaths worldwide due to ovarian cancer [1]. High-grade serous ovarian cancer (HGSOC) is the most co mmon and aggressive form, and is often found as distant metastasis at the time of initial diagnosis due to the lack of specific symptoms [2]. Compared with other histological types, HGSOC exhibits a higher tendency to recur and develop resistance to chemotherapy within 2 years of diagnosis [3]. (Source: Europ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 18, 2024 Category: OBGYN Authors: Deyu Hu, Jun Qian, Fenghua Yin, Bing Wei, Jiayu Wang, Huijuan Zhang, Haiou Yang Tags: Full length article Source Type: research

Meta-analysis of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer
Cervical cancer is one of the most common gynaecological malignancies, and although the level of screening and early prevention of cervical cancer has improved considerably in recent years, cervical cancer remains an important malignancy threatening women's health [1]. The current incidence of cervical cancer in China poses a serious challenge [2]. Traditional surgery is controversial for patients with cervical cancer of stage IIb and above [3]. However, neither improvements in surgical techniques and methods nor advances in radiotherapy equipment and techniques have significantly improved cervical cancer survival rates fo...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 18, 2024 Category: OBGYN Authors: Daying Wang, Xiuli Fang Tags: Review article Source Type: research

Should we should consider day 3 blastomere number during single vitrified-warmed blastocyst transfer cycle? A retrospective study
The success of frozen-warmed transfer cycles has improved markedly with the emergence of vitrification (VIT). Reportedly, vitrified-warmed embryos/blastocysts transfer cycles achieve equivalent or higher clinical outcomes than fresh embryos/blastocysts transfer cycles [1,2]. Furthermore, assisted reproductive technology (ART) centers worldwide utilizes single vitrified-warmed blastocyst transfer to obtain a single healthy baby. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 17, 2024 Category: OBGYN Authors: Haisu Zhou, Lianmin Ye, Huan Zhang, Yi Zheng, Wumin Jin Tags: Full length article Source Type: research

Saliva-based microRNA diagnostic signature for the superficial peritoneal endometriosis phenotype
Patients with superficial peritoneal endometriosis (SPE) present with symptoms suggestive of endometriosis but clinical and imaging exams are inconclusive. Consequently, laparoscopy is usually necessary to confirm diagnosis. The present study aimed to evaluate the accuracy of microRNAs (miRNAs) to diagnose patients with SPE from the ENDOmiARN cohort (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 17, 2024 Category: OBGYN Authors: Sofiane Bendifallah, Yohann Dabi, St éphane Suisse, Johanna Ilic, Léa Delbos, Mathieu Poilblanc, Philippe Descamps, Francois Golfier, Ludmila Jornea, Delphine Bouteiller, Cyril Touboul, Anne Puchar, Emile Daraï Tags: Full length article Source Type: research

Inside Back Cover - Editors with images
(Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 16, 2024 Category: OBGYN Source Type: research

Prenatal diagnosis and outcomes for fetuses with suspected pelvic kidney
Pelvic kidney is a form of renal ectopia, occurring with a frequency of 1 in 900 live births [1]. The pelvic kidneys are located in the presacral region, below the aortic bifurcation. Pelvic region localization is due to a lack of elevation of the kidneys in the early embryonic period [2]. The pelvic kidneys were malrotated and their hiluses were displaced anteriorly. Ultrasonographic diagnosis of the pelvic kidney is difficult due to the shadow of the pelvic iliac crests and intestines. The anterior position of the hilum, horizontal placement of the kidney, and smaller size of the kidney make diagnosis more difficult. (So...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 15, 2024 Category: OBGYN Authors: Refaettin Sahin, Atakan Tanacan, Hakki Serbetci, Osman Onur Ozkavak, Murat Haksever, Alperen Simsek, Ozgur Kara, Dilek Sahin Tags: Full length article Source Type: research

Perinatal Science International: a new meeting of the European Association of Perinatal Medicine
Over March 7-9th 2024, a group of around 42 academics, clinicians, basic scientists, and policymakers with an interest in perinatal medicine came together on the historic island of San Servolo in the Venetian lagoon, for the first meeting of Perinatal Science International. Here we describe the genesis of Perinatal Science International, the rationale for its establishment, insights that emerged at the initial meeting, and our ambitions for future editions. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 15, 2024 Category: OBGYN Authors: Neena Modi, Bo Jacobsson, Diogo Ayres de Campos, K. Beardsall, J.P. Boardman, Y.S. Chong, V. Cornelius, G. Ekman-Ordeberg, L. Fabbri, S. Kumar, T. Lavin, C. Lees, R. Luengo-Fernandez, R. Menon, V. Niklas, E. Schleussner, O. Simetka, W. Tarnow-Mordi, M. Tu Tags: Short communication Source Type: research

Vaginal foreign body in the pediatric patient: A systematic review
Vaginal foreign objects represent a clinical and diagnostical challenge in pediatric gynecology, necessitating a thorough understanding of their clinical presentation and optimal management. Several case reports, case series and retrospective studies have been published, highlighting rare or complex cases. A recent narrative review that included patients with a self-inserted object up to the age of 20, presented an overview of 40 recent cases [1]. However, a comprehensive systematic review of literature is lacking. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 15, 2024 Category: OBGYN Authors: E. Umans, M. Boogaerts, B. Vergauwe, A. Verest, S. Van Calenbergh Tags: Review article Source Type: research

Effectiveness and safety of fezolinetant in alleviating vasomotor symptoms linked to Menopause.: A systematic review and Meta-Analysis
Menopause defined as the permanent cessation of ovarian function in women that occurs on average between the ages of 45 and 55  years is not a health condition [1]. It is a normal transition that most females naturally go through during their life and could be induced medically through chemotherapy interventions or surgically by bilateral oophorectomy [2,3]. The average age of menopause in the United States is between 51 and 52. Menopause occurs in approximately 5 % of women by the age of 45 while the majority will have completed their menstrual cycles by the time they reach age 60 [4]. (Source: European Journal of Obs...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 13, 2024 Category: OBGYN Authors: Ahmed A. Abo Elnaga, Mohamed A. Alsaied, Abdelrahman M. Elettreby, Alaa Ramadan Tags: Full length article Source Type: research

Transvaginal ultrasound with bowel preparation versus transvaginal ultrasound with bowel preparation and water contrast for diagnosing Recto-Sigmoid endometriosis. A systematic review and Meta-Analysis
Transvaginal ultrasound is effective in diagnosing endometriosis involving the rectosigmoid bowel. Some authors suggest enhanced detection of rectosigmoid involvement with bowel preparation. Conversely, conflicting views argue that bowel preparation may not improve diagnostic precision, yielding similar results to rectal water contrast. No existing meta-analysis compares these approaches. Our study aims to conduct a meta-analysis to evaluate the diagnostic performance of transvaginal ultrasound with bowel preparation, with and without rectal water contrast. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 11, 2024 Category: OBGYN Authors: Sara Madaruelo, Elena Satorres, Teresa Arruffat, Mariana Louren ço, Blanca Novillo-Del Álamo, Stefano Guerriero, Juan Luis Alcazar Tags: Review article Source Type: research

Endocan: A biomarker for endothelial dysfunction and inflammation, linking maternal obesity and pediatric obesity in a cohort of preterm neonates
The prevalence of obesity in reproductive aged women in the United States is approaching 40  %, and is thus the most common risk factor for pregnancy complications [1,2]. It has been well established that maternal obesity in pregnancy is associated with increased risks for the mother and the neonate. Maternal risks include gestational diabetes, preeclampsia, sleep apnea, cesarean section , venous thromboembolism, wound dehiscence, and epidural anesthesia failure [2,3]. Fetal and neonatal risks include congenital anomalies, difficulty in ultrasonographic diagnosis of anomalies, increased likelihood of cell free fetal DNA ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 11, 2024 Category: OBGYN Authors: E. Holthaus, M. O'Neill, W. Jeske, P. DeChristopher, J. Goodman, L. Glynn, S. Levin, J. Muraskas Tags: Full length article Source Type: research

Successful management of fetal hypoxia due to amniotic banding at 26 weeks of pregnancy: A case report of a rare survival
Amniotic banding is a rare condition that can lead to structural limb anomalies, fetal distress and adverse obstetric outcomes. The main hypothesis for its etiology is a rupture of the amniotic membrane in early pregnancy, with the formation of tightly entangling strands around the fetus. These strands can constrict, incise, and subsequently amputate limb parts, the neck or head. More rarely, the amniotic banding can affect the umbilical cord, leading to fetal distress or potential intra-uterine fetal demise (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 11, 2024 Category: OBGYN Authors: Florian Waerlop, Isabelle Dehaene, Kristien Roelens Source Type: research

Brief Communication: A case report of dilation and evacuation for cephalopagus conjoined twin pregnancy at 22 weeks
We recently encountered an interesting case of a 24  year old gravida 1 para 0 patient who presented with known cephalopagus conjoined twins at 22 weeks 1 day gestational age desiring dilation and evacuation (D&E) for termination of pregnancy. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 10, 2024 Category: OBGYN Authors: Megan Masten, Paige Kendall, Rebecca Cohen Source Type: research